• 생명과학회지
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• 제18권9호
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• pp.1290-1298
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• 2008

송이는 담자균문, 주름버섯목, 송이과에 속하며 맛이 좋은 식용 버섯으로 예로부터 사람의 위궤양이나 위암의 치료효과는 물론 생쥐의 Sarcoma 180과 Ehrlich Sarcoma에도 효과가 있다고 알려져 있다. 본 연구에서는 송이의 자실체로부터 중성염용액, 열수 및 메탄올을 이용하여 조다당류를 추출하고 ICR mice에 주사하여 항암 및 면역증강 효과를 조사하였다. NIH3T3, Sarcoma 180, HepG2, HT-29 등의 암세포에 대한 독성을 조사한 결과 각각의 암세포는 2 mg/ml의 조다당류 농도에서는 세포독성을 나타내지 않았다. Sarcoma 180이 접종된 ICR mouse에 자실체에서 추출한 각각의 조다당류를 투여한 실험군은 대조군에 비해 평균수명이 각각 23.4$\sim$37.2% 연장되었다. 메탄올과 열수로 추출한 조다당류를 0.2$\sim$0.5 mg/ml의 농도로 투여한 실험군 생쥐의 B 임파구 alkaline phosphatase 활성은 대조군에 비해 각각 2.17$\sim$11.9배의 증가하였다. 중성염추출 조다당류를 50 mg/kg body weight의 농도로 투여한 생쥐의 총 복강 세포 수와 백혈구의 수는 대조군에 비하여 각각 6배와 1.5배 증가하였다. 따라서 송이의 자실체에서 추출한 조다당류는 생쥐의 Sarcoma 180에 대해 항암작용 및 면역증강 작용을 나타내는 것으로 확인되었다.

• 한국동물학회지
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• 제23권4호
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• pp.229-238
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• 1980

高麗人蔘抽出液의 효과를 관찰하고자 실시되었다. 대조군은 15일 동안에 관찰되었으며 인삼투여군은 Sarcoma-180에 감염된 마우스에 인삼추출액을 매일 경구투여하여 15일째에 관찰 비교하였다. 그 결과는 아래와 같다. 1) 肉腫癌쥐에 있어서 癌감염후 15일간 赤血球와 血小板의 수에는 有意性變化가 없었으나, 白血球는 初期에 증가되다가 中期 이후부터는 급격히 감소하였다. 그러나 人蔘抽出液處理群에서는 심한 감소현상은 나타나지 않았다. 이는 白血球가 生體防禦의 작용을 한다는 이론에 人蔘抽出液이 이를 보조해 준 것으로 판단된다. 2) 肉腫癌쥐의 血淸蛋白은 非選擇性 蛋白漏出型 血淸蛋白盆畵像을 보였다. 人蔘抽出液處理群에서도 비슷한 현상을 보였으나 對照群에 비하여 심하지는 않았다. 이는 人蔘抽出液이 肉腫癌쥐에 肉腫癌의 發育에 있어서 약간의 遲延性 내지는 免疫性을 가지게 하는 것으로 사료된다. 3) 肉腫癌쥐에 있어서의 serum cholesterol의 함량은 中期까지는 증가되다가 末期에서는 감소되었다. 그러나 人蔘抽出液處理群에서는 약간의 증가현상을 보였다. 末期에 감소되는 현상은 여러 가지 원인중 특히 攝食量의 부족에 기인되는 것으로 추측되는바, 인삼추출액이 담癌體에 대하여 약간의 耐性을 가지게 함으로서 攝食量이 줄지 않음에 기인되는 것으로 추측된다. 4) 肉腫癌쥐의 serum total lipid는 癌이 진전됨에 따라서 증가되었다. 그리고 $\\alpha-, \\beta-$lipoprotein은 감소현상을 보였으나 pre $\\beta$-lipopotein은 급격히 증가되었다. 人蔘抽出液處理群에서는 對照群에서의 初期의 값을 보여주었다. 이러한 현상 역시 人蔘抽出液이 위와 같은 이론에 의해서 生體를 보호해 준 것으로 추측되며 肉腫癌에 대하여 약간의 耐性을 갖게한 결과로 판단된다.

• Journal of Chest Surgery
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• 제46권2호
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• pp.159-161
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• 2013

Synovial sarcoma is a malignant soft tissue tumor that most commonly occurs in the extremities of young and middle-aged adults, in the vicinity of large joints. Although synovial sarcoma is frequently associated with joints, it may arise in unexpected sites, such as the mediastinum, heart, lung, pleura, or chest wall. Primary synovial sarcoma of the pleura is rare. To date, nearly 36 cases of primary synovial sarcoma of the pleura have been reported since Gaertner et al. published the first case in 1996. The oncologic characteristics, treatment, and prognosis for pleural synovial sarcomas are not well defined because of a paucity of data. However, a multimodal approach, including surgical resection, chemotherapy, and radiotherapy, has generally been suggested. We report the outcome of one patient with primary pleural synovial sarcoma treated with radical resection and adjuvant treatment.

