Lithospermic acid modulate the Action potential duration by increasing Ica current in the rat ventricular myocyte

  • An, Seong-Hun (Professional Graduate School of Oriental Medicine, Wonkwang University College of Oriental Medicine) ;
  • Kang, Dae-Gill (Professional Graduate School of Oriental Medicine, Wonkwang University College of Oriental Medicin) ;
  • Lee, Ho-Sup (Professional Graduate School of Oriental Medicine, Wonkwang University College of Oriental Medicin) ;
  • Lee, Suk-Ho (Department of Physiology and National Research Laboratory for celluar signaling Seoul National University College of Medicin) ;
  • Earm, Yung-E (Department of Physiology and National Research Laboratory for celluar signaling Seoul National University College of Medicine)
  • Published : 2001.06.01

Abstract

We observed the APD of rat ventricle myocyte and the effects of Lithospermic acid that was separated at Salvia miltiorrhiza having used in Oriental medicine by using classical whole cell patch clamp technique. We classified APD into APD30mV, APD0mV, APD-50mV, APD-60mV by cell membrane potential and the mean of cell resting membrane potential was -69.44${\pm}$1.72 mV.(omitted)

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