• 재활복지
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• 제21권1호
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• pp.27-46
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• 2017

본 연구의 목적은 시각장애인용 고용준비도 검사지를 개발하는 데 있다. 개발과정은 체계적인 개발절차에 따라 문헌연구를 통해 검사 요인을 구성하고, 학계 및 현장 전문가 의견조사, 파일럿 테스트를 통해 검사지를 최종 완성하였다. 검사지의 신뢰도와 타당도를 검증하기 위해 구직시각장애인을 대상으로 평가를 실시하여 253명의 평가 자료를 수집하였다. 검사도구의 신뢰도 및 타당도 검증을 위해 주성분 분석, 확인적 요인분석, 상관분석 등을 사용하였다. 신뢰도 분석결과, 구인별 신뢰도 계수는 0.88-0.92로 요인별 하위 문항 간 내적일관성이 양호한 것으로 확인되었다. 타당도 분석결과, 9개 구인별 주성분 요인분석에서 단일차원성이 양호하고, 확인적 요인분석 결과에서도 구조방정식 모형이 적합한 것으로 나타나 구인타당도는 양호한 것으로 평가되었다. 공인타당도 검증을 위해 고용준비도 검사와 직업스크리닝 검사 간 상관관계 분석을 실시한 결과, 상관계수값이 0.501로 나타나 공인타당도가 양호한 것으로 확인되었다. 이상의 결과에서, 시각장애인 고용준비도 검사는 평가도구로서 심리측정학적으로 타당성이 있는 것으로 확인되었다.

• 정신신체의학
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• 제31권2호
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• pp.43-49
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• 2023

우리나라의 경우, 이식 대기자에 비해 공여 장기 수가 부족하여 생체 장기기증에 대한 의존도가 높으며, 생체 장기기증 건수도 지속적으로 증가하고 있다. 특히, 생체 신장 이식 건수는 전 세계적으로 높기 때문에 생체 신장 공여자에 대한 이식 전 정신사회적 평가의 중요성이 부각되고 있다. 이전 연구에 따르면 이식 전 공여자 평가 시 사전 동의 여부 및 수술 위험성에 대한 인지 여부를 파악하는 것이 중요하며 이를 위해 다음과 같은 평가 도구들을 시행할 수 있다. ELPAT living organ donor Psychological Assessment Tool (EPAT), Live Donor Assessment Tool (LDAT), Living Donation Expectancies Questionnaire (LDEQ), Minnesota Multiphasic Personality Inventory-2 questionnaire (MMPI-2). 이식 전 정신사회적 평가 도구에 관한 문헌을 검토한 후, 한국의 생체 신장 기증자에 대한 법적 고려 사항을 살펴본 후 생체 신장 공여자에 대한 효과적인 이식 전 선별 평가 방법을 제안하려 한다.

• 생물정신의학
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• 제4권1호
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• pp.3-11
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• 1997

Disturbances in memory are the most common problem in patients with an organic mental syndrome. Other patients with significant psychiatric disorders also often have difficulty with memory. So it is very important in the clinical practice of psychiatry to understand the biological and neurocognitive mechanisms of memory proessing, and to develop the assessment tools with which memory function can be evaluated reliably and validly. Moreover, memory researches provide an important viewpoint from which we can understand the pathophysiological mechanisms of major neuropsychiatric illnesses. This article focuses on our understanding of memory functions in clinical and neurobiological aspects. The relevant material will be presented in four parts : 1) terminologies needed in defining major stages of various types of memory processing : 2) neurochemical and neuroanatomical basis of memory processing : 3) brief bed-side screening tests and more comprehensive neuropsychological tests for the evaluation of memory function : 4) the characteristics of memory dysfunction in several major psychiatric illnesses.

• Toxicological Research
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• 제11권1호
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• pp.103-108
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• 1995

Rat renal proximal tubule suspension was prepared from adult male Sprague Dawley rat (250-300g) by mechanical (non-enzymatical) method and evaluated as a pontential model for mechanistic studies and early screening of nephrotoxicity, using anionic antibiotics (cephaloridine). Cephaloridine (CPL) produced an increase in LDH release into media. This release results from decrease a proximal tubule cell viability and subsequently increase the permeability of cell viability and subsequently increase the permeability of cell membrane. Since loss of intracellular potassium and ATP into media is the sign of disruption of cell membrane, especially basolateral membrane (BLM), CPL induced proximal tubule cell compromise also appear be associated with BLM, maybe $Na^+-K^+$ ATPase. Also seen was significant depression in brush border membrane (BBM) ALP activity and no significantly increase in BBM GGT activities. The inhibition of typical anion, PAH accumulation (especially, CPL 5 mM) and cation, TEA (especially, 4hours incubation) were seen dose dependently. This is because of CPL accumulation in renal proximal tubule and increase of cytotoxicity.

