• Proceedings of the Korean Society of Embryo Transfer Conference
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• 2003.10a
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• pp.9-19
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• 2003

Pig organ is thought to be the most suitable nonhuman organ for xenotransplanstation. However, one of the major constraints to using pig organs for xenotransplantation is human natural antibody-mediated hyperacute rejection (HAR). Elimination of a(1,3) galactosyltransferase (GGTA1) from the pig is expected to be a solution to the problem of hyperacute rejection. ry1any efforts have made characterization of GGTA1 in structure and function. improvement in the technique of DNA transfection of somatic cells and advancement of the pig NT, a specific modification has been made to one copy of the GGTA1 gene by Missouri group in 2002. To date because homozygousity of the genetic modification has been achieved in this gene, the role of gala(1,3) gal specific natural antibody in HAR and the efficacy of xenotransplantation in a nonhuman primate model will be addressed. If other genes are found to be involved in rejection of pig donors by primates, the technology will be available to modify those genes so that rejection can be overcome.

• Proceedings of the KSPS conference
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• 1996.10a
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• pp.149-154
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• 1996

Since the 1980s, a number of professionals in the ESL/EFL field have investigated the role of pronunciation in the ESL/EFL curriculum. Applying the insights gained from the second language acquisition research, these efforts have focused on the integration of pronunciation teaching and learning into the communicative curriculum, with a shift towards overall intelligibility as the primary goal of pronunciation teaching and learning. The present study reports on the efficacy of audio-visual aids and hyper-pronunciation training method in teaching the productions of English consonants to Japanese college students. The talk will focus on the implications of the present study, and the presenter makes suggestions to teaching pronunciation to Japanese learners.

• Asia pacific journal of information systems
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• v.5 no.1
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• pp.164-185
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• 1995

A considerable number of empirical studies have been conducted into the impact of graphical presentation of information on decision making performance. Very limited attention has been, however, devoted to the role of graphs as a means of delivering feedback. This paper investigated this issue by varying the presentation formats of outcome feedback in time series forecasting contexts. It was found that overall feedback was not decision-effective. Even enlarged and more salient feedback was of little value to overcome the conservative behavior. The results doubted the efficacy of graphical feedback in the design of EIS/DSS. Feedback did not appear to be a simple mechanism and further research is required to investigate its cognitive processes.

• Journal of Korea Society of Industrial Information Systems
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• v.3 no.1
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• pp.117-139
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• 1998

This study is intended to identify the factors affecting the successful information warehouse (IW) implementation through the technology acceptance model. As the IW has played an important role with the organizations, it has become a strategic management tool. However, because the building of an IWS requires a great amound of financing and a multi-period, managers should consider identifying the variables as a predictor of IWS success. The related research areas, such as TAM , TRA, and innovation diffusion theory, and previous research associated with the EWS success factors are reviewed in this paper. Based on the hypotheses presented , the study will empirically test the relationships between six external variable-user involvement, computer self-efficacy, OLAP characteristics, problem difficulty , user training and top management support-and system utilization via user's perceptions of ease of use, unusefulness. This study semmes to be a first attempt in this research area, and its results will provide general guidclines for IWS project managers to enhancement the like hood of system succes.

• Toxicological Research
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• v.30 no.1
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• pp.1-5
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• 2014

Xenograft models of human cancer play an important role in the screening and evaluation of candidates for new anticancer agents. The models, which are derived from human tumor cell lines and are classified according to the transplant site, such as ectopic xenograft and orthotopic xenograft, are still utilized to evaluate therapeutic efficacy and toxicity. The metastasis model is modified for the evaluation and prediction of cancer progression. Recently, animal models are made from patient-derived tumor tissue. The patient-derived tumor xenograft models with physiological characters similar to those of patients have been established for personalized medicine. In the discovery of anticancer drugs, standard animal models save time and money and provide evidence to support clinical trials. The current strategy for using xenograft models as an informative tool is introduced.

