• 대한한의학방제학회지
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• 제20권1호
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• pp.123-132
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• 2012

Objectives : The purpose of this study is to find out herb-pair prototype composed of Zanthoxyli Fructus, to examine compatibility regulation between them and to classify them into seven features of compatibility. Methods : To search usages of Zanthoxyli Fructus compatibility, we have investigated the classics of herb and prescription such as "五十二病方"(Fifty-two kinds of Diseases), "黃帝內經"(The Medical Classic of Yellow Emperor), "傷寒論"(Treatise on Febrile Caused by Cold), "金匱要略"(Synopsis of Prescriptions of The Golden), "附廣肘后方"(Handbook of Prescriptions for Emergencies), "本草綱目"(Compendium of Materia Medica), "得配本草"(Deukbae Materia Medica). Results : In these books Zanthoxyli Fructus was paired with below herbs; 桂(Cinnamomi Cortex), 薑(Zingiberis Rhizoma), 吳茱萸(Evodiae Fructus), 細辛(Asari Radix), 茴香(Foeniculi Fructus), 肉荳蔲(Cistanches Herba), 釜下土(Terba Flava Usta), 益智仁(Alpinae Oxyphyllae Fructus), 飴(Saccharum Granorum), 葱白(Allii Radix), 梨(Pyrus), 牙皂(Gleditsia Fructus), 杏仁(Armeniacae Amarum Semen), 蕎麥粉(Fagopyrum esculentum Moench), 胡粉(Minium), 白朮(Atractylodis Rhizoma White), 蒼朮(Atractylodis Rhizoma), 麻子仁(Cannabis Fructus), 大麥蘗(Hordei Fructus Germiniatus), 麴(Massa Medicata Fermentata), 生地黃(Rehmanniae Radix), 茯苓(Poria), 牡蛎(Ostreae Concha), 白礬(Alumen), 雄黃(Realgar), 烏頭(Aconiti Radix), 附子(Aconiti Lateralis Preparata Radix). Conclusions : Zanthoxyli Fructus herb-pair classified by seven features of compatibility are as follows; 1. Mutual reinforcement compatibility with : Cinnamomi Cortex, Zingiberis Rhizoma, Evodiae Fructus, Asari Radix, Foeniculi Fructus, Cistanches Herba, Terba Flava Usta, Alpinae Oxyphyllae Fructus, Saccharum Granorum, Allii Radix, Pyrus, Gleditsia Fructus. 2. Mutual assistance compatibility with : Armeniacae Amarum Semen, Fagopyrum esculentum Moench, Minium, Atractylodis Rhizoma White, Atractylodis Rhizoma, Cannabis Fructus, Hordei Fructus Germiniatus, Massa Medicata Fermentata, Rehmanniae Radix, Poria, Ostreae Concha, Alumen. 3. Mutual restraint compatibility with: Realgar, Aconiti Radix, Aconiti Lateralis Preparata Radix) 4. Mutual detoxication compatibility with: 桑汁(Juice of Mori Folium), 桑根汁(Juice of Morus Cortex), 大蒜(Allii Bulbus), 薺苨(Remotiflori Radix), 桂汁(Juice of Cinnamomi Cortex).

• 대한한의학방제학회지
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• 제28권1호
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• pp.15-27
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• 2020

Objectives : We selected three herb-combined remedies, Bigihwan (BGH), Daechilgitang (DCGT) and Mokwhyangbinranghwan (MHBRH), through Donguibogam text-mining analysis, and evaluated their anti-cancer effects on human hepatocellular carcinoma Hep3B cells. Methods : Cytotoxicity was assessed by an MTT assay. Apoptosis rate, autophagy and ROS level were detected by flow cytometry. The autophagy was also observed by Cyto-ID staining fluorescence microscopy. The expression of autophagy, mitophagy and pexophagy regulatory proteins was detected by Western blot analysis. Results : BGH showed the strongest effect among the three prescriptions in inhibiting Hep3B cell viability, which was associated with the induction of apoptosis and autophagy. Autophagy blockers improved cell viability and reduced apoptosis after BGH and DCGT treatments, indicating that autophagy by these prescriptions enhanced Hep3B cells against their cytotoxicity. However, MHBRH enhanced the reduction of cell viability and apoptosis by autophagy blockers. Induction of autophagy by BGH treatment was associated with mitophagy due to mitochondrial dysfunction than DCGT and MHBRH-treated cells. In addition, induction of apoptosis by BGH treatment was ROS-dependent and showed the possibility of pexophagy involvement. Conclusion : Although further studies need to be conducted to study the efficacy and mechanism of accurate anticancer activity, the present results will serve as important sources of understanding the mechanism of action of herbal remedies prescribed for liver disease as documented in Donguibogam.

