• Title/Summary/Keyword: safety benefits

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Analysis of Efficiency of Recombinant pOPINEneo-3C-GFP Vector with p53 Tumor Suppression Gene Inserted (p53 암억제 유전자가 삽입된 재조합 pOPINEneo-3C-GFP 벡터의 효율 분석)

  • Sa, Young-Hee;Choi, Chang-Shik;Lee, Ki Hwan;Hong, Seong-Karp
    • Proceedings of the Korean Institute of Information and Commucation Sciences Conference
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    • 2019.05a
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    • pp.533-536
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    • 2019
  • Recombinant baculoviruses are widely used to express heterologous genes in cultured insect cells. Recombinant baculoviruses can serve as gene-transfer vectors for expression of recombinant proteins in a wide range of mammalian cell types. Baculovirus system has significant benefits in view of safety, large-scale, and high level of gene expression. In this study, baculoviral vectors which were reconstructed from pOPINEneo-3C-GFP vector, were recombined with cytomegalovirus (CMV) promoter, green fluorescent protein (GFP), and p53 with NcoI and XhoI. These recombinant vectors were infected with various cells and cell lines. The baculovirus vector thus developed was analyzed by comparing the metastasis and expression of the recombinant genes with conventional vectors. These results suggest that the baculovirus vector has higher efficiency in metastasis and expression than the control vector. This work was supported by a grant from Mid-Career Researcher Program(NRF-2016R1A2B4016552) through the National Research Foundation of Korea(NRF) funded by the Ministry of Science, ICT & Future Planning(MSIP).

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Development and analysis of assessment model of a village-level rural living services for response to rural depopulation (농촌 과소화 대응을 위한 마을 단위 농촌생활서비스 평가 모델의 개발 및 분석)

  • Hong, Sangwon;Bae, Seung-Jong;Kim, Dong-Hyeon;Kim, Soo-Jin;Kim, Jungtae;Jang, Taeil
    • Journal of Korean Society of Rural Planning
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    • v.27 no.1
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    • pp.57-70
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    • 2021
  • The degree of benefits of living services related to the quality of life can solve the depopulation problem, and it is necessary to be able to quantitatively analyze problems related to the quality of life in rural areas in order to cope with the rural depopulation. The purpose of this study was to develop the assessment model of a village-level rural living service that reflects the regional characteristics of rural villages to evaluate the level of rural living services for response rural depopulation. Based on the review of previous related studies, the evaluation index was composed of seven sectors of education, health, welfare, culture, environment, safety, and convenience, and the assessment model of a rural living service was established. This model was evaluated through a sample survey of 90 villages in Nonsan-si, Seongju-gun, and Pyeongchang-gun. As a result of the rural life services evaluation by Si and Gun, Seongju-gun, which is affected by nearby large cities, has the largest variation by village level and is assessed at a lower level overall than other Si and Gun. As a result of the rural life services evaluation by 7 sectors, in the case of health and welfare, low scores were shown in the assessment model, but the level of residents' satisfaction was mid-level. In particular, in the case of Seongju-gun, there were significant differences in the assessment model and the survey results of the level of residents' satisfaction in the health and welfare sectors due to the influence of nearby large cities. As a result of analyzing the number of villages corresponding to the top 30% and the bottom 30% of the evaluation results for each sector, it was analyzed that the villages with the highest evaluation results in Pyeongchang-gun in both the assessment model and the level of residents' satisfaction. It implies that quantitative analysis of data based index and accessibility as well as level satisfaction of residents are necessary.

An Analysis of the Relative Importance of Park Services for User-Oriented Smart Park Development (이용자 중심의 스마트공원 조성을 위한 공원서비스의 상대적 중요도 분석)

  • Lee, Ju-Yong;Lee, Hyung-Sook
    • Journal of the Korean Institute of Landscape Architecture
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    • v.49 no.4
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    • pp.55-63
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    • 2021
  • Interest in smart parks has been increasing due to the recent rapid rise of smart cities, but concerns are growing over the development of technology-oriented smart parks. The purpose of this study is to evaluate the relative importance of park services through Focus Group Interviews and the Analytic Hierarchy Process (AHP) to develop user-oriented smart parks in the future. To this end, literature on park functions and services was reviewed, and interviews with experts in the field of landscape architecture and IT were conducted to derive service items. The AHP model consisted of four values, and 15 park services were established and used to survey 38 landscape experts. As a result, services for improving the park's essential functions, such as contact with nature, relaxation, and exercise-walking, were deemed important. Services related to the environment and safety in response to climate change, such as the amelioration of pollution and heatwaves were also high. The importance of social integration services was relatively low, but it was considered an important service to when enhancing community participation. Future smart parks should enhance the health benefits of contact with nature rather than implementing excessive artificial facilities and technology. Additionally, smart technology will need to be applied based on users' needs while reflecting local characteristics. Efforts should be made to enhance user intimacy and improve the understanding of smart parks by strengthening public relations education.

