• 동아시아식생활학회지
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• 제14권5호
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• pp.407-417
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• 2004

This study was conducted to investigate the application possibility of leaf and stem extract(LSE) extracted from the mixture of leaf and stem of ginseng radix(Panax ginseng CA. Meyer). This study measured the intake levels and efficiency ratio, growth rate, absorption ratio of carbohydrate, lipid and protein of rat by feeding with LSE during 6 weeks. We analyse the hematological and serum metabolic variables, serum lipid concentrations. Total diet and protein intake levels were low, but efficiency ratios were significantly high in LSE administered groups than the control group. Weight gain, liver and kidney weight of LSE groups were significantly higher than the control group. Blood RBC, Hct, Hb, total protein and albumin concentrations were reasonable levels in LSE administered groups compared to the basal diet group. Also serum total cholesterol, LDL-cholesterol, triglyceride contents of LSE groups were low, but HDL-cholesterol level was higher than the basal diet group. These results imply that leaf and stem of ginseng radix could be used as possible food resources, functional food material and feed stuff.

• Journal of Nutrition and Health
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• 제17권2호
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• pp.137-144
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• 1984

Due to the fact that blood gathering is not readily accepted by people, it has been difficult to make a full-scale study on zinc through blood analysis. For that reason, in this paper, a correlation of zinc contents in serum and hair was studied to find out whether only hair, which is relatively easy to collect, can be used for a measurement of zinc content. The subjects were 47 healthy female collegians selected at random whose average age was 22, mean height 159.1cm and average weight 49.7kg. The mean zinc value in serum of subjects was ${107.1}\pm{29.0}{\mu}g{/100ml}$, while the mean value in hair was ${150.2}\pm{42.7}ppm$. Correlation analysis shows that there was a significant correlation in zinc contents of serum and hair ( p<0.01). The results shows that measuring zinc level by using only hair samples would be satisfactory. But the use of hair sample for a measurement of zinc level has one demerit. That is, the method is more likely to be subjected to contamination because it makes more complicated procedures in sample preparation than the method of using blood sample.

• 생명과학회지
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• 제23권11호
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• pp.1371-1380
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• 2013

Monascus purpureus 균주에 의해 발효된 당귀분말을 식이 중에 5% 수준으로 첨가하여 30% 알코올과 함께 4주간 흰쥐에 급여한 후 혈중 지질 농도 및 조직 내 산화 스트레스에 미치는 영향에 대하여 검토하였다. 혈중 중성지질 농도 및 유리 지방산 농도는 알코올 대조군(Alc)에서의 증가가 알코올 실험군에서 모두 감소하였고, 특히 발효당귀군(AFAG)에서 낮은 감소수치를 보였다. 혈중 총 콜레스테롤 농도는 전반적으로 유의적인 차이는 없었으나, HDL-cholesterol 농도에서 발효당귀군(AFAG)이 증가수치를 나타내었다. 간장, 심장, 비장,신장, 고환 및 혈청에서 생체막 과산화지질 생성 정도는 정상군(N)에 비해 알코올 대조군(Alc)에서 유의적으로 증가하였고, 이러한 증가는 발효당귀군(AFAG)과 양성 대조군(ASM)에서 정상 수준으로 회복되었다. 간 조직 내 내인성 항산화 물질인 glutathione 농도는 알코올 대조군(Alc)에서 유의적으로 감소하였고, 발효당귀군(AFAG)에서 유의적으로 증가하여, 과산화 지질 생성정도와 glutathione 농도는 유의적인 차이가 인정되었다. 이상의 실험결과 발효당귀는 알코올 투여 동물실험에서 혈중 지질 개선효과는 물론 조직 내 항산화 활성증가로 산화스트레스를 경감시키는 효능이 있는 것으로 사료되며, 향후 간 독성 개선에 효능을 가지는 건강식품 개발 가능성이 높은 소재로 판단되어진다.

