• 한국소성가공학회:학술대회논문집
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• 한국소성가공학회 2009년도 춘계학술대회 논문집
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• pp.199-202
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• 2009

In roll forming process, a sheet metal is continuously progressively formed into a product with required cross-section and longitudinal shape, such as a circular tube with required diameter, wall-thickness and straightness, by passing through a series of forming rolls in arranged in tandem. Tn this process, each pair of forming rolls installed in a forming machine play a particular role in making up the required cross-section and longitudinal shape of the product. In recent years, that process is often applied to the bumper rail in the automotive industries. In this study, a optimal Front Bumper Beam manufacturing technology, model deign and proper roll-pass sequences can be suggested by forming number of roll-pass and bending angle. And also effects of the process parameters on the final shape formed by roll forming defects were evaluated.

• 한국정밀공학회지
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• 제27권3호
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• pp.111-117
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• 2010

The repeated unit cell structure is applied to the composite, the carbon nano tube and sandwich panel. In this paper, a study on the stiffness of unit cell structure has been performed with the tube support plate of the steam generator. For this, repeated unit cell structure's equivalent elastic constant and poisson's ratio was evaluated through FEA and tests under the elastic range load. Also we evaluated the effect on the specimen size from results.

• 복합신소재구조학회 논문집
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• 제1권2호
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• pp.44-50
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• 2010

본 연구에서는 노후교량 바닥판 대체용으로 단품(Modular) GFRP 바닥판 구조에 대한 거동분석을 실험을 통행 실시하였다. 그 바닥판의 성능평가로서 축소모형(1/5)의 시험편 3개에 대한 실험적 연구를 수행하였다. 시험편은 박스튜브를 갖는 샌드위치 판이다. 교량바닥판의 구성재료는 유리섬유와 에폭시 레진이다. 모든 시험편에 대한 실험결과로서 최대강도, 강성 및 변형능력으로 나타내었다. 실험적 결과의 타당성을 검증하기 위해 유한요소해석을 하여 비교하였다.

• 국제강구조저널
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• 제18권5호
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• pp.1666-1683
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• 2018

To explore seismic behavior of blind bolted concrete-filled steel tube (CFST) frames infilled with precast sandwich composite wall panels (SCWPs), a series tests of blind bolted square CFST frames with precast SCWPs under lateral low-cyclic loading were conducted. The influence of the type of wall concrete, wall-to-frame connection and steel brace setting, etc. on the hysteretic curves and failure modes of the type of composite structure was investigated. The seismic behavior of the blind bolted CFST frames with precast SCWPs was evaluated in terms of lateral load-displacement relation curves, strength and stiffness degradation, crack patterns of SCWPs, energy dissipation capacity and ductility. Then, a finite element (FE) analysis modeling using ABAQUS software was developed in considering the nonlinear material properties and complex components interaction. Comparison indicated that the FE analytical results coincided well with the test results. Both the experimental and numerical results indicated that setting the external precast SCWPs could heighten the load carrying capacities and rigidities of the blind bolted CFST frames by using reasonable connectors between frame and SCWPs. These experimental studies and FE analysis would enable improvement in the practical design of the SCWPs in fabricated CFST structure buildings.

• Macromolecular Research
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• 제11권5호
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• pp.334-340
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• 2003

