• Toxicological Research
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• 제17권
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• pp.47-57
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• 2001

Alzheimer's disease (AD) is the most common cause of dementia in the elderly, and its pathology is characterized by the presence of numerous numbers of senile plaques and neurofibrillary tangles. Several genetic and transgenic studies have indicated that excess amount of $\beta$-amyloid protein (A$\beta$) is produced by mutations of $\beta$TEX>$\beta$-amyloid precursor protein and causes learning impairment. Moreover, $A\beta$ has a toxic effect on cultured nerve cells. To prepare AD model animals, we have examined continuous (2 weeks) infusion of $A\beta$ into the cerebral ventricle of rats. Continuous infusion of $A\beta$ induces learning impairment in water maze and passive avoidance tasks, and decreases choline acetyltransferase activity in the frontal cortex and hippocampus. Immunohistochemical analysis revealed diffuse depositions of $A\beta$ in the cerebral cortex and hippocampus around the ventricle. Furthermore, the nicotine-evoked release of acetylcholine and dopamine in the frontal cortex/hippocampus and striatum, respectively, is decreased in the $A\beta$-infused group. Perfusion of nicotine (50 $\mu\textrm{M}$) reduced the amplitude of electrically evoked population spikes in the CA1 pyramidal cells of the control group, but not in those of the $A\beta$-infused group, suggesting the impairment of nicotinic signaling in the $A\beta$-infused group. In fact, Kd, but not Bmax, values for ［$^3H$］ cytisine binding in the hippocampus significantly increased in the $A\beta$-infused rats. suggesting the decrease in affinity of nicotinic acetylcholine receptors. Long-term potentiation (LTP) induced by tetanic stimulations in CA1 pyramidal cells, which is thought to be an essential mechanism underlying learning and memory, was readily observed in the control group, whereas it was impaired in the $A\beta$-infused group. Taken together, these results suggest that $A\beta$ infusion impairs the signal transduction mechanisms via nicotinic acetylcholine receptors. This dysfunction may be responsible, at least in part, for the impairment of LTP induction and may lead to learning and memory impairment. We also found the reduction of glutathione- and Mn-superoxide dismutase-like immunoreactivity in the brains of $A\beta$-infused rats. Administration of antioxidants or nootropics alleviated learning and memory impairment induced by $A\beta$ infusion. We believe that investigation of currently available transgenic and non-transgenic animal models for AD will help to clarify the pathogenic mechanisms and allow assessment of new therapeutic strategies.

• The Journal of the Korea Contents Association
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• 제13권8호
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• pp.152-159
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• 2013

Delinquency young people committed society as evolves is also increasing rapidly. Juvenile delinquency that occurred recently is serious. As a result, young people are feeling fear of delinquency. Fear of delinquency young people feel, a major impact on the personality development of the youth of the period of growth. In particular, the violent delinquency, to give a physical impact, damage youth receives is large. As well as physical damage to people in and around the juvenile victims, given the damage mental serious form, fear violent delinquency has been shown in many previous studies. Therefore, in this study you have the purpose to study the effects on the reaction of juvenile victims for fear of delinquency caused by the delinquency of violence. Set randomly on campus and external experience and damage directly or indirectly, are classified into action evasive action defensive reaction of fear by delinquency, factors that affect the risk caused by violent delinquency, Daegu after conducting a survey of high school students in general in the areas in which we tested the hypothesis. As a result of the verification, exerting a significant influence in order to act defensive becomes clear, experience of direct damage and experience of damage indirect fear of delinquency, avoided experience of direct damage it was found to exert a significant effect on to the action manner.

• Journal of Engineering Education Research
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• 제20권6호
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• pp.68-75
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• 2017

