• Journal of Pharmaceutical Investigation
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• v.39 no.2
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• pp.111-115
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• 2009

The pharmacokinetics of cyclosporin A (CsA) after single and multiple oral dosing of new CsA self-micro-emulsifying drug delivery system (SMEDDS) in dogs were estimated. A single dose study was performed following a two-way crossover design against six dogs with reference SMEDDS. For a multiple dose study, three dogs were allocated for each drug, and 100 mg of drug was administered daily for 6 days. Whole blood concentration of CsA was analyzed by radio-immunoassay. Both drug showed identical blood concentration profiles in both studies, and no statistical difference was detected in pharmacokinetic parameters. The relative bioavailabilities of test SMEDDS were 91.4% and 89.1%, respectively, in the single dose study and the last day of multiple dose study. Especially, multiple dose study proved the good relationship between C-0/C-2 and AUC for reference SMEDDS, which is an indispensable part of therapeutic drug monitoring. These results suggest newly formulated CsA SMEDDS possibly shows identical pharmacokinetics and pharmacodynamic behaviors in clinical trials.

• Journal of Korean Academy of Nursing
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• v.41 no.1
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• pp.72-79
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• 2011

Purpose: The study was done to identify factors influencing Yangsaeng in elders. Methods: Data were collected by questionnaires from 907 elders in D metropolitan city. Measures were Yangsaeng, perceived health status, self-efficacy, and self esteem. Data were analyzed using frequencies, means and standard deviation, t-test, one-way ANOVA, Pearson correlation coefficients, and stepwise multiple regression with SPSS/WIN 13.0 version. Results: The mean score for Yangsaeng the participants was 3.56, out of a possible 5. There were significant differences in Yangsaeng according to age, education level, monthly income, marital status, family structure, and periodic health examination. Yangsaeng correlated positively with perceived health status, self-efficacy and self-esteem. According to the research, factors influencing Yangseng in elders were self-esteem, perceived health status, self-efficacy, family structure, and marital status. Conclusion: The positive correlation between Yangsaeng and health promotion behavior and perceived health status, self-efficacy, and self-esteem identified in this study can have an impact on strategies to improve the health of Korean elders. Therefore, the results can be used as a reference for future studies.

• Child Health Nursing Research
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• v.11 no.4
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• pp.465-471
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• 2005

Purpose: The purpose of this study was to identify the self-image of adolescents with cancer. Method: This study was a descriptive study. The participants in the study were 75 adolescents recruited from four medical centers in Seoul and all were receiving cancer therapy Korean Offer Self-Image Questionnaire was used and data were analyzed using the SPSS program. Result & Conclusions: The self-image of adolescents with cancer exists within the average range, but all groups of adolescents with cancer had a more positive self-image than Korean reference groups. The reason why adolescents with cancer showed a relatively positive self-image despite their painful experiences, is because they developed new value systems and view point through their experiences and teaming to cope with their situation. This research revealed that relapse affects the self-image of adolescents and therefore it is important to note that adolescents with relapses need more intensive interventions to maintain their positive self-image. In order to help with their coping process, further research on the factors that affect self-image in adolescents with cancer is also needed.

• Journal of the Korean Society of Marine Environment & Safety
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• v.30 no.1
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• pp.108-117
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• 2024

In this study, simulations based on computational fluid dynamics were performed for self-propulsion performance prediction of a catamaran that has asymmetrical inside and outside hull form and numerous knuckle lines. In the simulations, the Moving Reference Frame (MRF) or Sliding Mesh (SDM) techniques were used, and the rotation angle of the propeller per time step was different to identify the difference using the analysis technique and condition. The propeller rotation angle used in the MRF technique was 1˚ and those used in the SDM technique were 1˚, 5˚, or 10˚. The torque of the propeller was similar in both the techniques; however, the thrust and resistance of the hull were computed lower when the SDM technique was applied than when the MRF technique was applied, and higher as the rotation angle of the propeller per time step in the SDM technique was smaller in the simulations for several revolutions of the propeller to estimate the self-propulsion condition. The revolutions, thrust, and torque of the propeller in the self-propulsion condition obtained using linear interpolation and the delivered power, wake fraction, thrust deduction factor, and revolutions of the propeller obtained using the full-scale prediction method showed the same trend for both the techniques; however, most of the self-propulsion efficiency showed the opposite trend for these techniques. The accuracy of the propeller wake was low in the simulations when the MRF technique was applied, and slight difference existed in the expression of the wake according to the rotation angle of the propeller per time step when the SDM technique was applied.

