• Journal of the Korean Society for Aeronautical & Space Sciences
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• v.46 no.12
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• pp.986-993
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• 2018

Lateral thrust jet has better maneuverability performance than the control surface like the conventional fin for attitude control or orbital transition of guided weapons. However, in the supersonic region, a jet interaction flow occurs due to the lateral thrust jet during flight, and a complicated flow structure is exhibited by the interaction of the shock wave, boundary layer flow, and the vortex flow. Especially, hit-to-kill interceptors require precise control and maneuvering, so it is necessary to analyze the effect of jet interaction flow. Conventional jet interaction analyses were performed under low altitude conditions, but there are not many cases in the case of medium altitude condition, which has different flow characteristics. In this study, jet interaction flow analysis is performed on the lateral jet controlled interceptor operating at medium altitude. Based on the results, the structural characteristics of the flow field and the changes of aerodynamic coefficient are analyzed.

• Publications of The Korean Astronomical Society
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• v.12 no.1
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• pp.173-183
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• 1997

We have numerically simulated the evolution of supernova remnant VRO 42.05.01(G166.0+43) in order to understand its morphology m radio and X-ray observations as well as the dynamical interaction of the supernova remnant with the surrounding interstellar medium. The Radio and ROSAT observations suggest that the unusual morphology of VRO 42.05.01 is caused by a supernova blast wave breaking out of the cloud boundary where the supernova event occurred, and expanding into another cloud across a much less dense and presumably hot cavity. Our numerical results are consistent with the interactions of a passing supernova blast wave with the clouds across the cavity. We discuss the implications of our results on the dynamics of VRO 42.05.01 such as the reverse shocks, the rejuvenation of the hot cavity, and the reflected shocks formed by the reverse shock collisions. We have theoretically mapped the radio continuum(1.4 GHz) and X-ray(0.1~2 keV) morphology which are consistent with the observational ones.

• BMB Reports
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• v.49 no.6
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• pp.337-343
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• 2016

Understanding of trafficking, processing, and degradation mechanisms of amyloid precursor protein (APP) is important because APP can be processed to produce β-amyloid (Aβ), a key pathogenic molecule in Alzheimer's disease (AD). Here, we found that APP contains KFERQ motif at its C-terminus, a consensus sequence for chaperone-mediated autophagy (CMA) or microautophagy which are another types of autophagy for degradation of pathogenic molecules in neurodegenerative diseases. Deletion of KFERQ in APP increased C-terminal fragments (CTFs) and secreted N-terminal fragments of APP and kept it away from lysosomes. KFERQ deletion did not abolish the interaction of APP or its cleaved products with heat shock cognate protein 70 (Hsc70), a protein necessary for CMA or microautophagy. These findings suggest that KFERQ motif is important for normal processing and degradation of APP to preclude the accumulation of APP-CTFs although it may not be important for CMA or microautophagy.

• International Journal of Oral Biology
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• v.37 no.3
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• pp.130-136
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• 2012

The GroEL heat-shock protein from Fusobacterium nucleatum, a periodontopathogen, activates risk factors for atherosclerosis in human microvascular endothelial cells (HMEC-1) and ApoE-/- mice. In this study, we analyzed the signaling pathways by which F. nucleatum GroEL induces the proinflammatory factors in HMEC-1 cells known to be risk factors associated with the development of atherosclerosis and identified the cellular receptor used by GroEL. The MAPK and NF-${\kappa}B$ signaling pathways were found to be activated by GroEL to induce the expression of interleukin-8 (IL-8), monocyte chemoattractant protein 1 (MCP-1), intercellular adhesion molecule 1 (ICAM-1), vascular cell adhesion molecule 1 (VCAM-1), E-selectin, and tissue factor (TF). These effects were inhibited by a TLR4 knockdown. Our results thus indicate that TLR4 is a key receptor that mediates the interaction of F. nucleatum GroEL with HMEC-1 cells and subsequently induces an inflammatory response via the MAPK and NF-${\kappa}B$ pathways.

