• 한국경제지리학회지
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• 제16권2호
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• pp.310-321
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• 2013

본 연구는 지역발전정책의 새로운 기조로 등장하는 사회적 혁신의 개념과 단계별 발달과정을 이해하고 사회적 혁신을 위한 공공부문의 역할을 규정하였다. 지역정책을 위한 개발사업의 집행자로서 도시 개발공사가 공간정책에서 다루어져야 하는 문제는 오늘날 빈곤, 삶의 질, 행복 등 사회적 영역으로 확대되면서 사회적 혁신으로 나아가야 하는 필요성이 더욱 높아지고 있다. 이러한 맥락에서 본 연구는 사회적 혁신에 있어 공공부문의 역할 평가를 위한 기본 틀을 구축하고, 우리나라 도시 개발공사를 대상으로 사회적 혁신에 있어 위상과 한계를 평가하였다. 그 결과 대부분의 공사는 주택 및 택지개발사업의 공공성 증진을 위한 다양한 노력을 전개하고 있고, 지역사회에 대한 공헌도 활발하지만 궁극적으로 사회적 혁신으로 나아가기 위한 역량 구축과 아이디어를 실천하는 시도는 미흡한 것으로 나타났다. 지역 및 공간정책에 있어 사회적 혁신에 대한 수요 증대는 향후 도시 개발공사와 함께 관련 지역개발의 공공부문 주체들에게 커다란 과제를 제기하고 있으며, 이에 대한 연구와 정책적 대응이 적극적으로 모색되어야 하는 시점이다.

• Journal of Genetic Medicine
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• 제12권2호
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• pp.92-95
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• 2015

Purpose: Increased maternal age is a major risk factor for chromosomal abnormalities. The maternal age-specific risk of fetal trisomy was theoretically calculated. We investigated the actual frequency of fetal trisomy between 16 and 24 gestational weeks in pregnant women over the age of 34 at delivery. Materials and Methods: We retrospectively, over a four-year period, reviewed the medical records of women with singleton pregnancies that started their antenatal care before the 10th week of pregnancy. Pregnant women aged 34 to 45 years at the time of delivery were enrolled and divided into groups of one-year intervals. We investigated the frequency of Down syndrome and all trisomies as a function of the maternal age and compared with the theoretical maternal-age-specific risk. Results: Of the 5,858 pregnant women enrolled in the study, the rate of trisomy 21 was 0.29% (17 cases). The observed frequencies of trisomy 21 in women with maternal ages of 35 years and 40 years were 1:1,116 and 1:141, respectively. The rate of all trisomies was 0.39% (23 cases). The observed frequencies of all trisomies in women with maternal ages of 35 years and 40 years were 1:372 and 1:56, respectively. Conclusion: The frequencies of Down syndrome and all trisomies were proportional to the maternal age. However, the observed frequencies of Down syndrome and all trisomies between the 16 and 24 gestational weeks were lower than the theoretical rates.

• 의료법학
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• 제13권2호
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• pp.79-113
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• 2012

This study focuses on the protection of trial subjects, who participate in clinical trials for new drug. It takes long time to develop new drugs and the clinical trials are required. Usually, pharmaceutical company, which develop new drug, request a research institution(usually, hospital) to investigate the examination of security and side effects of new drug. The institution recruit trial subject to participate in the trials. The contract for clinical research of investigational new drug is concluded between the pharmaceutical company and the institution. This thesis studies the legal regulations for protection of participants of clinical research for new drug. In this respect the first matter of this study is to seek which relation between pharmaceutical firm and participants of clinical trials. Especially, there is a question which the trial subject is entitled to demand the pharmaceutical company which requested clinical trials the institution to supply the investigational new drug, after the contract for clinical trials had terminated or cancelled. This study take into account the liability of the pharmaceutical company to trial subject. Secondly, it is researched the roles and authority of Institutional Review Board(IRB). IRB is Research Ethics Committee of the institution, in which clinical trials for new drug are conducted. According to the rule of Korea good clinical practice(KGCP), IRB is the mandatory organization which is authorized to approve, secure approval or disapprove the clinical trials for investigational new drug in the institution. The important roles are the review of ethical perspective of trial research and the protection of trial subject. Thirdly, this paper focuses if the participants are to be paid for the participation for clinical research. This is ethical aspect of clinical trials. It is resonable that the participant is reimbursed for expenditure such as travels, and other expenses incurred in participation in trials. It is not allowed that the benefit of clinical trials is paid to trial subject. The payment should not function as financial inducements for participations of trials. Finally, the voluntary consent of the trial subject is required. The institution ought to inform the subject, who would like to participate in trials, and it ought to received informed consent in writing for subject. In this regard, it is matter that trial subject has ability of consent. It is principle that the subject as severely psychogeriatric patient has not ability of consent. However, it is required that not only healthy people but also patients are allowed to take part in clinical trials of new drug, in order to confirm which the investigation new drug is secure. Therefore there are cases, in which the legal representative of subject consent the participation of the trials. In addition, it is very important that the regulations concerning clinical trials of new drug is to be systematically well-modified. The approach of legal and political approach is needed to achieve this purpose.

