• 대한소아치과학회지
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• 제6권1호
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• pp.53-63
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• 1979

To Study the eruption pattern of the mandibular second permanent molar, the author took 425 cases of Oblique Cephalogram from 6 to 13 years old children and observed the vertical and mesiodistal directional change and tooth axis change. The following results were obtained. : 1. The eruption pattern of the mandibular second permanent molar was changed at about 10.0~10.1 ages or calcification stage IX. 2. At the early stage, the path of eruption of the mandibular second parmanent molar directed upward and forward and after calcification stage IX it changed to the direction of upward. 3. At the early stage, the distance from the distal end of the mandibular first permanent molar to the anterior portion of the ascending ramus was 0.9~1.0 times larger than the mesio-distal diameter of the mandibular second molar, but at the later stage it was increased 1.4 times larger than the mesio-distal diameter of the mandibular second permanent molar.

• Journal of the Korean Society for Industrial and Applied Mathematics
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• 제25권4호
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• pp.224-261
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• 2021

The interest in implicit-explicit (IMEX) integration methods has emerged as an alternative for dealing in a computationally cost-effective way with stiff ordinary differential equations arising from practical modeling problems. In this paper, we introduce implicit-explicit second derivative linear multi-step methods (IMEX SDLMM) with error control. The proposed IMEX SDLMM is based on second derivative backward differentiation formulas (SDBDF) and recursive SDBDF. The IMEX second derivative schemes are constructed with order p ranging from p = 1 to 8. The methods are numerically validated on well-known stiff equations.

• 말소리와 음성과학
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• 제10권4호
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• pp.19-29
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• 2018

The present study investigated whether there are differences in articulation rate by gender, age, and individual speakers in a spontaneous speech corpus produced by 40 Seoul Korean speakers. This study measured their articulation rates using a second-per-syllable metric and a syllable-per-second metric. The findings are as follows. First, in spontaneous Seoul Korean speech, there was a gender difference in articulation rates only in age group 10-19, among whom men tended to speak faster than women. Second, individual speakers showed variability in their rates of articulation. The tendency for some speakers to speak faster than others was variable. Finally, there were metric differences in articulation rate. That is, regarding the coefficients of variation, the values of the second-per-syllable metric were much higher than those for the syllable-per-second metric. The articulation rate for the syllable-per-second metric tended to be more distinct among individual speakers. The present results imply that data gathered in a corpus of Seoul Korean spontaneous speech may reflect speaker-specific differences in articulatory movements.

• Kyungpook Mathematical Journal
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• 제47권3호
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• pp.341-345
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• 2007

In this paper we show that the second order mock theta function, given by Hikami, is bounded and satisfies the second condition for the mock theta functions.

• 대한치과보철학회:학술대회논문집
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• 대한치과보철학회 1999년도 Asian Academy of Prosthodntics. Korean Academy of Prosthodontics
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• pp.77.2-78
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• 1999

• Asian Pacific Journal of Cancer Prevention
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• 제14권12호
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• pp.7501-7508
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• 2013

Background: Chronic myeloid leukemia (CML) is a myeloproliferative disorder of hematopoietic stem cell scarrying the Philadelphia (Ph) chromosome and an oncogenic BCR-ABL1 fusion gene. The tyrosine kinase inhibitor (TKI) of BCR-ABL1 kinase is a treatment of choice for control of CML. Objective: Recent studies have demonstrated that miRNAs within exosomes from cancer cells play crucial roles in initiation and progression. This study was performed to assess miRNAs within exosomes of K562 cells. Methods: miRNA microarray analysis of K562 cells and K562 cell-derived exosomes was conducted with the 6th generation miRCURYTM LNA Array (v.16.0). Gene ontology and Kyoto Encyclopedia of Genes and Genomes (KEGG) analyses were also carried out. GO terms and signaling pathways were categorized into 66 classes (including homophilic cell adhesion, negative regulation of apoptotic process, cell adhesion) and 26 signaling pathways (such as Wnt). Results: In exosomes, 49 miRNAs were up regulated as compared to K562 cells, and two of them were further confirmed by quantitative real-time PCR. There are differentially expressed miRNAs between K562 cell derived-exosomes and K562 cells. Conclusion: Selectively expressed miRNAs in exosomes may promote the development of CML via effects on interactions (e.g. adhesion) of CML cells with their microenvironment.

