Proceedings of the PSK Conference (대한약학회:학술대회논문집)

The Pharmaceutical Society of Korea (대한약학회)
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Diacylglycerol Acyltransferase Inhibitors from the Fruits of Evodia rutaecarpa and the Root of Salvia miltiorrhiza

  • Ko, Jeong-Suk (Laboratory of Lipid Metabolism Korea Research Institute of Bioscience and Biotechnology) ;
  • Chung, Mi-Yeon (Korea Research Institute of Bioscience and Biotechnology and College of Pharmacy Chungnam National University) ;
  • Ryu , Shi-Young (Korea Research Institute of Bioscience and Biotechnology and College of Pharmacy Chungnam National University) ;
  • Kang, Jong-Seong (Korea Research Institute of Bioscience and Biotechnology and College of Pharmacy Chungnam National University) ;
  • Rho, Mun-Chual (Korea Research Institute of Bioscience and Biotechnology and College of Pharmacy Chungnam National University) ;
  • Lee, Hyun-Sun (Korea Research Institute of Bioscience and Biotechnology and College of Pharmacy Chungnam National University) ;
  • Kim, Young-Kook (Korea Research Institute of Bioscience and Biotechnology and College of Pharmacy Chungnam National University)
  • Published : 2002.10.01
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Abstract

Acyl CoA:diacylglycerol acyltransferase (DGAT) is a key enzyme involved in triacylglycerol synthesis. Too much accumulation of triacylglycerol in certain organs and tissues of the body causes high risk conditions of fatty liver. obesity and hypertriglyceridemia. leading to serious diseases of atherosclerosis. Therefore, DGAT inhibition may be worthwhile strategy for the treatment of triglyceride metabolism disorders. such as obesity or hypertriglyceridemia. (omitted)

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