• International Journal of Vascular Biomedical Engineering
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• v.4 no.2
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• pp.7-12
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• 2006

The present study investigated the effects of the osmotic environment on the rheological properties of erythrocytes and their suspensions. In an iso-osmotic medium, erythrocytes forming a biconcave discocyte under resting conditions, exhibited high deformability. In a low-osmotic medium, the deformability of erythrocytes, which swelled and exhibited a spherical shape, significantly decreased at a high shear stress and the high-shear viscosity of the cell suspension was slightly higher than that of normal blood. Hyper-osmotic stress, however, which caused to form echinocytes, decreased cell deformability but exhibited smaller viscosity in low shear rates than iso-osmotic blood viscosity. These results showed a close relation with the aggregability measurements, in that hypertonic blood showed lower aggregability than the hypotonic and isotonic RBC suspensions. These findings indicate that the physicochemical environment has a strong influence on the rheological properties of the erythrocyte and its suspensions.

• Journal of Power System Engineering
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• v.5 no.1
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• pp.80-88
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• 2001

The spot welding method has been used in the joining of structures, automotive body, railway carriage, aircraft, household electric appliances, precision parts etc., because of brief working, easy automation, available mass production, and convenience. In this paper, the effects of welding conditions on the fatigue life and the prediction of fatigue life based on fracture mechanics theory of spot welded joint were investigated. Fatigue tests were conducted with the tensile-shear specimens welded in the various current using cold rolled steel sheets. Fatigue life of spot welded joint was predicted and compared with experimental results. Using FEM(finite element method), we analysed the distribution of stress and the condition of deformation on the environments of nugget.

• Proceedings of the Korean Society for Technology of Plasticity Conference
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• 2004.10a
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• pp.93-96
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• 2004

This paper presents a study on defects in pearlite lamella structure of high carbon steel by means of finite-element method(FEM) simulation. High-carbon pearlite steel wire is characterized by its nano-sized microstructure feature of alternation ferrite and cementite. The likely fatigue crack is located on interface of the lamella structure where the maximum amplitude of the longitudinal shear stress and transverse shear stress was calculated during cyclic loading. The FEM is proposed for maximum shear stress from loading of lamella structure, and a method is predicted to analyze the likely fatigue crack generation. It is possible to obtain the important basic data which can be guaranteed in the ductility of high carbon steel wire by using FEM simulation.

• Molecules and Cells
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• v.37 no.6
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• pp.435-440
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• 2014

Hemodynamic shear stress, the frictional force acting on vascular endothelial cells, is crucial for endothelial homeostasis under normal physiological conditions. When discussing blood flow effects on various forms of endothelial (dys)function, one considers two flow patterns: steady laminar flow and disturbed flow because endothelial cells respond differently to these flow types both in vivo and in vitro. Laminar flow which exerts steady laminar shear stress is atheroprotective while disturbed flow creates an atheroprone environment. Emerging evidence has provided new insights into the cellular mechanisms of flowdependent regulation of vascular function that leads to cardiovascular events such as atherosclerosis, atherothrombosis, and myocardial infarction. In order to study effects of shear stress and different types of flow, various models have been used. In this review, we will summarize our current views on how disturbed flow-mediated signaling pathways are involved in the development of atherosclerosis.

• Proceedings of the KSR Conference
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• 2001.05a
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• pp.249-256
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• 2001

This study investigated the shear stiffness of level of small strain with time effect. Time effect consists of rest time, loading rate of recent and current stress path. In addition, for the measurement of small strain, overconsolidated state was represented in a triaxial cell, and drained stress path tests were carried out. Test results show that the loading rate of recent stress path has no effects on the stiffness of very small strain, but the shear stiffness of level of small strain increases with it. Finally, the rest time and the loading rate of current stress path have the effects on the shear stiffness of initial and small strain.

