• Title/Summary/Keyword: safe use

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The Need for Clinical Practice Guidelines in Usage of Mahuang in Weight Loss (마황의 안전성에 대한 논란과 비만 치료에 있어서 마황 사용 지침의 필요성)

  • Jang, In-Soo;Yang, Chang-Sop;Hwang, Eui-Hyoung
    • Journal of Korean Medicine for Obesity Research
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    • v.7 no.1
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    • pp.23-29
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    • 2007
  • Background : Mahuang (Ephedra sinica) has been used widely to treat respiratory disease in traditional medicine for over thousands years. Mahuang preparations contain approximately $0.75{\sim}1%$ ephedrine alkaloids. Recently in North America, the Eephedra alkaloids has aroused a controversy due to its adverse effects in those using whole extracts as "dietary supplements" for weight loss or athletic performance enhancement. Objective : To discuss the need for clinical practice guidelines on the use of Mahuang. Results and Conclusion : It is widely assumed that Mahuang is one of the useful medicines and is safe for human body. Most of scientific literatures support that the safety of Mahuang prescription in common dosage. However, it has been claimed that there were some warnings and apprehensions about the harmfulness of Mahuang as dietary supplements. This article does not negate the fact that it is necessary to pay more attention for use of Mahuang in clinical situations. We assert that the establishment of clinical practice guideline on the use of Mahuang, which is based on scientific materials and consensus, is required in traditional medicine.

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Clinical Study on Safety and Efficacy of JiSaiXin (Recombinant Human Granulocyte Colony Stimulating Factor Injection Manufactured in China) for Chinese Undergoing Chemotherapy

  • Wang, Lin;Huang, Xin-En
    • Asian Pacific Journal of Cancer Prevention
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    • v.16 no.1
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    • pp.299-301
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    • 2015
  • Objectives: To assess safety and efficacy of JiSaiXin (Recombinant Human Granulocyte Colony Stimulating Factor Injection manufactured in China, G-CSF) 150ug per day for three days and whether this regimen could reduce the incidence of febrile neutropenia caused by chemotherapy. Method: From July 2014 to December 2014 patients treated by chemotherapy in our hospital were randomly divided into two groups: Group A with prophylactic use of G-CSF (JiSaiXin) 24 hours after chemotherapy for consecutive 3 days; and Group B with G-CSF (JiSaiXin) after neutropenia. Routine blood tests were performed 7 days and 14 days after chemotherapy. Results: A total of 100 patients fulfilled study criteria, and the incidence of severe neutropenia (grade III/IV) and the incidence of febrile neutropenia in Group A were lower than those in Group B. Nine patients were found severe neutropenia (grade III/IV) in Group B, but one in Group A, three febrile neutropenia in Group B, but 0 in Group A. Conclusions: This study suggested that prophylactic use of G-CSF (JiSaiXin) 150ug per day 24 hours after chemotherapy for consecutive 3 days is safe and could be effective for preventing febrile neutropenia in patients with chemotherapy.

Key Management for Wireless Interworking (무선 네트워크 연동을 위한 키 관리)

  • Cho, Tae-Nam;Han, Jin-Hee;Jun, Sung-Ik
    • The KIPS Transactions:PartC
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    • v.14C no.1 s.111
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    • pp.7-16
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    • 2007
  • 3G telecommunication and wireless LAN provide various wireless communication services with their own native advantages and disadvantages. Currently WiBro service was developed to make up for the disadvantages of those services, and 3G-WLAN-WiBro underworking system which enables a user who uses triple-mode terminals to use those three networks was proposed. Even though each network adopts mutual authentication process between users and networks to provide security and accounting, they use different authentication protocols. In this paper, integrated authentication and key management protocol is proposed which makes use of previously used authentication information and supports safe roaming when a user moves from one network to another one under a same service provider on the 3G-WLAN-WiBro interworking network.

