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http://dx.doi.org/10.14406/acu.2019.014

Herbal Medicine Treatment for Induction and Maintenance of Remission in Ulcerative Colitis: A Case Report  

Lee, Byung-Hee (Hanstep Korean Medicine Clinic)
Won, Jiyoon (Department of Korean Medical Science, Graduate School, Kyung Hee University)
Lee, Hyangsook (Department of Korean Medical Science, Graduate School, Kyung Hee University)
Publication Information
Korean Journal of Acupuncture / v.36, no.3, 2019 , pp. 181-187 More about this Journal
Abstract
This case report details induction and maintenance of remission in a 34-year-old female patient with ulcerative colitis (UC) after Korean herbal medicine treatment. The patient diagnosed as UC after a series of examinations including endoscopy in a western medical hospital mainly presented bloody diarrhea and dyspepsia and symptoms were persistent even with medications. She was given individualized Korean herbal medicine prescriptions for 7 months and the symptoms were monitored during treatment and no adverse events were reported. After clinical remission, endoscopic remission was also confirmed by colonoscopy. Clinical remission was maintained for 30 months after treatment without Western medication for UC. This case report shows that Korean herbal medicine treatment may have the potential for complete remission of UC and further research is warranted.
Keywords
ulcerative colitis; inflammatory bowel disease; herbal medicine; remission;
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Times Cited By KSCI : 8  (Citation Analysis)
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1 Guo M, Ding S, Zhao C, Gu X, He X, Huang K, et al. Red Ginseng and Semen Coicis can improve the structure of gut microbiota and relieve the symptoms of ulcerative colitis. J Ethnopharmacol. 2015 ; 162 : 7-13. https://doi.org/10.1016/j.jep.2014.12.029   DOI
2 Jeon Y, Bang K, Shin M, Lee J, Chang Y, Jin J. Regulatory effects of glycyrrhizae radix extract on DSS-induced ulcerative colitis. BMC Complement Altern Med. 2016 ; 16(1) : 459. https://doi.org/10.1186/s12906-016-1390-8   DOI
3 Periasamy S, Wu WH, Chien SP, Liu CT, Liu MY. Dietary Ziziphus jujuba Fruit Attenuates Colitis-Associated Tumorigenesis: A Pivotal Role of the NF-kappaB/IL-6/JAK1/STAT3 Pathway. Nutr Cancer. 2019 : 1-13. https://doi.org/10.1080/01635581.2019.1615515
4 Lee I, Hyun Y, Kim D. Berberine ameliorates TNBS-induced colitis by inhibiting lipid peroxidation, enterobacterial growth and NF-kappaB activation. Eur J Pharmacol. 2010 ; 648(1-3) : 162-70. https://doi.org/10.1016/j.ejphar.2010.08.046   DOI
5 Walmsley RS. Comment on an optimized patient-reported ulcerative colitis disease activity measure derived from the mayo score and the simple clinical colitis activity index. Inflamm Bowel Dis. 2014 ; 20(12) : E25-6. https://doi.org/10.1097/mib.0000000000000248   DOI
6 Martins NB, Peppercorn MA. Inflammatory bowel disease. Am J Manag Care. 2004 ; 10(8) : 544-52.
7 Langholz E. Current trends in inflammatory bowel disease: the natural history. Therap Adv Gastroenterol. 2010 ; 3(2) : 77-86. https://doi.org/10.1177/1756283X10361304   DOI
8 Song I. Inflammatory bowel disease in Korean. Korean Journal of Medicine. 1999 ; 57(4) : 661-75.
9 Sakamoto N, Kono S, Wakai K, Fukuda Y, Satome M, Shimoyama T, et al. Dietary risk factors for inflammatory bowel disease: a multicenter case-control study in Japan. Inflamm Bowel Dis. 2005 ; 11(2) : 154-63. https://doi.org/10.1097/00054725-200502000-00009   DOI
10 Kwak M, Cha J, Lee H, Choi Y, Seo S, Ko K, et al. Emerging trends of inflammatory bowel disease in South Korea: A nationwide population-based study. J Gastroenterol Hepatol. 2019 ; 34(6) : 1018-26.   DOI
11 Shaw SY, Blanchard JF, Bernstein CN. Association between the use of antibiotics in the first year of life and pediatric inflammatory bowel disease. Am J Gastroenterol. 2010 ; 105(12) : 2687-92. https://doi.org/10.1038/ajg.2010.398   DOI
12 Curkovic I, Egbring M, Kullak-Ublick GA. Risks of inflammatory bowel disease treatment with glucocorticosteroids and aminosalicylates. Dig Dis. 2013 ; 31(3-4) : 368-73. https://doi.org/10.1159/000354699   DOI
13 Zenlea T, Peppercorn MA. Immunosuppressive therapies for inflammatory bowel disease. World J Gastroenterol. 2014 ; 20(12) : 3146-52. https://doi.org/10.3748/wjg.v20.i12.3146   DOI
14 Papamichael K, Lin S, Moore M, Papaioannou G, Sattler L, Cheifetz AS. Infliximab in inflammatory bowel disease. Ther Adv Chronic Dis. 2019 ; 10 : 2040622319838443. https://doi.org/10.1177/2040622319838443
15 Jang H, Sun J, Sun T. A Case Report of Chengsim Yeunja-Tang for Ankylosing Spondylitis associated with Severe Ulcerative Colitis. Korean J Orient Int Med. 2005 ; 26(3) : 685-91.