• Asian Pacific Journal of Cancer Prevention
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• 제16권15호
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• pp.6481-6490
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• 2015

Background: Esophageal cancer (EC) is among the most common malignancies in Eastern Africa, but the occurrence of EC in Sudan has rarely been described in the scientific literature. This paper reports the results of a consecutive case series of all EC patients who visited one of the two public cancer treatment centers in the country in 1999-2012, providing a first description of this disease in a treatment center located in central Sudan. Materials and Methods: Clinical and demographic data for all EC patients who visited the Department of Oncology of the National Cancer Institute at the University of Gezira (NCI-UG) from 1999 to the end of 2012 were abstracted and tabulated by sex, tumor type and other characteristics. Results: A total of 448 EC patients visited NCI-UG in 1999-2012, and the annual number of EC cases increased steadily from 1999. Squamous cell carcinoma (SCC) was the predominant EC tumor type (90%), and adenocarcinoma (ADC) was reported in 9.4% of the EC cases. The overall male-to-female ratio for EC was 1:1.8, but the ratio was tumor type-dependent, being 1:2 for SCC and 2:1 for ADC. Only 20% of EC patients reported having ever used tobacco and/or alcohol, and the vast majority of these patients were male. At the time of EC diagnosis, 47.3% of the patients resided in Gezira State. Some EC patients from Gezira State seek out-of-state treatment in the national capital of Khartoum instead of visiting NCI-UG. Conclusions: The annual number of EC patients visiting NCI-UG has increased in recent years, approximately half of these patients being from Gezira State. Although this consecutive series of EC patients who visited NCI-UG was complete, it did not capture all EC patients from the state. A populationbased cancer registry would provide more complete data required to better understand EC patterns and risk factors.

• Asian Pacific Journal of Cancer Prevention
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• 제13권8호
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• pp.3841-3850
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• 2012

Objective: The objective of this study was to explore the knowledge and perceptions of Malaysian tradition healers towards cancer and cancer prevention. Methodology: A total of 25 participants agreed to participate in this qualitative study during the period from $20^{th}$ July 2011 until $24^{th}$ of September 2011. The proposal of this study was approved by the Ethics Committee of Management and Science University (MSU). Once the participant agreed to be interviewed, date, time and place of the interviews were determined. Consent form was obtained from participants before the interview began. Participants were briefed about the study and its purpose, and after asking their permissions, their replies were recorded. The data was organized into themes and analyzed manually. Results: Twenty-five Malaysian traditional healers participated in this qualitative study. The age of participants ranged between 26 to 78 years old. The majority were in the age group of 31-60 years old, male, Chinese, degree holders with a monthly income ranging from 1,000-5,000 Ringgit Malaysia (RM) and were married (56%, 80%, 48%, 52%, 68%, 84% respectively). The majority defined cancer as having high cholesterol or abscess accumulation. A few of them defined cancer as a type of cell growth. The majority mentioned that food and unhealthy lifestyles are the primary causes of cancer. Surprisingly some of them mentioned that cancer is caused by interference by ghosts. Regarding the diagnosis of cancer, the majority mentioned that they refer their patients to modern physicians' medical report when it comes to diagnosing or treating patients with cancer. The most common cancers that many patients came to seek treatment were breast cancers, followed by colon cancers, liver and lung cancers. Conclusions: Despite good knowledgeabout the causes of cancer among traditional healers, misconceptions still exist. Insufficient knowledge about the definition of cancer was noted among the traditional healers. This urges immediate action by the Ministry of Health of Malaysia to set up a strict regulation and regular monitoring of the traditional healers nationally. Traditional and Complementary Medicine may be integrated into the healthcare system and need to have sustained cooperation for the benefit of patients since about 80% of patients use traditional medicines.

