• BMB Reports
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• v.39 no.3
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• pp.247-252
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• 2006

A rapid method for the detection of Hepatitis E Virus (HEV) was developed by utilizing nano-gold labeled oligonucleotide probes, silver stain enhancement and the microarray technique. The 5'-end -$NH_2$ modified oligonucleotide probes were immobilized on the surface of the chip base as the capture probe. The detection probe was made of the 3'-end -SH modified oligonucleotide probe and nano-gold colloid. The optimal concentrations of these two probes were determined. To test the detection sensitivity and specificity of this technique, a conservative fragment of the virus RNA was amplified by the RT-PCR/PCR one step amplification. The cDNA was hybridized with the capture probes and the detection probes on microarray. The detection signal was amplified by silver stain enhancement and could be identified by naked eyes. 100 fM of amplicon could be detected out on the microarray. As the results, preparation of nano-gold was improved and faster. Development time also was shortened to 2 min. Thus, considering high efficiency, low cost, good specificity and high sensitivity, this technique is alternative for the detection of HEV.

• Journal of Ocean Engineering and Technology
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• v.34 no.4
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• pp.253-262
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• 2020

This study provides a comparative analysis of experiments-based enhancements and sensitivity evaluations for the structural design of an automatic ocean salt collector under various load conditions. The sizing variables of the structural members were considered as design factors. The strength and weight performances were selected as output responses. The design of experiments used in the comparative study consisted of the orthogonal array design, Box-Behnken design, and central composite design. The response surface model, one of the metamodels, was applied to the approximate model generation. The design enhancement performance metrics, including numerical costs and weight minimization, according to the design of experiments, were compared from the best design case results. The central composite design method showed the most enhanced design results for the structural design of the automatic ocean salt collector.

• Journal of the Institute of Electronics Engineers of Korea SP
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• v.44 no.5
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• pp.20-27
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• 2007

Generally, the TFT-LCD image signal have nonuniform brightness and are composed of largely varying background signal, noise signal and abruptly changing Mura signal within Mura region. In this paper, Mura region enhancing algorithms using the proposed modified-MTF, which describes how human-visual-system's sensitivity varies in frequency domain, is proposed. The validity of the proposed algorithm was demonstrated ideal 1-dimensional signal and also then it was also tested TFT-LCD image. By the experimental results, the proposed algorithm is very effective in TFT-LCD image Mura enhancement.

• Journal of the Optical Society of Korea
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• v.15 no.4
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• pp.329-334
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• 2011

We proposed a poly-dimethylsiloxane (PDMS)-coated fiber Bragg grating (FBG) temperature sensor for enhancing temperature sensitivity. By embedding the bare FBG in a temperature-sensitive elastomeric polymer, the temperature sensitivity of the proposed structure could be effectively improved by 4.2 times higher than those of the conventional bare-type FBG sensors due to the high thermal expansion coefficient of the PDMS. We analyzed the temperature-sensitivity enhancement effect with the increased Bragg wavelength shift in our structure and dependence on the temperature sensitivity with respect to the cross-section area of the PDMS.

• Proceedings of the Korean Magnestics Society Conference
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• 2000.09a
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• pp.187-188
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• 2000

• Proceedings of the Korean Radioactive Waste Society Conference
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• 2017.05a
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• pp.413-414
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• 2017

• Korean Chemical Engineering Research
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• v.49 no.4
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• pp.400-404
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• 2011

Many studies on polydiacetylene(PDA) have been investigated to apply to chemical and biological sensors due to their unique optical properties of color change from blue to red and fluorescence change from non-fluorescence to red fluorescence. Especially, high sensitivity against specific molecules is very important to apply polydiacetylenes to various sensors. In this study, we examined the effect of sensitivity enhancement of 10,12-pentacosadynoic acid(PCDA) vesicles in detection ${\alpha}$-cyclodextrin(CD) according to control of vesicle size by filters with different pore sizes and polymerization temperature. Colorimetric response(CR) was calculated using visible spectrometer. In order to investigate the effect of vesicle size on sensitivity of PDA vesicles, two PCDA vesicles were filtered without filtration and with 0.22 ${\mu}m$ filter. The two PCDA vesicles were polymerized at $25^{\circ}C$ and were incubated with ${\alpha}$-CD(5 mM) for 30 min. The CRs of the former and latter vesicles were 31.4% and 74.0%, respectively. Then, two PCDA vesicles filtered with 0.22 ${\mu}m$ filter were polymerized at $25^{\circ}C$ and $5^{\circ}C$ and were reacted with ${\alpha}$-CD(5 mM) for 30 min to examine the effect of polymerization temperature. The CRs of the former and latter vesicles were 74.0 and 99.2%, respectively. This suggests that vesicle sizes and polymerization temperature are key factors in enhancing the sensitivity of PDA vesicles. In addition, these results are expected to be useful to apply the PDA vesicles as biosensors to detect DNA, protein, and cells.

• Journal of radiological science and technology
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• v.6 no.1
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• pp.43-67
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• 1983

In order to increase the sensitivity of the photographic emulsion, one of the chemical sensitizers hydroxymethane sulfonic acid sodium salt(HMS) was applied through the chemical ripening process and following four types of emulsion were prepared. Their grain sizes were determined through the electron microscope. The ranges of average grain sizes were $0.05-0.40{\mu}m$ for silver chlorobromide emulsion of low sensitivity $0.10-0.45{\mu}m$ for the silver chlorobromide emulsion of medium sensitivity, $0.60-1.05{\mu}m$ for the silver iodobromide emulsion of high sensitivity, and $0.90-1.55{\mu}m$ for the ammonical silver iodobromide emulsion of high sensitivity. Through the reduction sensitization with HMS, they showed significant sensitivity enhancement by the increment of HMS concentration above pH 5.5 and pBr 3.0. Required sensitivity was obtained above pH 6.2 and pBr 3.3 when sulfur and gold sensitization were applied. Fog formed along the reduction sensitization was successfully prevented by the addition of 5.5-dimethylhydantion.

• Proceedings of the KIEE Conference
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• 2003.07a
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• pp.196-198
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• 2003

The low load power factor causes various problems such as the increase of the power loss and the voltage instability. The demand of reactive power increases continuously with the growth of active power and the restructuring of electric power companies makes the integrated management of ractive power troublesome, from which the systematic control of load power factor is required. In this paper, the load power factor sensitivity of the generation cost is derived and its effects in supplying the reactive power and enhancing the load power factor are analyzed in a small-scale power system. The load power factor sensitivity of the generation cost is applied for determining the locations and capacities of reactive power compensation devices. It is shown that the generation cost can be reduced and the system power factor can be enhanced effectively using the load power factor sensitivity.

• KIEE International Transactions on Power Engineering
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• v.5A no.3
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• pp.252-259
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• 2005

Various problems such as increase of power loss and voltage instability may often occur in the case of low load power factor. The demand of reactive power increases continuously with the growth of active power and restructuring of electric power companies makes the comprehensive management of reactive power a troublesome problem, so that the systematic control of load power factor is required. In this paper, the load power factor sensitivity of generation cost is derived and it is used for effectively determining the locations of reactive power compensation devices and for enhancing the load power factor appropriately. In addition, voltage variation penalty cost is introduced and integrated costs including voltage variation penalty cost are used for determining the value of load power factor from the point of view of economic investment and voltage regulation. It is shown through application to a large-scale power system that the load power factor can be enhanced effectively using the load power factor sensitivity and the integrated cost.