Respiratory support with heated humidified high flow nasal cannula in preterm infants

  • Jeon, Ga Won
    • Clinical and Experimental Pediatrics
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    • v.59 no.10
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    • pp.389-394
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    • 2016
  • The incidence of bronchopulmonary dysplasia (BPD) has not decreased over the last decade. The most important way to decrease BPD is by weaning the patient from the ventilator as soon as possible in order to reduce ventilator-induced lung injury that underlies BPD, and by using a noninvasive ventilator (NIV). Use of a heated, humidified, high flow nasal cannula (HHHFNC), which is the most recently introduced NIV mode for respiratory support in preterm infants, is rapidly increasing in many neonatal intensive care units due to the technical ease of use without sealing, and the attending physician's preference compared to other NIV modes. A number of studies have shown that nasal breakdown and neonatal complications were lower when using a HHHFNC than when using nasal continuous positive airway pressure (nCPAP), or nasal intermittent positive pressure ventilation. The rates of extubation failure during respiratory support were not different between patients who used HHHFNC and nCPAP. However, data from the use of HHHFNC as the initial respiratory support "after birth", particularly in extremely preterm infants, are lacking. Although the HHHFNC is efficacious and safe, large randomized controlled trials are needed before the HHHFNC can be considered an NIV standard, particularly for extremely preterm infants.

Representative Evaluation of Topographical Characteristics of Road Surface for Tire Contact Force Analysis (노면 표면거칠기 특성의 대표값 정량화와 타이어 접촉력 해석 기법에 대한 고찰)

  • Seo, Beom Gyo;Sung, In-Ha
    • Tribology and Lubricants
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    • v.33 no.6
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    • pp.303-308
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    • 2017
  • Most automobile tire companies have not yet considered the geometric information of a road at the design stage of a tire because the topographical characterization of a road surface is very difficult owing to its vastness and randomness. A road surface shows variable surface roughness values according to magnification, and thus, the contact force between the road and tire significantly fluctuates with respect to the scale. In this study, we make an attempt to define a representative value for surface topographical information at multi-scale levels. To represent surface topography, we use a statistical method called power spectral density (PSD). We use the fast Fourier transform (FFT) and PSD to analyze the height profiles of a random surface. The FFT and PSD of a surface help in obtaining a fractal dimension, which is a representative value of surface topography at all length scales. We develop three surfaces with different fractal dimensions. We use finite element analysis (FEA) to observe the contact forces between a tire and the road surfaces with three different fractal dimensions. The results from FEA reveal that an increase in the fractal dimension decreases the contact length between the tire and road surfaces. On the contrary, the average contact force increases. This result indicates that designing and manufacturing a tire considering the fractal dimension of a road makes safe driving possible, owing to the improvement in service life and braking performance of the tire.

Survey on work platforms of the Mobile Scaffolding (이동식비계 작업발판의 사용 실태조사)

  • Choi, Seung-Ju;Choi, Don-Heung;Shin, Woon-Chul
    • Journal of the Korea Safety Management & Science
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    • v.15 no.2
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    • pp.79-84
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    • 2013
  • According to the statistics of occupational accidents in 2009, the scaffolds and work platforms were main objects causing fall accidents in construction sites. But many workers install and use the work platforms on the mobile scaffolding without considering about safety standards. We had conducted a nationwide survey about how workers obey safety standards for the work platforms of the mobile scaffolding. As the result of a survey, no one follow a gap standard between materials of work platforms and installation of toe board. And it is a low proportion that comply with the install of safety guard rails and the use of stoppers. This is lack of consciousness for the safety certification and regulations. For safe use a mobile scaffolding, It is needed to educate a manager on the safety standards and to develop a product to install and dismantle easily.

Factors Associated with Relative Schoolbag Weight and Musculoskeletal Symptoms Among Elementary School Children (초등학생의 상대적인 책가방 무게와 근골격계 증상에 영향을 미치는 요인)

