• Asian Pacific Journal of Cancer Prevention
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• 제16권8호
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• pp.3457-3461
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• 2015

Background: Previous studies have suggested that Morinda citrifolia (Noni) has potential to reduce cancer risk. Objective: The purpose of this study was to investigate the effect of Noni, cisplatin, and their combination on DNA repair genes in the SiHa cervical cancer cell line. Materials and Methods: SiHa cells were cultured and treated with 10% Noni, $10{\mu}g/dl$ cisplatin or their combination for 24 hours. Post culturing, the cells were pelleted, RNA extracted, and processed for investigating DNA repair genes by real time PCR. Results: The expression of nucleotide excision repair genes ERCC1, ERCC2, and ERCC4 and base excision repair gene XRCC1 was increased 4 fold, 8.9 fold, 4 fold, and 5.5 fold, respectively, on treatment with Noni as compared to untreated controls (p<0.05). In contrast, expression was found to be decreased 22 fold, 13 fold, 16 fold, and 23 fold on treatment with cisplatin (p<0.05). However, the combination of Noni and cisplatin led to an increase of 2 fold, 1.6 fold, 3 fold, 1.2 fold, respectively (p<0.05). Conclusions: Noni enhanced the expression of DNA repair genes by itself and in combination with cisplatin. However, high expression of DNA repair genes at mRNA level only signifies efficient DNA transcription of the above mentioned genes; further investigations are needed to evaluate the DNA repair protein expression.

• Asian Pacific Journal of Cancer Prevention
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• 제14권5호
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• pp.3045-3050
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• 2013

Purpose: Hepatic resection is arguably the preferred treatment for huge hepatocellular carcinoma (H-HCC). Estimating the remnant liver volume is therefore essential. This study aimed to evaluate the feasibility of using computer-assisted volumetric analysis for this purpose. Methods: The study involved 40 patients with H-HCC. Laboratory examinations were conducted, and a contrast CT-scan revealed that 30 cases out of the participating 40 had single-lesion tumors. The remaining 10 had less than three satellite tumors. With the consensus of the team, two physicians conducted computer-assisted 3D segmentation of the liver, tumor, and vessels in each case. Volume was automatically computed from each segmented/labeled anatomical field. To estimate the resection volume, virtual lobectomy was applied to the main tumor. A margin greater than 1 cm was applied to the satellite tumors. Resectability was predicted by computing a ratio of functional liver resection (R) as (Vresected-Vtumor)/(Vtotal-Vtumor) x 100%, applying a threshold of 50% and 60% for cirrhotic and non-cirrhotic cases, respectively. This estimation was then compared with surgical findings. Results: Out of the 22 patients who had undergone hepatectomies, only one had an R that exceeded the threshold. Among the remaining 18 patients with non-resectable H-HCC, 12 had Rs that exceeded the specified ratio and the remaining 6 had Rs that were < 50%. Four of the patients who had Rs less than 50% underwent incomplete surgery due to operative findings of more extensive satellite tumors, vascular invasion, or metastasis. The other two cases did not undergo surgery because of the high risk involved in removing the tumor. Overall, the ratio of functional liver resection for estimating resectability correlated well with the other surgical findings. Conclusion: Efficient pre-operative resectability assessment of H-HCC using computer-assisted volumetric analysis is feasible.

• 자동차안전학회지
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• 제7권2호
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• pp.15-18
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• 2015

The availability of in-depth accident data is a prerequisite for each efficient traffic safety management system. Identification and definition of the relevant problem together with knowledge of the data and parameters describing this problem is essential for its successful solution. Comprehensive, up-to-date, accident data is needed for recognition of the scope of road safety problems and for raising public awareness. Reliable and relevant data enable the identification of the contributory factors of the individual accidents, and an unveiling of the background of the risk behaviour of the road users. It offers the best way to explore the prevention of accidents, and ways to implement measures to reduce accident severity. In this study, reviewing the existing iGlad and GIDAS system, KIDAS data format can be finalized through feasibility evaluation. The progressive approach is proposed to successful settlement of Korea in-depth accident study. As the initial stage of in-depth investigation DB construction, the KIDAS is not repetition of the current police based TAAS. It is essential part of improving vehicle safety and reduction of traffic fatality in Korea. 72 Contributing factors like road and traffic characteristics, vehicle parameters, and information about the people involved in the accident have to be investigated and registered as well in the KIDAS.

• 한국정보시스템학회지:정보시스템연구
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• 제12권2호
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• pp.129-149
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• 2003

One of the important applications in Enterprise Resource Planning(ERP) systems is the Manufacturing Resource Planning(MRPII) system using Bill of Material(BOM). The manufacturing resource planning determines the quantity and timing of the production or purchase of subassemblies and raw materials needed to support the Master Production Scheduling(MPS). The bill of material is the recipe, a list of the materials needed to make a product. This paper intends to suggest a component-based materials management system using Unified Modeling Language(UML), as an application system for automobile part industry. Applying component based materials management systems designed with UML methodology, we analyzed the workflow and the document on materials management process from production planning to inventory management, and implemented a prototype of efficient materials management system, as a surrogate of existing material requirement planning(MRPI) system. To produce many other assemblies for a automobile part firm, component parts are assembled into subassemblies that are joined to assemble the finished product. Through the system suggested in this study, the level of inventory has cut down and the cost of inventory management has decreased. Also, the development method using UML makes the analysis and design phase to shorten in implementation period of MRPII system. The implementation of materials management system using CBD shows the ease of use in software reuse and the interoperability with corporate Internal information system. The result of applying object-oriented CBD technique is to minimize the risk of life cycle and facilitate the reuse of software as mentioned to limitation of information engineering methodology.

