• Korean Journal of Clinical Pharmacy
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• v.23 no.3
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• pp.239-247
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• 2013

Background: Fixed drug combinations are formulations containing two or more active ingredients in a single dosage form. Such combination therapies are commonly applied to improve efficacy, reduce adverse events and replace co-administration, etc. National and international guidelines for hypertension treatment recommend addition of other classes of antihypertensive drugs rather than incremental dose of mono-therapy, when blood pressure is not adequately controlled. Thus, many dual combinations of antihypertensive drugs have been approved and pharmaceutical companies are recently interested in developing antihypertensive triple combinations. Clinical trial designs for the fixed combinations are various depending on the target patients, dosage and clinical endpoints. Thereby, further discussions for the clinical trials of antihypertensive triple therapies are required regarding the indication claimed. Conclusion: This article provides a review for the assessment of the label and medical reports of the clinical trials on antihypertensive triple therapies in advanced foreign countries.

• Nuclear Engineering and Technology
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• v.32 no.4
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• pp.316-327
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• 2000

The Emergency Core Cooling System in current nuclear power plants typically has a considerable number of complex functions and largely cumbersome operator interfaces. Functions for initiation, switch-over between various phases of operation, interlocks, monitoring, and alarming are usually performed by relays and analog comparator logic which are difficult to maintain and test. To improve problems of an analog based ECC (Emergency Core Cooling) System, the trip computer for ECCS based on Dynamic Safety System (DSS) is implemented. The DSS is a computer based reactor protection system that has fail-safe nature and performs a dynamic self-testing. The most important feature of the DSS is the introduction of test signal that send the system into a tripped state. The test signals are interleaved with the plant signals to produce an output which switches between a tripped and health state. The dynamic operation is a key feature of the failsafe design of the system. In this work, a possible implementation of the DSS using PLC is presented for a CANDU Reactor. ECC System of the CANDU Reactor is selected as the reference system.

• Fire Science and Engineering
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• v.25 no.3
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• pp.63-71
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• 2011

In this study, it was evaluated the fire risk of an electric heater as representative seasonal appliances. Two type of electric heaters were used in experiments. When electric heaters were operated, temperature variation was measured around the heater. Internal structure was understood by Nondestructive inspection. It was evaluated the tire risk of electric heaters, when flammable materials were positioned ear a heater. It was also estimated the probability of a tire in case of malfunction of a safety tip-over witch. When a heater was operated in a normal condition, temperature was maintained under $80^{\circ}C$ around the heater. The possibility of a fire is very high, when a heater is covered with flammable materials or malfunction of safety parts (safety tip-over switch, anti-overheating devices).

• International Journal of Safety
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• v.10 no.2
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• pp.10-15
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• 2011

The reconfigurable control systems based on feedback controls are utilized to compensate for damages of actuators in control systems. Such systems have multiple feedback controls and switch them in accordance with the degrees of the failures of the actuators. In order to be able to assess those systems, this paper develops a method to obtain reliabilities of reconfigurable dynamical systems which are interconnected in parallel / series configuration. By calculating reliabilities of interconnected dynamical systems, it is possible to assess many dynamical systems by comparing their reliabilities. Firstly, reliabilities of subsystems are obtained according to the definitions of the failures in terms of robust reliability for each subsystem. Then, the reliability of overall system is calculated from reliabilities of subsystems, using the methodology employed for probabilistic safety assessment. Failure rates of subsystems with feedbacks for reconfiguration change in certain time periods because of the switching of feedback controls. In order to deal with this, combinations of subsystems which compose overall system for each time period are derived by the methodology mentioned above and then integrated to calculate the reliability of overall system for a specific time. An illustrative example shows the validity and details of the proposed method.

• Journal of the Korea Safety Management & Science
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• v.19 no.4
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• pp.115-123
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• 2017

Recently there is a growing interest in the airborne spread of virus. In particular, there is growing interest in secondary infection through the air in the hospital. The distribution of air-born virus depends on ventilation system installed in a hospital. In this study, simulations were carried out to predict the move of air-born virus by ventilation system at hospital. Simulation results showed that pressure distribution was -372.05Pa ~ -3.45 Pa at 1st floor incase of only used mechanical exhaust at bathroom, shower stall, storage, kitchen etc.. if ventilation switch from used mechanical exhaust to mechanical exhaust & mechanical supply. Simulation results showed that pressure distribution was -336.44Pa at stair hall < -0.2Pa at bathroom < mean 1.19Pa at other room. So simulation results showed that using all of the mechanical supply and mechanical exhaust was more effective then the mechanical exhaust for maintain the pressure distribution in hospital. It was also showed that when using the mechanical supply and mechanical exhaust more effectively prevention of air born virus diffusion.

• Journal of The Korea Institute of Healthcare Architecture
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• v.28 no.2
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• pp.17-29
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• 2022

Purpose: In terms of efficiency and safety, this study attempted to organize data on the operation methods and architectural planning of infectious diseases hospitals. Methods: The results obtained through on-site and interview surveys with hospital officials and medical staffs at four infectious diseases hospitals under construction were summarized based on those original business plans and facility guidelines. Results: First, the operational methods to secure safety and operational efficiency were summarized for each department which are major hospital functions of infectious disease hospitals. Second, as the architectural planning, the characteristics of space and circulation of each department are summarized. For safety of medical staff, negative pressure and non-negative pressure zone have to completely separated. In addition medical staff wears PPE and enters the negative pressure zone and returns in the order of admiral, shower, and gowning in the PPE undressing room after patient treatment. In case of operational efficiency, flexible operation is required in normal and crisis situations. For example, it is important for The Ward to gradually switch to negative pressure beds in times of crisis from normal situation and the outpatient department considers the composition of negative pressure and non-negative pressure outpatient spaces that can operate in parallel even in crisis situations. Implications: Infectious disease hospitals require flexible operation and appropriate facilities for normal and crisis situations.

