• International Journal of Advanced Culture Technology
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• 제10권4호
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• pp.369-375
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• 2022

The educational environment of the era of age of uncertainty and human and disaster, where nothing is predictable, so it is bringing about many changes. The purpose of this study is to suggest the implications of Integrative arts therapy in the educational field of unpredictable times as a way to move the minds of people living in various educational changes. As for the research method, the characteristics of the integrative arts therapy shown in the previous studies were examined through the literature method, and then through the cases in the modern education environment practiced we propose three things. First, in the field of university education, students should have an integrative arts therapy approach in terms of teaching methods, and also, second, in order to recover from failure and frustration, continuous gratitude sharing training to discover and acknowledge positivity in the situation by changing perspectives should improve students' self-esteem and self-efficacy. Third, professors should play the role of facilitators and also coaches in knowledge transfer. Therefore the coaching process should be integrated into the process of sustainable education when the integrative arts therapy is approached from the pedagogical curriculum.

• 한국컴퓨터정보학회논문지
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• 제27권11호
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• pp.305-314
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• 2022

본 연구는 중국 안산시의 초중등학교 교사들의 "사회적 사고방식"을 연구하려는 시도가 이루어졌다. 연구를 진행하기 위해 안산시에 있는 298명 교사를 선정하여 설문조사를 실시하였다. 본 연구는 문헌조사와 설문조사를 결합한 방법을 채택하였다. 그 결과 안산시 초·중등학교 교사들의 전반적인 '사회심리학' 수준이 상대적으로 높은 것으로 나타났다. 교육 배경이 다른 교사의 직업 만족도에는 상당한 차이가 있습니다. 경로 모델은 변수 간의 상호 작용 메커니즘을 보여줍니다. 일반적인 자기 효능감과 업무 몰입도는 이 메커니즘에서 중요한 역할을 합니다.

• 한국IT서비스학회지
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• 제22권4호
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• pp.123-140
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• 2023

In recent times, the global economy has been subject to increasing volatility, which has made it considerably more difficult to accurately predict economic indicators compared to previous periods. In response to this challenge, the present study conducts an exploratory investigation that aims to predict the Business Survey Index (BSI) by leveraging data mining techniques on both structured and unstructured data sources. For the structured data, we have collected information regarding foreign, domestic, and industrial conditions, while the unstructured data consists of content extracted from newspaper articles. By employing an extensive set of 44 distinct data mining techniques, our research strives to enhance the BSI prediction accuracy and provide valuable insights. The results of our analysis demonstrate that the highest predictive power was attained when using data exclusively from the t-1 period. Interestingly, this suggests that previous timeframes play a vital role in forecasting the BSI effectively. The findings of this study hold significant implications for economic decision-makers, as they will not only facilitate better-informed decisions but also serve as a robust foundation for predicting a wide range of other economic indicators. By improving the prediction of crucial economic metrics, this study ultimately aims to contribute to the overall efficacy of economic policy-making and decision processes.

• 대한방사성의약품학회지
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• 제6권2호
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• pp.155-164
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• 2020

Polyethylene glycol (PEG) has been the most commonly used polymer for the past few decades in the field of biomedical applications due to its gold standard stealth effect. PEGylation of antibody-drug conjugates, liposomes, peptides, nanoparticles, and proteins is done to improve their pharmaceutical efficacy and pharmacokinetic properties. PEGylation of antibodies with various PEG linkers improves targeting ability by increasing the blood circulation time and thus enhances the biodistribution profiles. It also assists in minimizing the immediate capture by the reticuloendothelial system. In this review, we summarize the effect of PEG linkers in an antibody conjugation and their pharmacokinetics in the field of biomedical imaging.

• 셀메드
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• 제12권1호
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• pp.5.1-5.8
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• 2022

Ābzan(sitz bath or hydration therapy) is one of the important and widely practised methods of regimenal therapy used for local evacuation or diversion of morbid humours described for various diseases in Unani system of medicine. Itis a type of bath in which hips and buttocks are immersed in water, either plain or medicated for therapeutic effects. Thus, it serves as an important and effective external mode of treatment. It has been successfully practised by Greeko-Arab physicians in the management of almost all types of gynaecological disorders like genital prolapse, leucorrhoea, pruritus vulvae, menstrual disorders, infertility, pelvic inflammatory diseases etc, but its efficacy has been proved in very few gynaecological diseases only. Hence, there is a need for systemic review to investigate the effectiveness of sitz bath in gynaecological disorders to generate scientific based evidence for the clinician as well as for common public. Based on the available literature, this review article suggests that the sitz bath has a scientific evidence-based effect in treating gynaecological diseases.

• 한국축산식품학회지
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• 제42권2호
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• pp.197-209
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• 2022

Extracellular vesicles (EVs) are nanosized vesicles secreted from cells into the extracellular environment and are composed of a lipid bilayer that contains cargos with biological activity, such as lipids, proteins, mRNAs, and noncoding microRNAs (miRNAs). Due to their biological activity and their role in cell-to-cell communication, interest in EVs is rapidly increasing. Bovine milk is a food consumed by people of all ages around the world that contains not only a significant amount of nutrients but also EVs. Milk-derived EVs also exhibit biological activity similar to other source-derived EVs, and studies on bovine milk EVs have been conducted in various research fields regarding sufficient milk production. In particular, not only are the effects of milk EVs themselves being studied, but the possibility of using them as drug carriers or biomarkers is also being studied. In this review, the characteristics and cargo of milk EVs are summarized, as well as their uptake and stability, efficacy and biological effects as carriers, and future research directions are presented.

