• 제목/요약/키워드: root disease

검색결과 1,022건 처리시간 0.024초

New hydroperoxylated and 20,24-epoxylated dammarane triterpenes from the rot roots of Panax notoginseng

  • Shang, Jia-Huan;Sun, Wen-Jie;Zhu, Hong-Tao;Wang, Dong;Yang, Chong-Ren;Zhang, Ying-Jun
    • Journal of Ginseng Research
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    • 제44권3호
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    • pp.405-412
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    • 2020
  • Background: Root rot is a serious destructive disease of Panax notoginseng, a famous cultivated araliaceous herb called Sanqi or Tianqi in Southwest China. Methods: The chemical substances of Sanqi rot roots were explored by chromatographic techniques. MS, 1D/2D-NMR, and single crystal X-ray diffraction were applied to determine the structures. Murine macrophage RAW264.7 and five human cancer cell lines were used separately for evaluating the antiinflammatory and cytotoxic activities. Results and Conclusion: Thirty dammarane-type triterpenes and saponins were isolated from the rot roots of P. notoginseng. Among them, seven triterpenes, namely, 20(S)-dammar-25-ene-24(S)-hydroperoxyl-3β,6α,12β,20-tetrol (1), 20(S)-dammar-3-oxo-23-ene-25-hydroperoxyl-6α,12β,20-triol (2), 20(S)-dammar-12-oxo-23-ene-25-hydroperoxyl-3β,6α,20-triol (3), 20(S)-dammar-3-oxo-23-ene-25-hydroperoxyl-12β,20-diol (4), 20(S),24(R)-epoxy-3,4-seco-dammar-25-hydroxy-12-one-3-oic acid (5), 20(S),24(R)-epoxy-3,4-seco-dammar-25-hydroxy-12-one-3-oic acid methyl ester (6), and 6α-hydroxy-22,23,24,25,26,27-hexanordammar-3,12,20-trione (7), are new compounds. In addition, 12 known ones (12-16 and 19-25) were reported in Sanqi for the first time. The new Compound 1 showed comparable antiinflammatory activity on inhibition of NO production to the positive control, whereas the known compounds 9, 12, 13, and 16 displayed moderate cytotoxicities against five human cancer cell lines. The results will provide scientific basis for understanding the chemical constituents of Sanqi rot roots and new candidates for searching antiinflammatory and antitumor agents.

누난 증후군 환자의 구강 내 특징 : 증례 보고 (Oral Features in a Child with Noonan Syndrome : A Case Report)

  • 황인경;이연주;심도희;마연주
    • 대한소아치과학회지
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    • 제45권1호
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    • pp.115-122
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    • 2018
  • 누난 증후군은 특이한 얼굴 모습, 작은 키, 선천적 심장질환을 보이는 유전 질환으로 성별에 관계없이 신생아 1000 - 2500명 당 1명의 유병률을 보인다. 누난 증후군으로 진단된 11세 소년이 상악 우측 견치의 위치이상을 주소로 내원하였다. 그는 선천적 폐동맥 협착증을 진단받았으며, 성장발달 지연을 보였다. 지혈에는 문제가 없었으며, 얼굴은 누난 증후군의 특징적 모습을 보였다. 구강검사 시 치성 2급 부정교합, 전방돌출 된 전치, 얕은 피개교합을 보였다. 방사선학적 검사상 상악 우측 견치의 위치이상 및 맹출 경로의 이상으로 상악 우측 측절치의 치근 흡수가 관찰되었다. 측모두부 방사선사진상 상하악의 골격적 패턴은 정상범주에 있었다. 가철성 교정장치를 이용하여 매복치를 견인했다. 본 증례의 누난 증후군 증상 및 구강 내 이상 소견은 심하지 않으나 유병률에 비해 많이 다루어지지 않아 본 증례발표를 통해 누난 증후군 환자의 구강 내 특징 및 치과적 관리 방법에 대해 언급하고자 하였다.