• 대한한의학방제학회지
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• 제31권4호
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• pp.315-325
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• 2023

Objectives : Recently, research has been actively conducted on the efficacy of complexes based on oriental medicine prescriptions for improving immune activity and allergies. In this study, In this study, we aimed to examine the effect of Angelica gigas Nakai and Corni fructus extract (AC), medicinal herbs, among candidate drugs derived through preliminary experiments with various components of oriental medicine prescriptions for allergies, on allergies in RBL-2H3 cells. Methods : We evaluated the effect of the ethanol extract of Ulmus on the allergic inflammatory response in anti-DNP-IgE activated DNP-HSA in RBL-2H3 cells. Cell toxicity was determined by WST-1 assay and the markers of degranulation such as beta-hexosaminidase, histamine, TNF-α and IL-6 production of inflammatory mediators and FcεRI-mediated expression. Results : The results showed that treatment with AC extract (20, 40 and 80㎍/㎖) noncytotoxic levels and significantly inhibited the release of β-hexosaminidase, histamine and the production of TNF-α and IL-6 in RBL-2H3 by the antigen stimulation. Conclusions : These results indicate that AC extract exhibits anti-allergic activity through inhibition of degranulation and inhibition of inflammatory mediators and cytokine release. These findings suggest that AC extract may have potential as a prophylactic and therapeutic agent for the treatment of various allergic diseases.

• 경영과학
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• 제28권2호
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• pp.93-103
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• 2011

This paper has aimed to identify marketing variables which affect physicians' prescription of drug. Based on a literature review this paper derives the three factors (indirect commercial source, direct commercial source, academic information source) of information sources that physicians rely on for medicines, the three factors (research supporting activity, marketing supporting activity, medicine information supporting activity) of promotion activities physicians prefer, and the four factors (indirect quality of medicine, direct quality of medicine, experience of using medicine, price and design of medicine) of prescription criteria physicians use. Then it investigates using canonical correlation analysis whether or not physicians' prescriptions are affected by the information sources, the promotion activities, and the type of physicians. From the canonical correlation analysis this paper derives the meaningful three canonical functions of prescription for drugs. The first function explains the prescription which is insensitive to marketing activities, the second function does the prescription which is sensitive to them, and the final function does the prescription which is not affected by them.

• 대한한의학방제학회지
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• 제22권2호
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• pp.55-61
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• 2014

Objectives : The purpose of this study is to improve the fomula efficiency and prevent the resource abuse by clarifying the origin of kinds of Cinnamomum cassia Presl. Methods : 1. We researched "Shennongbencaojing", "Bencaogangmu", "Shanghanlun", "Jinguiyaolue", "Dongeuibogam", and other books. 2. Choosing a related words such as Cinnamomi ramulus(Gye-ji), Cassiae Cortex Interior(Gye-sim), Cinamomi Cortex(Yuk-gye). 3. Searching prescriptions: We searched prescriptions containing the Cinnamon in above books, and compared the differency among them. Conclusions : 1. Cinnamomi ramulus(Gye-ji) used for Shanghanlun contains Cinamomi Cortex(Yuk-gye), Cinnamomi ramulus(Gye-ji) and Cassiae Cortex Interior(Gye-sim) written in the Korean Pharmacopoeia. 2. Cinamomi Cortex(Yuk-gye) is the thick cortex of trunk of Cinnamomum cassia. It has functions like downwarding and warming-tonifying, and it is mainly used for Palmi-won(Bawei-yuan). 3. Cassiae Cortex Interior(Gye-sim) is about 30% of Cinamomi Cortex(Yuk-gye) middle layer, removing outer and inner cortex. Its main functions are regulating heart, coordinating the heart and kidney, and dispelling stastic blood and it is mainly used for Gyejibokryoung-hwan(Guizhifuling-wan) and Dangguisoo-san(Dangguixu-san). 4. Current Cinnamomi ramulus(Gye-ji) is a twig. thus, it means a small branch. Its main functions are upwarding, transversing, and exterior-effusing and it is mainly used for Gyeji-tang(Guizhijiagui-tang) and Gyejigagye-tang(Guizhi-tang).