• 한국동물생명공학회지
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• 제38권2호
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• pp.47-53
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• 2023

Despite numerous advances in in-vitro embryo production (IVP), many documented factors have been shown to influence the development of mammalian preimplantation embryos and the success of IVP. In this sense, elevated levels of reactive oxygen species (ROS) correlate with poor outcomes in assisted reproductive technologies (ART) due to oxidative stress (OS), which results from an imbalance between ROS production and neutralization. Indeed, excessive production of ROS compromises the structural and functional integrity of gametes and embryos both in vivo and in vitro. In particular, OS damages proteins, lipids, and DNA and accelerates cell apoptosis. Several in-vivo and in-vitro studies report an improvement in qualityrelevant parameters after the use of various antioxidants. In this review, we focus on OS and the source of free radicals and their effects on oocytes, sperm, and the embryo during IVP. In addition, antioxidants and their important role in IVP, supplementation during oocyte in vitro maturation (IVM), in vitro culture (IVC), and semen extenders were discussed. Nevertheless, various methods for determining the level of ROS in germ cells have been briefly described. Still, it is crucial to develop standardized antioxidant supplement systems to improve overall IVP success. Further studies should explore the safety, efficacy, mechanism of action, and combination of different antioxidants to improve IVP outcomes.

• 한국환경과학회:학술대회논문집
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• 한국환경과학회 2020년도 정기학술대회 발표논문집
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• pp.221-221
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• 2020

Curcumin, a hydrophobic polyphenol derived from turmeric, has been used a food additive and as a herbal medicine for the treatment of various diseases. In the present study, we found the functional role of a nanosphere loaded with curcumin (CN) in the promotion of the motility of human umbilical cord blood derived mesenchymal stem cells (hUCB-MSCs) during the wound closure. We found that the efficacy of hUCB-MSCs migration induced by CN was 1000-fold higher than that of curcumin powder. CN significantly increased the motility of hUCB-MSCs by activating c-Src, which is responsible for the phosphorylation of protein kinase C (PKC) and extracellular signal-regulated kinase (ERK). CN induced the expression levels of α-actinin-1, profilin-1 and filamentous-actin, as regulated by the phosphorylation of nuclear factor-kappa B during its promotion of cell migration. In a mouse skin excisional wound model, we found that transplantation of UCB-MSCs pre-treated with CN enhances wound closure, granulation, and re-epithelialization at mouse skin wound sites. These results indicate that CN is a functional agent that promotes the mobilization of UCB-MSCs for cutaneous wound repair.

• 융합경영연구
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• 제4권4호
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• pp.29-35
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• 2016

This study has focused on the transfer of infants and Toddlers-protecting responsibilities from families to infants and Toddlers education agencies due to an increase of a double-income family and nuclear family. It is because there is insufficient safe play space from the moment when infants and Toddlers return from infants and Toddlers education agencies to home due to a high crowding of housing and increase of vehicle, and there can be difficulties to take responsibilities of infants and Toddlers safety with a mere recognition and effort of parent. Thus, to suggest a safety education through mutual contact between the communities and agencies supporting parent role in a level of social welfare, its potential has been identified through a frequency analysis on 60 participants of experimental group who have trained a safety education and 60 participants of control group who have not trained a safety education. As a result of frequency analysis, the increase in safety condition in Korea, safety and development of infants and Toddlers, safety of play materials, and safety knowledge on general part of facility safety has detected and the practice of safety and safety consciousness has also identified to be more effective. The results of this study has shown a potential to verify its efficacy if it is verified through an elaborative model of safety education based on parents of young infants and Toddlers family.

• Journal of Chest Surgery
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• 제56권2호
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• pp.67-74
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• 2023

Perioperative treatment with conventional cytotoxic chemotherapy for resectable non-small cell lung cancer (NSCLC) has proven clinical benefits in terms of achieving a higher overall survival (OS) rate. With its success in the palliative treatment of NSCLC, immune checkpoint blockade (ICB) has now become an essential component of treatment, even as neoadjuvant or adjuvant therapy in patients with operable NSCLC. Both pre- and post-surgery ICB applications have proven clinical efficacy in preventing disease recurrence. In addition, neoadjuvant ICB combined with cytotoxic chemotherapy has shown a significantly higher rate of pathologic regression of viable tumors compared with cytotoxic chemotherapy alone. To confirm this, an early signal of OS benefit has been shown in a selected population, with programmed death ligand 1 expression ≥50%. Furthermore, applying ICB both pre- and post-surgery enhances its clinical benefits, as is currently under evaluation in ongoing phase III trials. Simultaneously, as the number of available perioperative treatment options increases, the variables to be considered for making treatment decisions become more complex. Thus, the role of a multidisciplinary team-based treatment approach has not been fully emphasized. This review presents up-to-date pivotal data that lead to practical changes in managing resectable NSCLC. From the medical oncologist's perspective, it is time to dance with surgeons to decide on the sequence of systemic treatment, particularly the ICB-based approach, accompanying surgery for operable NSCLC.