• Journal of Medicine and Life Science
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• v.17 no.2
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• pp.47-52
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• 2020

Glucagon regulates glucose and fat metabolism as well as being involved in the production of ketone bodies. The new antidiabetic drug, a sodium-glucose co-transporter-2 inhibitor, increases glucagon, and reduces the risk of cardiovascular death and hospitalization due to heart failure. The presence of metabolic syndrome is an important risk factor for cardiovascular diseases(CVD) in type 2 diabetes(T2DM) patients. We, thus, investigated the association between glucagon levels and metabolic syndrome in T2DM patients. This cross-sectional study involved 317 T2DM patients. Fasting and postprandial (30 min after ingestion of a standard mixed meal) glucagon levels were measured. Metabolic syndrome was defined according to the criteria of the International Diabetes Federation. A multiple regression logistic analysis was employed for statistical evaluation. A total of 219 (69%) subjects had metabolic syndrome. The fasting and postprandial glucagon levels did not differ between the group with metabolic syndrome and the group without. Postprandial glucagon levels increased significantly with the increase in the number of metabolic syndrome components, but the fasting levels did not. However, a hierarchical logistic regression analysis revealed that the postprandial glucagon levels did not contribute significantly to metabolic syndrome even after adjusting for other covariates. Fasting and postprandial glucagon levels are not associated with metabolic syndrome in T2DM patients. However, further studies are needed to investigate the relationship between glucagon and cardiovascular risk in patients with T2DM.

• International Journal of Highway Engineering
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• v.8 no.3 s.29
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• pp.1-19
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• 2006

Researches on method for quantitative analysis applied with decision-making in consideration of variation in risk factors based on GIS(Geographic Information System) concluded as follows. Firstly, by way of decision-making in consideration of variation in risk factors, quantitative analysis performed for the existing route was applied to the new route, which would bring about reliable criteria in route planning and basic design stage. Secondly, horizontal and vertical alignment were easily available out of GIS for relatively speedy design and analysis with three dimensional alignment by decision-making in route planning. Thirdly, automation of route alignment is possible by utilizing quantitative evaluation system established in this research so that a risk analysis can be carried out in a relatively short time. Therefore it will eventually contribute to further development of road design technology.

• Korean Journal of Radiology
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• v.21 no.5
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• pp.598-604
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• 2020

Objective: Proper management of lymph nodes (LNs) with ultrasonographic (US) indeterminate features in thyroid cancer patients remains elusive. We aimed to evaluate the malignancy risk and US findings predictive of malignancy for US indeterminate LNs in preoperative thyroid cancer patients through node-by-node correlation. Materials and Methods: A total of 348 LNs in 284 thyroid cancer patients, who underwent fine-needle aspiration or core-needle biopsy between December 2006 and June 2015, were included. We determined the malignancy risks for US probably benign, indeterminate, and suspicious categories. For US indeterminate LNs, which had neither echogenic hilum nor hilar vascularity in the absence of any suspicious finding, US findings were compared between benign and metastatic LNs using Mann-Whitney U test and Fisher's exact test. Results: US imaging diagnoses were probably benign in 20.7% (n = 72) cases, indeterminate in 23.6% (n = 82), and suspicious in 55.7% (n = 194). Malignancy risk of US indeterminate LNs (19.5% [16/82]) differed from those of the US probably benign (2.8% [2/72]) (p = 0.002) and US suspicious LNs (78.4% [152/194]) (p < 0.001). Among US indeterminate LNs, there were no significant differences in short, long, and long-to-short diameter (L/S) ratios between benign and metastatic LNs (3.9 vs. 3.8 mm, p = 0.619; 7.3 vs. 7.3 mm, p = 0.590; 1.9 vs. 1.9, p = 0.652). Conclusion: US indeterminate LNs were frequently encountered during preoperative evaluation and had intermediate malignancy risk. Given the lack of discriminative power of size criteria and L/S ratio, clinical factors such as surgical strategy and node size should be considered for proper triage of US indeterminate LNs in thyroid cancer.

