• Title/Summary/Keyword: salvia

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Hepatoprotective Activity of Salviae miltiorrhizae Radix Extract (단삼(丹蔘) 엑기스의 간보호작용)

  • Eun, Jae-Soon;Lim, Jong-Pil;Park, Yi-Kyu;Yeom, Jeong-Ryeol;Choi, Dong-Seong;Ahn, Moon-Seng
    • Korean Journal of Pharmacognosy
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    • v.22 no.2
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    • pp.95-100
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    • 1991
  • Salviae miltiorrhizae(SM) Radix extract increased $[^3H]-thymidine$ incorporation into rat hepatocytes at the concentration ranging from $5{\times}10^{-5}\;to\;5{\times}10^{-1}mg/ml$. It decreased the activities of s-GOT and s-GPT in cirrhotic rats induced by $CCl_4$, TAA and D-GalN, respectively and reduced the sleeping time induced by hexobarbital in $CCl_4$,TAA and D-GalN intoxicated mice, respectively. SM extract shortened the half-life of sulfobromophthalein in $CCl_4$ intoxicated rats.

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Screening of the Inhibitory Activity of Medicinal Plants against VHR Dual-Specificity Protein Tyrosine Phosphatase (DS- PTPase) (생약의 VHR Dual - Specificity Protein Tyrosine Phosphatase (DS-PTPase) 저해 활성 검색)

  • Lee, Myung-Sun;Bae, Eun-Young;Oh, Won-Keun;Ahn, Soon-Cheol;Kim, Bo-Yeon;Sohn, Cheon-Bae;Ahn, Jong-Seog
    • Korean Journal of Pharmacognosy
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    • v.33 no.1 s.128
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    • pp.69-73
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    • 2002
  • The methanol extracts of 162 herbal medicines were screened for the inhibitory activity against VHR dualspecificity protein tyrosine phosphatase (DS-PTPase). Seventeen medicinal plants, Scutellaria baicalensis, Cuscuta chinensis, Caesalpinia sappan, Arecae pericarpium, Rubus coreanus, Machilus thunbergii, Amsonia elliptica Cinnamomum cassia, Arisaema erubescens, Pueraria thunbergiana, Dendrobium moniliforme, Mentha arvensis, Peucedanum japonicum, Salvia miltiorrhiza, Leonurus sibiricus, Siegesbeckia orientalis, Prunella vulgaris showed potent VHR DS-PTPase inhibitory activity.

RESVERATROL APPEARS TO AFFECT IN A DIFFERENT WAY PRIMARY VS. FIXED DNA DAMAGE INDUCED BY $H_2O_2$ IN MAMMALIAN CELLS IN VITRO

  • Salvia, Rosella-De;Fabiola Festa;Ruggero Ricordy;Paolo Perticone;Cristina Mucc;Renata Cozzi
    • Proceedings of the Korean Society of Toxicology Conference
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    • 2001.10a
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    • pp.108-109
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    • 2001
  • Resveratrol (3, 5, 4'-trihydroxystilbene) is a naturally occuring molecule, synthesized by several plants in response to different stresses. Recently many studies performed in human and mammalian cells demonstrated the involment of resveratrol in the modulation of several biological processes (inhibition of lipidic peroxidation, platelet aggregation, estrogenic activity). It has also been found to possess scavenging and antioxidant properties (1).(omitted)

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GC-MS Analysis of Diterpene Quinone Constituents of Salviae Miltiorrhizae Radix and Biological Activity

  • Park, Hee-Juhn;Lee, Seung-Bae;Lee, Eun;Cha, Bae-Chun;Park, Moo-Young;Lee, Sung-Mok;Chung, Won -Tae
    • Journal of the Korean Society of Food Science and Nutrition
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    • v.24 no.3
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    • pp.459-465
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    • 1995
  • The ether extract of Salviae miltiorrhizae Radix(SMR) was fractioned to give five subfractions, so that two subfractions of them were recrystallized to yield each pure diterpene quinone pigment. On the basis of spectral evidence, these two compounds were identified as tanshinone II and crytotanshinone. Cryptotanshinone exhibited both of a potent platelet anti-aggregating activity in vitro and a potent antimicrobial activity. GC-MS analysis of the other extract showed that tanshinone II was contained in the largest proportion of all the diterpene quinones. In addition, GC-MS analysis gave other valuable analytical informations.

