• Title/Summary/Keyword: safety index

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10% Pentastarch Versus 5% Albumin Solution for Volume Expansion Following Cariopulmonary Bypass in Patients Undergoing Open Heart Surgery (개심수술후 혈량 증가를 위한 10% Pentastarch와 5% Albumin 용액의 비교연구)

  • 장병철
    • Journal of Chest Surgery
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    • v.27 no.3
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    • pp.177-186
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    • 1994
  • Pentastarch is a hydroxyethyl starch similar to hetastarch, but lower average molecular weight and fewer hydroxyethyl groups which result in enhanced enzymatic hydrolysis and faster renal elimination.This report was performed to compare the clinical efficacy and safety of 10 % pentastarch[Pentaspan , group I] for plasma volume expansion after open heart surgery with that of 5% albumin[Plasmanate, group II]. There were no statistically significant differences between the group I [n=18] and group II [n:19] in the preoperative parameters [age, sex, body weight] and operative parameters[bypass time, aorta cross clamping time]. During the first 24 hours after arrival of the patient in the surgical intensive care unit, colloid solution [500--1000 ml] was infused to maintain left atrial pressure of more than 8 mmHg, or cardiac index of 2.0 L/min/M2 of more. In results, there were 3 complications of hypotension immediately after infusion of 5 % albumin solution and 2 among the 3 patients were excluded for the study. However there was no complication after infusion of 10 % pentastarch solution. Hemodynamic responses to infusion was similar for both groups, although in group I a greater increase in both left atrial pressure[mean 1.8 versus 0.7 mmHg, p< 0.05] and right atrial pressure [mean 2.2 versus 1.7 mmHg, p < 0.05] was observed during infusion of the first 500 ml. There were no significant differences in any of the measured respiratory parameters[PaO2, intrapulmonary shunt, and effective lung compliance]. Homodilution with colloid significantly reduced hemoglobin [mean 1.2 versus 0.8 gm/dl], and serum protein and albumin level[total protein;4.8$\pm$ 0.5 versus 5.2 $\pm$0.5 gm/dl, p < 0.05: albumin: 3.2 $\pm$0.4 versus 3.6 $\pm$0.6 gm/dl, p < 0.05] by 6:00 AM on 1 day postoperatively, however there were no significant differences on 7 day postoperatively. The mean serum colloid osmotic pressure and osmolarity was similar in both group.There were no abnormal findings of liver function and kidney function in all the patients. There were no significant between-group differences in bleeding time, platelets, prothrombin time, activated partial thromboplastin time and amount of chest tube output measured on 1st and 7th postoperative day. These findings demonstrated that 10% pentastarch is more effective and safe for plasma volume expension than 5 % albumin solution with no adverse effects on coagulation. Also 10 % pentastarch is less expensive than 5 % albumin and it would appeare to be a reasonable first choice for plasma volume expansion.

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A Study on the Relation between IRI and PrI (평탄성 지수 IRI와 PrI의 상관관계에 관한 연구)

  • Kim, Kook-Han;Lee, Byung-Duck;Choi, Go-Il;Yang, Sung-Cheol
    • International Journal of Highway Engineering
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    • v.5 no.1 s.15
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    • pp.11-18
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    • 2003
  • Road roughness, as the key factor influencing not only drivers' ride quality and safety but also pavement deterioration, is one of the most important pavement performance indicator to be evaluated by users' subjective assessment. For this reason, a specific number of the pavement roughness has been adopted to monitor the condition of a road for pavement management systems and to evaluate the quality of newly constructed sections, however, none of the unified methodology was internationally accepted. In Korea highway network, road roughness has been used mainly to evaluate newly placed pavement by using 7.6m CP (California Profile meter) to calculate PrI (Profile Index). But this instrument is manually operated to measure road profiles by traffic closure and their interpretation depends on personal bias. Therefore, problems arisen from the manually operated instrument will be overcome by using the APL (Longitudinal Profile Analyzer) which can be operated in the speed of 80km per hour. A study was conducted to correlate the relation from both concrete and asphalt pavement between IRI (measured by APL) and PrI (measured by 7.6m CP). Test results showed that there was a good correlation between IRI and PrI.

