• Tuberculosis and Respiratory Diseases
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• 제74권2호
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• pp.56-62
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• 2013

Background: The purpose of this study was to evaluate the relationship of pulmonary function impairment (PFI) and coronary artery calcification (CAC) by multi-detector computed tomography (MDCT), and the effect of pneumoconiosis on CAC or PFI. Methods: Seventy-six subjects exposed to inorganic dusts underwent coronary artery calcium scoring by MDCT, spirometry, laboratory tests, and a standardized questionnaire. CAC was quantified using a commercial software (Rapidia ver. 2.8), and all the subjects were divided into two categories according to total calcium scores (TCSs), either the non-calcified (<1) or the calcified (${\geq}1$) group. Obstructive pulmonary function impairment (OPFI) was defined as forced expiratory volume in one second/forced vital capacity ($FEV_1$/FVC, %)<70, and as $FEV_1$/FVC (%){\geq}70 and FVC<80 for restrictive pulmonary function impairment (RPFI) by spirometry. All subjects were classified as either the case (profusion${\geq}1/0$) or the control (profusion${\leq}0/1$) group by pneumoconiosis findings on simple digital radiograph. Results: Of the 76 subjects, 35 subjects (46.1%) had a CAC. Age and hypertension were different significantly between the non-calcified and the calcified group (p<0.05). Subjects with pneumoconiosis were more frequent in the calcified group than those in the non-calcified group (p=0.099). $FEV_1$/FVC (%) was significantly correlated with TCSs (r=-0.316, p=0.005). Subjects with OPFI tended to increase significantly with increasing of TCS (4.82, p=0.028), but not significantly in RPFI (2.18, p=0.140). Subjects with OPFI were significantly increased in the case group compared to those in the control group. Conclusion: CAC is significantly correlated with OPFI, and CAC and OPFI may be affected by pneumoconiosis findings.

• 동의생리병리학회지
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• 제31권6호
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• pp.328-333
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• 2017

Desomodii Herba (DH) has been shown to exhibit pharmacologyical activities, such as increase myocaridal contraction and secretion of hepatic bile. DH is used to reduce pain caused by rheumatoid arthritis(RA) in Korean medicine. However, the DH exact(DHE) effect and mechanism on rheumatoid arthritis are unknown. In this study, we aimed at the inhibitory effect of DHE on rheumatoid arthritis, and investigated the effect in collagen-induced mice arthritis model and TNF-${\alpha}$ induced MMP-1 and MMP-3 expression including the molecular basis in rheumatoid arthritis synovial fibroblasts (RASFs).The effect of DHE on RA was measured by clinical scoring system. In RASFs, expression of MMP-1 and MMP-3 was assessed by Western blotting and real-time PCR. Also, Western blotting used to evaluate the phosphorylation levels of p38, ERK and JNK and activation of NF-${\kappa}B$ and AP-1. Our results showed that DHE reduced collagen-induced arthritis in mice. DHE inhibits TNF-${\alpha}$ induced MMP-1 and MMP-3 expression and mRNA levels in RASFs. The inhibitory effect of DHE was mediated by the inhibition of the AP-1/JNK signaling pathway. Taken together, our results suggest that the DHE may have preventive potential for rheumatoid arthritis.

• 환경정책연구
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• 제4권1호
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• pp.93-111
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• 2005

토양의 질(Soil Quality)에 대한 개념은 과거 식량생산을 위한 기반으로서의 토양에 대한 연구부터 1970년대 후반 Warkentin and fletcher(1977)에 의해 제안된 환경의 구성 요소로서의 토양에 대한 연구에 이르기까지 수많은 변화를 거쳐 왔다. 토양의 질에 대한 개념은 그 관점에 따라 다르지만 토양이 본래의 기능을 효과적으로 수행할 수 있는 용량으로 요약할 수 있다. 국제경제협력개발기구(OECD)에서도 토양의 질을 농업환경의 주요지표로 설정하여 토양유실과 토양탄소를 토양질 평가의 세부지표로 제시하였으며, 각 국가별로 활발한 연구가 수행 중에 있다. 본 논문에서는 현재까지 제안된 토양질의 주요 개념을 살펴보고 국내외의 토양질 평가체계를 비교 분석하고자 하였다. 토양질의 평가 체계는 최소자료군(Minimum Data Set)을 이용한 토양질 지표의 선정, 선별된 지표의 표준점수화함수(Standard Scoring Function), 각 지표의 통합을 통한 토양질의 점수화의 세 단계로 구분하여 분석하였다. 토양의 질 지표는 물리 화학 생물학적 지표로 분류할 수 있으며, 이 중 토양침식, 전용적밀도, 토심, 입단안정화도, 토성, 수분보유력, 유효수분함량은 물리적 질 지표로 주로 사용된다. 화학적 질 지표로는 유기물, pH, 전기전도도, 질소 인산 가리, 중금속 등이 있고, 생물학적 지표로는 미생물탄소 질소, 무기화 가능한 질소, 토양호흡이 주로 사용된다. 또한, 토양질 지표의 직접적인 측정이 어려운 경우에는 토양특성 환산식(Pedotransfer Function)을 이용하여 각 지표의 값을 추정할 수 있다. 현재 선진국에서는 SINDY를 비롯한 다양한 프로그램을 구축하고 있으며, 국내에서도 국가적인 차원의 자료구축을 통해 선별된 최소자료군의 계량화모델을 확립하여 웹기반의 프로그램을 구축해야 할 것이다. 현재까지 토양질의 계량화에 대한 연구는 주로 작물의 수량을 중심으로 이루어졌지만 향후 지속가능한 토양환경의 관리를 위해서는 환경의 질과 인간의 건강을 종합적으로 고려한 토양의 질 지표 개발에 대한 연구가 필요할 것이다.