Delphi Survey for COVID-19 Vaccination in Korean Children Between 5 and 11 Years Old (국내 5-11세 소아의 코로나19 백신 접종에 대한 델파이 연구)

  • Choe, Young June;Lee, Young Hwa;Choi, Jae Hong
    • Pediatric Infection and Vaccine
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    • v.29 no.1
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    • pp.37-45
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    • 2022
  • Purpose: During the coronavirus disease 2019 (COVID-19) pandemic, we conducted a Delphi survey that included the experts from the field of COVID-19 immunization in children aged 5-11 years. The aim was to organize collective expert opinions on COVID-19 vaccination in young children in the Republic of Korea, and so thus assist the vaccination policy. Methods: The panels included pediatric infectious disease specialists, preventive medicine experts, infectious disease physicians, and COVID-19 vaccine experts consulting the Ministry of Health and Welfare. The Delphi survey was conducted online using a questionnaire from February 14 to February 27, 2022. Results: The Delphi panels agreed that children were vulnerable to COVID-19, and the severity of illness was modest. Furthermore the panels reported that children with chronic illness were more susceptible to a worsening clinical course. There were generally positive opinions on the effectiveness of COVID-19 vaccination in children aged 5-11 years, and experts gathered a slightly positive opinion that the adverse events of pediatric COVID-19 were not numerous. The benefits of COVID-19 vaccination were evaluated at a level similar to the potential risks in children. Currently, the only approved mRNA platform vaccine in children seemed to be sustainable; however, the recombinant protein platform COVID-19 vaccines were evaluated as better options. Conclusions: Due to the surge of the Omicron variant and an increase in pediatric cases, the COVID-19 vaccination in young children may have to be considered. Panels had neutral opinions regarding the COVID-19 vaccination in children aged 5-11 years. Thus monitoring of the epidemiology and the data about the safety of COVID-19 vaccination should be continued.

Estimating milk production losses by heat stress and its impacts on greenhouse gas emissions in Korean dairy farms

  • Geun-woo, Park;Mohammad, Ataallahi;Seon Yong, Ham;Se Jong, Oh;Ki-Youn, Kim;Kyu-Hyun, Park
    • Journal of Animal Science and Technology
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    • v.64 no.4
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    • pp.770-781
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    • 2022
  • Meteorological disasters caused by climate change like heat, cold waves, and unusually long rainy seasons affect the milk productivity of cows. Studies have been conducted on how milk productivity and milk compositions change due to heat stress (HS). However, the estimation of losses in milk production due to HS and hereby environmental impacts of greenhouse gas (GHG) emissions are yet to be evaluated in Korean dairy farms. Dairy milk production and milk compositions data from March to October 2018, provided by the Korea Dairy Committee (KDC), were used to compare regional milk production with the temperature-humidity index (THI). Raw data for the daily temperature and relative humidity in 2018 were obtained from the Korea Meteorological Administration (KMA). This data was used to calculate the THI and the difference between the maximum and minimum temperature changing rate, as the average daily temperature range, to show the extent to which the temperature gap can affect milk productivity. The amount of milk was calculated based on the price of 926 won/kg from KDC. The results showed that the average milk production rate was the highest within the THI range 60-73 in three regions in May: Chulwon (northern region), Hwasung (central region), and Gunwi (southern region). The average milk production decreased by 4.96 ± 1.48% in northern region, 7.12 ± 2.36% in central region, and 7.94 ± 2.57% in southern region from June to August, which had a THI range of 73 or more, when compared to May. Based on the results, the level of THI should be maintained like May. If so, the farmers can earn a profit of 9,128,730 won/farm in northern region, 9,967,880 won/farm in central region, and 12,245,300 won/farm in southern region. Additionally, the average number of cows raised can be reduced by 2.41 ± 0.35 heads/farm, thereby reducing GHG emissions by 29.61 ± 4.36 kg CO2eq/day on average. Overall, the conclusion suggests that maintaining environmental conditions in the summer that are similar to those in May is necessary. This knowledge can be used for basic research to persuade farmers to change farm facilities to increase the economic benefits and improve animal welfare.

