• Asian Pacific Journal of Cancer Prevention
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• 제15권7호
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• pp.3139-3144
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• 2014

Background: Medical treatment for eliminating the side effects of cancer therapy may not always be efficacious. Acupuncture is one of the most widely accepted alternative and complementary therapies in use today. In this study, we investigated the efficacy of acupuncture in patients experiencing cancer treatment side effects, including nausea, vomiting, pain, poor sleep quality and anxiety. Materials and Methods: A total of 45 inpatients who underwent chemotherapy between February and April 2013 in the Oncology Department of Numune Hospital were included in our study. Acupuncture was administered to the patients one day prior to chemotherapy, on the day of chemotherapy and one day after chemotherapy. The patients were evaluated on nausea, vomiting, pain, sleep quality and anxiety before the chemotherapy and on the $4^{th}$ day of chemotherapy. Results: Of the 45 patients included in the study, 18 (40%) were female and 27 (60%) were male. A total of 25 (55.6%) had an elementary school education; 32 patients (71%) had stage 4 cancer and were treated with palliative chemotherapy (the patient characteristics are shown in Table 1). Statistically significant decreases (p<0.001) in pain, nausea, vomiting, insomnia and anxiety scores were observed after the acupuncture treatment compared to baseline. There were no differences in the age, gender, education level, stage or metastasis levels between the patient groups whose symptoms improved or were unchanged. Conclusions: Our study showed that acupuncture has positive effects in cancer treatment patients who experience nausea, vomiting, pain, poor sleep quality and anxiety as side effects of chemotherapy. Chemotherapy-related side effects in cancer patients could be decreased by the concurrent use of acupuncture.

• Journal of Korean Neurosurgical Society
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• 제66권4호
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• pp.465-475
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• 2023

Objective : Our objective is to analyze the occurrence, clinical course and risk factors for glioma patients with leptomeningeal metastasis (LM) according to different metastasis patterns and clinical variables. Methods : We retrospectively reviewed data from 376 World Health Organization (WHO) grade II-IV adult glioma patients who were treated in the National Cancer Center from 2001 to 2020. Patients who underwent surgery at other institutions, those without initial images or those with pathologically unconfirmed cases were excluded. LM was diagnosed based on magnetic resonance imaging (MRI) findings or cerebrospinal fluid (CSF) cytology. The metastasis pattern was categorized as nodular or linear according to the enhancement pattern. Tumor proximity to the CSF space was classified as involved or separated, whereas location of the tumor was dichotomized as midline, for tumors residing in the thalamus, basal ganglia and brainstem, or lateral, for tumors residing in the cerebral and cerebellar hemispheres. Results : A total of 138 patients were enrolled in the study. A total of 44 patients (38%) were diagnosed with LM during a median follow-up of 9 months (range, 0-60). Among the clinical variables, tumor proximity to CSF space, the location of the tumor and the WHO grade were significant factors for LM development in univariate analysis. In multivariate analysis, the midline location of the tumor and WHO grade IV gliomas were the most significant factor for LM development. The hazard ratio was 2.624 for midline located gliomas (95% confidence interval [CI], 1.384-4.974; p=0.003) and 3.008 for WHO grade IV gliomas (95% CI, 1.379-6.561; p=0.006). Conclusion : Midline location and histological grading are an important factor for LM in glioma patients. The proximity to the CSF circulation pathway is also an important factor for WHO grade IV glioma LM. Patients carrying high risks should be followed up more thoroughly.

