• Archives of Pharmacal Research
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• 제19권5호
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• pp.342-347
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• 1996

Doxorubicin, one of the clinically most useful anticancer agents, is used alone or in combination with other drugs against a wide variety of tumors, recently. But cancer cells developed resistance to this agent in many ways. This resistance is an important limiting factor of doxorubicin for anticancer drug. We newly established doxorubicin-resistant HCT15/CL02 subline from parental HCT15 human adenocarcinoma colon cancer cells. HCT15/CL02 revealed resistance to doxorubicin about 85-fold of its parental cells, and it also revealed cross-resistance to actinomycin D, etoposide and vinblastine but not to displatin and tamoxifen. And verapamil, a reversal agent of multidrug-resistance (MDR) by P-glycoprotein, elevated the cytotoxicity of doxorubicin against both HCT15 and GCT15/CL02 cells. But the relative resistant rate was not reduced. Verapamil had no effects on the tosicity of cisplatin to the both cell lines. These results indicate that HCT15/CL02 cells have some functionally complex mechanisms for MDR.

• Archives of Pharmacal Research
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• 제22권2호
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• pp.151-156
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• 1999

Despite the impressive antitumor activity of cisplatin, two major limitations of the drug, that is severe side effects and drug-resistance of cancer cells, make its use difficult of r cancer therapy. These limitations have resulted in a greate deal of effort having been expended into structural modifications of cisplatin. In this study, we tested two novel cisplatin analogues, (CPA)2 Pt[DOLYM] (COMP-I) and (DACH)Pt[DOLYM] (CoMP-II), for the mode of cytotoxic action against human tumor cells comparing with cisplatin and carboplatin in vitro. These two novel analogues had considerable cytotoxic activities against five kinds of human solid tumor cells, and especially COMP-II was more effective on HCT15 colon cancer cells than other compounds. In addition, COMP-II had cytostatic activity at low concentrations (10~0.3${\mu}g/ml$), but other compounds revealed little effect on tumor growth at the low concentration.

• International journal of advanced smart convergence
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• 제12권4호
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• pp.418-425
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• 2023

This study examined the importance of screening for changing bodybuilding and fitness category. The screening criteria for bodybuilding, the background and reason for the creation of new bodybuilding and fitness items, the screening criteria for new items, and the use of drugs were described. The current bodybuilding gives high marks to excessive muscles and excessive diet conditions, and new bodybuilding category have been newly established in line with the recent global trend of pursuing natural beauty over abnormally excessive muscles, and the screening criteria also prioritize the balance of ideal and overall muscles to fit your height and weight. In addition, fitness events such as physique and bikini are gaining popularity with the establishment because they focus on not excessive muscles and natural elements of the body that ordinary people can challenge. Since athletes as well as ordinary people are using drugs to increase muscles and suffer side effects, IFBB(International Federation of BodyBuilding) and KBBF(Korea Body Building Federation) should consider and improve the current bodybuilding screening standards that avoid excessive muscles, and it is believed that bodybuilding and fitness events will develop only when strict punishment and continuous anti-doping education are carried out.

• 한국응용약물학회:학술대회논문집
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• 한국응용약물학회 1998년도 Proceedings of UNESCO-internetwork Cooperative Regional Seminar and Workshop on Bioassay Guided Isolation of Bioactive Substances from Natural Products and Microbial Products
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• pp.183-183
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• 1998

Telomerase synthesizes telomeric DNA repeats onto chromosome ends de novo. Telomerase activation and telomere shortening in human somatic cells have been implicated in cell tumorigenesis and immortalization. In order to find the potential inhibitors against telomerase activitiy which can be used as potential anticancer agents, we screened about 100 kinds of natural products after partition into n-hexane, ethyl acetate and aqueous layers from methanol extracts. The inhibitory effects of these materials against telomerase enzyme activity were tested in 293T cell culture using telomeric repeat amplification protocol(TRAP). The incorporation of $\^$32/P-dGTP into amplified DNA was measured by adsorption to Whatman DE81 paper instead of using TRAP assay for screening the extracts of natural products. Strong effective compounds were not found in this study but DE81 filter spotting method may be a useful model for the screening. Some of the compounds which showed somewhat inhibitory effects had cytotoxic effects also.

• 노동경제논집
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• 제34권2호
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• pp.79-107
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• 2011

본 연구는 우리나라의 청년노동시장에서 영어점수가 (1) 선별효과, (2) 신호효과 및 (3) 임금효과에 미치는 영향에 관하여 분석했다. 분석 결과는 다음과 같다. 첫째, 영어점수는 선별 신호과정에서 선별도구 및 신호기재로 이용되고 있는 것으로 나타났다. 둘째, 일정 수준 이하의 영어점수를 보유한 구직자는 선별 신호과정에서 불이익을 받는 것으로 나타났다. 마지막으로 능력편의를 통제한 도구변수법을 이용하여도 영어점수의 임금프리미엄이 존재하는 것으로 나타났다.