흡연이 치주 판막술후 치유에 미치는 영향 (The effect of smoking on the healing response following flap debridement surgery)

  • 조규성;이정태;최성호;이승원;채중규;김종관
    • Journal of Periodontal and Implant Science
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    • 제29권1호
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    • pp.103-115
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    • 1999
  • The ultimate goal of periodontal therapy is the regeneration of periodontal tissue which has been lost due to destructive periodontal disease. Various periodontal procedures have been used throughout the years in an attempt to reestablish attachment of periodontal tissues to root surfaces affected by periodontitis. Flap debridement surgery has been demonstrated to be a successful procedure in gaining the probing attachment level and reducing probing depth. A tendency towards impaired wound healing following periodontal procedures in smokers has been clinically documented. But, previous clinical studies on healing response in smokers are based on a retrospective design. The purpose of this study was to evaluate the treatment outcome following flap debridement surgery in smokers compared to nonsmokers. 25 patients with moderate to advanced periodontitis were included for study. Among these patients, 13 patients were smokers, and 12 patients were nonsmokers. Mucoperiosteal flap was raised with the sulcular incision. No antibiotic treatment was administered postsurgery. The patients was recalled at monthly intervals during a period of 6 months following the surgery. The patients were received supragingival scaling and oral hygiene reinforcement. All the recordings, including modified O' Leary plaque control record, bleeding on probing, probing pocket depth, probing attachment level,were recorded, presurgery and 6 months postsurgery. The changes of all the recordings at 6 months after flap debridement surgery revealed the following results: 1. PI on all the dentitions and surgical sites showed no statistical significance between smokers and nonsmokers at presurgery. But, smokers demonstrated a significantly lower % of PI than nonsmokers at 6 months postsurgery. 2. Smokers demonstrated a greater % of BOP sites than nonsmokers on the surgical sites and all the dentitions, presurgery and 6 months postsurgery. But, there was no statistical significance between two groups. 3. Smokers exhibited significantly less reduction of probing depth in the 3 mm or less probing pocket depth(PPD) group, 6mm or more PPD group and total PPD group when compared to nonsmokers at 6 months postsurgery. 4. Smokers exhibited significantly less gain of probing attachment level(PAL) in the 3mm or less PPD group, 6 mm or more PPD group and total PPD group when compared to nonsmokers at 6 months postsurgery.

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전과 답에서의 콩 생육특성과 수량성 (Growth Characteristics and Yield Potentials of Soybeans in Upland and Paddy Field)

  • 황영현;박상구
    • 한국작물학회지
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    • 제38권4호
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    • pp.336-342
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    • 1993
  • 1. 개화성기까지의 지상부와 지하부 대부분 생육형질은 전에서 보다 답에서 더 큰값을 보였으나, 근류수는 다에서 현저히 작아 윤환답 콩재배에서는 근류접종이 필요하다고 생각되어 진다. 2. 조파 단작(4월 20일 파종)으로 윤환답에 콩을 재배하면, 만파재배시 양저바이러스(SMV-N)에 저항성을 보였던 대부분 현재의 장려품종들이 심하게 이병되었다. 그러나 경미한 모자이크바이러스(SMV) 이병정도를 보이는 일부 장려품종(장백콩과 은하콩 등)과 대부분의 도입품종들은 양저바이러스에 전연 이병이 되지 않고 대부분 높은 수량성을 보였다. 3. 콩의 토양별 평균 종실수량은 전보다 답에서 높았으나, 동일 토양내의 파종시기 또는 동일 파종기내의 토양간 평균 수종간에는 차이가 없었다. 4. Ha당 4톤 이상의 수량을 보인 품종은 답에서는 Williams79, 남해콩, Union 및 SS77053이었고, 전에서는 Union뿐이었다. 공시품종중 장엽콩과 단엽콩은 답의 모든 파종기에서 종실수량이 ha당 3톤 이상이고 변이계수가 10% 이하로 안정 다수이었다. 5. 답전윤환답의 조파에서 다수성인 품종들은 황금콩에 비하여 경장이 크고 주경전수가 많으며 분지수가 SS77053을 제외하고는 적은 일반적으로 초기발아 및 입묘에 유리한 중소입종들로 내병성, 특히 양저 바이러스에 저항성이 높은것들이었다.