• Journal of Nutrition and Health
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• 제20권1호
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• pp.38-45
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• 1987

This study was performed to investigate the effect of dietary vitamin E supplement and kinds of lipid on the vitamin E concentration and lipid composition in serum of the rats fed fro seven weeks. Supplemented vitamin E was 300mg/kg diet as DL-α-tocopherol acetate, and 15% of corn oil or beef tallow was added to standard diet. The results were as follows ; 1) Body weight and feed efficiency ratio were significantly increased by supplement with vitamin E, corn oil and beef tallow. 2) Serum vitamin E concentration increased significantly by supplement of vitamin E and beef tallow on the diets, while one of corn oil fed group decreased significantly . 3) The contents of triglyceride, total cholesterol, phospholipid in serum were significantly increased in the beef tallow group, and the vitamin E only -supplemented group showed significantly lower serum cholesterol in serum increased significantly in the vitamin E only -fed group and vitamin E plus corn oil-fed group. 4) The content of HDL-cholesterol in serum increased significantly in the vitamin E only -fed group and vitmain e plus corn oil -fed group. 5) The ratio of VLDL, LDL-cholesterol content to HDL-cholesterol one in serum was significantly low in the vitamin E only-supplemented group and corn oil group, and was significantly higher in the beef tallow group than in the corn oil group.

• 한국응용과학기술학회지
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• 제3권2호
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• pp.49-64
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• 1986

This experiment is carried out to study effect of choline-deficient diet on serum and liver lipid contents of male rats. The experimental animals use 36 male Sprague-Dawley rats weighing about $100{\pm}3g$. They are classified into 7 groups and fed to experimental diets which are composed of 0.8% choline-supplement of deficient diets in addition to 14% corn oil, 14% corn margarine and 14% lipids mixed with 4% corn oil and 10% corn margarine, respectively. After feeding for 4 weeks, I measure lipid concentration of serum and liver, and the result are as follows. 1. The choline-deficient diet group decreases slightly the rates of weight gain and feed efficiency as compared with those of the choline-supplement diet group, but increases liver weight. 2. The choline-dificient diet group decreases the serum concentrations of total cholesterol (TC), free cholesterol, HDL-choelsterol, VLDL, LDL-cholesterol and phospholipid (PL), but increases the contents of triglyceride and the ratios of cholesterol/HDL-cholesterol and triglyceride/PL, and indicates no remarkable-difference in the ratio of TC/PL. 3. As compared with the choline-supplement diet group, the choline-deficient diet group contains the higher liver contents of total lipids, free cholesterol and triglyceride, and gives little difference in the liver contents of total cholesterol and phospholipid(PL), and presents the higher ratios of VLDL, LDL-cholesterol/HDL-cholesterol and TG/PL in the liver.4. In the choline-deficient diet group, the coutents of serum and liver lipid is not influenced by the kind of dietary fat. On the other hand, the choline-supplemented diet group indicates a significantly lower content of phospholipid in the corn margarine-added diet group than in the corn oil-added diet group. As aforementioned results, I think that the choline-deficient diet induces fatty liver in male rats without relation to kind of fatty acid, and cholines-upplement diet with saturated fatty acid makes the more decrease of liver phospholipid than that with polyunsaturated fatty acid.

• 생명과학회지
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• 제18권12호
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• pp.1739-1744
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• 2008

본 연구는 50 mg/kg의 STZ로 유발된 당뇨쥐에서 단기간 운동과 capsaicin 섭취가 혈중지질, 항산화 효소 및 Akt량에 미치는 영향을 알아보고자 31마리의 흰쥐를 대상으로 실험 하였다. 운동 군과 운동과 capsaicin을 병행한 군에서는 당뇨 유발 일주일 후 부터 15 m/min, 0%의 경사도로 25분간 주5회 2주간 트레드밀 운동을 실시하여 다음과 같은 결과를 얻었다. 혈중 지질 농도는 capsaicin 섭취와 운동을 병행한 군에서 TG는 유의하게 감소하였고, HDL-C는 다른 군에 비해 유의하게 높게 나타났고, ROS는 당뇨군을 제외한 모든 군에서 유의하게 감소하였다. CAT는 capsaicin만 섭취한 군에서 유의하게 증가하였고, SOD은 운동만 처치한 군과 capsaicin만 섭취한 군에서 유의하게 높았으며, GSH는 당뇨군을 제외한 모든 군에서 유의하게 높은 것으로 각각 나타났다. Akt효소는 capsaicin만 섭취한 군, p-Akt는 운동군에서 유의하게 증가하였다.