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Crime-Prevention in the Community and the Security Activity (환경설계를 통한 범죄예방과 민간경비의 역할)

  • Jang, Ye-Jin
    • Korean Security Journal
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    • no.17
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    • pp.301-316
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    • 2008
  • The occurrence of complicating, multilateral social condition demands the strategy for facing many social state and consolidating public security against criminal loss. The lacking ability of local police for preventing crime can't satisfy the demand of security and can't get rid of fear of crime. At last, it brings a distrust of public confidence and became a factor of serious social crisis. We have problems - not only making an alternative plan for preventing crime, but also introducing CPTED(Crime Prevention Through Environmental Design) by environmental design, to expect crime prevention and to select systemic crime prevention system and the most suitable model. And we have a goal - to recognize the importance of guard activity for local crime, analyse public safety activity in community & focusing guard activity as a strategy for them, apply CPTED in police and private security company as a local crime prevention & setting effective model, and, make it as an index for preventing & dealing with intellectual, brutal crime. The rapid growth in the guarding-activity field lighten the burden of police for crime-prevention. But the misjudgement of some people blocks it to be settled institutionally. It needs to reconsider what is the effective crime-prevention method, at this point of time when the all parts of a nation changing into unlimited competitive, private self-control system.

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Availability Evaluation of TOC as the Environmental Standard - Survey of Lakes in Nakdong River Basin - (환경기준으로서의 TOC에 대한 활용성 평가 - 낙동강수계 호소를 대상으로 -)

  • Choi, Byoungwoo;Kang, Meea
    • Journal of Wetlands Research
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    • v.20 no.2
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    • pp.173-180
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    • 2018
  • The utilization of TOC(Total organic carbon), a new environmental standard, was evaluated for 30 lakes in the Nakdong River Basin, which is used for drinking and agricultural usage. The active use of water resources begins with securing satisfactory water quality. Since this allows people and nature to maintain stability of quality, water quality standards are being tightened to ensure good water quality. In order to improve the pollution level of organic matter in lakes in the living environment, it is important to use the appropriate organic substance index. The relationship between the newly introduced TOC and the existing COD(Chemical oxygen demand) in the targeted lake was positively correlated with the possibility of replacing the TOC with COD. However, the environmental grade standard using TOC is better than the environmental grade standard using COD, so it has the same effect as that of the grade of water quality using TOC as an organic substance factor. This indicates the limitation of TOC to directly replace existing COD when trying to determine or improve the quality level using organic indicators of lakes. Therefore, in order to secure the qualitative safety of the lake, it is required to strengthen environmental standards of TOC in terms of water quality grade. In addition, the correlation between TOC and COD shows a great difference depending on the utilization characteristics of the lake. This requires clear scientific identification, and it requires continuous monitoring of COD that has been used to accumulate indicators of lake organic matter.

Flora and Vegetation Structure in a 15-Year-Old Artificial Wetland (조성 후 15년이 경과한 인공습지의 식물상과 식생구조)

  • Son, Deokjoo;Lee, Hyohyemi;Lee, Eun Ju;Cho, Kang-Hyun;Kwon, Dongmin
    • Ecology and Resilient Infrastructure
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    • v.2 no.1
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    • pp.54-63
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    • 2015
  • This study was conducted to investigate the flora and vegetation structure at a 15-year-old artificial wetland for the water purification in Jincheon, Korea. The percentage of species number of obligate wetland plants and facultative wetland plants totaled 40%, whereas that of obligate upland plants and facultative upland plants was 57%. This result showed that the artificial wetland in the study experienced terrestrialization. The number of annual and biennial plants that are pioneer vegetation in a successional stage was lower than that of perennial herbs as a result of the long-term stabilization of vegetation. From the results of DCA (detrended correspondence analysis), water depth played an important role on the classification of vegetation structure in an old artificial wetland. Species diversity was higher in the terrestrialized plant communities such as Iris pseudacorus and Aster koraiensis than in any other wetland communities. Plant communities could be classified according to the wetland indices; obligate upland for A. koraiensis community, facultative wetlands for Carex dispalata var. dispalata and I. pseudacorus community, and obligate wetlands for Nymphoides peltata, Nymphaea tetragona, Phragmites communis, Potamogeton maackianus, and Typha angustifolia community. In conclusion, this result suggests that wetland vegetation should be maintained against terrestrialization through the proper management of sedimentation and hydrological regime in an artificial wetland.