• 천문학회보
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• 제41권1호
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• pp.72.1-72.1
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• 2016

Current and planned large-volume surveys such as the Sloan Digital Sky Survey extended Baryon Oscillation Spectroscopic Survey (SDSS IV-eBOSS) or the Dark Energy Spectroscopic Instrument (DESI) will use Luminous Red Galaxies (LRGs) and Emission Line Galaxies (ELGs) to map the cosmic web up to z~1.7, and will allow one to accurately constrain cosmological models and obtain crucial information on the nature of dark energy and the expansion history of the Universe in novel epochs - particularly by measuring the Baryon Acoustic Oscillation (BAO) feature with improved accuracy. To this end, we present here a study of the spatial distribution and clustering of a sample of LRGs and ELGs obtained from a sub-volume of the MultiDark simulation complemented by different semi-analytic prescriptions, and investigate how these two different populations trace the cosmic web at different redshift intervals - along with their synergy. This is the first step towards the interpretation of upcoming ELG and LRG data.

• 대한한의학방제학회지
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• 제14권1호
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• pp.201-203
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• 2006

There are people. however, who do not understand what science means, especially among those practicing Oriental Medicine. They associate science with machines and consider that science is something not applicable to Oriental Medicine because Medicine is for humans not for machines. Science is a system of knowledge of universal facts and laws obtained based on objectivity, which under the same conditions gives the same results no matter when, where and how it is done and no matter who does it. To achieve development of that level, knowledge and technology from all areas should be considered and, if found useful, should be accepted. The immediate hurdle is to make Bang-Jae Science understood. So far Bang-Jae Discipline as understood by the practitioners of Oriental Medicine is nothing more than selecting prescriptions inherited from the predecessors that match given symptoms. To make Bang-Jae Discipline a science. i.e. Bang-Jae Science, we should not only study the traditional literature to gather data, experiment and verify with them one after another. make them objective and carry our scientific systemization. It takes fresh and creative trials but it will surely contribute to the future medical science.

• 대한한의학방제학회지
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• 제13권1호
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• pp.179-194
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• 2005

This study was investigated to make sure the usage of prescriptions in which Perilla frutescens is used as a main herbal medicine in Donguibogam. Through the investigation on main treatment, pathology, etiology and nature of disease, dosage in the relevant prescriptions, The consequences are as follows; 1. The Perilla frutescens is used in 15 treatment fields which contain the cough, cold chapter ect. 2. The Perilla frutescens is used as a main heral medicine in 30 natures of disease such as cough-relative disease, an asthma, an external wind and cold, etc. 3. The Perilla frutescens is used for various pathology in the exogenous etiological factor, endogenous etiological factor, exo-endogeneous etiological factor and non-exo-endogeneous etiological factor. 4. The Perilla frutescens is used in a range of $1.2g{\sim}10g$ in relevant prescription. The main dosage is 4g. 5. The Perilla frutescens is used with various crude herbs in accordance with the pathogeny. The Perilla frutescens has been used to reduce heat from the lungs, to relieve asthma, to promote qi's movement and to soothe fetal movement etc. According to the results, 1 suggest to use the Perilla frutescens in a various pathogenic fields. The Perilla frutescens is able to remove not only pathogenic heat from the cough-relative disease, but also pathogenic asthma, an external winds and colds, etc.

• International Journal of Computer Science & Network Security
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• 제24권3호
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• pp.43-52
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• 2024

Health Monitoring System is a sophisticating technology and another way to the normal/regular management of the health of the patient. This Health Monitoring Mobile Application is a contribution from our side to the public and to the overall health industry in Pakistan. With the help of Health mobile application, the users will be able to store their medical records, prescriptions and retrieve them later. The users can store and keep track of their vital readings (heart rate, blood pressure, fasting glucose, random glucose). The mobile application also shows hospitals that are nearby in case the user wants to avail of any medical help. An important feature of the application is the symptoms-based disease prediction, the user selects the symptoms which he has and then the application will name certain diseases that match those symptoms based on relevant algorithms. The major advances and issues have been discussed, and as well as potential tasks to health monitoring will be identified and evaluated.

• Korean Journal of Acupuncture
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• 제36권3호
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• pp.181-187
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• 2019

This case report details induction and maintenance of remission in a 34-year-old female patient with ulcerative colitis (UC) after Korean herbal medicine treatment. The patient diagnosed as UC after a series of examinations including endoscopy in a western medical hospital mainly presented bloody diarrhea and dyspepsia and symptoms were persistent even with medications. She was given individualized Korean herbal medicine prescriptions for 7 months and the symptoms were monitored during treatment and no adverse events were reported. After clinical remission, endoscopic remission was also confirmed by colonoscopy. Clinical remission was maintained for 30 months after treatment without Western medication for UC. This case report shows that Korean herbal medicine treatment may have the potential for complete remission of UC and further research is warranted.