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발치 창에 삽입한 임시 수복물의 치은형태 보존 효과 (Effect of immediate provisional restoration on the preservation of gingival contour)

  • 이진규;이주연;최점일
    • Journal of Periodontal and Implant Science
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    • 제33권4호
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    • pp.563-571
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    • 2003
  • One of the central components of periodontal therapy is the improvement of esthetics. The presence and appearance of interdental papillae plays an important role of periodontal esthetics. The aim of the present study was to investigate how immediate provisional restoration preserve the shape of interdental papilla around the extraction socket and the width of bucco-lingual of gingiva. Another aim was to investigate the change in the interdental papilla and the amount of vertical bone fill of a extraction socket in relation to the interdental alveolar bone levels adjacent the alveolar socket. A total of 19 patients (11 male, 8 female, mean age of 50.57${\pm}$8.16), who visited the Department of Periodontology, Pusan National University and had more than one anterior tooth scheduled to be extracted due to an advanced periodontal disease were included in the present study. After initial periodontal therapy, the extracted teeth were reshaped of the root and placed into the socket followed by splinting with adjacent teeth with self-curing resin. The width of hucco-lingual of gingiva and interdental papilla height were measured at baseline, 1, 3, 6, 9 and 12 month and the periapical radiographic examination were taken at baseline, 6 and 12month following the extraction. The amount of vertical bone fill in the extraction socket were calculated. At 12 months following the extraction, the changes in mesial and distal interdental papilla and the width of bucco-lingual showed -1.06${\pm}$0.48mm, -0.844${\pm}$0.50mm, -1.50${\pm}$0.96m, relatively. The positional change in the interproximal papillae was significantly associated with the interdental bone level adjacent to the extraction socket(p=0.028). The higher the interproximal bone level adjacent the extraction socket, the greater the amount of bone fill in the extraction socket(p<0.001). In conclusion, it was thought that immediate provisional restoration could minimize the loss of the width of bucco-lingual and interproximal papillae around the extraction socket. In addition, the higher the interproximal bone level adjacent the extraction socket, the greater the amount of bone fill and the smaller the reduction of papillary height around the extraction socket.

소아치과에서 Cone beam형 전산화단층영상을 이용한 환자의 평가 (THE EVALUATION OF THE PATIENTS TAKING CBCT IN DEPARTMENT OF PEDIATRIC DENTISTRY)

  • 전혜진;양연미;김재곤;백병주
    • 대한소아치과학회지
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    • 제39권3호
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    • pp.249-256
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    • 2012
  • 본 연구는 전북대학교 치과병원 소아치과에서 2005년 1월부터 2011년 7월까지 6년 7개월 동안 촬영된 Cone beam형 전산화단층영상(CBCT)를 통해 소아치과 영역에서의 CBCT의 활용도를 평가하고자 한다. 1. CBCT 촬영 환자는 총 252명, 촬영횟수 279회였으며, 남자 151회(54.1%), 여자 128회(45.9%)였다. 2. 연령에 따라 9~12세 군 53%, 6~8세 군 24%, 그리고 13~15세 군이 15%였다. 3. 촬영 주소는 매복치의 위치 및 형태 확인 49.1%, 정중과잉치 19.4%, 과잉치 7.9%, 맹출 중인 치아의 위치 및 근관의 형태 7.2%, 낭종 5.4%, 염증성 병소 3.9%, 치아종 3.9%, 그리고 종양이 2.2%를 보였다. 4. 치료 내용은 발치 29.7%, 교정적 정출 및 배열 24.0%, 정기 검진 16.5%, 타과 의뢰 11.5%, 근관 치료 3.9%, 조대술 3.9%, 외과적 제거술 2.9%, 그리고 적출술이 1.1%를 보였다.

