• The Journal of Korean Association of Computer Education
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• v.10 no.5
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• pp.43-51
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• 2007

We have developed a peer agent to support programming learning and analyzed its educational effects in a programming course. The agent acts as a tutor or a tutee. The role of a tutor/tutee is like the role of a navigator/driver in pair programming. While students are learning with the peer agent, the students' programming abilities are modeled. Based on the student's model, the peer agent provides appropriate feedbacks and contents to the learner. The peer agent gives positive effects on learners' achievement and self-efficacy in a programming course. It means that the peer agent system helps the learner in an affective domain as well as a cognitive domain.

• 대한예방의학회:학술대회논문집
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• 1994.02b
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• pp.270-284
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• 1994

Interim analyses of randomized trials enable investigators to make more efficient use of limited research resources and to satisfy ethical requirements that a regimen be discontinued as soon as it has been established to have an inferior efficacy/toxicity profile. Unfortunately. the integrity and credibility of these trials can be compromised if inappropriate procedures are used in monitoring interim data. 'In this paper we discuss how group sequential designs provide useful guidelines that enable one to satisfy the valid objectives of interim monitoring while avoiding undesirable consequences, and we consider how flexible one can be in the way such designs are implemented. We also provide motivation for the role of data-monitoring committees in preserving study integrity and credibility in either government- or industry-sponsored trials. In our view. these committees should have multidisciplinary representation and membership limited to individuals free of apparent significant conflict of interest, and ideally should be the only individuals to whom the data analysis center provides interim results on relative efficacy of treatment regimens. Finally. we discuss some important practical issues such as estimation following group sequential testing, anal ysis of secondary outcomes after using a group sequential design applied to a primary outcome, early stopping of negative trials. and the role of administrative analyses.

• Tuberculosis and Respiratory Diseases
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• v.85 no.2
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• pp.111-121
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• 2022

Multidrug-resistant tuberculosis (MDR-TB) is caused by an organism that is resistant to both rifampicin and isoniazid. Extensively drug-resistant TB, a rare type of MDR-TB, is caused by an organism that is resistant to quinolone and one of group A TB drugs (i.e., linezolid and bedaquiline). In 2018, the World Health Organization revised the groupings of TB medicines and reclassified linezolid as a group A drug for the treatment of MDR-TB. Linezolid is a synthetic antimicrobial agent in the oxazolidinone class. Although linezolid has a good efficacy, it can cause substantial adverse events, especially hematologic toxicity. In both TB infection and linezolid mechanism of action, mitochondrial dysfunction plays an important role. In this concise review, characteristics of linezolid as an anti-TB drug are summarized, including its efficacy, pathogenesis of hematologic toxicity highlighting mitochondrial dysfunction, and the monitoring and management of hematologic toxicity.

• IMMUNE NETWORK
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• v.21 no.3
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• pp.21.1-21.22
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• 2021

Myeloid-derived suppressor cells (MDSCs) have strong immunosuppressive activity and are morphologically similar to conventional monocytes and granulocytes. The development and classification of these cells have, however, been controversial. The activation network of MDSCs is relatively complex, and their mechanism of action is poorly understood, creating an avenue for further research. In recent years, MDSCs have been found to play an important role in immune regulation and in effectively inhibiting the activity of effector lymphocytes. Under certain conditions, particularly in the case of tissue damage or inflammation, MDSCs play a leading role in the immune response of the central nervous system. In cancer, however, this can lead to tumor immune evasion and the development of related diseases. Under cancerous conditions, tumors often alter bone marrow formation, thus affecting progenitor cell differentiation, and ultimately, MDSC accumulation. MDSCs are important contributors to tumor progression and play a key role in promoting tumor growth and metastasis, and even reduce the efficacy of immunotherapy. Currently, a number of studies have demonstrated that MDSCs play a key regulatory role in many clinical diseases. In light of these studies, this review discusses the origin of MDSCs, the mechanisms underlying their activation, their role in a variety of clinical diseases, and their function in immune response regulation.