• The Korean Journal of Physiology and Pharmacology
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• 제18권4호
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• pp.333-339
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• 2014

Exendin-4 (Ex-4), a glucagon-like peptide-1 receptor (GLP-1R) agonist, has been known to reverse hepatic steatosis in ob/ob mice. Although many studies have evaluated molecular targets of Ex-4, its mechanism of action on hepatic steatosis and fibrosis has not fully been determined. In the liver, glucose transporter 4 (GLUT4) is mainly expressed in hepatocytes, endothelial cells and hepatic stellate cells (HSCs). In the present study, the effects of Ex-4 on GLUT4 expression were determined in the liver of ob/ob mice. Ob/ob mice were treated with Ex-4 for 10 weeks. Serum metabolic parameters, hepatic triglyceride levels, and liver tissues were evaluated for hepatic steatosis. The weights of the whole body and liver in ob/ob mice were reduced by long-term Ex-4 treatment. Serum metabolic parameters, hepatic steatosis, and hepatic fibrosis in ob/ob mice were reduced by Ex-4. Particularly, Ex-4 improved hepatic steatosis by enhancing GLUT4 via GLP-1R activation in ob/ob mice. Ex-4 treatment also inhibited hepatic fibrosis by decreasing expression of connective tissue growth factor in HSCs of ob/ob mice. Our data suggest that GLP-1 agonists exert a protective effect on hepatic steatosis and fibrosis in obesity and type 2 diabetes.

• 한국치위생학회지
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• 제10권5호
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• pp.877-885
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• 2010

Objectives : This study was carried out with the aim of utilizing it as basic data in a plan for oral health promotion by analyzing oral-health awareness in high school students of some districts in our country, and by analyzing physical, mental and social influential factors in oral health, through using OHIP(Oral Health Impact Profile). Methods : It surveyed by carrying out self-administered questionnaire research targeting 536 boy & girl high school students in the 1st and the 2nd grade at 3 high schools in some districts of Gyeonggi Province. Results : 1. As for experience of having not visited dental clinic, a case of having not visited accounted for 32.5%. On the other hand, a case of having visited accounted for 67.5%. As for the appearance of oral health education, only 2.8% responded as saying of having experience. 97.2% responded as saying of having not taken oral health education. 2. As for oral health state perceived by oneself, the response as saying of 'thinking it to be healthy' and that 'there is something wrong' showed the distribution of 34.1% that is the same ratio. As for oral health interest, a case of having a little interest(58.4%) or of being so much interested(12.5%) showed 70.9%. A case of having no special interest(24.8%) or of having no interest at all(4.3%) showed the level of 29.1%.3. As for oral health knowledge, the toothbrushing knowledge was the highest with 4.54 marks out of 6-point perfection. The toothbrush knowledge(4-point perfection) showed low point with 2.05 marks. 4. By gender, a case of men was high in OHIP(Oral Health Impact Profile) for the functional restriction and physical pain. On the other hand, in the remaining sphere, women were indicated to be high in OHIP. The statistically significant difference was indicated in the spheres such as physical pain, psychological discomfort, a drop in psychological ability, a drop in social ability, and social separation. 5. According to oral health state perceived by oneself, a case of thinking it to be healthy was indicated to be high in OHIP for every sphere. A case of thinking it to have gum disease was indicated to be low in OHIP for every sphere. The statistically significant difference was indicated in every sphere except the sphere of functional restriction. 6. As for a factor of having influence upon OHIP according to oral health knowledge, it was indicated that the higher toothbrush knowledge leads to having more influence upon OHIP. Conclusions : It could be known that the oral health knowledge and OHIP are varied as well according to the oral health interest level. Also, the oral health education proper for subjects is not being performed. Even as for frequency of visiting the dentist, a regular visit is failing to be made. In consideration of these points, the diversified and effective educational program is likely considered to be necessarily developed and improved that subjects can have more interest in oral health.

• Asian Pacific Journal of Cancer Prevention
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• 제14권12호
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• pp.7165-7169
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• 2013