• Korean Journal of Organic Agriculture
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• v.17 no.1
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• pp.35-53
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• 2009

The theme-type self-harvest concept proposed in this research will be applied as a relevant reference in planning and realizing urban-rural exchange facilities at the village level. The aim of this paper is to describe the concept, to characterize the self-harvesters and organic farmers involved, to illustrate the ecological, economic and social interaction and the possible constraints of the concept. What is more important, however, is to develop programs for consultants, organic farmers and green-minded consumers, to vitalize direct transaction. The proponents of self-harvest are convinced that this concept leads to ecological, economic and social benefits, which will help to design a sustainable food supply system for small, medium and large cities.

• International Journal of Internet, Broadcasting and Communication
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• v.15 no.4
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• pp.21-30
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• 2023

The aim of this study is to investigate how travelers' destination visit intentions are influenced by avatar self-congruence in the metaverse platform. We extended the impression management theory by considering both perceived enjoyment and social engagement, and illustrated the interaction effect based on users' digital age. To achieve this, we conducted an online survey with 302 users. The survey results revealed that avatar self-congruence significantly influenced users in terms of perceived enjoyment and social engagement, thereby affecting their destination visit intentions. This study also revealed a significant interaction effect between digital age type and avatar self-congruence on users' perceived enjoyment. The results of this study are expected to provide not only a theoretical reference for metaverse research and travel research but also managerial implications for destination management and metaverse applications.

• International Journal of Knowledge Content Development & Technology
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• v.14 no.2
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• pp.81-97
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• 2024

The study investigated computer literacy skills as a determinant of electronic reference sources utilization among selected secondary school students in Ado-Odo Ota Local Government, Ogun State, Nigeria. Four specific objectives with conforming research questions guided the study. Descriptive survey research design was adopted for the study. The population of the study comprises of SSS3 students of the three selected Community Secondary Schools in Ado Odo Ota. A sample size of 150 was used for the study. The instrument for data collection was a self-developed structured questionnaire. Data collected was analyzed using frequency and percentages. Findings of the study revealed that majority of secondary school students were not aware of the availability of electronic reference sources. It also revealed that the level of their computer literacy skills was below average. Majority of them have never used computer before and the few of them that have used computer before used it in their homes, their friend's homes or in the cyber café. It was found that lack of formal training on the use of electronic reference sources, lack of access to computer, lack of awareness of availability of electronic reference sources, lack of funds for internet subscriptions, over dependency on printed reference sources and lack of motivation to use electronic reference sources were the major hindrances to the use of electronic reference sources among secondary school students. It was recommended that the school librarians and teachers should play a role in creating awareness among secondary school students about the availability of online/ electronic reference sources among others.

• Korean Journal of Cognitive Science
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• v.21 no.2
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• pp.253-282
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• 2010

Two experiments were conducted to explore the effects of anaphora and demonstrative ellipsis on reference resolution. This study assumed that two type of ellipsis could be sensitive to antecedents' saliency: the reverse typicality and mention order of antecedents. The muti-task approach measured the antecedent's activation level and processing load for the conflict resolution of theories of anaphoric resolution. In Experiment 1, using ellipsis for anaphora, participants read a series of sentence pairs by self-paced and performed a probe recognition test. The results showed the main effects of antecedent's typicality and mention order in both tasks. In Experiment 2, using noun phrase without demonstrative for anaphora, participants read a series of sentence pairs by self-paced and performed a probe recognition test. The results showed main effects of mention order of antecedents for probe recognition task only. The first antecedent was recognized faster than the second one. The results of two experiments suggested that anaphora type and antecedent's saliency were dynamically interact in reference resolution for Korean.

• Proceedings of the KIEE Conference
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• 1988.11a
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• pp.430-433
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• 1988

An adaptive control system for D.C servo drive is developed via minimum variance control theory. The problem of designing this controller under varying load conditions is discussed. A robust self tuning controller that can track a constant reference and reject constant load disturbance is developed. Simulation study shows that the controller has excellent adaptation, capability as well as transient recovery under load changes.

• English Language & Literature Teaching
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• no.5
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• pp.63-78
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• 1999

In this paper, I explain why local obviation (Condition B of Chomskys binding theory) should be viewed as a relative phenomenon, and establish a correlation between Local Obviation (henceforth LO) effects and the Referential Hierarchy of Korean anaphors proposed in Lee (1997): ku (he) > caki (self) > casin (self) > cakicasin (selfself) = selo (each other). I show that LO characterized as a relative phenomenon may enable us to view Conditions B and C of the binding theory simply as an instantiation of varying degrees of (long distance) disjoint reference effects on the same continuum.