• Asia pacific journal of information systems
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• v.23 no.3
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• pp.131-154
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• 2013

New internet technologies have created a revolutionary new platform which allows consumers to make decision about product price and quality quickly and provides information about themselves through the transcript of online reviews. By expressing their feelings toward products or services on virtual opinion platforms, users extend their influence into cyberspace as electronic word-of-mouth (e-WOM). Existing research indicates that an impact of eWOM on the consumer decision process is influential. For both academic researchers and practitioners, investigating this phenomenon of information sharing in online website is essential given the increasing number of consumers using them as sources of purchase decisions. It is worthwhile to examine the extent to which opinion seekers are willing to accept and adopt online reviews and which factors encourage adoption. Discerning the most motivating aspects of information adoption in particular, could help electronic marketers better promote their brand and presence on the internet. The objectives of this study are to investigate how online WOM influences a persons' purchase decision by discovering which factors encourage information adoption. Especially focused on the self-efficacy, this research investigates how self-efficacy affects on information usefulness and adoption of online information. Although people are exposed to same review or comment about product or service, some accept the reviews while others do not. We notice that accepting online reviews mainly depends on the person's preference or personal characteristics. This study empirically examines this issue by using cognitive dissonance theory. Specifically, in the movie industry, we address few questions-is always positive WOM generating positive effect? What if the movie isn't the person's favorite genre? What if the person who is very self-assertive so doesn't take other's opinion easily? In these cases of cognitive dissonance, is always WOM generating same result? While many studies have focused on one direct of WOM which indicates positive (or negative) informative reviews or comments generate positive (or negative) results and more (or less) profits, this study investigates not only directional properties of WOM but also how people change their opinion towards product or service positive to negative, negative to positive through the online WOM. An experiment was conducted quantitatively by using a sample of 168 users who have experience within the online movie review site, 'Naver Movie'. Users were required to complete a survey regarding reviews and comments taken from the real movie page. The data reflected user's perceptions of online WOM information that determined users' adoption level. Analysis results provide empirical support for the proposed theoretical perspective. When user can't agree with the opinion of online WOM information, in other words, when cognitive dissonance between online WOM information and users' preference occurs, perceived self-efficacy significantly decreases customers' perception of usefulness. And this perception of usefulness plays an important role in determining users' intention to adopt online WOM information. Most of researches have been concentrated on characteristics of online WOM itself such as quality or vividness of information, credibility of source and direction of online WOM, etc. for describing effect of online WOM, but our results suggest that users' personal character (e.g., self-efficacy) plays decisive role for acceptance of online WOM information. Higher self-efficacy means lower possibility to accept the information that represents counter opinion because of cognitive dissonance, whereas the people that have lower self-efficacy are willing to accept the online WOM information as true and refer to purchase decision. This study suggests a model for understanding role of direction of online WOM information. Also, our result implicates the importance of online review supervision and personalized information service by confirming switching opinion negative to positive is more difficult than positive to negative through the online WOM information. This implication would help marketers to manage online reviews of their products or services.

• Asian Pacific Journal of Cancer Prevention
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• v.15 no.24
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• pp.10783-10786
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• 2015

Background: Smoking remains the major preventable cause of death worldwide, especially cancer-related death. Evidence clearly indicates that tobacco-related morbidity and mortality is reduced by smoking cessation. Pharmacists are well-positioned to provide tobacco cessation services an involvement of pharmacists in smoking cessation is encouraged by several organizations. While Indonesia's prevalence of smoking is in the first rank in Asian countries, none of the pharmacy schools in Indonesia are currently offering tobacco-related courses in their existing curricula at present. Our study aimed to develop and to evaluate the effectiveness of tobacco education (TE) for pharmacy students in Indonesia. Materials and Methods: A 6-hour TE was developed and evaluated using pre-test/post-test with control group design. A total of 137 fifth-year pharmacy students at Gadjah Mada University (GMU), Yogyakarta, were chosen as an intervention group while a total of 105 fifth-year students of Islamic University of Indonesia, (UII) served as the control group. Knowledge, perceived-role, self-efficacy, and ability to perform counseling using the 5A's framework were evaluated. Results: A significant improvement (P < 0.001) in knowledge, perceived-role, and self-efficacy was found in the intervention group but not in the control group. In addition, we revealed that 89.7% of the intervention group were able to perform counseling using 5A's. Conclusions: The developed TE significantly improved student knowledge, perceived-rolse, self-efficacy, and created an ability to perform cessation counseling. Integration of TE education in curricula of Indonesian pharmacy schools nation-wide should be encouraged.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.19 no.10
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• pp.467-474
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• 2018