• Toxicological Research
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• 제29권3호
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• pp.217-219
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• 2013

Hypertension is a serious health problem due to high frequency and concomitant other diseases including cardiovascular and renal dysfunction. Olmesartan cilexetil is a new antihypertensive drug associated with angiotensin II receptor antagonist. This study was conducted to evaluate the mutagenicity of olmesartan cilexetil by bacterial reverse mutation test using Salmonella typhimurium (TA100, TA1535, TA98, and TA1537) and Escherichia coli (WP2 uvrA). At the concentrations of 0, 62, 185, 556, 1667, and 5000 ${\mu}g$/plate, olmesartan cilexetil was negative in both Salmonella typhimurium and Escherichia coli regardless of presence or absence of metabolic activation system (S9 mix). These results demonstrate that olmesartan cilexetil does not induce bacterial reverse mutation.

• 생물정신의학
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• 제7권2호
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• pp.123-130
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• 2000

The development of inexpensive high throughput methods to identify individual DNA sequences is important to the future growth of medical genetics. This has become increasingly apparent as psychiatric geneticists focus more attention on the molecular basis of complex multifactorial diseases at which most of psychiatric disease is estimated. Furthermore, candidate gene approaches used in identifying disease associated genes necessitate screening large sequence blocks for changes tracking with the disease state. Even after such genes are isolated, large scale mutational analysis will often be needed for risk assessment studies to define the likely medical consequences of carrying a mutated gene. This review provide basic knowledge of up-to-date technology, cDNA microarray which enables above mentioned various research themes.

• Toxicological Research
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• 제17권
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• pp.241-249
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• 2001

Toxicology is under challenge from several new trends in science and technology, namely computer, the Internet, genome projects, genomic technologies, and combinatorial chemistry. These new trends will drastically change research style of toxicology. In addition to conventional uni cellular tests and animal tests using rodents, computer simulation, DNA chips (microarrays), in vivo tests using simple model organisms such as nematodesor flies become important routine screening tests. How to arrange these tests in tiers will become a new problem. Endocrine disruptors hypothesis is a good example for this kind of futuristic approach. Computer, particularly the Internet, is also enabling toxicologists and regulatory experts to collaborate more closely. The IPCS (International Program for Chemical Safety) which is ajoint project of WHO, ILO and UNEP, is a well-known international collaborative research for chemical risk assessments. The GINC project of IPCS is an effort to utilize the Internet for such collaborations. Some efforts were also made to establish regional collaboration network in East Asia under this project.

• Environmental Analysis Health and Toxicology
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• 제16권4호
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• pp.143-151
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• 2001

Six rivers were selected as preliminary screening sites to determine the test conditions of Microtox in assessing the toxicity of the sediment. In addition, a pH range of 6.0∼6.5 was established in testing pore water, aqueous extracts and organic extracts. Each extractable fraction of sediment showed different toxicities. Therefore, in order to properly examine the toxicity in the sediment, all extractable fractions of sediment samples needed to be tested with Microtox. Thus, sediment samples were additionally collected from at least 4 secondary sites within 50∼100ｍ area of the primary sampling site to reduce any variation or deviation in toxicity assessment. From all sediment toxicity data that was collected from this study, it was concluded that the Keumho river was the most polluted with the highest sediment toxicity of all the rivers analyzed and needed further detailed research on its pollution problem.

• Nuclear Engineering and Technology
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• 제31권6호
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• pp.23-38
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• 1999

This study addresses the reference spent fuel and its characteristics for developing a geological repository concept. As a disposal capacity of the reference repository system to be developed, spent fuel inventories were projected based on the basis of the Nuclear Energy Plan of the Long-term National Power Program. The reference spent fuel encompassing a variability in characteristics of all existing and future spent fuels of interest was defined. Key parameters in the reference fuel screening processes were the nuclear and mechanical design parameters and the burnup histories for existing spent fuels as of 1996 and for future spent fuels with the more extended burnup the initial enrichment and its expected turnup. The selected reference fuel was characterized in terms of initial enrichment, bumup, dimension, gross weight and age. Also the isotopic composition and the radiological properties are quantitatively identified. This information provided in this study could be used as input for repository system development and performance assessment and applied in fuel material balance evaluation for the various types of back-end fuel cycle studies.

• 한국콘크리트학회:학술대회논문집
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• 한국콘크리트학회 2010년도 춘계 학술대회 제22권1호
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• pp.117-118
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• 2010

본 연구에서는 기존에 제안된 저층 철근콘크리트 건물의 간이 내진성능 평가법1)을 토대로 국내 S, G 및 J지역에 현존하는 철근콘크리트 학교건물을 대상으로 내진성능을 평가하여 결과를 검토함과 동시에 지진피해율 정도를 추정하여 입력지진동 크기(0.1g~0.25g)에 따른 지진피해율 분포를 상정하였다.