• 한국임상약학회지
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• 제23권3호
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• pp.239-247
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• 2013

Background: Fixed drug combinations are formulations containing two or more active ingredients in a single dosage form. Such combination therapies are commonly applied to improve efficacy, reduce adverse events and replace co-administration, etc. National and international guidelines for hypertension treatment recommend addition of other classes of antihypertensive drugs rather than incremental dose of mono-therapy, when blood pressure is not adequately controlled. Thus, many dual combinations of antihypertensive drugs have been approved and pharmaceutical companies are recently interested in developing antihypertensive triple combinations. Clinical trial designs for the fixed combinations are various depending on the target patients, dosage and clinical endpoints. Thereby, further discussions for the clinical trials of antihypertensive triple therapies are required regarding the indication claimed. Conclusion: This article provides a review for the assessment of the label and medical reports of the clinical trials on antihypertensive triple therapies in advanced foreign countries.

• Nuclear Engineering and Technology
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• 제32권4호
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• pp.316-327
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• 2000

The Emergency Core Cooling System in current nuclear power plants typically has a considerable number of complex functions and largely cumbersome operator interfaces. Functions for initiation, switch-over between various phases of operation, interlocks, monitoring, and alarming are usually performed by relays and analog comparator logic which are difficult to maintain and test. To improve problems of an analog based ECC (Emergency Core Cooling) System, the trip computer for ECCS based on Dynamic Safety System (DSS) is implemented. The DSS is a computer based reactor protection system that has fail-safe nature and performs a dynamic self-testing. The most important feature of the DSS is the introduction of test signal that send the system into a tripped state. The test signals are interleaved with the plant signals to produce an output which switches between a tripped and health state. The dynamic operation is a key feature of the failsafe design of the system. In this work, a possible implementation of the DSS using PLC is presented for a CANDU Reactor. ECC System of the CANDU Reactor is selected as the reference system.

• 한국화재소방학회논문지
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• 제25권3호
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• pp.63-71
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• 2011

본 연구에서는 대표적인 계절용기기인 전기히터에 대하여 발화위험성을 평가하였다. 실험에는 2종류의 전기히터가 사용되었다. 전기히터 가동 시 히터 표면 및 주변의 온도변화를 측정하였으며, 내부 비파괴검사를 통하여 전기히터 내부구조를 파악하였다. 전기히터 화재원인 중 가장 높은 비율을 차지하는 가연물 근접방치에 의한 화재위험성을 평가하였다. 또한 전도 안전스위치 오작동에 의한 발화위험성을 평가하였다. 정상작동 시 전기히터 발열제 주위에서 온도가 $80^{\circ}C$ 이하로 유지되었다. 전기히터 가동 중 가연물 낙하 등으로 인하여 히터를 덮거나 안전장치(전도안전스위치, 과열방지장치)의 오작동 등에 의해 발화위험성이 상존하고 있다.

• International Journal of Safety
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• 제10권2호
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• pp.10-15
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• 2011

The reconfigurable control systems based on feedback controls are utilized to compensate for damages of actuators in control systems. Such systems have multiple feedback controls and switch them in accordance with the degrees of the failures of the actuators. In order to be able to assess those systems, this paper develops a method to obtain reliabilities of reconfigurable dynamical systems which are interconnected in parallel / series configuration. By calculating reliabilities of interconnected dynamical systems, it is possible to assess many dynamical systems by comparing their reliabilities. Firstly, reliabilities of subsystems are obtained according to the definitions of the failures in terms of robust reliability for each subsystem. Then, the reliability of overall system is calculated from reliabilities of subsystems, using the methodology employed for probabilistic safety assessment. Failure rates of subsystems with feedbacks for reconfiguration change in certain time periods because of the switching of feedback controls. In order to deal with this, combinations of subsystems which compose overall system for each time period are derived by the methodology mentioned above and then integrated to calculate the reliability of overall system for a specific time. An illustrative example shows the validity and details of the proposed method.