This study was conducted to investigate the effect of unmarried women's self-efficacy and sex role stereotypes on sexual assertiveness. This study is a descriptive research study. The subjects of this study were unmarried women who had experience of dating. Data collection was conducted by online from July 17th to 19th, 2018. The final 190 subjects were the subject of the study and data analysis was performed using the SPSS 24.0 program. Pearson's correlation was used for correlations between variables, and multiple regression analysis was performed to determine the effect on sexual assertiveness. The results showed that there was a significant difference in the scores of the sexual assertiveness according to the age, having a boyfriend, number of intimate relationship, and sexual intercourse experience. There was a positive correlation between sexual assertiveness and self-efficacy, while there was a negative correlation between sexual assertiveness and sex role stereotypes. Factors influencing sexual assertiveness were sexual intercourse experience and sex role stereotypes, which accounted for 41.7%. This study was meaningful in that it analyzed the factors influencing sexual assertiveness among unmarried women who are not college students. In order to increase the sexual assertiveness of unmarried women, it is necessary to have a program that takes into account stereotypes of sex roles.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.18 no.6
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• pp.219-227
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• 2017

The purpose of this study is to verify the mediating effects of self-efficacy in correlation between conscientiousness and neuroticism among the Big Five personality traits and stress coping strategies. The following two study questions were formulated. Study Question 1: What is the correlation between the Big Five personality traits, stress coping strategies, and self-efficacy Study Question 2: Among the Big Five personality traits, conscientiousness and neuroticism are selected as clinically very meaningful variables that represent mental health in undergraduates. If so, does self-efficacy play a mediating role in the correlation between conscientiousness and neuroticism and stress coping strategies To verify the two study questions, the Big Five personality traits, stress coping strategies scale, and self-efficacy scale were measured for a sample of 462 freshmen attending D University located in Chungcheong. First, according to the results of correlation analysis, neuroticism and self-efficacy showed a negative correlation, and conscientiousness showed a positive correlation. Regarding the Big Five personality traits and stress coping strategies, conscientiousness showed a negative correlation with avoidance-orientation among stress coping strategies. Neuroticism showed a negative correlation with social support and problem solving-orientation among stress coping strategies. Second, according to the results of analyzing the mediating effects of self-efficacy through hierarchical regression analysis, self-efficacy exerted partial mediating effects only in correlation between neuroticism and avoidance-orientation. This study is significant in its anticipation of undergraduates' stress coping, personality factors can be usefully employed as psychological constructs, and particularly, when an undergraduate reveals the neuroticism factor, which is one of the predictors for mental health, and the tendencies of avoidance among stress coping strategies, educational interventions for self-efficacy are needed to reduce their mental stress.

• Knowledge Management Research
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• v.23 no.4
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• pp.207-231
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• 2022

The purpose of this study is to identify the relationship between PJF(person-job fit) and members' organizational commitment focusing on the mediating factor. Previous Studies have found that person-job fit has positive effect on organizational commitment, and self-efficacy has positive effect on the organizational commitment. On the other hand, the studies to identify whether self-efficacy has a role in mediation between PJF and the members' organizational commitment has been insufficient. To that end, we considered self-efficacy as the mediator of the relationship between PJF and organizational commitment. We used the data which to perform national policy research from 690 workers at a small or medium firm. As a result of verifying the suitability of the research model, it was suitable for the acceptance criteria. Besides the hierarchical regression analysis, bootstrapping was conducted to verify significance of mediating effect of self-efficacy. The main results are as follows. First, the variables, PJF, self-efficacy and organizational commitment showed a positive correlation. Second, PJF has a positive effect on self-efficacy and organizational commitment significantly. Also self-efficacy has a positive effect on organizational commitment significantly. Third, the mediating effect of self-efficacy in the relationship between PJF and organizational commitment is significant. In order to improve person-job fit, this study suggested that SMEs' owners should consider job rotation system and career development program for employees. Based on this study result and implications, we discussed limit of research and direction for future research.

• CELLMED
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• v.8 no.2
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• pp.8.1-8.5
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• 2018

Nitric oxide (NO) is a small diffusible molecule which plays an important role in various physiological activities. NO is a notable molecule, functioning as a cytotoxic agent and cellular messenger. There has been considerable interest in NO production by activated macrophages because this gaseous metabolite plays a fundamental role in the cytotoxic and cytostatic effects of macrophages towards invasive micro-organisms and tumour cells. No is a bioactive free radical that has been implicated in many physiological functions, plays a critical role during inflammation and therefore constitutes a potential target for developing therapeutics for inflammatory diseases. The use of medicinal plants by the population has been an important alternative the resource in the treatment of various diseases. Its growing acceptance in the medical community has been due to the fact that several plants with biological activities have been scientifically investigated and their efficacy and safety have been proven. In this review, discussed suppressive effects of No production by traditional medicines in RAW 264.7 and THP-1 macrophages.