In order to fabricate new sustained delivery device of nerve growth factor (NGF), we developed NGF-loaded biodegradable poly(L-lactide-co-glycolide) (PLGA, the mole ratio of lactide to glycolide 75:25, molecular weight: 83,000 and 43,000 g/mole, respectively) film by novel and simple sandwich solvent casting method for the possibility of the application of neural tissue engineering. PLGA was copolymerized by direct condensation reaction and the molecular weight was controlled by reaction time. Released behavior of NGF from NGF-loaded films was characterized by enzyme linked immunosorbent assay (ELISA) and degradation characteristics were observed by scanning electron microscopy (SEM) and gel permeation chromatography (GPC). The bioactivity of released NGF was identified using a rat pheochromocytoma (PC-12) cell based bioassay. The release of NGF from the NGF-loaded PLGA films was prolonged over 35 days with zero-order rate of 0.5-0.8 ng NGF/day without initial burst and could be controlled by the variations of molecular weight and NGF loading amount. After 7 days NGF released in phosphate buffered saline and PC-12 cell cultured on the NGF-loaded PLGA film for 3 days. The released NGF stimulated neurite sprouting in cultured PC-12 cells, that is to say, the remained NGF in the NGF/PLGA film at 37 $^{\circ}C$ for 7 days was still bioactive. This study suggested that NGF-loaded PLGA sandwich film is released the desired period in delivery system and useful neuronal growth culture as nerve contact guidance tube for the application of neural tissue engineering.

• Steel and Composite Structures
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• 제25권3호
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• pp.287-298
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• 2017

The present study aims to determine the structural response of full scaled rectangular columns under both of vertical and lateral loads using numerical methods. In the study, the composite columns considering full concrete filled circular steel tube (FCFRST) and concrete filled double-skin rectangular steel tube (CFDSRST) section types are numerically modelled using ANSYS software. Vertical and lateral loads are applied to models to assess the structural response of the composite elements. Also similar investigations are done for reinforced concrete rectangular (RCR) columns to compare the results with those of composite elements. The analyses of the systems are statically performed for both linear and nonlinear materials. In linear static analyses, both of vertical and lateral loads are applied to models as only one step. However in nonlinear analyses, while vertical loads are applied to model as only one step, lateral loads are applied to systems as step by step. The displacement and stress changes in some critical nodes and sections and contour diagrams are reported by graphs and figures. At the end of the study, it is demonstrated that the nonlinear models reveal more accurate result then those of linear models. Also, it is highlighted that composite columns provide more and more safety, ductility compared to reinforced concrete column.

• Steel and Composite Structures
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• 제21권3호
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• pp.605-628
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• 2016

The energy absorption characteristics of diamond core sandwich cylindrical columns under axial crushing process depend greatly on the amount of material which participates in the plastic deformation. Both the single-objective and multi-objective optimizations are performed for columns under axial crushing load with core thickness and helix pitch of the honeycomb core as design variables. Models are optimized by multi-objective particle swarm optimization (MOPSO) algorithm to achieve maximum specific energy absorption (SEA) capacity and minimum peak crushing force (PCF). Results show that optimization improves the energy absorption characteristics with constrained and unconstrained peak crashing load. Also, it is concluded that the aluminum tube has a better energy absorption capability rather than steel tube at a certain peak crushing force. The results justify that the interaction effects between the honeycomb and column walls greatly improve the energy absorption efficiency. A ranking technique for order preference (TOPSIS) is then used to sort the non-dominated solutions by the preference of decision makers. That is, a multi-criteria decision which consists of MOPSO and TOPSIS is presented to find out a compromise solution for decision makers. Furthermore, local and global sensitivity analyses are performed to assess the effect of design variable values on the SEA and PCF functions in design domain. Based on the sensitivity analysis results, it is concluded that for both models, the helix pitch of the honeycomb core has greater effect on the sensitivity of SEA, while, the core thickness has greater effect on the sensitivity of PCF.

• 한국복합재료학회:학술대회논문집
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• 한국복합재료학회 2002년도 추계학술발표대회 논문집
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• pp.228-232
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• 2002

본 연구에서는 다목적 실용위성 2호기에 적용된 금속 구조물 중 알루미늄 샌드위치 패널 구조인 탑재체 플랫폼과 튜브 스트럿(tube strut) 구조에 복합재료 응용기술을 적용하였다. 복합재료 구조로의 대체 설계에서도 관성하중 및 음향진동등과 같은 극심한 발사환경과 더불어 운용하게 될 우주 열환경을 고려하였다. 연구의 목적은 금속소재보다 비강도, 비강성이 우수한 복합재료를 위성 구조물에 사용함으로써 무게를 경량화함에 있다.

