• Journal of Korean Neurosurgical Society
• /
• v.41 no.5
• /
• pp.306-313
• /
• 2007

Objective : In permanent distal middle cerebral artery occlusion [pdMCAO] model of rats, the temporal order of subcellular translocation is not fully understood yet. We studied translocation sequence of cytochrome c and apoptosis inducing factor [AIF] after pdMCAO and patterns of expression. Methods : Twenty-one male rats - with ten minutes, 1, 4, 8, 24 and 48 hours of pdMCAO groups - were enrolled. At core and penumbra area of each cerebral cortex, Western blotting of cytochrome c and AIF were performed using cytosolic fractions and then compared with sham specimens. With 48 hours group, the expression of cytochrome c and AIF was examined with immunofluorescent staining. Results : Compared to sham, the cytosolic translocation of cytochrome c significantly increased at all time points [p<0.05]. As early as 10 min after onset of ischemia, it was increased significantly [p<0.01]. The cytosolic translocation of AIF showed gradual increase with the passage of time and significantly increased 8 hours after [p<0.05]. As late as 24 hours and 48 hours after onset of ischemia, there were increased most significantly [p<0.01]. At penumbra, both proteins failed to show significant increase at all time points. At 48 hours after ischemia, colocalization of cytochrome c and AIF were confirmed. Conclusion : Cytosolic translocation of cytochrome c peaks much earlier than that of AIF in pdMCAO model of rat. Caspase dependent apoptosis activates soon after ischemia and later, it can be reinforced by gradually increasing AIF in ischemic core.

• Journal of the Korean Vacuum Society
• /
• v.20 no.4
• /
• pp.258-265
• /
• 2011

A zero-dimensional global model simulator for atmospheric pressure oxygen plasmas has been developed. The simulation model considers the configurations similar to that of plasma needle device. The simulation results show that those species of O, $O_3$, $O_2*$ and ${O_2}^+$ have the highest density in sequence. Electrons dissipate most of their energy through the collisions with oxygen molecules. If the input power increases, the density of most species also increases as much as three-boy collision for the creation of ozone is weakened and hence the density of ozone decreases. The body to volume ratio also affects the plasma density.

• Korean Chemical Engineering Research
• /
• v.52 no.3
• /
• pp.307-313
• /
• 2014

In this study, an optimization process design has been performed to separate 99.9 mol% of Isobutyl Acetate from binary azeotropic mixture of Isobutyl Acetate and Isobutyl Alcohol system using a Pressure Swing Distillation (PSD). PSD is used to separate binary azeotropic mixtures using the difference between the relative volatilities and azeotropic compositions by changing the system pressure. Non-Random Two Liquid (NRTL) model for liquid phase and the Peng-Robinson equation for vapor phase are used. An optimization study for the reflux ratio and feed stage locations which minimize the total reboiler heat duties are studied. Since PSD process consists of two columns, i.e. high pressure and low pressure, the effect of column sequence on the optimum conditions is reported.

• KIISE Transactions on Computing Practices
• /
• v.21 no.1
• /
• pp.94-99
• /
• 2015

With the recent machine learning paradigm of using nonparametric Bayesian statistics and statistical inference based on random sampling, the Dirichlet distribution finds many uses in a variety of graphical models. It is a multivariate generalization of the gamma distribution and is defined on a continuous (K-1)-simplex. This paper presents a sampling method for a Dirichlet distribution for the problem of dividing an integer X into a sequence of K integers which sum to X. The target samples in our problem are all positive integer vectors when multiplied by a given X. They must be sampled from the correspondingly gridded simplex. In this paper we develop a Markov Chain Monte Carlo (MCMC) proposal distribution for the neighborhood grid points on the simplex and then present the complete algorithm based on the Metropolis-Hastings algorithm. The proposed algorithm can be used for the Markov model, HMM, and Semi-Markov model for accurate state-duration modeling. It can also be used for the Gamma-Dirichlet HMM to model q the global-local duration distributions.

• Journal of the Korea Academia-Industrial cooperation Society
• /
• v.10 no.6
• /
• pp.1337-1345
• /
• 2009

In the railway, the delay of a train may affect the schedule of other trains. Hence, the timetable management activity involving overtaking and transferring becomes an important issue. The timetable rescheduling is the conflict resolution of the disrupted schedule and a matter of deciding the sequence of moves among trains and the place for meeting. In Korea, there are few cases where operations research models were applied to railway timetable rescheduling problem in consideration of the transfer between Korea Train eXpress (KTX) trains and conventional trains. Hence, we present a mathematical approach that can minimize the total delay of the whole trains secondly. We applied the model to the exemplary section of a double-line track, the Gyung-Boo Line, and it is confirmed that the mathematical model could effectively address the transfer service as well as the complicated railway conflicts of Gyung-Boo Line.