• Interaction and multiscale mechanics
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• v.1 no.2
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• pp.251-278
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• 2008

In this study, we investigate the discontinuous-derivative treatment at the gas-liquid interface in underwater explosion (UNDEX) problems by using the Moving Least Squares-Smoothed Particle Hydrodynamics (MLS-SPH) method, which is known as one of the particle methods suitable for problems where large deformation and inhomogeneity occur in the whole domain. Because the numerical oscillation of pressure arises from derivative discontinuity in the UNDEX analysis using the standard SPH method, the MLS shape function with Discontinuous-derivative Basis Function (DBF) that is able to represent the derivative discontinuity of field function is utilized in the MLS-SPH formulation in order to suppress the nonphysical pressure oscillation. The effectiveness of the MLS-SPH with DBF is demonstrated in comparison with the standard SPH and conventional MLS-SPH though a shock tube problem and benchmark standard problems of UNDEX of a trinitrotoluene (TNT) charge.

• Journal of the Korean Society of Propulsion Engineers
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• v.5 no.2
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• pp.8-15
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• 2001

In the continuing quest for increased turbomachinery efficiency, the part played by blade profile shape remains crucial. The application of a heated thin metallic film with CTA(constant temperature anemometer) to the measurements of the laminar and turbulent boundary layer behavior(shock-boundary layer-interaction) in a transonic wind tunnel. Results of measurements with hot-film sensors on transonic compressor blades are extremely difficult to interpret because of ambiguous probe signals due to the complexity of the local flow pattern. In order to get the explicit information and give the designer to interpret characteristic signals from hot-film probes, a method was developed by comparing the results with other measuring technic results.

• The Bulletin of The Korean Astronomical Society
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• v.38 no.2
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• pp.40.1-40.1
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• 2013

We perform a set of N-body/SPH simulations of galaxy interactions between early- and late-type galaxies with the mass ratio of 2 to 1. We show that mass transfer during a fly by interaction (the closest approach distance ~50kpc) can cause the morphology transformation of an early-type galaxy to a late type. In our simulations, we vary the orbital parameters of the interactions and the cold gas fraction of the late-type galaxy to compare how the morphology transformation is affected by the amount of mass transfer and orbital angular momentum of cold gas accreted to the early type. We also include hot halo gas in the galaxy models and show the location of the tidal bridge can be influenced by the shock generated during the collision.

• Journal of Mechanical Science and Technology
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• v.17 no.11
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• pp.1784-1792
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• 2003

A hybrid method with supercompact multiwavelets is suggested as an efficient and practical method to compress CFD dataset. Supercompact multiwavelets provide various advantages such as compact support and orthogonality in CFD data compression. The compactness is a crucial condition for approximated representation of CFD data to avoid unnecessary interaction between remotely spaced data across various singularities such as shock and vortices. But the supercompact multiwavelet method has to fit the CFD grid size to a product of integer and power of two, m${\times}$2$^n$. To resolve this problem, the hybrid method with combination of 3, 2 and 1 dimensional version of wavelets is studied. With the hybrid method, any arbitrary size can be handled without any shrinkage or expansion of the original problem. The presented method allows high data compression ratio for fluid simulation data. Several numerical tests substantiate large data compression ratios for flow field simulation successfully.

• Proceedings of the Korean Society of Propulsion Engineers Conference
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• 2009.11a
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• pp.3-8
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• 2009

Wall flush mounted injector with various orifice shape and injection conditions, were examined to enhance jet penetration and mixing in supersonic cross flow, in view of application to air-breathing accelerator vehicle. Orifice shapes with high aspect ratio were found to preferable for better penetration in the cold flow, and in the reacting flow for scramjet-mode combustion conditions. However, the effectiveness of the high aspect ratio was diminished in the dual-mode combustion conditions. Supersonic injection was applied to the high aspect ratio orifice, and further increase in penetration was observed in the cold and reactive flow for scramjet-mode combustion conditions, however, mixing enhancement due to mixing layer / pseudo-shock wave system interaction was dominant in the dual-mode combustion conditions. Difficulty in attaining ignition in the case with the high aspect ratio orifice was encountered during the combustion tests.

• 유체기계공업학회:학술대회논문집
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• 2006.08a
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• pp.423-426
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• 2006

An analysis is made of flow and rocket motion during a supersonic separation stage of air-launching rocket(ALR) from the mother plane. Three-dimensional compressible Navier-Stokes equations is numerically solved to analyze the steady/unsteady flow field around the rocket which is being separated from the mother plane configuration(F-4E Phantom). The simulation results clearly demonstrate the effect of shock-expansion wave interaction between the rocket and the mother plane. To predict the behavior of the ALR according to the change of the C.G., three cases of numerical analysis are performed. As a result, a design-guideline of supersonic air-launching rocket for the safe separation is proposed.