• 한국경영과학회:학술대회논문집
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• 한국경영과학회 1988년도 추계학술발표회 발표논문초록집; 서울시립대학교 사회과학관, 서울; 5 Nov. 1988
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• pp.5-5
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• 1988

• 융합정보논문지
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• 제10권5호
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• pp.42-50
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• 2020

본 연구의 목적은 간호대학생들의 자궁경부암 검진 여부를 파악하고, 자궁경부암 지식, 예방행위의도가 자궁경부암 검진에 미치는 영향을 확인하여. 이들의 자궁경부암 검진율 향상을 위한 효과적인 전략수립에 기초자료를 제공하기 위함이다. 연구대상은 G광역시와 J도에 소재한 대학교 3곳의 간호대학생 192명을 대상으로 하였다. 자료는 SPSS/WIN 23.0 프로그램을 이용하여 분석하였으며, 빈도분석, t-test, χ²-test, 로지스틱회귀분석을 시행하였다. 간호대학생의 자궁경부암 검진에 영향을 미치는 요인은 연령, 성경험 유무, 예방행위의도로 확인되었다. 자궁경부암 검진률을 향상시키기 위해, 건강전문가가 성경험이 시작되기 전인 학령기부터 대학생시기까지 학교와 의료기관에서 시행하는 단계적이며, 지속적인 자궁경부암 예방행위의도 증진 교육 및 프로그램 개발이 필요하다.

• 지역사회간호학회지
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• 제21권3호
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• pp.273-281
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• 2010

Purpose: This study was to explore the effects of breast cancer education for college students on their mother's breast cancer screening promotion. Methods: This study used a one-group pretest and posttest design. Data were collected from September to November, 2007 from a sample of 80 college students and their mothers using a survey questionnaire, which asked about demographic variables, concerns over health and breast cancer, communication, stage of change and attitude (pros and cons) related to breast cancer, and confidence in breast self-examination. The college students received education about breast cancer for 50 minutes and then they educated their mothers about breast cancer. Data were analyzed with descriptive statistics and paired t-test. Results: The mean age of the college students was 22.0 years, and that of their mothers 49.4 years with a range from 43 to 58 years. After receiving education on breast cancer, there were significant changes in the mean scores of concerns about health and breast cancer, communication, pros in mammography, and confidence in practicing breast self-examination. Conclusion: This study indicates that education on breast cancer to mothers through their college-age daughters is effective and can be utilized to promote breast cancer screening for women.

• 한국농촌간호학회지
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• 제11권2호
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• pp.17-28
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• 2016

Purpose: This study aimed to determine the effects of a 'Customized Integrated Health Care Program' for male living alone in a single region and assist health promotion of the participants. Methods: This study was one-group pretest-posttest design. Eleven participants in the 'Happy Cooking Class for Male Living Alone' who made 100% of attendance from February 18 to September 8, 2016 were analyzed. Nonparametric paired T-test was performed to determine the differences in Blood pressure(BP), Blood sugar(BS), Cholesterol, Hemoglobin(Hb), Dementia screening test, Depression screening test of the participants in the Customized Integrated Health Care Program. Results: After applying the 'Customized Integrated Health Care Program', Hb level(z=-2.724, p=.006) and Dementia screening test(z=-1.974, p=.048) increased statistically significantly. Conclusion: As the elderly living alone increase in number, it seems that social support networks and health care programs contribute to health promotion of the participants and positively affect the rest of their life.

• 한국자원식물학회지
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• 제5권2호
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• pp.85-93
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• 1992

This experiment was Conducted ta screening for the anti-cancer efficacy from the wild plants which are naturally growing in the Korea. The results are as follows. The results were shown thatZea may L. nad significantly effects on mediculal efficacy anganist anti-tumor by usulg the totalpacked cell volume methods and also, severals plants, such as Sofonum nigrum, Patrinia hispidoBunge, Eragrostis, ferrugenia Beauv, Salaginela pouzolgiana Spring, Platrycarya strobilacea Bunge,Codonopsis lanceolata Benth. et Hook fil. which are collected from Giri and Mooju mountain in Koreaand Nagano in Japan were showed effects on auti-tumor. But the pharmaceologial activities ofPharbitis nil Choisy was believed to strong effec on anti - cancer tumors, while toxicity of its wasshown high that induced te kill all used mice. Extraction of Patrinia hispida Bunge, Pharbitis nilChoisy, Toilis japonica DC, Eragrostis erruginea Beauv. and Forsythia koreana Nakai showed effec-tively supressed on growth rate of cancer tumor by the below 50 percent of T/C ratio at 30mg /mlof extraction from plant. That Is strong activity while Reynouxria japonica Houtt. was observed onlymild activities. The above results many possibly suggest that Patrinia hispido Bunge and Eragrostisferrugina Beauv. inhibited the growth of cancer tumor by the both total packed cell volume methodand cytotoxicity method. Although basic research is still going on, we will find out an accurate moth-od for developing useful medicinal plant to improve pharmacological activites against anti-cancertumor, especialy, in Eragrostis ferruginea Beauv.