• Journal of the Korea Society for Simulation
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• v.15 no.4
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• pp.119-128
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• 2006

A turnout system which permits trains to pass from one track to another is a combination of the switch, the crossing, lead rails which are necessary to connect the switch and the crossing, two guard rails and a switch machine for operating the switch. A turnout is the sole moving part among the railway components and has complex configuration, so the safety has always been raised an issue. In Korea, it is planned to adopt the high speed tilting train, which operates at the maximum speed of 200km/h, at conventional lines by the year of 2010. However, for the application of the tilting train to conventional lines, it is prerequisite to establish a stable turnout system allowing the tilting train to pass through it without reducing speed. Therefore, the improved turnout system for the speed-up of conventional lines has been developed and the prototype of the turnout system has been constructed. In this study, simulation of noise and vibration around the improved turnout system was performed in order to predict the generation level of noise and vibration due to passing of the tilting train through the turnout system.

• Journal of the Korean Society of Fisheries and Ocean Technology
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• v.52 no.4
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• pp.364-371
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• 2016

The analysis on the international safety management code (ISM Code) and case of foreign national safety management for fishing vessel was conducted to serve as a basic data on the introduction of safety management system (SMS) for a deep-sea fishing vessel in Korea. As a result, Maritime New Zealand (MNZ) has managed operations of SMS in the maritime rules according to the Maritime Transport Act since 1994. MNZ underwent a safe ship management (SSM), which includes elements applied to shipping companies, ship and verification of the ISM Code for ships, except ISM Code application since 1998. In 2014 the introduction of the advanced maritime operator safety system (MOSS) superior to the SSM by MNZ was promoted actively switch and enforcement. Meanwhile, the safe operation manual of Japanese fishing vessel includes large part of the contents of the ISM Code, and voluntary implementation to fit the realities of the fishing vessel. The law application of SMS for a deep-sea fishing vessel after the newly establishment of the Ocean Industry Development Act to SMS would be advantageous to the schematic management, supervision, maintenance and application and, in 2016 from the implementation of maritime safety supervisor for a deep-sea fishing vessel that the management and supervision through the fishing vessel will be the efficient operation. The configuration of the safety management system in a deep-sea fishing vessel should be included as an element of ISM Code. The introduction of such a system is gradually applicable, such as nationality overseas vessel case study of the ISM Code, and vessels that are excluded from the application will be implemented as autonomous as Japan. The results are expected to contribute to sustainable development in the ocean industry safety culture spread throughout the ocean industry through the enhancement of safety fishing competency and safety management responsibility of fisher.

• Journal of the Institute of Electronics and Information Engineers
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• v.51 no.10
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• pp.197-203
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• 2014

The safety and arming device(SAD), one of the components of the fuzes, shall provide safety that is consistent with handling, storage, transportation, use, and disposal. In this paper, we describes the design of the SAD which includes the solenoid assembly and the solenoid driving circuit to improve the safety of the fuzes. The solenoid assembly consists of a coil assembly, a restoring spring, and a core. The solenoid assembly is added in the SAD as an additional safety device. In case of the normal circumstances, the core of the solenoid assembly restrains the $1^{st}$ and $2^{nd}$ safety devices of the SAD for those devices not to operate at all, so that the SAD can secure safety for storage, transportation, and use. In contrast, when the battery power is provided to the solenoid driving circuit just before the flight, the core confirms the power level and starts removing the restraint from the $1^{st}$ and $2^{nd}$ safety devices of the SAD, and then the SAD is able to change its mode from safety mode to armed mode. After firing, once the SAD's operations complete, the turned-on arming switch stops providing the power to the solenoid assembly automatically. It can reduce the power consumption at solenoid assembly. Therefore, the proposed solenoid driving circuit for the solenoid assembly not only unlocks the restrained solenoid assembly from the safety devices, but also saves the power consumption during the flight.

• The Transactions of The Korean Institute of Electrical Engineers
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• v.62 no.4
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• pp.584-590
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• 2013

Depending on the operating characteristics, track circuit is installed for the purpose of control directly or indirectly of the signal device, point switch machine and other security device. These are mainly used for train detection, transmission of information, broken train detection and transmission of return current. Especially, the return current is related to signal system, power system and catenary line, and track circuit systems. It is one of the most important component shall be dealt for the safety of track side staff and for the protection of railway-related electrical system according to electrification. Therefore, an accurate analysis of the return current is needed to prevent the return current unbalance and the system induced disorder and failure due to an over current condition. Also, if the malfunction occurred by the return current harmonics, it can cause problems including train operation interruption. In this paper, we presented measurement and analysis method at return current and it's harmonics by train operation. By the test criteria, we evaluated for safety. Hereafter, it is expected to contribute to the field associated with it.