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Lithospermic acid modulate the Action potential duration by increasing Ica current in the rat ventricular myocyte

  • An, Seong-Hun;Kang, Dae-Gill;Lee, Ho-Sup;Lee, Suk-Ho;Earm, Yung-E
    • Proceedings of the Korean Biophysical Society Conference
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    • 2001.06a
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    • pp.55-55
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    • 2001
  • We observed the APD of rat ventricle myocyte and the effects of Lithospermic acid that was separated at Salvia miltiorrhiza having used in Oriental medicine by using classical whole cell patch clamp technique. We classified APD into APD30mV, APD0mV, APD-50mV, APD-60mV by cell membrane potential and the mean of cell resting membrane potential was -69.44${\pm}$1.72 mV.(omitted)

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Inhibition of Whole Blood Platelet aggregation from Traditional medicines (한약재의 전혈혈소판응집억제)

  • Jeon, Won-Kyung;Kim, Jung-Hee;Lee, A-Yeong;Kim, Ho-Kyoung
    • Korean Journal of Oriental Medicine
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    • v.9 no.2
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    • pp.55-67
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    • 2003
  • To evaluate anti-aggregatory activity of traditional prescriptions and medicines for treatment of Ohyul symptom, 70% methanol extracts were examined using collagen stimulated in vitro platelet aggregation by impedance method in rat whole blood. The crude extracts from DoHaekSeungKiTang, BoYangHwanOhTang, Caesalpinia sappan, Rhus verniciflua, Rheum palmatum, Polygonum cuspidatum, Salvia miltiorrhiza were found to inhibit platelet aggregation. The effective crude extracts of traditional medicine were fractionated to dichloromethane, ethyl acetate, butanol and aqueous layer. Polygonum cuspidatum, Caesalpinia sappan aud Rhus verniciflua ethyl acetate fractions concentration-dependently $(250-50{\mu}m/ml)$ inhibited the aggregation of platelet in whole blood induced by collagen. These results suggested that ethyl acetate fractions of Polygonum cuspidatum, Caesalpinia sappan and Rhus verniciflua have potent anti-aggregatory activity.

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Antimicrobial Activity of Korean Medicinal Plants and Herbal Formulations

  • Bhatt, Lok-Ranjan;Woo, Shin-Sun;Yu, Byung-Soo;Baek, Seung-Hwa
    • Journal of Physiology & Pathology in Korean Medicine
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    • v.21 no.3
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    • pp.755-759
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    • 2007
  • In this study, we screened twenty four extracts of eight medicinal plants and three extracts of the commercial product for their antimicrobial and antioxidant properties. Ethanol and ethyl acetate extracts were found active where as aqueous extracts were little or no active. Extracts of Sophora flavescens, Salvia miltlorrhiza and Glycyrrhiza uralensis showed strong activity againsttested organisms and could be the potential antimicrobial agent. The increase of antimicrobial and antioxidant activities of formulations might be due to synergic effect. The results also indicated that the activity of bamboo salt and herbal products can be enhanced by making appropriate formulations.

Screening of the Acetylcholinesterase Inhibitors from Medicinal Plants (생약의 아세틸콜린에스터라제 억제활성 검색)

  • Lee, Bong-Ho;Ryu, Geon-Seek;Lee, Eun Seog;Kang, Kye-Jung;Hwang, Dho-Yeun;Hong, Nam-Doo;Choi, Byoung-Wook
    • Korean Journal of Pharmacognosy
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    • v.28 no.4
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    • pp.167-173
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    • 1997
  • We have tested 101 species traditional medicinal plants on Acetylcholinester ase inhibition. Among them. Caesalpina sappan. Cnidium offcinale, Coptis japonica, Ephedra sinica, Eribotrya japonica, Gardenia jasminoides, Liriope platyphylla, Lonicera japonica, Paeonia suffruticosa, Phyllostachys nigra, Polygonum multiflorum, Prunella vulgaris, Rheum undulatum, Salvia miltiorrhiza and Uncaria rhynchophylla showed strong inhibition potency over 88%. In addition, Aconitum carmichaeli, Caesalphina sappan, Cinnamomun japonica, Citrus unshiu, Hordeum vulgare, Glycine max and Rehmannia glutinosa showed relatively good inhibition potency over 80%.

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Selection of Plant for Constructing Ecological Wetlands On the Rooftop Greening (옥상 내 인공 생태습지 조성에 적용 가능한 식물종 선발)

  • Kwon, Hyo Jin;Kim, Yoo Sun;Ryu, Byung Yeol
    • FLOWER RESEARCH JOURNAL
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    • v.18 no.2
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    • pp.117-124
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    • 2010
  • The purpose of this study was to create an artificial wetland in rooftop greening. We monitored species and changes of flora in wetland and rooftop greening. As shown the consideration and possibility of supplying the artificial wetland in rooftop greening through flora in wetland, this study tried to find methods to create a efficient flora space. This results are listed as belows. The species were applied to artificial wetland in rooftop greening and come up to 'General standard for selecting plants' among hydrophyte in wetlands. The plants of Potentilla kleiniana, Penthorum chinense, Scirpus radicans, Scirpus triqueter, Veronica undulata, Mentha arvensis var. piperascens, Salvia plebeian, Sagittaria aginashi, Aneilema keisak, Stachys riederi, Alisma canaliculatum, Eclipta prostrata, Sparganium stoloniferum turned out an appropriate species. This research was expected to create a various environment and component of species by introducing many types of plants in ecological wetland on rooftop greening.