• Proceedings of the EASDL Conference
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• 2010.11a
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• pp.47-47
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• 2010

Chilliness is a complaint among menopausal women in Japan, but increasing evidence indicates that young women also suffer from chilliness. However, neither diagnostic criteria nor drug therapies exist for treating chilliness. We noticed it and recently elucidated methodological issues related to identifying women with chills. Using a discriminant analysis, we demonstrated that four parameters were important determinants of chilliness. On the other hand, after repeated reports of serious adverse effects with hormone replacement therapy, much attention has been given to the development of new remedies to alleviate menopausal depressive state in women, but methods for their preclinical evaluation have not been clarified. We previously developed a procedure to predict the effect of candidate substance on the menopausal depressive-like state in female mice. Since either chilliness or mood disorder is known to disturb a quality of life in women, in this symposium, the efficacy of Korean red ginseng on chilliness in women and depressive-like state will be discussed.

• Korean Journal of Biological Psychiatry
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• v.3 no.1
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• pp.22-29
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• 1996

The introduction of chlorpromazine in the 1950's revolutionized the treatment of schizophrenia and ultimately led to the development of selective $D_2$ antagonists such as haloperidol, a goal in keeping with the prevalent theories at that time. However, limitations in the efficacy of these agents, a growing awareness of their side effects, and theoretical shifts in our understanding of schizophrenia have encouraged ongoing efforts to develop better 'atypical' antipsychotics. Clozapine, and subsequently risperidone, represent examples of these novel compounds, both of which incorporate shared serotonin-dopamine antagonism(SDA). The next years will be dominated by further development of SDA compounds, although a number of other lines of investigation are also being pursued.

• Journal of Information Technology Applications and Management
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• v.13 no.2
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• pp.67-86
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• 2006

Based on literature relating to the TAM (technology acceptance model) and TPB (theory of planned behavior), this study extends the TAM in a mobile banking context. The extended model was tested using LISREL analysis on the sample of 222 users who have experience with the banking service. The model was partially supported in a mobile banking context, accounting for 49% of the variance in the usage intention. The results showed that the perceived usefulness, the perceived credibility, and the perceived financial cost play a significant role in influencing the usage intention of the mobile banking service. In addition, instant connectivity and perceived credibility were found to influence the perceived usefulness, and self-efficacy and instant connectivity were found to influence the perceived ease of use. Implications of these findings are discussed for researchers and practitioners.

• Journal of Chest Surgery
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• v.53 no.4
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• pp.205-210
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• 2020

Esophageal anastomotic leak is the most common and serious complication following esophagectomy. However, the standard treatment for anastomotic leaks remains unclear. Recently, endoscopic vacuum therapy has become an important non-surgical alternative treatment method for patients with esophageal anastomotic leak. This treatment involves the endoscopic placement of a sponge connected to a nasogastric tube into the defect cavity or lumen. Subsequently, continuous negative pressure is delivered to the cavity through the tube. Several studies have reported a treatment success rate of 80% to 100%. In this study, we review the mechanism of action, the method of performing the procedure, its safety and efficacy, and prognostic factors for failure of endoscopic vacuum therapy in the management of patients with anastomotic leak, and on this basis attempted to confirm the possibility of establishing a standardized treatment protocol using endoscopic vacuum therapy.

• BMB Reports
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• v.52 no.1
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• pp.35-41
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• 2019

Cellular senescence, a permanent state of cell cycle arrest, is believed to have originally evolved to limit the proliferation of old or damaged cells. However, it has been recently shown that cellular senescence is a physiological and pathological program contributing to embryogenesis, immune response, and wound repair, as well as aging and age-related diseases. Unlike replicative senescence associated with telomere attrition, premature senescence rapidly occurs in response to various intrinsic and extrinsic insults. Thus, cellular senescence has also been considered suppressive mechanism of tumorigenesis. Current studies have revealed that therapy-induced senescence (TIS), a type of senescence caused by traditional cancer therapy, could play a critical role in cancer treatment. In this review, we outline the key features and the molecular pathways of cellular senescence. Better understanding of cellular senescence will provide insights into the development of powerful strategies to control cellular senescence for therapeutic benefit. Lastly, we discuss existing strategies for the induction of cancer cell senescence to improve efficacy of anticancer therapy.