• Asia-Pacific Journal of Business Venturing and Entrepreneurship
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• v.10 no.5
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• pp.15-26
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• 2015

Overall, college students tend to be immersed in the relatively safe employment, such as civil servants or public sector than start one's own business due to the lack of entrepreneurial spirit which made the great success in order to take the risk and innovative challenge. In this study, relationship between pre-founder of college students' self-determination, entrepreneurship, entrepreneurial intentions are to be determined. As a result, the implications were derived in order to make pre-founder various ways of career decision beside employment. Therefore start-up training courses was verified by moderating effects. The results are first, high self-determination(Autonomy, Efficacy) of the pre-founder made positive impact on entrepreneurial intention. Second, high self-determination(Autonomy, Efficacy) of the pre-founder made positive impact on entrepreneurship. Third, entrepreneurship of the pre-founder made positive impact on entrepreneurial intention. Fourth, entrepreneurship was carried out a full mediating role in the relationship between self-determination and entrepreneurial intention. Finally, Pre-founder group who have taken entrepreneurship education have showed a positive relationship between high self-determination(Autonomy, Competence, Relationship) and entrepreneurial intention. Based on these results, especially pre-founders, in order to improve the willingness of university students entrepreneurship, highly motivated intrinsic motivation is needed to ensure the student's self-determination in University education. It looks that can be achieved through the strengthening of entrepreneurship education for autonomy, competence, efficacy improvement.

• Journal of muscle and joint health
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• v.9 no.1
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• pp.5-17
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• 2002

The purpose of this one group pre and post test study was to evaluate the effect of self-help programs(SHP) which has been conducted from 1997 to 2000. The SHP was held by Korean Rheumatology Health Professionals Society(KRHP) once a week for 6 weeks for chronic arthritis patients in Korea. Eight hundred fifty five subjects completed the program at 43 sites. The effect of SHP were evaluated by flexibility, pain, activities of daily living(ADL), fatigue, depression and self-efficacy. After SHP, followings were found: 1. Participants' characteristics of SHP were most common in living in Seoul, women, sixties, high school graduates, house wifes, osteoarthritis, completed in 1999. 2. The flexibility of arm, knee, ankle joint were significantly increased, but the flexibility of the shoulder was not changed. 3. Level of pain was decreased significantly from 5.21 to 3.99, and the number of painful joints were decreased from 4.96 to 4.18 significantly. 4. The score of ADL was increased from 53.74 to 54.97 significantly. 5. The score of depression and self-efficacy was not changed. In conclusion, SHP was clearly proved to be an effective nursing intervention to Increase the flexibility of arm, knee, ankle joint and enhanced ADL. Also SHP decreased pain and fatigue. More research is needed to determine the role of self-efficacy and depression in the SHP, use of a randomized design and longer follow up period to understand more about the effects of the program.

• Korean Parent-Child Health Journal
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• v.6 no.2
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• pp.127-146
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• 2003

The purpose of this study is to investigate the seven-hour sexuality education program for senior high school girl students and apply it to them to find out how this program affects their sex-related knowledge, sexual attitudes, and the self-efficacy of sexual behavior practice. The ultimate goal of this study is that high school girl students are to prevent unwanted pregnancy, STD and AIDS, after attending this sexuality education program. A non-equivalent control group pretest-post test design was used for this study. The number of experimental group consisted of 80 girl students and the control group was composed of 80 girls, too. A total of 160 freshmen from two commercial girls' high schools were selected by a convenience sampling method. This study was carried out in commercial high schools located in Daejeon, Korea from July 15th to October 31st, 2002. To discover the need for sexuality education, the researcher surveyed with a pre-designed questionnaire to 160 girls from the two different commercial high schools. The sex education curriculum was developed on the basis of the need of high school girl students for sex education survey results and literature review and a teaching-learning planning model and health belief model. The experimental group was taught the sexuality education program for seven hours from October 19th to 23rd, 2002 and each period continued for 50 minutes. The SPSS(10.0) Windows statistics software was used to analyze the data, along with frequency, percentage, $X^2$-test, t-test, and paired t-test. The instruments' internal consistencies were tested by Cronbach's alpha coefficient. The results of this study were as follows: 1. The increment of sex-related knowledge score after seven hour sexuality education was significantly higher in experimental group (t=-10.88, p=.000). 2. The increment of sex-related attitude score after seven hour sexuality education was significantly higher in experimental group (t=-2.67, p=.009). 3. The increment of the practice of self-efficacy of sexual behavior score after seven hour sexuality education was significantly higher in experimental group(t=-4.95, p=.000). In conclusion, sexuality education programs based on high girl students' educational desire, characteristics of development, a teaching learning planning model, a health belief model were effective to improve sex-related knowledge, sexual attitudes and the self-efficacy of sexual behavior practice of commercial high school girl students. This result can contribute to expand the school nurse's role in the sex education area and to develop theory-based school health nursing.

