Asian Pacific Journal of Cancer Prevention

  • 제14권11호
  • /
  • Pages.6507-6512
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  • 2013
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  • 1513-7368(pISSN)
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  • 2476-762X(eISSN)
아시아태평양암예방학회 (Asian Pacific Journal of Cancer Prevention)
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CYP1A1 Genetic Polymorphisms and Risk for Esophageal Cancer: a Case-control Study in Central China

  • Yun, Yu-Xia (Department of Epidemiology and Biostatistics, College of Public Health) ;
  • Wang, Yan-Ping (Department of Epidemiology and Biostatistics, College of Public Health) ;
  • Wang, Peng (Department of Epidemiology and Biostatistics, College of Public Health) ;
  • Cui, Li-Hong (Digestive System Department, PLA Navy General Hospital) ;
  • Wang, Kai-Juan (Department of Epidemiology and Biostatistics, College of Public Health) ;
  • Zhang, Jian-Ying (Department of Epidemiology and Biostatistics, College of Public Health) ;
  • Dai, Li-Ping (Department of Epidemiology and Biostatistics, College of Public Health)
  • 발행 : 2013.11.30
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초록

The purpose of this study was to evaluate the associations of CYP1A1 genetic polymorphisms with the risk of developing esophageal cancer (EC). A case-control study was carried out in a Chinese population in which 157 hospital based EC cases and 157 population based healthy controls with 1:1 match by age and sex were included. PCR based restriction fragment length polymorphisms (PCR-RFLP) were used to detect genotypes in case and control groups. For the CYP1A1 Ile/Val polymorphism, comparing with wild genotype Ile/Ile, both the heterozygote genotype Ile/Val and the combined variant genotype Ile/Val+Val/Val increased the risk of esophageal cancer (OR: 2.05, 95%CI: 1.19-3.54, OR: 1.86, 95%CI: 1.11-3.12). No significant association was found between the CYP1A1 MspI polymorphism and EC. According to analysis of combined genotypes, the TC/AG combined genotype which contained both variant alleles of these two polymorphisms increased the risk of developing EC (OR: 2.12, 95%CI: 1.16-3.85). Our results suggested that genetic polymorphisms of CYP1A1 may increase the susceptibility to EC.