This study has a purpose to analyse changes in perception and image about engineering and technology of students who participated in the engineering camp. To achieve this objective, the questions were as follows. 1) What about participants' image difference for engineering before and after participating the engineering camp 2) What about participants' image difference for technology before and after participating the engineering camp. For this study, the program was progressed from Aug in 2017 and the data was collected from 88 students, middle school seniors and high school freshmen. The results of this study were as follows: First, secondary students perceived 'valuable(6.74)', 'meaningful(6.73)', 'rich(6.40)', 'collaborative(6.42)', 'nice(6.22)' as high image rank of the positive response for engineering. On the other hand, 'complex(3.59)', 'labored(3.80)', 'hard(4.66)', 'dangerous(4.48)', 'cold(4.86)' were perceived as low image rank of the negative response for engineering. We can realize that they generally has the image that engineering is valuable, meaningful and nice but also labored, complex and hard. The students who participated in the engineering camp showed the greatest difference in 'complex - simple' and 'dangerous - safe' engineering categories before and after the camp, followed by 'cold - hot', 'labored - easy', and 'hard - soft', respectively. Second, secondary students perceived 'meaningful(6.58)', 'valuable(6.55)', 'wide(6.38)', 'nice(6.37)', 'strong(6.25)' as high image rank of the positive response for technology. On the other hand, 'complex(3.85)', 'labored(3.93)', 'hard(4.62)', 'dangerous(4.72)', 'cold(5.05)' were perceived as low image rank of the negative response for technology. The students who participated in the engineering camp had the big change in 'hard - soft' technology category before and after the camp, followed by 'complex - simple', 'labored - easy', 'theoretical - practical' and 'dangerous - safe', respectively. We can see that the negative images for technology which were complex, labored, dangerous, theoretical was improved with positive image such as simple, easy, safe and practical, after conducting the engineering camp. In conclusion, both image recognitions for engineering and technology have improved after the camp. It means that interesting and entertaining engineering-technology program can boost interests in engineering and technology which felt difficult, so that images about them can be turned out positive. Also, it is possible to reduce avoidance of natural science and engineering subjects, as part of the purpose of training creative talents in science and engineering, so it can be said that the engineering camp is highly meaningful because it can lead students into the field of science and engineering.

• Journal of the Korean Institute of Landscape Architecture
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• 제45권6호
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• pp.90-97
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• 2017

Construction of urban emergency shelters based on disaster-prevention green space is an important part of an urban disaster response plan. The accessibility of disaster-prevention green space is directly related to the disaster prevention service effect of green space. Taking the Jung-gu and Nam-gu districts of Ulsan city as research targets, the accessibility of three green spaces was analyzed by a network analysis method based on information regarding the distribution of population and green space and the urban road network. Two indicators for evaluating the service effect of green spaces were service population rate and service area rate. The results showed that the accessibility of the emergency refuge parks (5min) and central refuge parks was relatively good but the service area rate and service population rate of the emergency refuge parks (3min) and temporary refuge parks was less than 60%. In view of the overall situation, the service effect of disaster-prevention green space is at this point only general in Ulsan and there is great room for improvement.

• Journal of Oriental Neuropsychiatry
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• 제32권3호
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• pp.167-184
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• 2021

Objectives: Operational definition and its validated measure of traditional Korean medicine (TKM) are pivotal for research studies and reliable clinics. There have been ten years of clinical studies on Eum-Yang (Yin-Yang) and Sasang typology using Sasang Personality Questionnaire (SPQ) of integrative biopsychology. The objective of this study was to perform a systematic review on the use of SPQ to provide insights and foundation for its further studies and clinical application. Methods: Clinical studies on SPQ were searched using five domestic and foreign research databases. Attained research articles were then subjected to predefined systematic reviews. Demographic characteristics of participants and research topics of articles were described. Psychological and physical features of SPQ and its subscales were reviewed and compiled to reveal biopsychological characteristics. Results: There were 33 articles with 15,085 participants on Eum-Yang (n=19) and Sasang typology (n=14). The SPQ-total score was in an increasing order of So-Eum, Tae-Eum, and So-Yang. Eum-Yang groups were categorized at a 3:4:3 ratio using %ile score of SPQ-total. The SPQ-total showed a significant positive correlation with Novelty-Seeking and a negative correlation with Harm-Avoidance in psychological perspective, while it was not significantly correlated with Body Mass Index or Ponderal Index in physical perspective. The SPQ-total and subscales explained psychopathological characteristics of stress recognition, negative emotion, problem behavior, and depression. Conclusions: The SPQ was found to be an objective biopsychological measure of TKM for Sasang typology and psychopathology. It would provide foundation for 'Korean Psychology' and multidisciplinary studies.

• Journal of Conservation Science
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• 제35권2호
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• pp.177-186
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• 2019

A Termiticide that is applied to the soil treatment method, one of the methods for preventing termites in Korea's wooden cultural properties, will be subjected to the leaching of the effective ingredient in treated soil by the moisture behavior of rain. As a result, termiticide is deteriorated and needs to be reprocessed, but the standards and evaluation methods are nonexistent in korea. Accordingly, a basic indoor evaluation measure was proposed for the evaluation of the effectiveness of the termiticide chamber and the calculation of the reprocessing period. First, avoidance and contact toxicity were assessed at two concentrations of the same termiticide as a method for assessing termiticide suitability. The evaluation of mortality revealed that the soil termiticide used in this experiment was non-repellent, and that death from contact was confirmed. Afterwards, artificial rainfall and soil penetration tests were conducted to determine efficacy of termiticide in soil and the approximate reprocessing period was calculated by comparing the weather data. Persistence evaluation revealed perforation by termites after continuous water exposure of more than about 160 to 170mm of water injection condition. Based on the results, compared with weather data for the last five years, the termiticide of concentration used in this experiment is expected to remain effective for about one year if treated after September. The purpose of this study was to provide basic data for the establishment of a manual for the selection of termiticide for soil treatment by calculating the efficacy for termite mortality and the duration of the leaching effectiveness by water behavior in soil.