16 Park S, Kim G, Shin S, Ko H. Constitution Therapy of Adolescent Ulcerative Colitis: A Case Report. Korean J Orient Int Med. 2017 ; 38(4) : 531-40. https://doi.org/10.22246/jikm.2017.38.4.531   DOI
17 Kim S, Kim H, Kim J, Lee S, Hong S, Kim W. Clinical Case of Symptoms Remaining after Western Medical Therapy in Ulcerative Colitis, with Herbal Medicine Dansamboheol-tang gagam, Acupuncture, and Moxibustion Treatment. Korean J Orient Int Med. 2007 ; 28(4) : 911-8.
18 Yoon S. A Case Report of a Patient with Active Ulcerative Colitis Treated with Do-Che Decoction-based Korean Medicine. J Korean Trad Oncol. 2012 ; 17(2) : 17-22.   DOI
19 Seo C, Lee H, Choi K, Lim D, Ryu H, Lee Y, et al. Two Cases of Ulcerative Colitis Diagnosed as Damp-Heat Dysentery Treated with Jakyaktang-gamibang. Korean J Orient Int Med. 2006 ; 27(4) : 984-90.
20 Lim D, Kim N, Lee H, Lee Y, Hong S, Kim H, et al. One Case of Ulcerative Colitis Improved by Gagam-Sukhongjeon. Herbal Formula Science. 2007 ; 15(1) : 229-37.
21 Hur J, Cho D, Son J, Kwak M, Kim D, Byun J, et al. A Case Report of Ulcerative Colitis Medicated by Danggwihwahyeolsan-gamibang and Gami-Jeonssibaekchulsan. Herbal Formula Science. 2007 ; 15(2) : 187-95.
22 Hwang J, Choi H, Baik Y, Jeong S, Shin G, Lee W. A Case of Pyungwijiyutang-gamibang Diagnosed as Constipation due to Stagnation of Eum with Ulcerative Colitis. Korean J Orient Int Med. 2007 ; 28(4) : 972-7.
23 Kim J. Consideration in the Interpretation of the Banhasasimtang. Master's Thesis. Woosuk University. 2017 : 57-8.
24 Rho E. Manual for ShanghanGeumgue formula-basic prescription. 1st ed. Seoul: Barunhanyak. 2018.
25 Nikkhah-Bodaghi M, Maleki I, Agah S, Hekmatdoost A. Zingiber officinale and oxidative stress in patients with ulcerative colitis: A randomized, placebo-controlled, clinical trial. Complement Ther Med. 2019 ; 43 : 1-6. https://doi.org/10.1016/j.ctim.2018.12.021   DOI
26 Lee B. Herbal medicine for inflammatory bowel disease: systematic review and exploratory practice algorithm through case series. PhD Thesis. Kyung Hee University. 2016 : 56-62.
27 Todo Y. Yakjing. 1st ed. Kyonggi-do : Mulgogisoop. 2014 : 102-22, 149-65, 261-9, 314-23.
28 Yu HL, Zhao TF, Wu H, Pan YZ, Zhang Q, Wang KL, et al. Pinellia ternata lectin exerts a pro-inflammatory effect on macrophages by inducing the release of pro-inflammatory cytokines, the activation of the nuclear factor-kappaB signaling pathway and the overproduction of reactive oxygen species. Int J Mol Med. 2015 ; 36(4) : 1127-35.   DOI
29 Jiang W, Seo G, Kim Y, Sohn D, Lee S. PF2405, standardized fraction of Scutellaria baicalensis, ameliorates colitis in vitro and in vivo. Arch Pharm Res. 2015 ; 38(6) : 1127-37. https://doi.org/10.1007/s12272-015-0553-3   DOI
30 Zhang M, Xu C, Liu D, Han MK, Wang L, Merlin D. Oral Delivery of Nanoparticles Loaded With Ginger Active Compound, 6-Shogaol, Attenuates Ulcerative Colitis and Promotes Wound Healing in a Murine Model of Ulcerative Colitis. J Crohns Colitis. 2018 ; 12(2) : 217-29. https://doi.org/10.1093/ecco-jcc/jjx115   DOI
31 Seong M, Woo J, Kang J, Jang Y, Choi S, Jang Y, et al. Oral administration of fermented wild ginseng ameliorates DSS-induced acute colitis by inhibiting NF-kappaB signaling and protects intestinal epithelial barrier. BMB Rep. 2015 ; 48(7) : 419-25. https://doi.org/10.5483/bmbrep.2015.48.7.039   DOI
32 Wehkamp J, Gotz M, Herrlinger K, Steurer W, Stange EF. Inflammatory bowel disease. Dtsch Arztebl. 2016 ; 113(5): 72-82. https://doi.org/10.3238/arztebl.2016.0072