• Journal of Physiology & Pathology in Korean Medicine
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• v.20 no.6
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• pp.1678-1727
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• 2006

This study was perfromed to develop the assessment guideline and endpoints for clinical trial with anticancer herbal medicine. The botanical products used to humans for long time may be applied to phase 3 clinical trial after submitting the evidences for safety and efficacy of them or completion of basic requirement of phase 1 and phase 2 for safety confirmation and dose determination. Syndrome improvement was chiefly evaluated by Zubrod and karnofsky(%) methods. We suggest the general clinical trial assessment with botanical products, by following assessment points, that is, tumor size for 50 points, survival fate for 10 points, major syndromes for 40 points. It is recommendable that the each symptom of Qi deficiency syndrome, blood deficiency syndrome and Qi stagnation syndrome was allocated by assessment points, Similarly, the each symptom was given the assessment points according to the severity of symptom, for example, slight for 3 points, moderate for 2 points and severe for 1 point in hepatocelluar carcinoma and lung cancer. Then, the efficacy of botanical products was evaluated by the difference between pre-treatment and post-treatment. Asking the neoplastic patients of questionnaire on physical, emotional, cognitive, social and role subjects availability, three more syndromes (Fatigue, Pain and Nausea/Vomit), quality of life(QOL) will be evaluated by GLM statistics. In addition, in case of lung cancer, 13 questions will be asked by the EORTC QLQ-C13 forms. As the assessment of endpoints for efficacy to reduce side effects induced by chemotherapy and radiotherapy, the data of image scanning and hemato-urinalysis can be usefully applied on immune response, weight loss, indigestion, hemopoietic damage and injury of liver and kidney, while the changes of syndromes of side effect can be evaluated by differentiation methods of Qi and blood and five viscera. However, it is still necessary to determine the ratio between scientific analytical method and Oriental differentiation method as well as confirm the Oriental assessment endpoints by clinical trial. In addition, we suggest the continuous development of assessment endpoints on other carcinomas except of hepatocelluar carcinoma and lung cancer in future.

• The Journal of Society for e-Business Studies
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• v.24 no.1
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• pp.49-89
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• 2019

Many studies have been conducted on adoption of healthcare applications. However, few studies have paid their attention to continuous usage intention of healthcare applications even though success of healthcare applications is determined by Continuous usage intention rather than adoption. Therefore, this study tried to identify the factors affecting the continuous usage intention of healthcare applications and examined the relationship between them empirically. In addition, the role of gender and age in the relationship was investigated. The results showed that self-efficacy and innovation had a significant effect on perceived ease of use of healthcare application, while self-efficacy, health information seeking, and enjoyment had a significant effect on perceived usefulness. Perceived ease of use and usefulness showed positive impact on continuous usage intention of healthcare application. Finally, age and gender had a moderator effect the relationship between perceived usefulness and continuous usage intention. This study is expected to make contributions to the existing research by identifying the factors affecting the Continuous usage intention of healthcare applications, but also to give a guideline for managers who want to provide healthcare application services.

• Journal of Industrial Convergence
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• v.21 no.4
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• pp.23-40
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• 2023

The style of leadership and leader's competence are expected to be an important role in the rapidly changing and uncertain circumstances of the business environment. In particular, rapid change of business environment requires organizations to innovate, and appropriate innovation can have a direct impact on an organization's competitive advantage and sustainability. In this regard, this study focused on transformational leadership as a factor that improves innovative behavior. In addition, the mediating effect of self-efficacy was verified in the process of transformational leadership leading to innovative behavior. Furthermore, the moderated mediating effect of psychological safety was also verified. To verify hypotheses, this study conducted a survey on 307 public officials who work in Chinese public institutions. The result was found that transformational leadership had a positive effect on innovative behavior by mediating effect of self-efficacy. However, contrary to the expectations of this study, the moderated mediation effect of psychological safety was found to be insignificant. The moderating effect of psychological safety showed an insignificant effect. It showed showed the different results from previous studies. In relation to these results, theoretical and practical implications were presented in this study. Overall, this study presented a plan to increase innovative behavior and verified the research model. In addition, the directions of future research for innovative behavior were presented.

