• Proceedings of the KSR Conference
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• 2008.06a
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• pp.1255-1263
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• 2008

A Safety Case is an railway organization's formal arrangement, through the provision of policies, resources and processes, to ensure the safety of its work activity within safety management system. An effective system helps the organization to identify and manage risks effectively. It allows an organization to demonstrate its capability in achieving its safety objectives and in meeting regulatory requirements. The purpose of this research is to give how to the risk assessments are described within Railway Safety Cases can be prepared and maintained to meet the criteria specified by the upcoming railway regulations. Through this research, we propose the elements of safety management system that include arrangements for the ongoing identification of hazards, assessment of risks and the implementation of necessary control measures.

• Journal of the Korea Safety Management & Science
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• v.10 no.1
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• pp.33-40
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• 2008

This paper reviewed the relationship among safety education/managerial factors, safety motivation and safety appliance, and the moderating effect of safety motivation. Based on the responses from 225 employees in small & medium manufacturing and construction industry, hierarchical regressional analysis showed that all education/managerial factors have positive relationships with safety motivation. Also, safety motivation has mediating effect between education/managerial factors(safety education, communication, system, precautionary activity) and safety appliance.

• Proceedings of the Safety Management and Science Conference
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• 2004.05a
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• pp.1-4
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• 2004

Need safety diagnostic indicator pointer that is objective as estimation basis to be scientific and manages systematically safety existing condition and level for city gas facilities. Safety diagnostic indicator pointer can divide by greatly two. One is management (Software) side that one that differ with mechanical (Hardware) side that handle laying stress on equipment connected with safety manages organization and management connected with safety. Weight appropriates according to specific gravity that relevant element occupies in facilities. To give so big value in particular element in grant of weight pays attention because break balance of whole guideline and should gives. Finally, efficient safety net may see effect before self-regulation inside by minimum target establishment by government and legal, systematic countermeasure establishment for this, strict law application and each business proprietor and though activity and user's active safety activity forms harmony properly.

• Proceedings of the KSR Conference
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• 2005.11a
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• pp.618-622
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• 2005

Railway safety case is an important measure for demonstrates operating company's capability, commitment and competence in accordance with Railway Regulation 2000 in UK. Safety case describes the scope of operation, definition and boundary of activity, risk analysis, system safety activity, annul safety plan. Relationships between' these components and company's policy, organization, human resource, control measure, investment plan are also included. A case study for Network Rail (infrastructure manager)'s safety case is described in this paper for the construction of safety rule and safety planning.

• Korean Journal of Veterinary Research
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• v.46 no.4
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• pp.315-322
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• 2006

Ethanol abuse is associated with liver injury, neurotoxicity, modulation of immune responses, and increased risk for cancer, whereas moderate ethanol consumption exerts protective effects against liver injury. However, the underlying signal transduction mechanisms of insulin-like growth factors (IGFs) which play an important regulatory role in various metabolism mechanisms are not well understood. We investigated the effects of ethanol-induced p42/44 activity on IGF-I secretion, IGF-I receptor and IGFBP-1 secretion using radioimmunoassay and western blotting in primary cultured rat hepatocytes. The p42/44 activity, IGF-I secretion and IGF-I receptor activity significantly accelerated compared to control at 10 and 30 min after 200 mM ethanol treatment, but then it became suppressed at 180 min. In contrast, IGFBP-1 secretion was inhibited compared to control at 30 min after 200 mM ethanol treatment, but increased at 180 min. The IGF-I secretion, IGF-I receptor and p42/44 activity at 30 min after 200 mM ethanol treatment accelerated with increasing ethanol concentration but IGFBP-1 secretion inhibited (p<0.05). The increased IGF-I secretion, inhibited IGFBP-1 secretion and IGF-IR activity by ethanol-induced temporal p42/44 activity at 30 min after ethanol treatment was blocked by treatment with PD98059. Alcohol dehydrogenase (ADH) inhibitor, 4-methylpyramazole blocked the changes of IGF-I secretion, IGFBP-1 secretion, and IGF-IR activity by ethanol-induced p42/44 activity at 30 and 180 min. Taken together, these results suggest that ethanol is involved in the modulation of IGF-I and IGFBP-1 secretion and IGF-IR activity by p42/44 activity in primary cultured rat hepatocytes. In addition, changing of p42/44 activity by ethanol was caused with ADH.

• Proceedings of the KSR Conference
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• 2008.11b
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• pp.2070-2074
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• 2008

It is necessary to develop the requirement management system that could trace hazards and manage safety requirements for risk control of railway accident as low as reasonably practicable. In this paper, the requirement management system for control of railway accident risk is introduced. The requirement management system is containing the railway system configuration and safety activity related with identified hazards. The system shall be used to derive safety requirements for risk controland support the traceability of hazards on railway's operation & management. In the future, the system will be applied in the areas such as risk assessment and management, performing safety assurance and revising national regulations etc. for continuous safety improvement in the railway.

• Journal of Korean Society of Industrial and Systems Engineering
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• v.44 no.4
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• pp.106-112
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• 2021

In the early 1960s, US Air Force lost missile launch bases during ICBM development by a defect in the missile design and operation plan. U.S. DoD realized the limitation of the existing accident prevention method. Therefore, the weapon development required system safety activity, and procurement projects of U.S. DoD applied MIL-STD-882(System Safety). Development projects of U.S. DoD more emphasized the importance of system safety after the space shuttle Challenger exploded in 1986. Currently, Airworthiness certification for military aircraft uses system safety to minimize accidents. The domestic defense aviation R&D projects also use the system safety for the airworthiness certification. However, non-aviation weapon R&D projects rarely applied system safety. This paper presents a system safety application method for domestic weapon R&D projects by studying the U.S. military standards/organizations and domestic defense aviation projects.

• Journal of Korean Society of Industrial and Systems Engineering
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• v.27 no.1
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• pp.24-31
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• 2004

With Zohar(1980)'s research on safety climate and industrial safety, occupational safety and health literatures begin to emphasize the influence of organizational context. Based on this research trend, this paper tried to review the relationship between individual/ organizational factors and occupational accidents. Based on the responses from 643 manufacturing workers, this paper reviewed the relationship between antecedents(safety knowledge, safety motivation, safety education, and safety precaution activity) and safety consequences(accident parts, accident number, resting days). The results of statistical analysis showed that many antecedents have significantly negative relationships with safety consequences.

• Proceedings of the KSR Conference
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• 2003.10b
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• pp.229-234
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• 2003

In this paper, the elemental components and improving purpose in advanced safety management system are reviewed to cope with a railway fire accident. And a considering procedure(V-cycle) of long-term plan for railway fire safety improvement is proposed. For the purpose of preventing recurrence of accident, items which have to be considered in the course of accident investigation and cause analysis are presented according to the stage of investigation activity.

• Journal of the Korean Society for Railway
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• v.9 no.4 s.35
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• pp.412-418
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• 2006

In this paper we deal with the APARP theory which has been applied for UK railway system and risk assessment method which has been using in the domestic railway system for the safety demonstration. Both techniques are applied to the ATP wayside equipment for interface. Also, fur the applications of each techniques a analysis of the safety activity and a possibility of the application of ALARP theory are evaluated. Finally, we generate requirements of the safety demonstration for the future domestic railway system by way of the analysis of some assumptions and requirement data which can be applied to the risk assessment of ALARP.