• 통합자연과학논문집
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• 제3권3호
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• pp.143-147
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• 2010

Since it is of great importance to know how a ligand binds to a receptor, there have been a lot of efforts to improve the quality of prediction of docking poses. Earlier efforts were focused on improving search algorithm and scoring function in a docking program resulting in a partial improvement with a lot of variations. Although these are basically very important and essential, more tangible improvements came from the reduction of search space. In a normal docking study, the approximate active site is assumed to be known. After defining active site, scoring functions and search algorithms are used to locate the expected binding pose within this search space. A good search algorithm will sample wisely toward the correct binding pose. By careful study of receptor structure, it was possible to prioritize sub-space in the active site using "receptor-based pharmacophores" or "hot spots". In a sense, these techniques reduce the search space from the beginning. Further improvements were made when the bound ligand structure is available, i.e., the searching could be directed by molecular similarity using ligand information. This could be very helpful to increase the accuracy of binding pose. In addition, if the biological activity data is available, docking program could be improved to the level of being useful in affinity prediction for a series of congeneric ligands. Since the number of co-crystal structures is increasing in protein databank, "Ligand-Guided Docking" to reduce the search space would be more important to improve the accuracy of docking pose prediction and the efficiency of virtual screening. Further improvements in this area would be useful to produce more reliable docking programs.

• 물과 미래
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• 제14권3호
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• pp.55-66
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• 1981

The theory and practice of water quality scoring and indexing are introduced. The monthly water analysis data are available for six stations long the down-stream Han River whthin the areal boundary of the Special City of Seoul. The data cover the period between 1975 and 1979 inclusive and contain the analytical findings on 37 water constituents including DO, BOD, temperature, total solids and etc. Sic parameters are selected form the 37 items, that, to the judgement of the writer, best reflect the water quality of the Han River. They are; dissolved oxggen saturation, pH, fecal coliform, total solids, BOD and nitrate+ammonia. For each of the six parameters, a subscore function is developed and graphically presented to facilitate the transform of a measurment of the arameter to a subscore on a common score(e.G. 0-100) The score of a sample is calculated as a fuction of the six subscores, using four different approaches; (1) the unweighted arithmetic water quality score, (2) the weighted arithmetic water quality score, (3)the unweighted multiplicative score and (4) the reduced (total) score. Independent of these calculated scores, the experts' score which is calculated by averaging the ratings of water quality experts is obtained and compared with each of the four calculated scores by means of the least square method. The experts' score compares most favorably with the "reduced" score with the correlation coefficient of 0.956 : therefore this method of water quality scoring is adopted to calculate the Han River water quality scores and indices. Water quality index data for Guiri, ukdo, Pokwangdong, Noryangjin, Yongdungpo and Kayang Stations, 1975-1979 are as follow: The overall water quality index data of the Han River between Guiri and Kayang Stations are found; 47.3 in 1976, 48.0 in 1977, 48.5 in 1978 and 54.7 in 1979, indicating the general trend towards water quality improvent in this part of the river, in terms of the increased water quality index by average 1.85 points per year during this period. Finally the optimum sampling frequencies distributed among the six stations, using an equation which takes into account the coefficients of variation of the water quality scores and indices arec calculated.alculated.