  • Yu, Kyoung Eun;Kim, Jin Sun
    • Child Health Nursing Research
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    • v.21 no.4
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    • pp.320-330
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    • 2015
  • Purpose: The purpose of this study was to investigate the use of schoolbags and the prevalence of musculoskeletal symptoms among elementary school children and to identify factors associated with relative schoolbag weight and musculoskeletal symptoms. Methods: A descriptive correlation study was conducted with 228 elementary school children in grades 4-6. A self-administered questionnaire was used for data collection. Descriptive statistics, t-test, ANOVA, $x^2$-test or Fisher's exact test, logistic regression analysis were used for data analysis. Results: Mean relative schoolbag weight (RSW) was 6.40%. Among participants, 13.2% carried more than 10% of their RSW. Only 49.6% of participants organized the contents in their school backpack correctly. Musculoskeletal symptoms were reported by 42.5% of participants. Results from logistic regression analysis identified grade was a significant factor predicting RSW, and gender, RSW, and using a locker were significant factors predicting musculoskeletal symptoms among schoolchildren. Conclusion: Although RSW of school children in this study was within the currently recommended load limit, a considerable proportion of school children were not following guidelines for safe schoolbag use. An effective schoolbag safety campaign for parents, students, and teachers needs to be developed and evaluated to prevent possible musculoskeletal symptoms related to schoolbag use.

Use Biologic Fibrin Adhesive in Otologic Surgery : Compared with Ammonium Sulfate Fibrin Adhesive and Tisseel$^{(R)}$ (중이수술에 인체에서 추출한 Fibrin 접착제의 이용 : Ammonium Sulfate fibrin 접착제와 Tisseel$^{(R)}$의 비교)

  • Lee, Hyung-Chul;Yang, Mi-Gyeung;Park, Mun-Heum
    • Journal of Yeungnam Medical Science
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    • v.8 no.1
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    • pp.127-135
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    • 1991
  • Successful middle ear surgery requires the availability of al safe, effective bonding material. Side effect caused by synthetic materials have led to the use of biologic adhesive. However, they carry the risk of transmission of infectious diseases if they are prepared from pooled human blood. The adhesive strength of ammonium sulfate fibrin adhesive produce an adhesive strength that is half that of the homologous commercial product. It is, however, good enough for use in several otolaryngological operations, tympanoplasty, facial nerve repair, reconstruction of ossicles, reconstruction of posterior wall of ear canal and obliteration of frontal sinus and mastoid antrum using bone dust.

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NEW DRUG THERAPY IN CHILD AND ADOLESCENT PSYCHIATRY ATYPICAL ANTIPSYCHOTICS (소아청소년 정신과 영역에서의 새로운 약물치료 ; 비정형 항정신병약물)

  • Bahn, Geon-Ho
    • Journal of the Korean Academy of Child and Adolescent Psychiatry
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    • v.14 no.1
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    • pp.26-35
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    • 2003
  • Conventional antipsychotics are commonly used to treat children and adolescents suffered from schizophrenia to other neuropsychiatric conditions. Regrettably, studies for typical antipsychotics report high rates of sedation, orthostatic hypotension, and extrapyramidal side effects. Over the past few years, atypical antipsychotics have been prescribed for use in adults with psychotic symptoms. Child psychiatrists have begun using these drugs to children and adolescents hoping safe and better alternatives to the conventional antipsychotics. However, there is not enough short-term and almost no long-term data about atypical antipsychotics for pediatric patients. Therefore, the purpose of this article is to review what is known about the use of the atypical antipsychotics in young patients. To do so, an appropriate approach to the use of these drugs in child and adolescent patients my be offered.

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Assessment Indexes for Activation of Urban Public Space (도시의 공공공간 활성화를 위한 평가 지표 연구)

  • Kim, Do-Gyoung;Moon, Jeong-Min
    • Journal of the Korean housing association
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    • v.24 no.3
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    • pp.109-119
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    • 2013
  • Today's urban spaces require diverse functions according to segmented social changes. Urban public space needs to be a field of mutual exchange, respect of diversity, and communication. According to these needs, an identity which reaches the public should be developed and realized. Therefore, this study is to present indexes for evaluating public space as a means to improve urban identity along with developing an awareness of possible problems. For this purpose, this study found out and analysed factors of evaluation indexes for the most fundamental public spaces which form cities in order to develop directions for deciding on indexes for public space and activation of that public space. An empirical analysis was conducted with the use of a questionnaire with evaluation indexes, reliability, and validity of properties of the space to be analysed and the evaluation items were tested. Based on the results, the study compared and analysed the differences between groups with independent variables (evaluation indexes) and general characteristics through a t-test. As a result, it was discovered that easy and safe accessibility in the use of urban parks as public space was statistically significant. Such results show that accessibility is the most significant factor in the use of parks.