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참고문헌

  1. Atinkaya C, Taspinar M, Sakiragaoglu O, et al (2012). The effect of CYP1A1, GSTT1 and GSTM1 polymorphisms on the risk of lung cancer: a case-control study. Hum Exp Toxicol, 31, 1074-80. https://doi.org/10.1177/0960327111428630
  2. Bailey LR, Roodi N, Verrier CS, et al (1998). Breast cancer and CYPIA1, GSTM1, and GSTT1 polymorphisms: evidence of a lack of association in Caucasians and African Americans. Cancer Res, 58, 65-70.
  3. Bartsch H, Nair U, Risch A, et al (2000). Genetic polymorphism of CYP genes, alone or in combination, as a risk modifier of tobacco-related cancers. Cancer Epidemiol Biomarkers Prev, 9, 3-28.
  4. Casson AG, Zheng Z, Chiasson D, et al (2003). Associations between genetic polymorphisms of Phase I and II metabolizing enzymes, p53 and susceptibility to esophageal adenocarcinoma. Cancer Detect Prev, 27, 139-46. https://doi.org/10.1016/S0361-090X(03)00033-3
  5. Dai LP, Wang YP, Wu XB, et al (2009). [Study on the association of cytochrome P450 polymorphisms and the risk of esophageal cancer: a meta-analysis]. Zhonghua Liu Xing Bing Xue Za Zhi, 30, 1198-202.
  6. Ding G, Xu W, Liu H, et al (2013). CYP1A1 MspI polymorphism is associated with prostate cancer susceptibility: evidence from a meta-analysis. Mol Biol Rep, 40, 3483-91. https://doi.org/10.1007/s11033-012-2423-0
  7. Guo W, Wang N, Li Y, Zhang JH (2005). Polymorphisms in tumor necrosis factor genes and susceptibility to esophageal squamous cell carcinoma and gastric cardiac adenocarcinoma in a population of high incidence region of North China. Chin Med J (Engl), 118, 1870-8.
  8. Hayashi S, Watanabe J, Nakachi K, Kawajiri K (1991). Genetic linkage of lung cancer-associated MspI polymorphisms with amino acid replacement in the heme binding region of the human cytochrome P450IA1 gene. J Biochem, 110, 407-11. https://doi.org/10.1093/oxfordjournals.jbchem.a123594
  9. Hayashi S, Watanabe J, Kawajiri K (1992). High susceptibility to lung cancer analyzed in terms of combined genotypes of P450IA1 and Mu-class glutathione S-transferase genes. Jpn J Cancer Res, 83, 866-70. https://doi.org/10.1111/j.1349-7006.1992.tb01992.x
  10. Hiyama T, Yoshihara M, Tanaka S, Chayama K (2007). Genetic polymorphisms and esophageal cancer risk. Int J Cancer, 121, 1643-58. https://doi.org/10.1002/ijc.23044
  11. Hori H, Kawano T, Endo M, Yuasa Y (1997). Genetic polymorphisms of tobacco- and alcohol-related metabolizing enzymes and human esophageal squamous cell carcinoma susceptibility. J Clin Gastroenterol, 25, 568-75. https://doi.org/10.1097/00004836-199712000-00003
  12. Kawajiri K, Nakachi K, Imai K, et al (1990). Identification of genetically high risk individuals to lung cancer by DNA polymorphisms of the cytochrome P450IA1 gene. FEBS Lett, 263, 131-3. https://doi.org/10.1016/0014-5793(90)80721-T
  13. Kopf PG, Walker MK (2010). 2,3,7,8-tetrachlorodibenzo-p-dioxin increases reactive oxygen species production in human endothelial cells via induction of cytochrome P4501A1. Toxicol Appl Pharmacol, 245, 91-9. https://doi.org/10.1016/j.taap.2010.02.007
  14. Landi MT, Bertazzi PA, Shields PG, et al (1994). Association between CYP1A1 genotype, mRNA expression and enzymatic activity in humans. Pharmacogenetics, 4, 242-6. https://doi.org/10.1097/00008571-199410000-00002
  15. Li T, Lu ZM, Chen KN, et al (2001). Human papillomavirus type 16 is an important infectious factor in the high incidence of esophageal cancer in Anyang area of China. Carcinogenesis, 22, 929-34. https://doi.org/10.1093/carcin/22.6.929
  16. Lopez-Cima MF, Alvarez-Avellon SM, Pascual T, et al (2012). Genetic polymorphisms in CYP1A1, GSTM1, GSTP1 and GSTT1 metabolic genes and risk of lung cancer in Asturias. BMC Cancer, 12, 433. https://doi.org/10.1186/1471-2407-12-433
  17. Lu J, Lian S, Sun X, et al (2000). [A case-control study on the risk factors of esophageal cancer in Linzhou]. Zhonghua Liu Xing Bing Xue Za Zhi, 21, 434-6.