• 대한안전경영과학회지
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• 제19권4호
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• pp.115-123
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• 2017

Recently there is a growing interest in the airborne spread of virus. In particular, there is growing interest in secondary infection through the air in the hospital. The distribution of air-born virus depends on ventilation system installed in a hospital. In this study, simulations were carried out to predict the move of air-born virus by ventilation system at hospital. Simulation results showed that pressure distribution was -372.05Pa ~ -3.45 Pa at 1st floor incase of only used mechanical exhaust at bathroom, shower stall, storage, kitchen etc.. if ventilation switch from used mechanical exhaust to mechanical exhaust & mechanical supply. Simulation results showed that pressure distribution was -336.44Pa at stair hall < -0.2Pa at bathroom < mean 1.19Pa at other room. So simulation results showed that using all of the mechanical supply and mechanical exhaust was more effective then the mechanical exhaust for maintain the pressure distribution in hospital. It was also showed that when using the mechanical supply and mechanical exhaust more effectively prevention of air born virus diffusion.

• 의료ㆍ복지 건축 : 한국의료복지건축학회 논문집
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• 제28권2호
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• pp.17-29
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• 2022

Purpose: In terms of efficiency and safety, this study attempted to organize data on the operation methods and architectural planning of infectious diseases hospitals. Methods: The results obtained through on-site and interview surveys with hospital officials and medical staffs at four infectious diseases hospitals under construction were summarized based on those original business plans and facility guidelines. Results: First, the operational methods to secure safety and operational efficiency were summarized for each department which are major hospital functions of infectious disease hospitals. Second, as the architectural planning, the characteristics of space and circulation of each department are summarized. For safety of medical staff, negative pressure and non-negative pressure zone have to completely separated. In addition medical staff wears PPE and enters the negative pressure zone and returns in the order of admiral, shower, and gowning in the PPE undressing room after patient treatment. In case of operational efficiency, flexible operation is required in normal and crisis situations. For example, it is important for The Ward to gradually switch to negative pressure beds in times of crisis from normal situation and the outpatient department considers the composition of negative pressure and non-negative pressure outpatient spaces that can operate in parallel even in crisis situations. Implications: Infectious disease hospitals require flexible operation and appropriate facilities for normal and crisis situations.

• 한국시뮬레이션학회논문지
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• 제15권4호
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• pp.119-128
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• 2006

철도운행에 있어 분기기는 열차를 주행선로에서 이웃한 선로로 이동시키는 매우 중요한 역할을 수행하는 장치로써 포인트부, 리드부 그리고 크로싱부로 이루어져 있다. 그러나 분기기는 레일 주변설비 중 유일한 가동부로 구조도 복잡하고 천이과정 중 차륜, 레일간의 급격한 운동변화가 필연적으로 발생되어 안전성 문제가 항상 거론되고 있다. 실제로, 국내외에서 차량의 탈선사고가 빈번히 발생되는 취약부위이기도 하다. 또한 차량, 궤도, 통신 그리고 전기 분야 등 분기기는 각각 다른 기능을 수행하는 매우 복잡한 장치들의 조합 시스템이므로 각각의 단위 개체들의 최적화만으로는 분기기의 전반적 성능을 향상시키기는 힘들며 이들에 대한 통합 기술의 확보가 필수적이다. 우리나라 철도는 기존선의 최고운행속도를 200km/h까지 향상 시키는 장기계획을 수립하고, 곡선부가 많은 우리나라 지형에 적합한 최고운행속도 180km/h의 틸팅열차를 개발 중이다. 그러나, 기존선로에 틸팅열차를 적용하기 위해서는 속고의 저감없이 틸팅열차를 통과시킬 수 있는 안정적인 분기기시스템의 확립이 선행되어야 한다. 본 연구에서는 틸팅열차 통과 시 기존선 속도향상을 위해 개발된 개량분기기 주변의 소음진동 정도를 예측하기 위해 시뮬레이션을 실시하였다.