• Korean Journal of Culture and Social Issue
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• 제8권2호
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• pp.105-135
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• 2002

The purpose of this study is to examine the experience of stress, coping and social support among students and their parents after Korea recovered from the recent economic crisis. A total of 634 students(primary school=135, junior high school=118, senior high school=168, and university=213) and 842 parents (fathers=421, mothers= 421), for a total of 1,476 participants, completed an open-ended questionnaire developed by the present researchers. For students, the most painful experience was related to problems in academic life, followed by problems in relationship. For father, the most painful experience was financial problems and for mothers, it was conflicts in the family. In stress situations, self-regulation was the most frequently adopted coping style by both students and adults. The second most frequently reported coping style was avoidance. In terms of social support, students reported receiving most support from friends, and the importance of friends became greater for the older students. Parents reported receiving most social support from their spouse. As for the type of social support, around half of students and parents reported receiving emotional support. Emotional support was viewed as being very important in reducing the stress experience related to academic life, problems in relationships, family conflict, and financial difficulties. The results of the present study will be compared to similar studies conducted before and during the economic crisis and the implications of these studies, as well as the importance of the indigenous Korean psychology, will be discussed.

• Journal of Intelligence and Information Systems
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• 제14권2호
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• pp.193-206
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• 2008

Medical diagnosis can be considered a classification task which classifies disease types from patient's condition data represented by a set of pre-defined attributes. This study proposes a hybrid genetic algorithm based classification method to develop classifiers for multidimensional pattern classification problems related with medical decision making. The classification problem can be solved by identifying separation boundaries which distinguish the various classes in the data pattern. The proposed method fits a finite number of regional agents to the data pattern by combining genetic algorithms and local adaptive operations. The local adaptive operations of an agent include expansion, avoidance and relocation, one of which is performed according to the agent's fitness value. The classifier system has been tested with well-known medical data sets from the UCI machine learning database, showing superior performance to other methods such as the nearest neighbor, decision tree, and neural networks.

• KSII Transactions on Internet and Information Systems (TIIS)
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• 제7권1호
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• pp.1-21
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• 2013

The release of IEEE 802.15.4e specification significantly develops IEEE 802.15.4. The most inspiring improvement is the enhancement for medium access control (MAC) sublayer. To study the performance of IEEE 802.15.4e MAC, in this paper we first present an overview of IEEE 802.15.4e and introduce three MAC mechanisms in IEEE 802.15.4e. And the major concern here is the Time Slotted Channel Hopping (TSCH) mode that provides deterministic access and increases network capacity. Then a detailed analytical Markov chain model for TSCH carrier sense multiple access with collision avoidance (CSMA-CA) is presented. Expressions which cover most of the crucial issues in performance analysis such as the packet loss rate, energy consumption, normalized throughput, and average access delay are presented. Finally the performance evaluation for the TSCH mode is given and we make a comprehensive comparison with unslotted CSMA-CA in non-beacon enabled mode of IEEE 802.15.4. It can validate IEEE 802.15.4e network can provide low energy consumption, deterministic access and increase network capacity.

• Animal cells and systems
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• 제15권4호
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• pp.279-286
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• 2011

Hypoxic ischemia injury is a common cause of functional brain damage, resulting from a decrease in cerebral blood flow and oxygen supply to the brain. The main problems associated with hypoxic ischemia to the brain are memory impairment and dopamine dysfunction. Hypothermia has been suggested to ameliorate the neurological impairment induced by various brain insults. In this study, we investigated the effects of hypothermia on memory function and dopamine synthesis following hypoxic ischemia to the brain in rats. For this purpose, a step-down avoidance task, a radial eight-arm maze task, and immunohistochemistry for tyrosine hydroxylase (TH) and 5-bromo-2'-deoxyuridine (BrdU) were performed. The present results indicated that the hypoxic ischemia-induced disturbance of the animal's performances and spatial working memory was associated with a decrement in TH expression in the substantia nigra and striatum, and an increase in cell proliferation in the hippocampal dentate gyrus. Hypothermia treatment improved the animals' performance and spatial working memory by suppressing the decrement in TH expression in the substantia nigra and striatum and the increase in cell proliferation in the dentate gyrus. We suggest that hypothermia can be an efficient therapeutic modality to facilitate recovery following hypoxic ischemia injury to the brain, presumably by modulating the dopaminergic cell loss.