• Journal of Life Science
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• v.27 no.8
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• pp.958-964
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• 2017

Autophagy plays an important role in cellular homeostasis and survival for cell recycling and various stresses within the cell. Recent studies have shown that autophagy activity modulates the expression of oncogene and tumor suppressor genes, leading to the development or suppression of cancer. Induction of autophagy is involved in preventing cancer development in normal cells and plays an important role in prompting a specific cell death mechanism in cancer cells with damaged cell death function. It is also known that autophagy inhibition increases the therapeutic efficacy by sensitizing cancer cells that are resistant to chemotherapy. However, the role of autophagy has not yet been fully understood in cancer treatment. Oral squamous cell carcinoma accounts for more than 90% of oral cancer and is the sixth most common cancer in the world. The incidence of oral cancer has increased by 50% over the last 20 years and the mortality rate is over 40% within 5 years after the onset. In oral cancers, the role of autophagy are described to look for tumor inhibitory in the early stages of tumor formation, like other cancers, indicating the dual functions involved in tumor cell survival include tumor progression stages. This review summarizes the various roles of autophagy in cancer cells and suggests the possibility of autophagy as a promising target for effective oral cancer therapy.

• Journal of the Korean Association of Oral and Maxillofacial Surgeons
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• v.30 no.5
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• pp.380-390
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• 2004

Bone healing plays an important role in orthognathic and craniofacial surgery. Bone tissue repair and regeneration are regulated by an array of growth and morphogenetic factors. Bone formation and remodeling require continuous generation of osteoprogenitor cells from bone marrow stromal cells, which generate and respond to a variety of growth factors with putative roles in hematopoiesis and mesenchymal differentiation. In this study, the efficacy of a single application of hepatocyte growth factor to promote bone regeneration in 5-mm experimental calvarial defects of adult male rats was assessed histologically and immunohistochemically. The result of the experimental site were compared with those of the contralateral contral side. None of the control and experimental bone defects demonstrated complete bone closure. Bone regeneration was found close th the margine and central part of the defects. At 1, 2 weeks, there were found much significant cellural mitotic activity and many inflammatory cells and osteoblasts on the experimental site than control site. At 4, 6 weeks, new bone apposition was founded in both site but, more apposition was seen at experimental site. At 8, 12 weeks, also, some differences was found that more apposition of new bone and collagen fiber was seen on experimental site. Our results have some possibility that HGF do a early positive role to repair the bone defect. More study will be needed.

• Journal of Korean Neurosurgical Society
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• v.37 no.3
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• pp.187-192
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• 2005

Objective: Spinal myeloma has been treated with radiation therapy and chemotherapy. However, the role of surgery was not fully evaluated. This study is performed to evaluate the efficacy of surgery in the treatment of spinal myeloma. Methods: 22 patients who were treated with surgery for spinal myeloma from August 1999 to April 2003 were analyzed. Radiological finding, surgical methods and result were reviewed in retrospective study. For compression fracture due to myeloma infiltration, percutaneous vertebroplasy(PVP) was done. Decompression surgery with or without fixation was performed for patients with neurologic deficit. The modalities of surgery consist of PVP (14 cases), corpectomy and fixation (7 cases), and laminectomy and epidural mass removal (3 cases). To evaluate clinical outcome, visual analogue pain score and Frankel neurological scale were used. Results: In 14 cases of PVP, total 57 vertebral segments were treated including 21 thoracic vertebral bodies and 36 lumbar vertebral bodies. Pain relief was achieved in all cases. The pain score changed from 7.7 (preoperatively) to 2.5 (postoperatively). And pain relief effect was maintained over than one year. Frankel grade improved in decompression cases. Conclusion: Surgical treatment can alleviate pain and improve neurologic deficit immediately in spinal myeloma patients.

• Asian Pacific Journal of Cancer Prevention
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• v.13 no.6
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• pp.2813-2818
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• 2012

Background: Considerable evidence suggests that metadherin (MTDH) is a potentially crucial mediator of tumor malignancy and an important therapeutic target for simultaneously enhancing chemotherapy efficacy and reducing metastasis risk. Inhibition of MTDH expression by RNA interference has been shown in several previous research, but silencing MTDH expression by microRNA (miRNA) interference in breast cancer has not been established. In the present study, we investigated the role of MTDH-miRNA in down-regulation of proliferation, motility and migration of breast carcinoma cells. Methods: Expression vectors of recombinant plasmids expressing artificial MTDH miRNA were constructed and transfected to knockdown MTDH expression in MDA-MB-231 breast cancer cells. Expression of MTDH mRNA and protein was detected by RT-PCR and Western blot, respectively. MTT assays were conducted to determine proliferation, and wound healing assays and transwell migration experiments for cell motility and migration. Results: Transfection of recombinant a plasmid of pcDNA-MTDH-miR-4 significantly suppressed the MTDH mRNA and protein levels more than 69% in MDA-MB-231 breast cancer cells. This knockdown significantly inhibited proliferation, motility and migration as compared with controls. Conclusions: MTDH-miRNA may play an important role in down-regulating proliferation, motility and migration in breast cancer cells, and should be considered as a potential small molecule inhibitor therapeutic targeting strategy for the future.