• Journal of Acupuncture Research
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• v.35 no.2
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• pp.61-68
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• 2018

Background: This study was performed to review the efficacy of national and international randomized controlled trials (RCT) investigating Chuna manipulative treatment for ankle sprains. Methods: Online databases (PubMed, Cochrane, EMBASE, CNKI, NDSL, OASIS), were searched for studies where Chuna treatment was performed for ankle sprains up to October 12th, 2017. Only RCT were selected that fulfilled the inclusion/exclusion criteria. Data were analyzed using the Cochrane risk of bias tool. Results: There were 676 studies retrieved from the databases, resulting in analysis of 24 RCT. There was an average of 7 treatment visits over a 7 day period and the most frequent evaluation tool used was efficacy rate, with drug therapy being the most common control used in the trials. In 15 RCT, several Chuna methods were used in combination, amongst which, the osteopathic technique was most common. Statistically significant improvement in evaluation indices was reported in 19 RCT, and in 3 RCT, statistically significant improvement was reported, but not for all indices. In the remaining 2 RCT, there were no significant differences in any of the evaluation indices. No adverse reactions were reported in any of the RCT, although it was unknown whether all the trial protocols indicated that adverse reactions should be monitored, and for this reason, the risk of bias was unclear. Conclusion: The review of 24 studies suggest that Chuna manipulative treatment for ankle sprains was effective in most cases, although, potential bias in these studies was difficult to evaluate.

• KSCE Journal of Civil and Environmental Engineering Research
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• v.26 no.1D
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• pp.169-175
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• 2006

Recently, slope failures are disastrous when they occur in mountainous area adjoining highways. The accidents associated with slope failures have increased due to rapid urbanization of mountainous area. Therefore, the inspection of slope is conducted to maintain road safety as well as road function. In this study, we apply to the remedy which is comparing existent description to advanced technology using GIS. We utilize a Terrestrial LiDAR, one of the advanced method, to generate precise and complete road slope model from expert point of view. In result, we extract hazardous slope information from external measurements referring to the evaluation criteria of external slope stability. We suggest not only the database but also the method of road risk evaluation based on internet GIS.

• Journal of Navigation and Port Research
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• v.44 no.4
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• pp.291-297
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• 2020

In recent years, an increase in deaths and injuries of port cargo handling workers, has raised the need for more effective accident management. The purpose of this study was to evaluate the accident risk for port cargo handling workers and assess ports with high accident risk within the Korean alternative ports using the Entropy & GRA (Grey Relational Analysis). To achieve this purpose, first, 11 Korean ports were selected and the evaluative factors for their outranking evaluation by brainstorming were extracted. Second, the Grey Relational Coefficient of 11 alternative ports was calculated using the GRA. This paper, finally, determined the priority orders of accident risk through calculation of the Grey Relational Grade as the link Grey Relational Coefficient method and the weights of the evaluative factors were calculated by using the Entropy method. In the proposed model, eight criteria such as cargo worker, old cargo worker, work hours, facilities environment, steel cargo volumes, cargo volumes, injury numbers, and death numbers were collected. Busan port was identified as highest accident risk port, and so it should be a top priority to develop a plan to mitigate the risk.

• Fire Science and Engineering
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• v.15 no.1
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• pp.84-92
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• 2001