• 한국ITS학회 논문지
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• 제15권4호
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• pp.44-53
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• 2016

오늘날 우리 주변에는 규모를 가늠할 수 없을 정도로 많은 정보와 데이터가 생산되는 '빅데이터(Big Data)'의 시대가 도래 하였으며, 그 중요성이 날로 커지고 있다. 교통분야에서는 전통적인 통행기반교통모형(Trip-Based Model)인 4단계 교통수요추정법의 한계가 드러나고 있으며, 활동기반교통모형(Activity-Based Model)을 이용한 수요 추정 방법이 교통계획에 새로운 패러다임으로 떠오르고 있다. 교통은 사람이나 물류의 공간상의 시간적 이동을 의미한다고 봤을 때 공간데이터와 밀접한 관련이 있다. 따라서 공간정보를 포함하고 있는 SNS를 대상으로 시계열적 공간정보를 추출하고, 이를 현재의 통행기반교통모형(Trip-Based Model) O/D와 비교 분석하여 그 특성을 파악하고 유용성을 검증하였다. 또한, 활동기반교통모형(Activity-Based Model)의 분석자료를 구축하여 교통시뮬레이터 프로그램을 이용해 시뮬레이션을 수행하고 그 결과를 고찰하였다. 연구결과 다수의 활동기반 교통모형 분석자료를 구축할 수 있었으며, 이번 연구를 통해 교통분야 빅데이터 활용의 기술적 한계를 극복할 수 있는 가능성을 확인하였고, 향후 발전방향을 모색하는 기회가 되었다.

• 치위생과학회지
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• 제15권4호
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• pp.509-517
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• 2015

본 연구는 청소년기 입시스트레스가 심한 인문계 고등학생을 대상으로 청소년의 스트레스의 수준을 파악하고 입시스트레스와 주관적 구강건강상태와의 관련성을 분석하고자 하였다. 2014년 9월 1일부터 9월 27일까지 부천시에 위치한 3개의 인문계 고등학교 재학생을 대상으로 자기기입식 설문조사를 실시하였고, PASW Statistics ver. 18.0 for Windows를 이용하여 최종 304부를 분석하였다. 인문계 고등학생들의 입시스트레스 수준은 전체적으로 2.71이었으며, 학년이 올라갈수록 입시스트레스가 심한 것으로 나타났다. 하위영역별 수준은 시험긴장/성적부진 스트레스가 3.08로 가장 높았고, 다음으로 미래불확실성(2.81), 부모압력(2.56), 여가생활부족(2.52) 스트레스의 순이었다. 입시스트레스와 연관성이 확인된 주관적 구강건강상태는 악관절장애, 구강점막질환, 구강건조였으며, 스트레스의 하위요소 중에서 시험긴장/성적부진 스트레스가 높을수록 치아우식증, 치주질환, 악관절장애, 구강점막질환, 구강건조 자각 정도가 유의하게 높았다. 고등학생의 입시스트레스 수준이 높을수록 구강질환 증상에 대한 자각이 높아지므로 구강관리를 통해 구강질환의 발현을 중지 및 감소시킬 필요가 있다. 이를 위해 올바른 치면세균막관리법을 포함한 구강건강관리능력을 습득시키기 위한 구강보건교육 프로그램이 제공되어야 한다. 또한 제공되는 프로그램에 본 연구에서 스트레스의 영향을 받는 것으로 확인된 구강건조, 악관절장애, 입안점막질환에 대한 관리법을 추가한다면 고등학생의 구강건강 향상에 도움이 될 수 있을 것으로 생각된다.

• 약학회지
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• 제37권3호
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• pp.235-242
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• 1993

