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http://dx.doi.org/10.15188/kjopp.2017.12.31.6.328

Extracts of Desmodii Herba Suppresses of Rheumatoid Arthritis  

Noh, Eun Mi (Center for Metabolic Function Regulation, Wonkwang University School of Medicine)
Song, Hyun Kyung (Center for Metabolic Function Regulation, Wonkwang University School of Medicine)
Kim, Jeong Mi (Center for Metabolic Function Regulation, Wonkwang University School of Medicine)
Lee, Guem San (Department of Herbology, School of Korean Medicine, Wonkwang University)
Kwon, Kang Beom (Center for Metabolic Function Regulation, Wonkwang University School of Medicine)
Lee, Young Rae (Center for Metabolic Function Regulation, Wonkwang University School of Medicine)
Publication Information
Journal of Physiology & Pathology in Korean Medicine / v.31, no.6, 2017 , pp. 328-333 More about this Journal
Abstract
Desomodii Herba (DH) has been shown to exhibit pharmacologyical activities, such as increase myocaridal contraction and secretion of hepatic bile. DH is used to reduce pain caused by rheumatoid arthritis(RA) in Korean medicine. However, the DH exact(DHE) effect and mechanism on rheumatoid arthritis are unknown. In this study, we aimed at the inhibitory effect of DHE on rheumatoid arthritis, and investigated the effect in collagen-induced mice arthritis model and TNF-${\alpha}$ induced MMP-1 and MMP-3 expression including the molecular basis in rheumatoid arthritis synovial fibroblasts (RASFs).The effect of DHE on RA was measured by clinical scoring system. In RASFs, expression of MMP-1 and MMP-3 was assessed by Western blotting and real-time PCR. Also, Western blotting used to evaluate the phosphorylation levels of p38, ERK and JNK and activation of NF-${\kappa}B$ and AP-1. Our results showed that DHE reduced collagen-induced arthritis in mice. DHE inhibits TNF-${\alpha}$ induced MMP-1 and MMP-3 expression and mRNA levels in RASFs. The inhibitory effect of DHE was mediated by the inhibition of the AP-1/JNK signaling pathway. Taken together, our results suggest that the DHE may have preventive potential for rheumatoid arthritis.
Keywords
Desomodii Herba(廣 金 錢 草 ); Rheumatoid arthritis; MMPs; AP-1;
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