• Asian Pacific Journal of Cancer Prevention
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• 제14권4호
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• pp.2269-2272
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• 2013

Matrix metalloproteinases (MMPs) degrade various components of the extracellular matrix and functional polymorphisms in encoding genes may contribute to genetic susceptibility to many cancers. Up to now, associations between MMP-7 (-181A>G) and digestive system cancer risk have remained inconclusive. To better understand the role of the MMP-7 (-181A>G) genotype in digestive cancer development, we conducted this comprehensive meta-analysis encompassing 3,518 cases and 4,596 controls. Overall, the MMP-7 (-181A>G) polymorphism was associated with higher digestive system cancer risk on homozygote comparison (GG vs. AA, OR=1.21, 95% CI = 1.12-1.60) and in a dominant model (GG/GA vs. AA, OR=1.16, 95% CI =1.03-1.46). On subgroup analysis, this polymorphism was significantly linked to higher risks for gastric cancer (GG vs. AA, OR=1.22, 95% CI = 1.02-1.46; GA vs. AA, OR=1.82, 95% CI =1.16-2.87; GG/GA vs. AA, OR=1.13, 95% CI =1.01-1.27; GG vs. GA/AA, OR= 1.25, 95% CI = 1.06-2.39. We also observed increased susceptibility to colorectal cancer and esophageal SCC in both homozygote (OR = 1.13, 95% CI = 1.06-1.26) and heterozygote comparisons (OR = 1.45, 95% CI = 1.11-1.91). In the stratified analysis by controls, significant effects were only observed in population-based studies (GA vs. AA, OR=1.16, 95% CI=1.08-1.50; GA/AA vs. GG, OR=1.10, 95% CI=1.01-1.72). According to the source of ethnicity, a significantly increased risk was found among Asian populations in the homozygote model (GG vs. AA, OR=1.40, 95% CI=1.12-1.69), heterozygote model (GA vs. AA, OR=1.26, 95% CI=1.02-1.51), and dominant model (GG/GA vs. AA, OR=1.18, 95% CI=1.08-1.55). Our findings suggest that the MMP-7 (-181A>G) polymorphism may be a risk factor for digestive system cancer, especially among Asian populations.

• Nutrition Research and Practice
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• 제5권6호
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• pp.560-568
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• 2011

Consumption of a diet consistent with dietary guidelines is believed to have a beneficial effect on the prevention of chronic diseases and the promotion of general health. This study was conducted to explore the relationship between adherence to the Korean Food Guidance System (KFGS), which was based on the 2010 revised KDRIs, and the risk of metabolic abnormalities. Five hundred and ninety-six Korean adults between 30 and 59 years of age were recruited by advertisement to the Bundang Jesaeng General Hospital (BJGH), and those not taking regular medications and without diagnoses of fulminant disease were included. Data were collected on anthropometric measurements, diagnostic parameters for metabolic syndrome (MetS), and 3-day dietary intakes from individuals in the study. The number of servings consumed from each food group was compared to the KFGS recommended servings for each of the 6 food groups. Poor adherence to the recommendations for servings of milk and dairy products (OR: 2.038, 1.128-3.682) was associated with a higher risk of MetS, and poor adherence to the guidelines for fruit consumption (OR: 1.849, 1.027-3.329) was associated with a higher risk for the existence an elevated waist circumference. Conversely, the consumption of meat, fish, eggs, and beans above the recommended number of servings was associated with a lower risk of having an elevated waist circumference (OR: 0.523, 0.288-0.950), and the consumption of vegetables above the recommended number of servings was associated with a reduced risk of having elevated fasting glucose (OR: 0.533, 0.298-0.954). These results suggest that adherence to the KFGS guidelines helps to prevent the development of MetS, but this association needs to be confirmed by prospective studies.

• Korean Chemical Engineering Research
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• 제60권4호
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• pp.506-511
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• 2022

화학물질관리법에서 장외영향평가서 및 위해관리계획서를 화학사고예방관리계획서로 일원화하는 제도가 시행되었다. 화학사고예방관리계획서에서 다루는 유해화학물질 중 사고대비물질은 화학사고의 발생 가능성이 높거나 화학사고가 발생한 경우에 그 피해 규모가 클 것으로 우려되는 화학물질로서 지정하고 있다. 본 연구에서는 사고대비물질별 규정수량 기준에 따른 위험도를 비교하고자 상위/하위 규정수량이 비슷한 화학물질을 특정하여 동일한 사고 시나리오를 선정하고 위험도 평가를 실시하였다. 연구대상물질은 암모니아, 염화수소, 이황화탄소, 벤젠 등 총 4종의 물질을 선정하였으며, DNV 사의 정량적 위험성 평가 프로그램인 Safeti 8.0을 활용하여 위험도를 비교 분석하였다. 그 결과, 비슷한 상위/하위규정수량임에도 불구하고 상대적으로 높은 위험도를 가지고 있는 물질을 확인할 수 있었다.

