• 한국약용작물학회:학술대회논문집
• /
• 2011.04a
• /
• pp.150-151
• /
• 2011

• 한국약용작물학회:학술대회논문집
• /
• 2011.04a
• /
• pp.146-147
• /
• 2011

• 한국약용작물학회:학술대회논문집
• /
• 2011.04a
• /
• pp.148-149
• /
• 2011

• 한국약용작물학회:학술대회논문집
• /
• 2011.09a
• /
• pp.178-179
• /
• 2011

• Advances in Traditional Medicine
• /
• v.8 no.3
• /
• pp.207-214
• /
• 2008

In recent years, the combined use of Herbal medicines and Western drugs has been increasing. Though certain problems may occur when both types of medicines are taken together, they havenot been adequately analyzed. It was reported that anticoagulation was enhanced in addition tobleeding when patients took long-term warfarin therapy in combination with Salvia miltiorrhiza(danshen), and laxative herbs accelerate intestinal transit and interfere with the absorption. Herbal constituents, curcumin, ginsenosides, piperine, catechins and silymarin were found to beinhibitors of P-glycoprotein. St John's wort induces the intestinal expression of P-glycoprotein. Anthraquinone, quercetin and coumarins were found to be a potent inhibitor of P-450. Glycyrrhizin or liquorice extracts, Garlic and St John's wort are a potent inducer of CYP3A4. This review provides a critical overview of interactions between herbal medicines and other drugs. Hence, it is necessary to study the pharmacodynamic and pharmacokinetic interactions of many herbal medicines between western drugs.

• The Journal of Korean Medicine
• /
• v.25 no.2
• /
• pp.22-32
• /
• 2004

Objectives: In order to determine the effect of CPs, experimental studies were performed in hyperlipidemia humans. The contents of serum total cholesterol, TG (triglyceride), LDL cholesterol, HDL cholesterol, AST/ALT and BUN/creatinine were measured. Methods: We made a comparative study of total cholesterol, TG (triglyceride), LDL cholesterol, HDL cholesterol, AST/ALT and BUN/creatinine during one month off and on for twenty patients with hyperlipidemia who visited Gunpo Oriental Medical Center of Wonkwang University from December 2002 to July 2003. Results: The following result were obtained: 1. The serum TG and total cholesterol of patients who took CPs for one month showed significant (p<0.01) decrease. 2. The serum HDL-cholesterol and LDL-cholesterol of patients who took CPs for one month showed significantly increase in HDL, and decrease in LDL (p<0.05). 3. The serum AST/ALT and BUN/creatinine of patients who took CPs for one month showed no significant effects. Conclusions: According to the results mentioned above, the effects of CPs on serum triglyceride and total cholesterol of hyperlipidemia patients were significantly confirmed for decreasing effects.

• Proceedings of the PSK Conference
• /
• 2002.10a
• /
• pp.375.4-376
• /
• 2002

Acyl CoA:diacylglycerol acyltransferase (DGAT) is a key enzyme involved in triacylglycerol synthesis. Too much accumulation of triacylglycerol in certain organs and tissues of the body causes high risk conditions of fatty liver. obesity and hypertriglyceridemia. leading to serious diseases of atherosclerosis. Therefore, DGAT inhibition may be worthwhile strategy for the treatment of triglyceride metabolism disorders. such as obesity or hypertriglyceridemia. (omitted)

• Korean Journal of Pharmacognosy
• /
• v.17 no.1
• /
• pp.19-22
• /
• 1986

As a continuation of the previous work, a second group of sixty solvent fractions prepared from twenty plant species were screened for their inhibitory effects on adenosine 5'-diphosphate (ADP)-, arachidonic acid (AA)- or collagen-induced rat platelet aggregation. The results suggested that five plant species including Angelica koreana, Cassia obtusifolia, Gastrodia elata, Paeonia lactiflora and Salvia miltiorrhiza are potential sources of inhibitors of platelet aggregation.

• Proceedings of the PSK Conference
• /
• 2000.04a
• /
• pp.171.2-171
• /
• 2000

• Proceedings of the Korean Society of Crop Science Conference
• /
• 2006.04a
• /
• pp.416-417
• /
• 2006