Purpose: The aim of this study was to evaluate any association of GSTM1 and GSTT1 null genotypes with the risk of lung cancer in a South Korean population. Methods: We conducted a large-scale, population-based case-control study including 3,933 lung cancer cases and 1,699 controls. Genotypes of GSTM1 and GSTT1 were determined using real-time polymerase chain reaction. Results: In logistic regression analysis adjusted for age and smoking, we did not find any association between GSTM1 or GSTT1 and LC risk in women. However, in men, the GSTM1 and GSTTI null genotypes were borderline associated with risk (OR=1.18, 95% CI=0.99-1.41 for GSTM1, OR=1.18, 95% CI=0.99-1.41 for GSTT1), and combined GSTM1 and GSTT1 null genotypes conferred an increased risk for LC in men (OR=1.39, 95% CI=1.08-1.78). The OR for the GSTT1 null genotype was greater in subjects aged 55 years old or younger (OR=1.45, 95% CI=1.09-1.92 for men; OR=1.36, 95% CI=0.97-1.90 for women), than in those over age 55 (OR=1.03, 95% CI=0.83-1.27 for men; OR=0.86, 95% CI=0.66-1.12 for women) in both genders (p for interaction <0.05). Conclusions: In the Korean population, the GSTM1 and GSTT1 null genotypes are risk factors for LC in men; the GSTT1 null genotype has a more prominent effect on LC risk in younger people (age 55 years and under) than in older individuals.

• Journal of Preventive Medicine and Public Health
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• 제32권3호
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• pp.297-305
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• 1999

Objectives: This study was conducted to evaluate factors related to the intention of participation in a worksite smoking cessation program. Methods: To explain the health behavior of participating intention in a worksite smoking cessation program, the health belief model(HBM) was used as study model, and 144 self-administered questionnaires were completed by electronic company workers. Variables of the health belief model were composed of perceived susceptibility to smokinginduced disease, perceived severity of smoking-induced disease, economical gain as perceived benefit of smoking cessation, and nicotine dependency as perceived barrier of smoking cessation. Variables of sociodemographics, smoking status, knowledge about adverse health effects of smoking, and cues to smoking cessation were used as modifying factors. Results: Perceived severity(POR=1.99, 95% CI: 1.03-3.83), perceived benefit(POR=2.11, 95% CI: 1.07-4.17), and perceived barrier(POR=0.29, 95% CI: 0.11-0.76) were significant variables to the intention of participation in a worksite smoking cessation program in the logistic regression analysis. The perceived severity was significantly affected by knowledge about adverse health effects of smoking(POR=2.17, 95% CI: 1.23-3.84). The perceived barrier was significantly affected by education level(POR=3.66, 95% CI: 1.17-11.44), age to first cigarette (POR=0.32, 95% CI: 0.10-0.98), pack-years(POR=5.47, 95% CI: 2.37-12.61). To the Perceived benefit, the model was not fitted. Conclusion: Our results found that counterplans improving the knowledge about adverse health effects of smoking, preventing early smoking, and decreasing smoking amount should be considered for an effective smoking ban policy.

• 한국치위생학회지
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• 제6권2호
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• pp.153-164
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• 2006

Purpose: The purpose of this study was to analyze level of dental health knowledge and behavior of mothers, health educators should encourage mother to have continuous dental care habits for lifelong dental health with practical education. Methods: The subjects in this study were 490 mothers of four-year, fifth-year and sixth-year from elementary school in Daegu areas. The data was collected through a structured questionnaire from 26, June to 27, June 2006. Collected data were analyzed into frequency and Chi-square test using SPSS 10.0 program. Result: First, no statistically significant relations were found between mothers, knowledge with general characteristics of subject(age, degree of education, yes or no of occupation, subjective economy). Second, mothers, number of toothbrushing were statistically significant relations with degree of education, yes or no of occupation as over three times a day. Third, no statistically significant relations were between visiting frequency of dental clinic for one years with general characteristics of subject(age, degree of education, yes or no of occupation, subjective economy). Fourth, yes or no of use in auxiliary oral hygiene device were statistically significant relations with degree of education, yes or no of occupation, subjective economy. Fifth, mothers, knowledge were statistically significant relations with auxiliary oral hygiene device.

