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Cytotoxic Compounds from Croton cascarilloides  

Sung, Tran Van (Institute of Chemistry, National Center for Natural Science and Technology)
Ahn, Byung-Zun (College of Pharmacy, Chungnam National University)
Cuong, Nguyen Manh (Institute of Chemistry, National Center for Natural Science and Technology)
Publication Information
Korean Journal of Pharmacognosy / v.33, no.3, 2002 , pp. 207-210 More about this Journal
Abstract
The methanol extract from the root of Croton cascarilloides Raeusch. was primarily evaluated for cytotoxic activity in the cultured human lung cancer cell line (A459) and showed cytotoxic potential with $ED_{50}$ value of $5.98\;{\mu}g/ml$. Bioassayguided fractionation of the root extract resulted in 3-acetyl aleuritolic acid, rubiadin-l-methyl ether, and julocrotine. The structures of the compounds were elucidated from the combination of spectroscopic data and references. In addition, the $^{13}C-NMR$ assignments of rubiadin-l-methyl ether were revised.
Keywords
Croton cascarilloides; Euphorbiaceae; 3-O-Acetyl-D-friedoolean-14-en-28-oic-acid (3-acetyl aleuritolic acid), Rubiadin-1-methyl ether; Julocrotine; Cytotoxicity;
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