하전작물 품종 및 재배기술의 1962년 이후 변천 (Changes in Variety and Cultural Practices of Soybean, Sweet Potato and Corn Since 1962 in Korea)

  • 홍은희;박근용
    • 한국작물학회지
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    • 제27권4호
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    • pp.462-469
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    • 1982
  • Since 1962, varietal development and dissemination for summer upland crops have been actively initiated by the Crop Experiment Station, Office of Rural Development, Suweon, Korea. The major breeding objectives of soybeans have been to develop varieties which are early maturing, disease resistant, and adaptable to late planting for after-barley cropping. Development of eleven new soybean varieties including Hwangkeumkong, Jangyeobkong, Danyeobkong, and Kwangkyo has greatly increased the soybean yield throughout country. For com, after development of Hwangok #2, a synthetic, in early 1960's, nine corn hybrids-single crosses, double-crosses, and three-way crosses-such as Jecheon-ok, Hoengseong-ok, Kwangok, Suweon #19, etc., have been disseminated mainly to Kangweon province, a major corn producing area in Korea, and drew up the yield over 4 tons per hectare. The major breeding objectives of sweet potato have been to develop varieties which have high starch content and root yield. Hwangmi, Hongmi, and Shinmi are three sweet potato varieties developed and disseminated by the Crop Experiment Station, Office of Rural Development and are grown most widely in Korea. Most of researches on cultural practices of upland crops have begun on a full scale from early 1960's. In soybeans, for example, no fertilizer but for barley was applied although the effects of phosphate and potassium fertilizers were great on soybeans in after-barley soybean croppings. The effects of heavy application of phosphate and calcium fertilizers on soybeans in newly reclaimed soils were recognized. Recently a mixed fertilizer for soybean (N; 40, P:70, K:60 kg/㏊) was developed and sold for soybean growers. The optimum planting densities of 220, 000 plants/ha in full-season cropping and 330, 000 pts/ha in after-barley cropping of soybeans were known from repeated experiments. For higher yield, a means of cultural practices such as transplanting-pinching, direct planting-pinching, and hilling-up, etc., were developed along with barley-stubble planting with no tillage and integrated herbicide application for labour savings. For sweet potato, cultural practices for planting date, harvesting date, fertilizer, and planting density were fully established. For early marketing, a technique of vinyl-mulching on sweet potato has also fully developed. For com, planting density of 37, 000 pts/ha in early 1960's has been changed to 55, 000 pts/ha for grain production and 67, 000 pts/ha for silage. The amounts of fertilizers have also been changed from 120-120-120kg/ha (N-P-K) in early 1960s to 180-150-150 kg/ha. These increases in number of plants per unit area and fertilizer levels have resulted in greater production for both grain and silage. At the same time, the production techniques of F1 seeds have also improved.

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In vitro 및 토양에서 추출물, 삼출물, 용액에 대한 세균의 화학주성 (Bacterial Chemotaxis to Extracts, Exudates, Solutions in Vitro and Soil)

  • 이민웅;김성일;심재욱;신현성;김광포
    • 한국식물병리학회지
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    • 제2권3호
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    • pp.165-173
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    • 1986
  • 토양추출물, 인삼삼출물과 용액이 Pseudomonas sp. P. fluorescens 및 Erwinia carotovora에 미치는 화학주성은 토양추출물처리, 삼출물 및 용액은 증류수 보다 이들 세균이동에 영향을 나타냈다. 고무관내 흙속으로 세균의 이동성은 P. fluorescens가 토양추출물처리 삼출물에서 주성을 나타냈으나, P. sp 와 E. caotovora는 주성이 없었다. 세균주성에 미치는 진균의 삼출액은 이동에 영향력을 나타내지 못하였다. 고무관내 흙을 진균으로 접종한 후에 세균의 주성은 Pseudomonas sp. 에서는 주성이 나타나지 않았으나, P. fluorescens와 E. carotovora는 F. solani, F. oxysporum 및 혼합균처리에서는 주성이 나타났다. Alternaria panax는 이들 세균에 대해 주성이 없었으나, E. carotovora는 A. panax에 대해 주성이 있었다. 토양유기물함량은 김포, 강화의 나병지와 건전지에는 낮았고, K함량은 김포의 건전지에 높았다. 세균분포는 괴산의 나병 및 건전지와 강화건전지에 진균은 금산 괴산의 나병 및 건전지에 많이 분포되었다. 방선균은 괴산건전지에 특히 많이 분포하였고 다음이 풍기나병지였다.