• 한국전산유체공학회:학술대회논문집
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• 2003.08a
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• pp.206-211
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• 2003

This paper reports the numerical results for blood flow of the sac squeezed by moving actuator in the TPLS(Twin Pulse Life Support System). Blood flow in the sac is assumed to be 3-dimensional unsteady newtonian fluid. where the blood flow interacts with the sac, which is activated by the moving actuator. The flow field is simulated numerically by using the FEM code, ADINA. It is well known that hemolysis is closely related to shear stress acted on blood flow. According to this fact, we simulate four models with different speed for moving actuator and examine the distribution of shear stress for each model. Numerical results show that maximum shear stress is strongly dependent on the actuator speed.

• Proceedings of the Korean Society of Machine Tool Engineers Conference
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• 2005.05a
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• pp.3-8
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• 2005

We introduced mechanical stimuli and micropatterned substrate with micro fibers to investigate the effects of those on neurite outgrowth along with nerve growth factor (NGF) in vitro. Microfiber substrates were fabricated using an electrospinning process. And PC-12 cells cultured on substrates were simulated with nerver growth factor and laminar flow shear stress in a fluid flow system The results suggest that microfiber substrates and fluid-induced shear stress are promising for simulating neuronal regeneration in a desired direction.

• Transactions of the Korean Society of Mechanical Engineers B
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• v.22 no.7
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• pp.992-1000
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• 1998

In the present study the behavior of laminar-wavy film flowing down a vertical plate was studied analytically. The effects of film Reynolds number and interfacial shear stress on the mean film thickness, wave amplitude, wave length, and wave celerity were analysed. The anayltical results on the periodic-wave falling film showed good agreements with experimental data for Re < 100. As the film Reynolds number increased, mean film thickness, wave amplitude, and wave celerity increased, but wave length decreased. Depending on the direction of interfacial shear stress, the shape of wavy interface was disturbed significantly, especially for the intermediate-wave. As the interfacial shear stress increased, for the periodic-wave film, wave amplitude and wave celerity increased, but mean film thickness and wave length decreased.

• Smart Structures and Systems
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• v.7 no.4
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• pp.289-302
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• 2011

In marine clay deposits, naturally formed or artificially reclaimed, the evaluation and monitoring of the consolidation process has been a critical issue in civil engineering practices due to the time frame required for completing the consolidation process, which range from several days to several years. While complementing the conventional iconographic method suggested by Casagrande and recently developed in-situ techniques that measure the shear wave, this study suggests an alternative experimental procedure that can be used to evaluate the consolidation state of marine clay deposits using the shear wave velocity. A laboratory consolidation testing apparatus was implemented with bimorph-type piezoelectric bender elements to determine the effective stress-shear wave velocity (${\sigma}^{\prime}-V_s$) relationship with the marine clays of interest. The in-situ consolidation state was then evaluated by comparing the in-situ shear wave velocity data with the effective stress-shear wave velocity relationships obtained from laboratory experiments. The suggested methodology was applied and verified at three different sites in South Korea, i.e., a foreshore site in Incheon, a submarine deposit in Busan, and an estuary delta deposit in Busan. It is found that the shear wave-based experimental procedure presented in this paper can be effectively and reliably used to evaluate the consolidation state of marine clay deposits.

• Geomechanics and Engineering
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• v.35 no.5
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• pp.475-486
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• 2023

Ballast particles have an irregular shape and are discrete in nature. Due to the discrete nature of ballast, it exhibits complex mechanical behaviour under loading conditions. The discrete element method (DEM) can model the behaviour of discrete particles under a multitude of loading conditions. DEM is used in this paper to simulate a series of three-dimensional direct shear tests in order to investigate the shear behaviour of railway ballast and its interaction at the microscopic level. Particle flow code in three dimension (PFC3D) models the irregular shape of ballast particles as clump particles. To investigate the influence of particle size distribution (PSD), real PSD of Indian railway ballast specification IRS:GE:1:2004, China high-speed rail (HSR) and French rail specifications are generated. PFC3D built-in linear contact model is used to simulate the interaction of ballast particles under various normal stresses, shearing rate and shear box sizes. The results indicate how shear resistance and volumetric changes in ballast assembly are affected by normal stress, shearing rate, PSD and shear box size. In addition to macroscopic behaviour, DEM represents the microscopic behaviour of ballast particles in the form of particle displacement at different stages of the shearing process.