  18. Lucas D, Menez C, Floch F, et al (1996). Cytochromes P4502E1 and P4501A1 genotypes and susceptibility to cirrhosis or upper aerodigestive tract cancer in alcoholic caucasians. Alcohol Clin Exp Res, 20, 1033-7. https://doi.org/10.1111/j.1530-0277.1996.tb01943.x
  19. Mao WM, Zheng WH, Ling ZQ (2011). Epidemiologic risk factors for esophageal cancer development. Asian Pac J Cancer Prev, 12, 2461-6.
  20. Morita S, Yano M, Shiozaki H, et al (1997). CYP1A1, CYP2E1 and GSTM1 polymorphisms are not associated with susceptibility to squamous-cell carcinoma of the esophagus. Int J Cancer, 71, 192-5. https://doi.org/10.1002/(SICI)1097-0215(19970410)71:2<192::AID-IJC11>3.0.CO;2-K
  21. Nakachi K, Imai K, Hayashi S, et al (1991). Genetic susceptibility to squamous cell carcinoma of the lung in relation to cigarette smoking dose. Cancer Res, 51, 5177-80.
  22. Nimura Y, Yokoyama S, Fujimori M, et al (1997). Genotyping of the CYP1A1 and GSTM1 genes in esophageal carcinoma patients with special reference to smoking. Cancer, 80, 852-7. https://doi.org/10.1002/(SICI)1097-0142(19970901)80:5<852::AID-CNCR4>3.0.CO;2-N
  23. Parkin DM, Laara E, Muir CS (1988). Estimates of the worldwide frequency of sixteen major cancers in 1980. Int J Cancer, 41, 184-97. https://doi.org/10.1002/ijc.2910410205
  24. Parkin DM, Bray F, Ferlay J, Pisani P (2005). Global cancer statistics, 2002. CA Cancer J Clin, 55, 74-108. https://doi.org/10.3322/canjclin.55.2.74
  25. Roth MJ, Dawsey SM, Wang G, et al (2000). Association between GSTM1*0 and squamous dysplasia of the esophagus in the high risk region of Linxian, China. Cancer Lett, 156, 73-81. https://doi.org/10.1016/S0304-3835(00)00442-0
  26. Sergentanis TN, Economopoulos KP, Choussein S, Vlahos NF (2012). Cytochrome P450 1A1 (CYP1A1) gene polymorphisms and ovarian cancer risk: a meta-analysis. Mol Biol Rep, 39, 9921-30. https://doi.org/10.1007/s11033-012-1860-0
  27. van Lieshout EM, Roelofs HM, Dekker S, et al (1999). Polymorphic expression of the glutathione S-transferase P1 gene and its susceptibility to Barrett’s esophagus and esophageal carcinoma. Cancer Res, 59, 586-9.
  28. Wang AH, Sun CS, Li LS, et al (2002a). Relationship of tobacco smoking CYP1A1 GSTM1 gene polymorphism and esophageal cancer in Xi’an. World J Gastroenterol, 8, 49-53. https://doi.org/10.3748/wjg.v8.i1.49
  29. Wang LD, Zheng S, Liu B, et al (2003). CYP1A1, GSTs and mEH polymorphisms and susceptibility to esophageal carcinoma: study of population from a high- incidence area in north China. World J Gastroenterol, 9, 1394-7. https://doi.org/10.3748/wjg.v9.i7.1394
  30. Wang XL, Greco M, Sim AS, et al (2002b). Effect of CYP1A1 MspI polymorphism on cigarette smoking related coronary artery disease and diabetes. Atherosclerosis, 162, 391-7. https://doi.org/10.1016/S0021-9150(01)00723-7
  31. Wu MT, Lee JM, Wu DC, et al (2002). Genetic polymorphisms of cytochrome P4501A1 and oesophageal squamous-cell carcinoma in Taiwan. Br J Cancer, 87, 529-32. https://doi.org/10.1038/sj.bjc.6600499
  32. Xing D, Tan W, Lin D (2003). Genetic polymorphisms and susceptibility to esophageal cancer among Chinese population (review). Oncol Rep, 10, 1615-23.
  33. Xu X, Kelsey KT, Wiencke JK, et al (1996). Cytochrome P450 CYP1A1 MspI polymorphism and lung cancer susceptibility. Cancer Epidemiol Biomarkers Prev, 5, 687-92.
  34. Yang L, Parkin DM, Li L, Chen Y (2003). Time trends in cancer mortality in China: 1987-1999. Int J Cancer, 106, 771-83. https://doi.org/10.1002/ijc.11300
  35. Zhang W, Bailey-Wilson JE, Li W, et al (2000). Segregation analysis of esophageal cancer in a moderately high-incidence area of northern China. Am J Hum Genet, 67, 110-9. https://doi.org/10.1086/302970
  36. Zhang ZY, Fasco MJ, Huang L, et al (1996). Characterization of purified human recombinant cytochrome P4501A1-Ile462 and -Val462: assessment of a role for the rare allele in carcinogenesis. Cancer Res, 56, 3926-33.
  37. Zhuo XG, Watanabe S (1999). Factor analysis of digestive cancer mortality and food consumption in 65 Chinese counties. J Epidemiol, 9, 275-84. https://doi.org/10.2188/jea.9.275

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