Research to Predict the Thermal Characteristics of Electro Hydrostatic Actuator for Aircraft (항공기용 전기-정유압식 작동기(Dual Redundant Asymmetric Tandem EHA)의 열특성 예측을 위한 연구)

  • Kim, Sang Seok;Park, Hyung Jun;Kim, Daeyeon;Kim, Dae Hyun;Kim, Sang Beom;Lee, Junwon;Choi, Jong Yoon
    • Journal of Aerospace System Engineering
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    • v.16 no.3
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    • pp.84-92
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    • 2022
  • The electro-hydrostatic actuator (EHA) recently has been used in flight control fields for aircraft because of its benefits of minimizing oil leakage and weight, improving safety, and etc. while independently operating the hydraulic power source and eliminating complex hydraulic piping. The aircraft of which EHA is installed inside, has the thermal management issue of EHA, because of its limited cooling source as compared with the aircraft which installs the traditional central hydraulic system. So, the thermal analysis model which predicts the thermal characteristics of EHA, is required to resolve this thermal management issue. In this study, an oil circulation circuit inside the hydraulic power module comprised of hydraulic pump and electrical motor for EHA was applied. This is for the purpose of developing the internal rotary group of hydraulic power module, which operates under the conditions of high rotation speed and hydraulic pressure. After formulating an appropriate thermal analysis model, the thermal analysis results with oil cooled or no oil cooled hydraulic control module were compared and reviewed, for the purpose of predicting the thermal characteristics of EHA.

Building plan research of Smart Ammunition Logistics System based on the 4th industrial technology (4차산업혁명기술 기반 스마트 탄약물류체계 구축 방안 연구)

  • Choi, Jong-Geun;Kim, Byung-Kyoo;Chang, Yoon Seok
    • Journal of Internet Computing and Services
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    • v.23 no.1
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    • pp.135-145
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    • 2022
  • This paper presented a method to build a predictable smart ammunition logistics system using the 4th industrial technology for ammunition logistics, which is the core functions in the field of defense and logistics. We have analyzed the current level of ammunition logistics with various perspectives such as domestic and overseas logistics policies, technology trends, ammunition logistics characteristics, the smart logistics certification measures by Ministry of Land, Infrastructure and Transport. As a result it is considered that the current ammunition logistics needs needs improvement. To improve this, we presented a direction based on the implications derived after analyzing various ongoing programs such as wired/wireless-based automation, smart ammunition depots, and logistics innovation of the army, navy, and air force that can be applied to the ammunition logistics. In order to implement a data-based smart ammunition logistics management system that can achieve innovation and efficiency of total life cycle while meeting changes in the battlefield environment, we presented 4 objectives such as "automation and modernization of field work", "3D-based storage management & improvement of issuing at war," and "data management for prediction-oriented ammunition management". it is expected that there will be benefits such as improvement of operational continuity, guarantee of ammunition reliability, budget reduction, improvement of inefficiencies such as delay, waiting, and double work, and reduction of accidents.

Comparative Study of Metro Service in Korea Using Servicescape (서비스스케이프를 활용한 한국의 지하철 서비스 비교연구)

  • Jia-Xing Long;Sung-Pil Lee
    • Journal of Service Research and Studies
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    • v.12 no.2
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    • pp.48-64
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    • 2022
  • The metro played a role in improving and alleviating the problems of urban ground transportation, promoting rational development of the city and at the same time leading the development of metro-related industries. There is no doubt that it had a double effect of enormous economic and social benefits on the development of the country as a whole. The purpose of this study is to apply the concept of servicescape to the metro and establish the definition of the Metro Servicescape(MSS). To this end, the service space and service facilities of the metro were analyzed, and the existing domestic and foreign literature related to servicescape was studied. First, this study defined the concept of servicescape of metro. Second, 10 elements suitable for the metro service landscape were derived through domestic and foreign service landscape studies. Third, through field surveys and analysis of metros in five cities in Seoul, Busan, Daegu, Daejeon, and Gwangju, the ranking of the current status of the domestic metro servicescapes was 203 Seoul metro, 197 Busan metro, 192 Daegu metro, 178 Gwangju metro, There were 172 metro lines in Daejeon. Among them, the four elements of comfort, sociality, cleanliness, and safety are the same, and accordingly, it seems that each city metro is the same standard. However, the six elements of aesthetics, spatiality, convenience, entertainment, openness and information were found to be different for each city metro. It is expected that the results of this study can provide a reference value for future metro service landscape research.