• Asian Pacific Journal of Cancer Prevention
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• 제14권1호
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• pp.261-265
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• 2013

Scutellaria barbata D. Don (S. barbata), a traditional Chinese medicine, is used to treat cancers, inflammation, and urinary diseases. This study aimed to determine any protective effects of S. barbata crude extract (CE-SB) against rat liver tumorigenesis induced by diethylnitrosamine (DENA). Liver malfunction indices in serum were measured by biochemical examination. Hematoxylin and eosin staining was performed to examine liver pathology. Contents of malondialdehyde (MDA) and superoxide dismutase (SOD) were measured in liver homogenates to evaluate oxidative stress. The levels of liver malfunction indices in the CE-SB groups, especially in the CE-SB high dose group, were lower than that of the model group (P<0.05). The results from histological examination indicated that the number of liver nodules in the CE-SB groups decreased compared with the model group (P<0.05). Content of MDA determined in liver was significantly decreased, and level of SOD elevated by CE-SB. CE-SB can inhibit experimental liver tumorigenesis and relieve hepatic injury in rats.

• Asian Pacific Journal of Cancer Prevention
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• 제16권9호
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• pp.3901-3905
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• 2015

Objective: Our aim was to investigation the roles of MHC class I chain-related gene A(MICA) and natural killer cell group 2D(NKG2D) in human renal cancer cells. Materials and Methods: The expression of membrane MICA (mMICA) on renal cells and NKG2D on NK cells were detected by flow cytometry (FCM); the content of sMICA were detected by enzyme linked immunosorbent assay (ELISA) and the distribution of mMICA on renal tumor tissues by immunohistochemistry; the interaction between MICA and NKG2D was observed by antibody closed method. Results: Our results showed that the expression of mMICA in renal cancer tissues was significantly higher than in controls, where the soluble MICA was not expressed. Cytotoxic activity of NK cells was significantly reduced after exposure to NKG2D and MICA antibodies (P<0.05), and serum containing sMICA can obviously lower the function of NKG2D (P<0.05). Conclusions: The interaction of mMICA and NKG2D play important roles in mediation of cytotoxicity of NK cells in RCC. On the other hand, sMICA may mediate tumor immune escape through down- regulated NKG2D expression.

• Asian Pacific Journal of Cancer Prevention
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• 제13권4호
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• pp.1477-1482
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• 2012

Squamous cell carcinoma and adenocarcinoma are the major histological types of non-small cell lung cancer. Because they differ on the basis of histopathological and clinical characteristics and their relationship with smoking, their etiologies may be different; for example, different tumor suppressor genes may be related to the genesis of each type. We used microarray data to construct three regulatory networks to identify potential genes related to lung adenocarcinoma and squamous cell carcinoma and investigated the similarity and specificity of them. In the network, some of the observed transcription factors and target genes had been previously proven to be related to lung adenocarcinoma and squamous cell carcinoma. We also found some new transcription factors and target genes related to SCC. The results demonstrated that regulatory network analysis is useful in connection analysis between lung adenocarcinoma and squamous cell carcinoma.

• Asian Pacific Journal of Cancer Prevention
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• 제14권11호
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• pp.6411-6413
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• 2013

Adenocarcinoma of esophagus (AE) is a complex disease, affected by a variety of genetic and environmental factors. Much evidence has shown that the MutY glycosylase homologue (MUTYH) plays a key role in the pathogenesis of many cancers. However, there have been no reports on influence on AE in the Han Chinese population. The objective of this study was to investigate this issue. A gene-based association study was conducted using three single nucleotide polymorphisms(SNPs) reported in previous studies. The three SNPs (rs3219463, rs3219472, rs3219489) were genotyped in 207 unrelated AE patients and 249 healthy controls in a case-control study using polymerase chain reaction and restriction fragment length polymorphism (PCR-RFLP). The results revealed that the genotype distribution of rs3219472 differed between the case and control groups (OR=1.66,95%CI=1.11-2.48, P=0.012), indicating that an association may exist between MUTYH and AE. These findings support a signifcant role for MUTYH in AE pathogenesis in the Han Chinese population.