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작약(芍藥) 분주묘(分株苗)의 활착불량(活着不良) 실태(實態)와 원인(原因) (The status and Causes of Rooting Failure on Growth of Divided Crown in Paeonia lactiflora Pallas Cultivation)

  • 김세종;김기재;박준홍;김정혜;박소득;최부술
    • 한국약용작물학회지
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    • 제5권3호
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    • pp.237-242
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    • 1997
  • 작약(芍藥) 분주묘(分株苗)의 활착불량(活着不良) 실태(實態)와 원인(原因)을 구명하기 위하여 시험 연구한 결과는 다음과 같다. 1. 작약 분주묘의 농가 포장 활착 실태 조사 결과 활착불량 피해율은 32%에 이르고 외형적 피해 실태는 무출현(無出現) 5.6%, 출현후(出現後) 고사(桔死) 20.7%, 출현후(出現後) 위조가 5.7%였다. 2. 활착불량 피해 정도별 농가 실태는 71%이상 피해를 본 필지가 4%, $70{\sim}41%$ 피해는 13%, $40{\sim}11%$ 피해는 45%로 많은 면적이 활착불량으로 인하여 결주가 된 것으로 나타났다. 3. 농가포장에서 정식시기에 따른 활착불량(活着不良) 피해율(被害率)은 가을 정식의 경우 18.2%인데 비하여 봄정식은 42.9%로 매우 높았고 실생묘(實生苗)보다는 분주묘(分株苗)에서 피해가 더 많았다. 4. 분주후 정식까지의 경과 일수가 길수록 생육과 수량이 크게 떨어졌고 봄정식시는 활착율이 66.7%로서 매우 낮았으며 종근소독과 토양살충제 혼용처리시 생육과 활착이 양호하였으나 무처리는 불량하였다. 5. 작약 분주묘의 활착불량(活着不良) 주원인(主原因)은 뿌리썩음병(Cylindrocarpon sp.)과 불량종(不良種) 묘(苗)로 나타났다.

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강활류(羌活類) 한약재(韓藥材)의 혈관이완(血管弛緩) 효과(效果) 비교(比較) 연구(硏究) (Vasorelaxant Effect of Gangwhal in Korean and Chinese on Rat Thoracic Aorta Rings)

  • 이경진;김덕수;함인혜;김호경;부영민;김호철;최호영
    • 대한본초학회지
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    • 제25권4호
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    • pp.69-75
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    • 2010
  • Objectives : The root and rhizome of "Gangwhal" have been used as a traditional medicine for the treatment of cold, fever, headache, swelling, arthritis, rhinitis, and cardiovascular diseases in Korea and china. In china, Gangwhal is well known as a useful oriental medicinal plant that treats cardiovascular diseases such as stroke, headache and hypertension, but little research exists about the effect of O. koreanum on cardiovascular disease. Therefore we investigated the vasorelaxant effects of O. koreanum and compared the vasorelaxant effects of four species of Gangwhal. Methods : The vasorelaxant effects of the ethanol extracts of Ostericum koreanum (NK and BK), Notopterygium incisium (NI), and N. forbesii (NF) on phenyleprine ($1{\mu}M$) or KCl (60mM) pre-contracted rat thoracic aorta rings were compared. The vasorelaxant effects of the water extract and ethanol extract of NK on phenyleprine ($1{\mu}M$) or KCl (60mM) pre-contracted rat thoracic aorta rings were compared. And the vasorelaxant effects of chloroform, ethylacetate and water fraction of ethanol extract of NK on phenyleprine ($1{\mu}M$) or KCl (60mM) pre-contracted rat thoracic aorta rings were compared. Results : Ethanol extracts of NK, BK, NI and NF relaxed rat thoracic aorta rings with a concentration-dependent manner, and NK showed the greatest vasorelaxant effect. And ethanol extract of NK was much more effective than water extract of NK. Finally, chloroform, ethylacetate and water fraction of ethanol extract of NK also relaxed rat thoracic aorta rings, and chloroform fraction showed the greatest vasorelaxant effect.