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http://dx.doi.org/10.5352/JLS.2013.23.11.1371

Effects of Monascus-fermented Angelica gigas Nakai on the Contents of Serum Lipid and Tissue Lipid Peroxidation in Alcohol Feeding Rats  

Ahn, Hee-Young (Department of Medical Biosciences, Graduate School, Dong-A University)
Park, Kyu-Rim (Department of Medical Biosciences, Graduate School, Dong-A University)
Kim, Yu-Ra (Department of Biotechnology, Graduate School, Dong-A University)
Yoon, Kyoung-Hoon (Department of Biotechnology, Graduate School, Dong-A University)
Kim, Jung-Wook (NMT, Co., Ltd.)
Cho, Young-Su (Department of Biotechnology, Dong-A University)
Publication Information
Journal of Life Science / v.23, no.11, 2013 , pp. 1371-1380 More about this Journal
Abstract
The effect of Monascus-fermented Angelica gigas Nakai (AFAG) on the contents of serum lipids and tissue lipid peroxidation was investigated in alcohol feeding rats (Alc group). The serum contents of total lipid and free fatty acid in the alcohol feeding rats were significantly increased, but these increases tended to decrease in the AFAG group. The content of serum triglyceride was also significantly decreased in the AFAG group compared to the other groups. The serum content of total-cholesterol was not significantly different between the normal group and the AFAG group. The content of HDL-cholesterol in serum was slightly increased in the AFAG group compared to the Alc group. The content of thiobarbituric acid reactive substances (TBARS) in the liver, heart, spleen, and testis were significantly increased in the Alc group compared to the normal group, but these increases were significantly decreased in the AFAG group. The content of liver zinc was decreased in the Alc group and it was significantly increased in the AFAG group, which suggested that the lipid peroxidation contents are inversely correlated with the liver zinc content. The hepatic glutathione concentration was significantly decreased in the Alc group, but this content was significantly increased in the AFAG group, and it showed the antioxidant ability of glutathione. These activities were also compared to the standard silymarin drug treatment. Thus, the findings of the present study indicated the significant antioxidant and antihyperlipidemic activity of Monascus-fermented Angelica gigas Nakai against ethanol-induced toxicity.
Keywords
Monascus-fermented Angelica gigas Nakai; thiobarbituric acid reactive substances (TBARS); reduced glutathione (GSH); antihyperlipidemic activity; alcohol;
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1 A.O.A.C. 1975. Official methods of analysis. 12th eds., Association of official analytical chemists. Washington DC, USA.
2 Aggett, P. J. and Comerford, J. G. 1995. Zinc and human health. Nutr Res 53, 16-22.
3 Bailey, S. M. and Cunningham, C. C. 2002. Contribution of mitochondria to oxidative stress associated with alcoholic liver disease. Free Radic Biol Med 32, 11-16.   DOI   ScienceOn
4 Beutler, E., Duron, O. and Kelly, B. M. 1963. Improved method for the determination of blood glutathione. J Lab Clin Med 61, 882-888.
5 Cha, J. Y., Jun, B. S., Yoo, K. S., Hahm, J. R. and Cho, Y. S. 2006. Fermented Chaga mushroom (Inonotusobliquus) effects on hypolipidemia and hepatoprotection in Otsuka-Long-EvansTokushima fatty rats. Food Sci Biotechnol 15, 122-127.   과학기술학회마을
6 Cha, J. Y., Kim, H. W., Heo, J. S., Ahn, H. Y., Eom, K. E., Heo, S. J. and Cho, Y. S. 2010. Ingredients analysis and biological activity of fermented Angelica gigas Nakai by mold. J Life Sci 20, 1385-1393.   과학기술학회마을   DOI   ScienceOn
7 Cha, J. Y., Park, J. C., Ann, H. Y., Eom, K. E., Park, B. K., Jun, B. S., Lee, C. H. and Cho, Y. S. 2009. Effect of Monascus purpureus-fermented Korean red ginseng powder on the serum lipid levels and antioxidative activity in rats. J Korean Soc Food Sci Nutr 38, 1153-1160.   과학기술학회마을   DOI   ScienceOn
8 Cha, J. Y., Park, S. H., Heo, J. S. and Cho, Y. S. 2008. Suppressive effect of administrated glutathione-enriched Saccharomyces cerevisiae FF-8 on the oxidative stress in alcoholic fatty liver. J Life Sci 18, 1053-1058.   과학기술학회마을   DOI   ScienceOn
9 Duncan, D. B. 1957. Multiple range test for correlated and heteroscedastic means. Biometrics 13, 164-176.   DOI   ScienceOn
10 French, K. T. 1989. Biochemical basis for alcohol-induced liver injury. Clin Biochem 22, 41-49.   DOI   ScienceOn
11 Friedman, R. B., Anderson, R. E., Entine, S. M. and Hirshberg, S. B. 1980. Effect of disease on clinical laboratory tests. Clinical Chem 26, 1D-476D.