Exploring the Cognitive Factors that Affect Pedestrian-Vehicle Crashes in Seoul, Korea : Application of Deep Learning Semantic Segmentation (서울시 보행자 교통사고에 영향을 미치는 인지적 요인 분석 : 딥러닝 기반의 의미론적 분할기법을 적용하여)

  • Ko, Dong-Won;Park, Seung-Hoon;Lee, Chang-Woo
    • The Journal of the Korea Contents Association
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    • v.22 no.5
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    • pp.288-304
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    • 2022
  • Walking is an eco-friendly and sustainable means of transportation that promotes health and endurance. Despite the positive health benefits of walking, pedestrian safety is a serious problem in Korea. Therefore, it is necessary to investigate with various studies to reduce pedestrian-vehicle crashes. In this study, the cognitive characteristics affecting pedestrian-vehicle crashes were considered by applying deep learning semantic segmentation. The main results are as follows. First, it was found that the risk of pedestrian-vehicle crashes increased when the ratio of buildings among cognitive factors increased and when the ratio of vegetation and the ratio of sky decreased. Second, the humps were shown to reduce the risk of pedestrian-related collisions. Third, the risk of pedestrian-vehicle crashes was found to increase in areas with many neighborhood roads with lower hierarchy. Fourth, traffic lights, crosswalks, and traffic signs do not have a practical effect on reducing pedestrian-vehicle crashes. This study considered existing physical neighborhood environmental factors as well as factors in cognitive aspects that comprise the visual elements of the streetscape. In fact, the cognitive characteristics were shown to have an effect on the occurrence of pedestrian- related collisions. Therefore, it is expected that this study will be used as fundamental research to create a pedestrian-friendly urban environment considering cognitive characteristics in the future.

Comparison of Kinematics and Myoelectrical Activity during Deadlift, with and without Variable Banded Resistance, in Healthy, Trained Athletes

  • Everett B. Lohman;Mansoor Alameri;Fulden Cakir;Chih Chieh Chia;Maxine Shih;Owee Mulay;Kezia Marceline;Simran Jaisinghani;Gurinder Bains;Michael DeLeon;Noha Daher
    • Physical Therapy Rehabilitation Science
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    • v.13 no.1
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    • pp.53-70
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    • 2024
  • Background: The conventional deadlift is a popular exercise for enhancing trunk, core, and lower extremity strength. However, its use in sports medicine is constrained by concerns of lumbar injuries, despite evidence supporting its safety and rehabilitative benefits. To optimize muscle activation using resistive bands in variable resistance therapy, we explored their feasibility in the deadlift. Design: Comparative experimental design Methods: Surface electromyography recorded muscle activity in the trunk and lower extremities during lifting, with normalization to the isometric Floor Lift using Maximal Voluntary Contraction. Kinematics were measured using inclinometer sensors to track hip and trunk sagittal plane angles. To prevent fatigue, each subject only used one of the three pairs of bands employed in the study. Results: Our study involved 45 healthy subjects (mean age: 30.4 ± 6.3 years) with similar baseline characteristics, except for years of lifting and strength-to-years-of-lifting ratio. Various resistance band groups exhibited significantly higher muscle activity than conventional deadlifts during different phases. The minimal resistance band group had notably higher muscle activity in the trunk, core, and lower extremity muscles, particularly in the end phase. The moderate resistance band group showed increased muscle activity in the mid-and end-phases. The maximum resistance band group demonstrated greater muscle activity in specific muscles during the early phase and overall higher activity in all trunk and lower extremity muscles in the mid and end phases of the deadlift (p<0.05). Conclusion: Our findings provide valuable insights into muscle activation with various resistance bands during deadlift exercise in clinical and gym settings. There appears to be a dose-response relationship between increased resistance bandwidth, external load, myoelectric activation, and range.