• 대한세포병리학회지
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• 제14권1호
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• pp.27-31
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• 2003

Poorly differentiated synovial sarcoma is a variant of synovial sarcoma. We report a case of poorly differentiated synovial sarcoma imprinted after resection. The patient was a 47-year-old woman with a right shoulder pain for 6 months. The cytologic features showed malignant round to oval, monotonous tumor cells with high nuclear to cytoplasmic ratio. Some tumor cells showed perivascular distribution and nuclear melding. Vague rosette-like structures were seen. On immunohistchemical stains, tumor cells were diffusely positive for CD99 and focally positive for epithelial membrane antigen. Ultrastructural examination showed desmosomes and microvilli.

• Journal of Chest Surgery
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• 제26권5호
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• pp.413-416
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• 1993

Extraskeletal osteogenic sarcoma is a rare malignant tumor of soft tissue, and its predilection sites are the extremity, retroperitoneum, trunk, and the head and neck area. To our knowledge 5 cases of primary involvement of the mediastinum have been reported. Because of its rarity and difficulty in exact diagnosis preoperatively, we report an extraskeletal osteogenic sarcoma in the anterior mediastinum. The patient was a thirty eight old male. He complained of cough and sputum over 2 months. The chest roentgenogram and the chest MRI[magnetic resonance image] were done and showed anterior mediastinal mass with calcification. Excision of the mass was done under the preoperative impression of thymoma, and the pathologic report was extraskeletal osteogenic sarcoma of the mediastinum.

• Journal of the Korean Association of Oral and Maxillofacial Surgeons
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• 제38권4호
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• pp.240-244
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• 2012

Myofibroblastic sarcoma is a rare tumor that mostly develops in the soft tissues of the head and neck. Within the oral cavity, a tongue lesion is the most common. A myofibroblastic sarcoma tends to recur locally instead of metastasizing. We encountered a myofibroblastic sarcoma of the mandible of a 9-year-old male and performed mass excision and additional marginal alveolectomy. So far, there is neither recurrence nor metastasis. We report this case because of the uncommon location of this tumor type and its surgical approach compared to other forms of sarcomas.

• Advances in pediatric surgery
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• 제15권1호
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• pp.80-85
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• 2009

Extraosseous Ewing's sarcoma is a rare primary malignant soft tissue tumor which is histologically identical to Ewing's sarcoma. This tumor tends to involve the soft tissue of the lower extremity and paravertebral region of adolescents and young adults but particularly rare in infants. We recently experienced a case of extraosseous Ewing's sarcoma which presented in the left arm of 4 months infant.

• Journal of Chest Surgery
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• 제47권1호
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• pp.47-50
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• 2014

Most cases of Ewing's sarcoma are reported in the bone, and extraosseous Ewing's sarcoma is an extremely rare disease. Here, we report a rare case of primary pulmonary Ewing's sarcoma in a patient with hemoptysis. The patient underwent right upper lung lobe lobectomy with adjuvant chemotherapy and radiation therapy and has been free of recurrent disease for 4 years.

• 대한세포병리학회지
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• 제5권1호
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• pp.28-34
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• 1994

Aspiration biopsy cytology is a convenient, easy and non-invasive method for diagnosis of tumors. The results and cytologic features of carcinoma in various organs have been reported frequently, however, those of soft tissue sarcoma are relatively rare to find. Here we describe fine needle aspiration cytologic features of various soft tissue sarcomas and discuss cytologic differential points. The material is 6 cases of soft tissue sarcoma that were confirmed by histologic examination. They are composed of 2 cases of dermatofibrosarcoma protuberans and one case of malignant fibrous histiocytoma, synovial sarcoma, alveolar soft pan sarcoma, and malignant schwannoma respectively.

• 대한세포병리학회지
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• 제17권1호
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• pp.69-74
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• 2006

Alveolar soft part sarcoma (ASPS) is a rare soft tissue sarcoma, which occurs predominantly in adolescents and young adults. The cytological characteristics of this condition have been described only rarely in the literature. Here, we report a case of alveolar soft part sarcoma. A 28-year-old man presented with a mass in his right buttock, which had persisted for three years. The mass was subjected to a fine needle aspiration cytology (FNAC). The smears were cellular. The observed tumor cells were round or polygonal, and exhibited vesicular nuclei with prominent nucleoli and finely granular cytoplasm. Naked nuclei were frequently detected. Tumor cells were arranged singularly, but occasionally in a pseudoalveolar pattern.