• 수산해양기술연구
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• 제52권4호
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• pp.364-371
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• 2016

The analysis on the international safety management code (ISM Code) and case of foreign national safety management for fishing vessel was conducted to serve as a basic data on the introduction of safety management system (SMS) for a deep-sea fishing vessel in Korea. As a result, Maritime New Zealand (MNZ) has managed operations of SMS in the maritime rules according to the Maritime Transport Act since 1994. MNZ underwent a safe ship management (SSM), which includes elements applied to shipping companies, ship and verification of the ISM Code for ships, except ISM Code application since 1998. In 2014 the introduction of the advanced maritime operator safety system (MOSS) superior to the SSM by MNZ was promoted actively switch and enforcement. Meanwhile, the safe operation manual of Japanese fishing vessel includes large part of the contents of the ISM Code, and voluntary implementation to fit the realities of the fishing vessel. The law application of SMS for a deep-sea fishing vessel after the newly establishment of the Ocean Industry Development Act to SMS would be advantageous to the schematic management, supervision, maintenance and application and, in 2016 from the implementation of maritime safety supervisor for a deep-sea fishing vessel that the management and supervision through the fishing vessel will be the efficient operation. The configuration of the safety management system in a deep-sea fishing vessel should be included as an element of ISM Code. The introduction of such a system is gradually applicable, such as nationality overseas vessel case study of the ISM Code, and vessels that are excluded from the application will be implemented as autonomous as Japan. The results are expected to contribute to sustainable development in the ocean industry safety culture spread throughout the ocean industry through the enhancement of safety fishing competency and safety management responsibility of fisher.

• 전자공학회논문지
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• 제51권10호
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• pp.197-203
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• 2014

신관 안전장전장치는 비행체의 수송, 저장, 취급 중의 안전을 절대적으로 보장하도록 설계되어야 한다. 본 논문에서는 비행체에 적용되는 신관 안전장전장치의 안전성을 증대시키기 위한 솔레노이드 조립체와 솔레노이드 조립체를 구동하기 위한 솔레노이드 구동회로를 포함한 신관 안전장전장치 설계에 대해 기술한다. 솔레노이드 조립체는 신관 안전장전장치에 적용한 추가적인 안전장치로서, 코일 조립체, 복원스프링, 코어 등으로 구성된다. 솔레노이드 조립체의 코어는 평상시에는 1차 안전장치를 구속하고 있어 1차 안전장치가 작동하는 것을 저지해줌으로써 비행체의 취급이나 수송 시 안전을 확보해주게 되며, 발사를 위한 비행체 배터리 전원이 인가 및 활성화되어 신관 안전장전장치에 공급되면, 솔레노이드 구동회로가 코어를 작동시켜 신관 안전장전장치의 1차 및 2차 안전장치를 해제시키는 역할을 한다. 또한, 솔레노이드 구동회로는 비행체 발사 이후, 신관 안전장전장치의 기계적 장전이 완료되어 장전스위치가 turn-on되면 솔레노이드 조립체에 인가되는 전원을 자동 차단시켜 비행 중의 전원 소모량을 줄일 수 있도록 하였다.

• 전기학회논문지
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• 제62권4호
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• pp.584-590
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• 2013

Depending on the operating characteristics, track circuit is installed for the purpose of control directly or indirectly of the signal device, point switch machine and other security device. These are mainly used for train detection, transmission of information, broken train detection and transmission of return current. Especially, the return current is related to signal system, power system and catenary line, and track circuit systems. It is one of the most important component shall be dealt for the safety of track side staff and for the protection of railway-related electrical system according to electrification. Therefore, an accurate analysis of the return current is needed to prevent the return current unbalance and the system induced disorder and failure due to an over current condition. Also, if the malfunction occurred by the return current harmonics, it can cause problems including train operation interruption. In this paper, we presented measurement and analysis method at return current and it's harmonics by train operation. By the test criteria, we evaluated for safety. Hereafter, it is expected to contribute to the field associated with it.