• IMMUNE NETWORK
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• 제7권4호
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• pp.203-208
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• 2007

Background: Angiogenesis mediated by VEGF constitutes a new target for anti-cancer therapy which has explored through different ways of intervention aiming at the blocking of the tumoral angiogenesis. In the present study, we developed the assays by which efficacies of anti-VEGF inhibitor candidates are evaluated at the various levels. Methods & Results: First, we developed two sandwich ELISAs using coated anti-VEGF Ab and soluble Flt-1 receptor fusion protein (sFlt-1/Fc). As low as 200 pg/ml of hVEGF diluted in human sera was detectable by these assays. In addition, we found that VEGF inhibitors ($2{\mu}g/ml$ of either anti-VEGF Ab or sFlt-1/Fc) completely block 5 ng/ml VEGF in these ELISAs. Subsequently, two bioassays, wound healing and HUVEC tube formation assays, revealed that anti-VEGF Ab $(1{\mu}g/ml)$ & sFlt-1/Fc Ab $(1{\mu}g/ml)$, or SU5416 (VEGFR tyrosine kinase inhibitor, $1{\mu}M$) prevents the activity of VEGF $(1{\sim}10ng/ml)$. Finally, secretion of MMP-9 by VEGF-stimulated macrophages was abolished by treatment of anti-VEGF Ab $(1{\mu}g/ml)$ in gelatin zymography. Conclusion: ELISAs together with bioassays developed in this study are appropriate for evaluation of the efficacy of inhibitors of VEGF.

• Journal of Periodontal and Implant Science
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• 제45권1호
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• pp.14-22
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• 2015

Purpose: The purpose of this study was to compare serum amyloid A (SAA) protein levels with high-sensitive C-reactive protein (hs-CRP) levels as markers of systemic inflammation in patients with chronic periodontitis. The association of serum titers of antibodies to periodontal microbiota and SAA/hs-CRP levels in periodontitis patients was also studied. Methods: A total of 110 individuals were included in this study. Patients were assessed for levels of hs-CRP and SAA. Nonfasting blood samples were collected from participants at the time of clinical examination. The diagnosis of adipose tissue disorders was made according to previously defined criteria. To determine SAA levels, a sandwich enzyme-linked immunosorbent assay was utilized. Paper points were transferred to a sterile tube to obtain a pool of samples for polymerase chain reaction processing and the identification of Porphyromonas gingivalis, Aggregatibacter actinomycetemcomitans, and Tannerella forsythia. The serum level of IgG1 and IgG2 antibodies to P. gingivalis, A. actinomycetemcomitans, and T. forsythia was also determined. Results: SAA and hs-CRP levels were higher in periodontitis patients than in controls (P<0.05). In bivariate analysis, high levels of hs-CRP (>3 mg/L) and SAA (>10 mg/L) were significantly associated with chronic periodontitis (P=0.004). The Spearman correlation analysis between acute-phase proteins showed that SAA positively correlated with hs-CRP (r=0.218, P=0.02). In the adjusted model, chronic periodontitis was associated with high levels of SAA (odds ratio [OR], 5.5; 95% confidence interval [CI], 1.6-18.2; P=0.005) and elevated hs-CRP levels (OR, 6.1, 95% CI, 1.6-23.6; P=0.008). Increased levels of serum IgG2 antibodies to P. gingivalis were associated with high levels of SAA (OR, 3.6; 95% CI, 1.4-8.5; P=0.005) and high concentrations of hs-CRP (OR, 4.3; 95% CI, 1.9-9.8; P<0.001). Conclusions: SAA and hs-CRP concentrations in patients with chronic periodontitis are comparably elevated. High serum titers of antibodies to P. gingivalis and the presence of periodontal disease are independently related to high SAA and hs-CRP levels.