12 Guo, A. J., Choi, R. C., Cheung, A. W., Li, J., Chen, I. X., Dong, T. T., Tsim, K. W. and Lau, B. W. 2009. Stimulation of Apolipoprotein A-IV expression in Caco-2/TC7 enterocytes and reduction of triglyceride formation in 3T3-L1 adipocytes by potential anti-obesity Chinese herbal medicines. Chin Med 4, 5.   DOI   ScienceOn
13 Heo, J. S., Cha, J. Y., Kim, H. W., Ahn, H. Y., Eom, K. E., Heo, S. J. and Cho, Y. S. 2010. Bioactive meterials and biological activity in the extracts of leaf, stem mixture and root from Angelica gigas Nakai. J Life Sci 20, 750-759.   DOI   ScienceOn
14 Lee, S., Lee, Y. S., Jung, S. H., Shin, K. H., Kim, B. K. and Kang, S. S. 2003. Antitumor activities of decursinol angelate and decursin from Angelic gigas. Arch Pharm Res 26, 717-730.
15 Jung, M. H., Lee, S. H., Ahn, E. M. and Lee, Y. M. 2009. Decursin and decursinol angelate inhibit VEGF-induced angiogenesis via suppression of the VEGFR-2-signaling pathway. Carcinogenesis 30, 655-661.   DOI   ScienceOn
16 Kang, D. Z., Um, J. B., Lee, S. K. and Lee, J. H. 2003. Content of rutin and monacoline K in the red buckwheat fermented with Monascus ruber. Korean J Food Sci Technol 35, 242-245.
17 Koo, B. K., Chung, J. M. and Lee, H. S. 1998. Biochemical evaluation of nutritional status of protein and lipid in patients with alcoholic liver disease. J Korean Soc Food Sci Nutr 27, 1236-1243.
18 Lee, S., Shin, D. S., Kim, J. S., Oh, K. B. and Kang, S. S. 2003. Antibacterial coumarins from Angelica gigas roots. Arch Pharm Res 26, 449-452.   DOI   ScienceOn
19 Lee, E. H. and Chyun, J. H. 2009. Effects of Chongkukjang intake on lipid metabolism and liver function in alcoholic fatty liver rats. J Korean Soc Food Sci Nutr 38, 1506-1515.   과학기술학회마을   DOI   ScienceOn
20 Lieber, C. S. 1993. Aetiology and pathogenesis of alcoholic liver disease. Baillieres Clin Gastroenterol 7, 581-608.   DOI   ScienceOn
21 Lu, S. C. 2009. Regulation of glutathione synthesis. Mol Aspects Med 30, 42-59.   DOI   ScienceOn
22 Mendenhall, C. L., Bradford, R. H. and Furman, R. H. 1969. Effects of ethanol on glycerolipid metabolism in rat liver. Biochem Biophys Acta 187, 501-509.   DOI   ScienceOn
23 Ohkawa, H., Ohishi, N. and Yagi, K. 1979. Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal Biochem 95, 351-358.   DOI   ScienceOn
24 Murakami, A., Kishimoto, M., Kawaguchi, M., Matsuura, T. and Ichikawa, T. 1998. Lipid peroxides and their relatives in organs of female rats fed diets containing excessive heme iron. J Korean Soc Food Sci Nutr 51, 9-15.   DOI   ScienceOn
25 Muriel, P., Garciapina, T., Perez-Alvarez, V. and Mourelle, M. 1992. Silymarin protects against paracetamol-induced lipid peroxidation and liver damage. J Appl Toxicol 12, 439-442.   DOI
26 Nordmann, R., Ribiere, C. and Rouach, H. 1992. Implication of free radical mechanism in ethanol-induced cellular injury. Free Rad Biol Med 12, 219-240.   DOI   ScienceOn
27 Pyo, Y. H. and Lee, T. C. 2007. The potential antioxidant capacity and angiotensin I-converting enzyme inhibitory activity of Monascus-fermented soybean extracts: evaluation of Monascus-fermented soybean extracts as multifunctional food additives. J Food Sci 72, S218-223.   DOI   ScienceOn
28 Stephan, A. M. and Wald, N. J. 1990. Trends in individual consumption of dietary fat in the United States 1920-1984. Am J Clin Nutr 52, 457-464.   DOI
29 Tsukahara, M., Shinzato, N., Tamaki, Y., Namihira, T. and Matsui, T. 2009. Red yeast rice fermentation by selected Monascus sp. with deep-red color, lovastatin production but no citrinin, and effect of temperature-shift cultivation on lovastatin production. Appl Biochem Biotechnol 158, 476-482.   DOI   ScienceOn
30 Wei, W., Li, C., Wang, Y. and Kritchevsky, D. 2006. Effect of Monascus purpureus-fermented rice on lipidemia and fatty liver in quail. Res Commun Mol Pathol Pharmacol 119, 67-75.
31 Won, H. R. 2005. Effect of hot water soluble extract from Angelicae Radix on the lipid metabolism and antioxidant defense system. Korean J Community Living Sci 16, 127-132.   과학기술학회마을
32 Yu, T. S., Choi, H. J. and Yoon, C. G. 2003. Effct of Monascus pigment extract on the alcohol metabolism in rats. J Korean Soc Food Sci Nutr 32, 603-607.   DOI   ScienceOn
33 Yu, T. S., Kim, H. H. and Yoon, C. G. 2003. Hepatic oxygen free radical metabolizing enzyme activities and serum lipid profile in rats fed diet supplemented with Monascus pigment. J Korean Soc Food Sci Nutr 32, 244-249.   과학기술학회마을   DOI   ScienceOn