• 한국직업건강간호학회지
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• 제18권2호
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• pp.205-218
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• 2009

Purpose: The purpose of this study was to learn the affective factors of case managers' occupational stress. Method: A total of 986 participants responded to a self-administered questionnaire that included 24 items of Korean Occupational Stress Questionnaire Short Form (KOSQSF), job satisfaction index, health behaviors, general characteristics, and variables related to work. The data collection of research was done from 17th to 21th of September, 2007. The data were analysed by t-test, ANOVA, and multiple regression with SPSS 11.1 package program. Result: The results of this study were as follows: The overall job satisfaction rate of men and women was highly than that of the Korean worker's standard. There were statistically significant differences in occupational stress in work place, work department, work position, smoking, treatment in out-patient clinic, subjective & relative health-status, work load, supervisor's review on work-ability, and job satisfaction. According to the multi-variate analysis, occupational stress(47.6%) was related to job satisfaction, workload, individual work-ability, supervisor's review on work-ability, health status and gender. Conclusion: Occupational stress varied depending on the ten variables and was influenced by job satisfaction(35.7%) and 5 other variables. The results suggest that further follow-up study on case managers is necessary to relieve their occupational stress.

• 한국의료질향상학회지
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• 제19권2호
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• pp.36-46
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• 2013

Objectives: The purpose of this study is to find a way to effectively introduce accreditation for ambulatory health care organization by identifying the physicians' attitude for accreditation and characteristics that affect thei r attitude. Methods: A web survey was conducted from February 15 to March 4, 2011 for 183 physicians who work in ambulatory health care organizations throughout the nation. Self-reported questionnaire was used for this study. SPSS WIN(version 12.0) was utilized for statistical analysis. Results: Physician's attitude towards accreditation for ambulatory health care organization was positive(25.7%), moderate(39.3%), and negative(35.0%). Clinics that practice as a group or which treat more patients per day showed more positive attitude(p<0.05). The result of ordinal regression analysis indicates the groups with daily patients over 100 showed 36.3 times more positive attitude than the one under 75(p<0.05). Conclusion: The accreditation for ambulatory health care organization has not been throughly discussed yet. Many physicians did not have knowledge about accreditation. Clinics that see more patients per day had more positive attitude for accreditation. It indicates the cost may play important role in voluntary participation in accreditation.

• 치위생과학회지
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• 제16권2호
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• pp.111-117
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• 2016

이번 연구는 생애 과도기이자 입시 스트레스를 비롯한 여러 스트레스를 겪고 있는 고등학생을 대상으로 청소년의 스트레스 인지수준이 식습관과 구강보건행태에 어떤 관련성이 있는지 파악하고자 전라북도 일부 지역에 위치한 고등학교 1~3학년을 대상으로 설문조사를 실시하여 다음과 같은 결론을 얻었다. 가장 높은 스트레스 유형은 학업 스트레스로 $3.09{\pm}0.89$를 보였고, 그 다음은 가정(가족) 스트레스가 $2.85{\pm}0.84$로 나타났다. 여학생보다 남학생이 치과의료기관을 이용할 가능성은 적은 것으로 나타났으며, 주관적 구강건강상태에서는 본인의 구강건강상태가 좋지 않다고 생각하거나 보통이라고 생각하는 사람의 치과의료기관을 방문할 가능성이 적은 것으로 나타났다(p<0.05). 또한 스트레스가 높을수록 치과의료기관을 방문할 가능성은 높은 것으로 나타났고(p<0.05), 성적이 상위권인 학생들이 규칙적인 식사를 할 가능성이 높게 나타났다(p<0.01). 스트레스가 높을수록 우식성 식품을 섭취할 가능성이 유의하게 높았으며(p<0.01), 성적이 중위권인 학생들이 우식성 식품을 섭취의 가능성이 높게 나타났으나(p<0.01), 상위권인 학생들은 우식성 식품의 섭취 가능성이 낮게 나타났다(p<0.05). 이상의 결과로 볼 때 스트레스 인지수준이 식습관과 구강보건행태에 영향을 주고 있음을 나타내므로 스트레스를 완화시키기 위해 학교 내에서는 고등학생들의 신체적, 정신적 건강을 증진시킬 수 있는 프로그램을 개발해야 하며, 바람직한 식습관 형성을 위해 실질적이고 체계적인 구강보건교 육이 필요할 것으로 생각된다.