• 한국경영과학회:학술대회논문집
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• 대한산업공학회/한국경영과학회 2002년도 춘계공동학술대회
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• pp.1044-1051
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• 2002

This paper proposes a two-phase mathematical programming approach by considering classification gap to solve the proposed credit scoring problem so as to complement any theoretical shortcomings. Specifically, by using the linear programming (LP) approach, phase 1 is to make the associated decisions such as issuing grant of credit or denial of credit to applicants. or to seek any additional information before making the final decision. Phase 2 is to find a cut-off value, which minimizes any misclassification penalty (cost) to be incurred due to granting credit to 'bad' loan applicant or denying credit to 'good' loan applicant by using the mixed-integer programming (MIP) approach. This approach is expected to and appropriate classification scores and a cut-off value with respect to deviation and misclassification cost, respectively. Statistical discriminant analysis methods have been commonly considered to deal with classification problems for credit scoring. In recent years, much theoretical research has focused on the application of mathematical programming techniques to the discriminant problems. It has been reported that mathematical programming techniques could outperform statistical discriminant techniques in some applications, while mathematical programming techniques may suffer from some theoretical shortcomings. The performance of the proposed two-phase approach is evaluated in this paper with line data and loan applicants data, by comparing with three other approaches including Fisher's linear discriminant function, logistic regression and some other existing mathematical programming approaches, which are considered as the performance benchmarks. The evaluation results show that the proposed two-phase mathematical programming approach outperforms the aforementioned statistical approaches. In some cases, two-phase mathematical programming approach marginally outperforms both the statistical approaches and the other existing mathematical programming approaches.

• 응용통계연구
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• 제20권3호
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• pp.573-584
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• 2007

기업의 신용을 평가하는데 있어 정확한 파산확률의 추정은 무엇보다도 중요한 요소이다. 선형로지스틱회귀모형보다 성능이 좋은 기대효용최대화 (Maximum Expected Utility) 모형이 제안되었다. 그러나 이 모형에 포함되어 있는 모수의 일부가 북미와 유럽지역의 자료를 토대로 경험적으로 추정되어진 것이므로 우리나라 기업에 바로 적용하기에는 무리가 있다. 따라서 우리나라 중소기업의 자료를 바탕으로 모수를 재추정하여 한국형 MEU모형을 제안하고자 한다. 34,057개의 중소기업을 이용하여 한국형 MEU모형을 설계한 결과, 기존의 북미 유럽형 모형과 차이가 많이 나는 것으로 나타났으며 성능면에서도 선형로지스틱회귀모형보다 전 산업분류에 걸쳐 한국형 MEU모형이 매우 우수한 것으로 나타났다.

• 정보처리학회논문지:컴퓨터 및 통신 시스템
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• 제9권1호
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• pp.17-24
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• 2020

본 논문에서는 합성곱 신경망 기반의 영화 평점 예측 구조를 제안한다. 제안하는 구조는 문장 분류을 위하 고안된 TextCNN를 세 가지 측면에서 확장하였다. 첫 번째로 문자 임베딩을 이용하여 단어의 다양한 변형들을 처리할 수 있다. 두 번째로 주목 메커니즘을 적용하여 중요한 특징을 더욱 부각하였다. 세 번째로 활성 함수의 출력을 1-10 사이의 평점으로 만드는 점수 함수를 제안하였다. 제안하는 영화 평점 예측 구조를 평가하기 위해서 영화 리뷰 데이터를 이용하여 평가해 본 결과 기존의 방법을 사용했을 때보다 더욱 낮은 MSE를 확인하였다. 이는 제안하는 영화 평점 예측 구조의 우수성을 보여 주었다.

• 품질경영학회지
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• 제43권3호
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• pp.373-382
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• 2015

Purpose: In this paper, we developed a reliability index (RI) to efficiently compare reliability of products based on the design, development and production information such as reliability tests, quality, product life-cycle management. RI also can be applied to reliability prediction of a novel product as well as comparison evaluation among existing products. Methods: For evaluating RI, we proposed evaluation process which is composed of five steps. Target modules are selected based on warranty data and correlation analysis. Scores of selected target modules are calculated by scoring function. Finally, weights of RI model are determined by optimization method. Results: This paper presented an empirical analysis based on failure data of mobile devices. In this case study, we demonstrated that there is a direct correlation between evaluated RI and field failure probability of each product. Conclusion: We proposed the index for comprehensive and effective assessment of product reliability level. From the procedure of this study, we expected to be applied for reliability estimation of novel products and deduction of field failure-related factors.

• 한국멀티미디어학회논문지
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• 제10권9호
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• pp.1185-1196
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• 2007

게임산업의 경쟁력을 강화하고 부가가치를 높이기 위하여 수요자가 요구하는 높은 만족도를 갖는 게임을 개발할 수 있도록 만족도를 정량적으로 평가하여 만족도 기준을 제시할 수 있는 연구 및 근거가 필요하다. 특히 만족도 요소들의 점수화와 모집단 분포의 추정은 중요한 과제로서 이를 통하여 어떤 게임이 다른 게임에 비하여 만족도가 높은지 낮은지를 알 수 있으며 만족도를 제고시키기 위하여 보완해야 할 요소들과 기술력을 예측할 수 있다. 본 연구에서는 게임 만족도 요소들의 접수분포를 정규화 하는 방법을 제 안하고 시뮬레이션을 통한 모수적 밀도함수 추정방법을 이용하여 모집단 분포를 추정하였다.