• Korean Journal of Pharmacognosy
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• v.33 no.3 s.130
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• pp.207-210
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• 2002

The methanol extract from the root of Croton cascarilloides Raeusch. was primarily evaluated for cytotoxic activity in the cultured human lung cancer cell line (A459) and showed cytotoxic potential with $ED_{50}$ value of $5.98\;{\mu}g/ml$. Bioassayguided fractionation of the root extract resulted in 3-acetyl aleuritolic acid, rubiadin-l-methyl ether, and julocrotine. The structures of the compounds were elucidated from the combination of spectroscopic data and references. In addition, the $^{13}C-NMR$ assignments of rubiadin-l-methyl ether were revised.

• Korean Journal of Pharmacognosy
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• v.37 no.4 s.147
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• pp.241-245
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• 2006

Morinda officinalis How. (Rubiaceae) has been used as tonic, warming, sex impulse and anti-inflammatory agents. Two known anthraquinones, rubiadin-1-methyl ether (I) and rubiadin (II) were isolated from root of M. officinalis. Their structures were identified using NMR and literature comparisons. The contents of I in eighteen M. officinalis were evaluated by HPLC-PDA. Chromatography was performed using a reversed-phase system with Luna $C_{18}$ (2) column and acetonitrile-water (50:50, v/v) with a flow rate of 1.0 mL/min under UV 280 nm. Under these conditions, the content of rubiadin-1-methyl ether was 0.013%.

• Natural Product Sciences
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• v.6 no.1
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• pp.40-43
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• 2000

The chemical investigation on the cell suspension culture of Morinda elliptica L. yielded eight anthraquinones, two of which, anthragallol-1,2-dimethyl ether (3) and purpurin-1-methyl ether (4), have not been isolated from the original plant. Other compounds isolated include nordamnacanthal (1), alizarin-1-methyl ether (2), rubiadin (5), soranjidiol (6), $lucidin-{\omega}-methyl$ ether (7), and morindone (8). The structures of anthraquinones were established based on spectral studies.