In today's world, rise in the establishment of social infrastructure resulting from population saturation in large cities has led to more extensive and frequent use of chemical materials on facilities. A result, unexpected and serious accidents, hazards, contingencies and disasters are more prevalent than ever. Such phenomenon calls for more devoted and concerted efforts towards finding ways to reduce the safety hazards that are seen to take place more often than before with the increase in the number of facilities that are prone to bring disaster and hazard coupled with the conventional safety problems that continue to exist even today. In developed countries, such challenge is addressed by various appropriate countermeasures drawn up by local professional committees on industrial facilities, whose members conduct offsite and onsite evaluation un the potential industrial disasters and its seriousness and provide their advice thereof. Against this backdrop, this study aims at identifying a comprehensive safety allowance level (safety acceptable level) when imposing limitation on the development of conventional or new facilities, for the fur pose of establishing a safety allowance level of disastrous and dangerous facilities in Korea. This is done by assessing and applying the level of danger each individual is exposed to in a randomly selected region (disastrous and dangerous areas in Seoul) based on probability of quantitative hazards, as well as simulation and calculation methods which include: i) social disaster evaluation method applying Quantified Risk Assessment of Health & Safety Executive of UK and Matrix of Risk of Evaluated Sources of Hazard; ii) Fault Tree or Event Tree Analysis and etc.

• Asian Pacific Journal of Cancer Prevention
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• v.17 no.sup3
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• pp.323-335
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• 2016

Breast cancer risk assessment has developed during years and evaluation of genetic factor affecting risk of breast cancer is an important component of this risk assessment. The aim of this meta-analysis was to investigate the role of XRCC1 polymorphisms (Arg194Trp, Arg280His and Arg399Gln) in risk of breast cancer among different population and categories of menopausal status.PubMed, Medline, Web of Science, and PubMed Central were systematically searched to identify studies evaluating association between breast cancer and XRCC1 gene polymorphisms (Arg194Trp, Arg280His and Arg399Gln). Two authors independently extracted required information. Odds Ratios were pooled for four genetic inheritance models using both fixed and the DerSimonian and Laird random-effect models. Egger's test and contour-enhanced funnel plot was used to evaluate publication bias and small study effect. Additional subgroup analysis was performed for menopausal status, ethnicity, and source of controls. After evaluation and applying inclusion criteria on extracted studies, fifty three studies were included in this meta-analysis. For polymorphisms of Arg194Trp and Arg280His, no significant association was observed in all genetic models. Arg194Trp had a protective effect in post-menopausal status only in homozygote model (OR=0.57 [0.37-0.88]). Arg399Gln showed significant association with breast cancer in homozygote (OR=1.21 [1.10-1.34]), dominant (OR=1.09 [1.03-1.15]) and recessive (OR=1.21 [1.09- 1.35]) genetic models. Arg399Gln was associated with higher risk in post-menopausal status for homozygote and heterozygote models. Our findings suggest that XRCC1 gene polymorphisms modify breast cancer risk in different populations and different categories of menopausal status.

• Journal of KIBIM
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• v.7 no.4
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• pp.21-30
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• 2017

Due to the rapidly aging population, the death rate of elderly people by safety accidents has been increasing. In particular, precautions are needed for falls prevention because they either directly or indirectly cause death. In the case of elderly people, most of the fall accidents occur in dense residential areas, and particularly, the staircase poses a risk of falling. Therefore, a safety assessment should be performed from the design phase. However, in general, staircases are designed using existing stair data or only aims to satisfy the installation criteria. Laws and regulations only define minimum requirements for safety, so it is not possible to prevent fall accidents even if they satisfy the requirements. Therefore, this study proposes a simulation-based method for evaluating the safety of staircases. The behavioral characteristics of the elderly are implemented to an virtual user in a virtual space including staircases, and fall accidents are evaluated by the evaluation logic related to the behavioral characteristics. The result shows that the safety of staircases can be preevaluated and reflected on the design to reduce the possibility of fall accidents of the elderly.

• Journal of the Society of Disaster Information
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• v.7 no.2
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• pp.96-109
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• 2011

In this study, risk categorized five safety management elements(equipment and structure, evacuation, lifesaving and fire extinguishing, performance based fire safety plan, operations management) were classified in order to establish safety system of underground space. Using classified safety management elements, assessment of fire hazard was performed. After calculating the grade of evaluation categories, assessment of fire hazard was suggested. The three grades of evaluation categories are classified as to importance and four criteria of evaluation are classified as to check result based on subdivisions.