• 지질공학
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• 제30권4호
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• pp.663-671
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• 2020

최근 국내에서는 산림지역 뿐만 아니라 대도시지역에서도 자연재해가 많이 발생하고 있으며, 이에 대한 국가적인 요구사항은 증가하고 있다. 특히 국도 비탈면 붕괴에 대하여 체계적으로 관리할 수 있는 사전 재해정보 시스템은 전무한 실정이다. 본 연구에서는 CSMS(Cut Slope Management System)에서 관리하는 강원도와 경상도 지역의 국도 비탈면 붕괴 정밀조사 보고서와 비탈면 기초조사를 토대로 비탈면 붕괴 유발 인자에 대한 빅데이터 분석을 실시하였다. 분석 결과를 바탕으로 붕괴 비탈면 위치와 기상정보를 반영하여 분류 기반 머신러닝 모형인 Adaboost를 통한 비탈면 붕괴 위험도 예측모형을 구축하였다. 또한 시각화 프로그램인 비탈면 붕괴 위험도 시각화 지도를 개발하여 기상여건 변화에 따른 비탈면 위험도 파악을 통한 선제적 재해재난 예방대책에 활용할 수 있음을 보여주고 있다.

• 대한안전경영과학회지
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• 제19권4호
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• pp.35-42
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• 2017

A number of plating companies have been exposed to the risk of fire due to unexpected temperature increasing of water or other reasons in a plating bath. Since the companies are not able to forecast the unexpected temperature increasing of plating bath and most of raw materials in the bath have low ignition temperature, it is easy to be exposed to the risk of fire. Thus, in previous study, we tried to monitor and notice the dangerous change of temperature of water immediately to prevent the risk of fire from plating process. However, unfortunately previous studies were not able to shut out the fundamental cause of fire since bath temperature sensor can detect air temperature when the level sensor was malfunctioned. In this paper we developed the Teflon heater which contains a built in temperature sensor and improved plating equipment system. Teflon heater is improved using Pt $100{\Omega}$ sensor which can detect until $600^{\circ}C$. When the bath temperature sensor detects over $60^{\circ}C$ or the Teflon heater sensor detects over $240^{\circ}C$ they temporarily shut down the heater to control temperature. Also relay completely shuts down main power when detects instant temperature is detected over 5% of $240^{\circ}C$ by the heater sensor to prevent teflon melting down and fire spreads. Developed plating equipment system can monitor a real time temperature in the teflon tube and bath water. Therefore we think the proposed plating equipment can eliminate the possibility of fire in plating processes fundamentally.

• 대한안전경영과학회지
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• 제26권2호
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• pp.43-53
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• 2024

This study analyzes the importance-performance analysis (IPA) of the 10 dimensions of the smart construction safety management system, and analyzes which dimensions are important and which dimensions are performing to determine key improvement tasks, incremental improvement tasks, Maintenance and reinforcement tasks and continuous maintenance tasks were derived. Among the 10 dimensions of the smart construction safety management system, the dimensions that are recognized as important by all field managers and field workers and have high performance are the automatic risk displacement measurement system, smart environmental sensor system, and heavy equipment seizure prevention system. However, areas that were perceived as having high importance but low performance were worker location tracking systems, smart safety helmet chin muscles, and smart safety ring fastening. Among the smart construction safety management systems perceived by field managers, areas for key improvement with high importance and low performance included worker location tracking system and smart safety ring fastening. Among the smart construction safety management systems perceived by field workers, the area for key improvement with high importance and low performance was the automatic risk displacement measurement system.

• 한국지반환경공학회 논문집
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• 제20권3호
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• pp.5-14
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• 2019

This study attempted to study the soil erosion dynamic in the Bagmati Basin of Nepal. In this study, an inclusive methodology that combines Revised Universal Soil Loss Equation (RUSLE) and GIS techniques was adopted to determine the distribution of soil loss in the study basin. As well, this study attempts to study the intensity of soil erosion in the seven different land use patterns in the Bagmati Basin. Soil loss is an associated phenomenon of hydrologic cycle and this dynamic phenomenon possesses threats to sustainability of basin hydrology, agriculture system, hydraulic structures in operation and overall ecosystem in a long run. Soil conservation works, and various planning and design of watersheds works demands quantification of soil loss. The results of the study in Bagmati Basin shows the total annual soil loss in the basin is 22.93 million tons with an average rate of 75.83T/ha/yr. The computed soil loss risk was divided into five classes from tolerable to severe and the spatial pattern was mapped for easy interpretation. Also, evaluation of soil loss in different land use categories shows barren area has highest rate of soil loss followed by agriculture area. This is a preliminary work and provides erosion risk scenario in the basin. The study can be further used for strategic planning of land use and hydrologic conservation works in a basin.