Computation of $Q_{10}$ Values and Shelf-life for Canned and Bottled Orange Juices (캔 및 병 오렌지쥬스의 저장온도에 따른 $Q_{10}$값 및 품질수명의 산정)

  • Lee, Nam-Kyung;Yoon, Jae-Young;Lee, Su-Rae
    • Korean Journal of Food Science and Technology
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    • v.27 no.5
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    • pp.748-752
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    • 1995
  • Canned and bottled orange juices currently sold in Korean market were stored for 24 weeks at 20, 30, 40 and $50^{\circ}C$ and analyzed after opening at 4 week intervals. Activation energy, $Q_{10}$ values and shelf-life at respective temperatures were calculated from the data on various quality indexes. Proposed indexes were lead, tin, iron and vitamin C contents in canned juices and vitamin C content and browning index in bottled juices and $Q_{10}$ values for these parameters were in the range of $1.3{\sim}2.0$. Shelf-life calculated for canned juices at 10, 20 and $30^{\circ}C$ were 10, 6 and 3 months and that in bottled juices, 24, 12 and 6 months, respectively. When the distribution temperature of juices in Korea is assumed to be $15^{\circ}C$ average, the optimum shelf-life was estimated to be 8 months in canned juices and 18 months in bottled juices. In order to ascertain the safety of canned orange juices, efforts are needed to re-examine the recommended distribution period, legal limit for lead and improvement of container materials.

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A Clinical Study of Electroacupuncture and Auricular Acupuncture for Abdominal Pain Relief in Patients with Pancreatitis: A Pilot Study (췌장염 환자의 복통 호전을 위한 전침 및 이침 치료 예비 임상연구 프로토콜)

  • Kang, Ha Ra;Lee, Yeon Sun;Kim, Hye Ryeon;Kim, Eun Jung;Kim, Kyung Ho;Kim, Kap Sung;Jung, Chan Yung;Lee, Jun Kyu
    • Korean Journal of Acupuncture
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    • v.34 no.1
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    • pp.47-55
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    • 2017
  • Objectives : The purpose of this study is to evaluate the feasibility of further acupuncture research as an effective alternative and safe treatment for abdominal pain control in patients with pancreatitis. Methods and Results : This study is an open-label, assessment-blind, parallel designed pilot clinical trial. Thirty participants will be assigned to the acupuncture group(n=15) and usual care group(n=15). All patients will receive the conventional standard-of-care(SOC) therapy, but only the experimental group will receive acupuncture therapy six times a week, and the duration of acupuncture therapy will be held up to 12 weeks or until the pains are to be resolved. For the conventional SOC therapy, painkiller will be given. In treatment group, the subjects will receive the identical SOC therapy in combination with electroacupuncture therapy on twelve acupuncture points(LI4, PC6, SP6, GB39, ST36, ST37), and auricular acupuncture therapy on five auricular acupuncture points(Sympathetic, Shen Men, Abdomen, Pancreas gall, and Spleen). The primary outcome will be measured using the visual analogue scale(VAS), and the secondary outcome will be measured using the painkiller demand, quality of life index and severity of pancreatitis by abdominal computed tomography(CT). Assessments will be made at baseline and at week 1, 4, 8 and 12. Results of abdominal CT will be evaluated at baseline and at week 12. Conclusions : The result of this trial will provide a basis for the effectiveness and safety of acupuncture treatment for abdominal pain in patients with pancreatitis.