• Journal of Nutrition and Health
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• 제27권1호
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• pp.90-99
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• 1994

This study was carried out to examine how dietary protein and calcium levels in rats fed fat-enriched diet affect the total lipid and cholesterol contents of blood and tissues. Male Sprauge-Dawley rats weighing approximately 200g were fed six purified diets which contained 18%(w/w) beef tallow, 1% (w/w) cholesterol, two source of protein, casein or isolated soy protein (ISP) and three levels of dietary calcium, 0.1%, 0.4% and 1.0%, first, for four weeks, and second, for eight weeks. The contents of the total lipid, cholesterol and triglyceride in blood, liver, heart and feces were determined. After four weeks feeding serum lipid and cholesterol concentrations significantly decreased in rats fed 1.0% (w/w) level calcium, regardless of dietrary protein sources. After eight weeks, these concentrations were significantly lower in the rats fed soy protein than in casein-fed rats. As dietary calcium level increased serum and tissue lipid and cholesterol contents were decreased and fecal lipid excretion increased. It is concluded that hypolipidemic and/or hypocholesterolemic effects of soy protein and calcium were partly due to decrease in lipid absorption.

• 대한가정학회지
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• 제42권10호
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• pp.143-152
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• 2004

This study presents the effects of serum lipids and blood glucose on retort Samgyetang intake in rats. For this purpose, we measured the ingredients and contents of Samgyetang, and produced a diet for experimental rats. The animal experiment was done in three different diet groups: control, Samgyetang(I) and Samgyetang(II). The results were as follows; 1) There was no sign of difference between the three groups in the body weight gain and food intake due to the effect of dietary component. 2) The density of serum triglyceride in the Samgyetang(II) group was decreased, but there was no sign of difference between the control group and Samgyetang(II). 3) There were no statistically significant differences of serum cholesterol and phospholipid among my of the diet groups. 4) The free fatty acid density and blood glucose level in the Samgyetang(I) and (II) groups were higher than in the control group. In the author's opinion, it is necessary to reexamine them for a long period through the animal experiment.

• 대한한의학회지
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• 제25권2호
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• pp.22-32
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• 2004

Objectives: In order to determine the effect of CPs, experimental studies were performed in hyperlipidemia humans. The contents of serum total cholesterol, TG (triglyceride), LDL cholesterol, HDL cholesterol, AST/ALT and BUN/creatinine were measured. Methods: We made a comparative study of total cholesterol, TG (triglyceride), LDL cholesterol, HDL cholesterol, AST/ALT and BUN/creatinine during one month off and on for twenty patients with hyperlipidemia who visited Gunpo Oriental Medical Center of Wonkwang University from December 2002 to July 2003. Results: The following result were obtained: 1. The serum TG and total cholesterol of patients who took CPs for one month showed significant (p<0.01) decrease. 2. The serum HDL-cholesterol and LDL-cholesterol of patients who took CPs for one month showed significantly increase in HDL, and decrease in LDL (p<0.05). 3. The serum AST/ALT and BUN/creatinine of patients who took CPs for one month showed no significant effects. Conclusions: According to the results mentioned above, the effects of CPs on serum triglyceride and total cholesterol of hyperlipidemia patients were significantly confirmed for decreasing effects.

• 동아시아식생활학회지
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• 제9권2호
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• pp.169-176
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• 1999

The purpose of this study was to investigate the relationships of dietary nutrients and serum heavy metals in college women living Choong-Nam area of Korea. The mean age, height, weight, and BMI were 22.9years, 158.74cm, 53.39kg, and 21.71kg/$m^2$ respectively. The mean daily energy intake was 85.9% of RDA for Koreans. The ratio of energy from carbohydrate, fat, and protein was 61:23:16. And the daily vitamin A, B$_2$, Ca were 90%, 78%, 60% of RDA for Korea, respectively. The mean serum levels of Pb, Cd, Cr were 0.190, 0.005, 0.025$\mu\textrm{g}$/$m\ell$, respectively. The serum Cd was significantly different with dietary carbohydrate(p＜0.05). And the serum Cr was significantly different with dietary protein intake(p＜0.05), phosphorus(p＜0.01), potassium(p＜0.05). respectively.