• Communications of Mathematical Education
• /
• v.28 no.2
• /
• pp.219-234
• /
• 2014

Music and mathematics have a lot of structural similarities. Major and minor triads used importantly in music are in a relationship of inversion in which the sequence of the intervals is reversed, which is equivalent to reflection in mathematics. Geometrical expressions help understand structures in music as well as mathematics, and a diagram that shows tonal relationships in music is called Tonnetz. Relationships of reflection between major and minor triads can easily be understood by using Tonnetz, and also, transpositions can be expressed in translation. This study looks into existing Tonnetz and introduces S-Tonnetz newly formed by a mathematical principle.

• Transactions of the Korean Society of Mechanical Engineers
• /
• v.14 no.1
• /
• pp.103-111
• /
• 1990

This paper presents a methodology for predicting stable crack growth and instability of a cracked body under monotonically increasing load. It is based on a model that incremental crack extensions and load increments after fracture initiation occur by turns in sequence and the criterion that the crack grows by an incremebt .delta.a when the opening displacement at the current crack tip increases by a critical value V$_{c}$. It is shown that the value I$_{c}$ = V$_{c}$/ .delta. a is a material constant characterizing ductile crack growth resistance. Along with the fracture initiation toughness value, the constant is used for the calculation of the loads against crack extensions by adding up each increment. The specimen failure is defined to occur when the necessary load increment for crack extension is zero or when the limit load in the current ligament is reached. The predicted failure loads are in good agreement with the avaliable experimental failure loads for the compact and center-cracked tension specimens of 7075-T651, 2024-T351 aluminum alloys and 304 stainless steel.steel.

• Composites Research
• /
• v.15 no.3
• /
• pp.18-29
• /
• 2002

The bending vibration and thermal flutter instability of spacecraft booms modeled as circular thin-walled beams of closed cross-section and subjected to thermal radiation loading is investigated in this paper. The thin-walled beam model incorporates a number of nonclassical effects of transverse shear, primary and secondary warping, rotary inertia and anisotropy of constituent materials. Thermally induced vibration response characteristics of a composite thin walled beam exhibiting the circumferantially uniform system(CUS) configuration are exploited in connection with the structural flapwise bending-lagwise bending coupling resulting from directional properties of fiber reinforced composite materials and from ply stacking sequence. The numerical simulations display deflection time-history as a function of the ply-angle of fibers of the composite materials, damping factor, incident angle of solar heat flux, as well as the boundary of the thermal flutter instability domain. The adaptive control are provided by a system of piezoelectric devices whose sensing and actuating functions are combined and that are bonded or embedded into the host structure.

• BMB Reports
• /
• v.34 no.1
• /
• pp.59-65
• /
• 2001

In subtractive hybridization, target sequences in the tester are enriched by hybridizing with an excess amount of driver, followed by removing the tester hybridized with the driver. All of existing subtractive cloning methods are designed to remove the tester/driver hybrid. The removal of hybrid, however, is often unsatisfactory For various reasons. In this study we developed a subtractive enrichment protocol in which the tester/driver can be completely removed by selecting only the tester/tester after hybridization. In this protocol both the tester and driver DNAs are ligated with same linker DNAs and amplified by polymerase chain reaction (PCR). The tester DNA is then digested with two different enzymes and used in subsequent hybridization with an excess driver. After hybridization, the DNA is ligated with the adaptor that is only compatible with the tester/tester. Since only the tester/tester can have the new adaptor, no tester/driver can be amplified by PCR in this protocol. Unlike other methods, a 100% subtraction efficiency can be achieved even though the enzymatic treatments used in the enrichment procedure are incomplete. Furthermore, only the hybridized tester DNA can have the new adaptor and be amplified by PCR, resulting in 100% denaturation in effect. The efficacy of this novel method was verified with the model system in which a known amount of the target sequence is included.

• The Journal of Korean Institute of Communications and Information Sciences
• /
• v.28 no.11B
• /
• pp.999-1006
• /
• 2003

In the paper, we investigate the impact of handoff on the packet delivery in the Mobile IPv6 networks, where the smooth handoff is adopted. That is measured by an 'unstable time period (UTP)', a 'silence time period(STP)', and a 'handoff time period (HTP)' in the mobile node's perspective. Then, we propose a queuing model to get the exact value of the handoff transient time. The numerical results show that the queuing delay for the handoff packets and the involved link (or route) capacities affect the estimated UTP, STP, and HTP. On the other hand, the damage of application caused by handoff will increases when the handoff transient time becomes longer. We show that the priority scheduling method can achieve shorter STP and UP than the FIFO scheduling method that is generally used in best-effort IP network.