• Asian Pacific Journal of Cancer Prevention
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• 제14권1호
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• pp.503-506
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• 2013

Objectives: To determine human papillomavirus (HPV) frequency, genotypes and the relation between cervical smear results, risk factors and types in women living in Manisa, Turkey. Materials and Methods: A total of 410 women were included in the study. Cervical specimens were obtained for linear array HPV genotyping and pathological testing. Conventional Pap test and Bethesda system were used for evaluation of cytology specimens. Results: A total of 410 women with a mean age of 34.9 years were tested. A positive result of any HPV was found in 35 patients (8.5%). Among them, 26 different serotypes of HPV were identified and the most frequent type was HPV 16 (28.5%) followed by type 45 and 53 (11.4%). Patients were infected by 65.7% high risk, 11.4% probable high risk and 22.9% low risk HPV types. Multiple HPV positive results were found in 13 patients (37.1%). Patients with single partner, history of abnormal smear or condyloma had positive HPV results and this was statistically significant (p<0.05). Correlation analysis showed a statistically weak relation between positive HPV and abnormal smear results (r=0.120). Conclusions: Determining HPV types of genital HPV infections is important for epidemiological studies. We have found the rate of positive HPV as 8.5% which implies the need for extended screening programs in order to diagnose oncogenic HPV at an early stage.

• Asian Pacific Journal of Cancer Prevention
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• 제14권11호
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• pp.6961-6964
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• 2013

Human papillomavirus (HPV) is a major cause of cervical cancer. More than 100 HPV genotypes have been identified; however the distribution varies geographically and according to ethnicity. The purpose of this study was to investigate the prevalence and distribution of HPV subtypes among Northeast Thai women. Subjects included 198 cases of SCCA and 198 age-matched, healthy controls. HPV-DNA was amplified by PCR using the consensus primers GP5+/6+ system followed by reverse line blot hybridization genotyping. The prevalence of high-risk HPV infection was 21 (10.1%) and 152 (76.8%) in the controls and in the cases, respectively. High-risk HPV significantly increased the risk for cervical cancer with an OR of 42.4 (95%CI: 22.4-81.4, p<0.001) and an adjusted OR of 40.7-fold (95%CI: 21.5-76.8, p <0.001). HPV-16 was the most prevalent HPV type in the SCCA (56.2%) followed by HPV-58 (17.8%) and HPV-18 (13.6%); whereas HPV-58 (46.4%) was a prominent genotype in the controls followed by HPV-16 (39.3%) and unidentified HPV types (25.0%). These findings indicate that HPV infection remains a critical risk factor for SCCA; particularly, HPV-16, HPV-58 and HPV-18. In order to eradicate cervical cancer, sustained health education, promoted use of prophylactics and a HPV-58 vaccine should be introduced in this region.

• Asian Pacific Journal of Cancer Prevention
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• 제14권11호
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• pp.6507-6512
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• 2013

The purpose of this study was to evaluate the associations of CYP1A1 genetic polymorphisms with the risk of developing esophageal cancer (EC). A case-control study was carried out in a Chinese population in which 157 hospital based EC cases and 157 population based healthy controls with 1:1 match by age and sex were included. PCR based restriction fragment length polymorphisms (PCR-RFLP) were used to detect genotypes in case and control groups. For the CYP1A1 Ile/Val polymorphism, comparing with wild genotype Ile/Ile, both the heterozygote genotype Ile/Val and the combined variant genotype Ile/Val+Val/Val increased the risk of esophageal cancer (OR: 2.05, 95%CI: 1.19-3.54, OR: 1.86, 95%CI: 1.11-3.12). No significant association was found between the CYP1A1 MspI polymorphism and EC. According to analysis of combined genotypes, the TC/AG combined genotype which contained both variant alleles of these two polymorphisms increased the risk of developing EC (OR: 2.12, 95%CI: 1.16-3.85). Our results suggested that genetic polymorphisms of CYP1A1 may increase the susceptibility to EC.