8-Fluorociprofloxacin(8-FCP) is an investigational quinolone derivative that is substituted with fluorine at the C-8 position of ciprofloxacin(CP). It was found that the in vitro activity of 8-FCP against Gram(+) bacteria was more potent that of CP, but the opposite against Gram(-) bacteria was true. However, 8-FCP showed better in vivo efficacy than CP against representative Gram(-) organisms, E. coli and K pneumoniae. In an attempt to seek for factors causing this discrepancy in the antibacterial activities, a comparative pharmacokinetic study of 8-FCP and CP was conducted in mice and rats treated either intravenously or orally at a single dose of 30 mg/kg. The pharmacokinetic parameters in mice were as follows; the mean peak serum concentrations(C$_{max}$) following i.v. and oral doses were 12.4 and 5.3 $\mu\textrm{g}$/ml for 8-FCP, and 9.5 and 2.5 $\mu\textrm{g}$/ml for CP, respectively. The terminal half-life(t$_{1/2\beta}$) was 72.9 min for 8-FCP, and 98.2 min for CP, and the oral bioavailability(F) was 89.9% for 8-FCP, and 50.5% for CP. In rats, the mean ($\pm$SD) $C_{max}$ after i.v. administration were 11.6$\pm$1.6 $\mu\textrm{g}$/ml for 8-FCP, and 10.2$\pm$1.3 $\mu\textrm{g}$/ml for CP, whereas oral administration produced $C_{max}$ of 5.9$\pm$1.8 $\mu\textrm{g}$/ml for 8-FCP and 1.1$\pm$0.9 $\mu\textrm{g}$/ml for CP, respectively. The t$_{1/2\beta}$ was 67.9$\pm$8.4 min for 8-FCP, and 76.4$\pm$7.2 min for CP. The F was 88.6$\pm$6.3% for 8-FCP, and 40.7$\pm$6.5% for CP. Marked differences were observed between the two quinolones in the $C_{max}$ and the area under the concentration-time curve obtained after oral administration in mice and rats. The extent of 8-FCP absorption in both mice and rats was approximately 2-fold higher than that of CP, suggesting that the fluorine atom attached to C-8 plays an important role in facilitating oral absorption from the gastrointestinal tract.

• 한국보육지원학회지
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• 제7권3호
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• pp.143-164
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• 2011

본 연구는 자연친화적 실외 환경에서의 놀이에 나타난 영아들의 경험 세계를 살펴, 그 의미를 도출해 보고 영아를 위한 자연친화적 실외놀이의 활성화 방안을 모색해 보는 계기를 마련하고자 하였다. 이를 위해 연구자는 부산시 동구에 위치한 S어린이집의 별님반과 꽃들반에 재원중인 22개월에서 33개월 사이의 영아 9명을 대상으로 영아들의 실외놀이를 참여관찰하고 원장, 교사와의 심층면담, 그리고 중요한 기록물들에 대한 분석을 포함한 질적 연구방법을 실시하였다. 본 연구의 결과, 영아들에게 자연친화적 실외 환경에서의 놀이 경험은 영아가 보육기관의 실내 공간에서는 제한 받았던 특별하고 다양한 경험 세계를 제공하고 있음을 알 수 있었다. 구체적으로는 첫째, 영아들은 '감각을 깨우는 탐색의 세계'를 경험하고 있었으며 둘째, '정서를 깨우는 소통의 세계'를 경험하고 있었다. 영아가 놀이 경험을 통해 보다 건강한 성장을 한다고 볼 때, 자연친화적 실외 환경은 오늘날 전형적인 인공 놀이터의 틀을 깨고 찾아가기에 충분한 가치를 지닌, 온전하고도 생기 넘치는 살아있는 놀이터라는 점과 영아들이 이러한 공간에서 깊이 몰입하여 놀이를 경험할 수 있도록 충분한 시간을 제공하는 방안이 모색되어야 한다는 점이 제안되었다.

• Asian Pacific Journal of Cancer Prevention
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• 제17권sup3호
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• pp.167-174
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• 2016

One of the major causes of morbidity and mortality in breast cancer patients is delay in seeking help. Leventhal's self-regulation model provides an appropriate framework to assess delay in seeking help. The aim of this study was to investigate the relationship between "illness perception" and "help seeking delay" in breast cancer patients based on Leventhal's self-regulation model. In this correlational descriptive study with convenience sampling conducted in 2013, participants were 120 women with breast cancer who were diagnosed in the last year and referred to chemotherapy and radiotherapy centers in Rasht, Iran. Data collection scales included demographic data, Revised Illness Perception Questionnaire (IPQ-R)and a researcher made questionnaire to measure the delay in seeking help. Pre-hospital delay (help seeking delay) was evaluated in 3 phases (assessment, disease, behavior). The data were analyzed using SPSS-19. The mean (SD) age calculated for the patients was $47.3{\pm}10.2$. Some 43% of the patients had a high school or higher education level and 82% were married. The "pre-hospital delay" was reported ${\geq}3months$. Logistic regression analysis showed that none of the illness perception components were correlated with appraisal and behavioral delay phases. In the illness delay phase, "time line" (p-value =0.04) and "risk factors"(p-value=0.03) had significant effects on reducing and "psychological attributions" had significant effects on increasing the delay (p-value =0.01). "Illness coherence" was correlated with decreased pre-hospital patient delay (p-value<0.01). Women's perceptions of breast cancer influences delay in seeking help. In addition to verifying the validity of Leventhal's self-regulation model in explaining delay in seeking help, the results signify the importance of the "illness delay phase" (decision to seek help) and educational interventions-counseling for women in the community.