Na3PO4 Flame Retardant Treatment on Lyocell Fiber for Thermal Stability and Anti-oxidation Properties (라이오셀의 열 안정 및 내산화 특성 향상을 위한 Na3PO4 내염화 처리)

  • Kim, Hyeong Gi;Kim, Eun Ae;Lee, Young-Seak;In, Se Jin
    • Fire Science and Engineering
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    • v.29 no.2
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    • pp.25-32
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    • 2015
  • The improved thermal stability and anti-oxidation properties of lyocell fiber were studied based on flame retardant treatment by using $Na_3PO_4$ solution. The optimized conditions of flame retardant treatment were studied on various concentrations of $Na_3PO_4$ and the mechanism was proposed through experimental results of thermal stability and anti-oxidation. The integral procedural decomposition temperature (IPDT), limiting oxygen index (LOI) and activation energy ($E_a$) increased 30, 160% respectively via flame retardant treatment. It is noted that thermal stability and anti-oxidation improved based on char and carbon layer formation by dehydrogenation and dissociation of C-C bond resulting the hindrance of oxygen and heat energy into polymer resin. The optimized conditions for efficient flame retardant property of lyocell fiber were provided using $Na_3PO_4$ solution and the mechanism was also studied based on experimental results such as initial decomposition temperature (IDT), IPDT, LOI and $E_a$.

A Linear Change of Leakage Current and Insulation Resistance of 22 kV Cables (22 kV 케이블의 누설전류 및 절연저항의 선형적 변화)

  • Um, Kee-Hong;Lee, Kwan-Woo
    • The Journal of the Institute of Internet, Broadcasting and Communication
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    • v.15 no.3
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    • pp.169-173
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    • 2015
  • This study is to predict the life exponent by measuring, over 7 years, the insulation resistance of high-voltage cables in 22 kV operation for 13 years. We found out the lifetime index in order to determine the time-dependent trend of deteriorating performance of power cables. The insulation resistances decreased according to elapsed time. We found that: the initial measurements of the cable systems were in agreement with the deterioration properties of the Arrhenius Law. By analyzing the life curve of the cable system, we also verified that the value of the life exponent (n) in the v-t characteristics defined by Weibull distribution has values from 10 to 11. When designing the cable system, the initial value of life exponent was chosen as 9 without any grounding. We have verified that the theoretical grounding based on the design safety of n=9 was actually the best one available. In the short term, we apply our research result to the diagnosis and evaluation of the power cables. In the long run, however, we plan to reduce the cost of the installation and management of cable systems in operation at power stations.

Analysis of the Water Quality Change Due to Water Level Control of Sayeon Dam (사연댐 수위조절시 수질변화 분석)

  • Lee, Sang Hyeon;Cho, Hong Je
    • Journal of Korea Water Resources Association
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    • v.46 no.11
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    • pp.1069-1078
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    • 2013
  • The Bangudae Petroglyphs, national treasure No. 285 is located within submerged upper districts of Sayeon dam supplying the main residential water in Ulsan. Of the many ways for the reservation of Petroglyphs located the altitude at 53~57 m, the plan that we take it out of the water lowering the water level from 60 m to 52 m has been examined mainly in case of controlling artificially the water level of the dam. In this paper, we examined expected problems from the loss of dam function and the change of water quality from water deterioration caused by the water level control of the Sayeon dam. Using the model of Vollenweider and CSTR (Continuous Stirred Tank Reactor), we analyzed the density change of BOD and COD, representative water quality index and the TP and TN, the main reason of algae growth. The result showed that the density of COD lowered a little but the density of TP and TN went up over 130% when controlling the water level from 60 m to 52 m. These changes cause a serious algae problem and if doing the water quality management as the density of TN and TP, the water quality would become worse. Water storage and supply residential water decreases, and the water quality becomes worse because of eutrophic state.