• 한국정보통신학회논문지
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• 제19권8호
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• pp.1797-1804
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• 2015

통합로그관리시스템은 보안 위험 사항을 예측하고 기관의 보안성 향상에 기여하여 적합한 보안 정책을 마련할 수 있도록 도와준다. 본 논문에서는 대용량의 로그 데이터를 저장할 수 있는 분산 데이터베이스 모델과 로그 수집 절차를 자동화하여 분석 시간을 줄일 수 있는 하둡 기반의 로그 분석 시스템을 설계하고 구현하였다. 제안하는 시스템에서는 HBase를 사용하여 데이터 용량에 따라 Scale-Out 방식으로 유연하게 저장할 수 있게 하였고 정규식을 이용하여 분석에 용이한 저장 기법을 제안하여 기존 시스템 대비 분석 속도를 높일 수 있다.

• KSBB Journal
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• 제27권6호
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• pp.381-386
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• 2012

Obesity increases the risk of many adult diseases, such as atherosclerosis, diabetes, hypertension, ischemic heart disease and breast cancer. Inhibition of adipogenesis is an effective way in the anti-obesity management. Because of main components of Saururus chinensis is flavonoid, it has been showed some improvement by its antioxidant effects on the atherosclerosis, heart disease and diabetic hyperlipidemia. But mechanism of anti-obesity effect of S. chinensis is not clear. We investigated the effects of ethanol extracts of S. chinensis on adipogenesis in the 3T3-L1 pre-adipocyte. The 3T3-L1 cell line is commonly used to study adipogenesis in vitro. In this study, ethanol extracts of S. chinensis significantly decrease the lipid accumulation in the 3T3-L1 cells proved by measuring triglyceride contents and Oil red O staining. The proposed mechanism of inhibition of adipogenesis in the 3T3-L1 cells with ethanol extracts of S. chinensis is down-regulation of transcriptional factors and adipocyte-specific genes such CCAAT/enhancer binding protein ${\alpha}$ ($C/EBP{\alpha}$) and Peroxisome proliferator activated receptor ${\gamma}$ ($PPAR{\gamma}$) in concentration dependent pattern. These results suggest that ethanol extracts of S. chinensis inhibits adipognesis in the 3T3-L1 cells and can be used as a safe and efficient natural substance to manage anti-obesity.

• 한국정보과학회논문지:정보통신
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• 제31권2호
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• pp.146-157
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• 2004

이동 사용자에게 지속적인 서비스품질 보장을 제공하기 위해서는 일반적으로 사용자 방문할 것으로 예상되는 지역에 사전에 중복적으로 자원을 예약하는 방안을 사용한다. 이와 같은 방식에서 관건이 되는 문제는 중복적 자원 예약에 의한 자원 낭비를 줄이면서도 서비스품질 보장의 연속성을 유지하는 것이다. 본 논문에서는 지리적으로 인접한 두 개의 무선 네트워크 도메인 사이에 두 도메인에 모두 속하는 그레이 셀을 두는 무선 네트워크 구조를 제안하고, 이를 이용하여 무선 네트워크에서의 중복적인 자원 예약을 완전히 제거하면서도 도메인 간 이동으로 인한 일시적 자원 예약 단절을 크게 줄일 수 있는 방안을 제안하였다. 시뮬레이션을 통하여 제안한 방안은 도메인 간 이동이 발생하는 경우에도 도메인 내에서 이동 할 때와 유사한 성능을 보이며, 예약 단절 시간이나 패킷 손실율면에서 기존의 방법보다 훨씬 나은 성능을 제공함을 볼 수 있었다.

• 정보처리학회논문지D
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• 제9D권6호
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• pp.1043-1054
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• 2002

본 논문은 국내 자동차산업을 대상으로 개발된 응용시스템으로, UML(Unified Modeling Language)을 이용한 XML(eXtensible Markup Language)기반의 안전한 전자조달(E-Procurement) 시스템을 제안하고 있다. 컴포넌트 개발기법인 UML 방법론의 활용으로 자동차산업의 구매업무 Workflow가 분석되었으며, XML 기반의 EDI(Electronic Data Interchange)와 전자서명 기능을 구현함으로써 기업간 구매업무를 자동화하는 효율적인 E-Procurement 시스템 프로토타입이 구현되었다. 또한 본 논문은 기존 정보공학방법론에서 한계로 지적되던 S/W의 재사용성과 Life Cycle의 위험을 줄인 컴포넌트 개발기법을 활용하고, 기업내 Legacy 시스템인 ERP와의 연동을 가능하게 하였다. 본 시스템은 기존 시스템이 제공하지 못하는 워크플로우(workflow)분석 및 설계, 컴포넌트 개발, 기업내부 시스템과의 연동, 그리고 전자문서의 무결성과 인증을 위한 XML 전자서명을 적용하는 해법을 제안하고 있다.

• 한국통신학회논문지
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• 제35권4B호
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• pp.620-629
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• 2010

지상파 아날로그 텔레비전 방송의 종료시기가 확정됨에 따라 텔레비전 방송의 디지털화에 많은 관심이 집중되고 있어 상대적으로 라디오의 디지털화는 논의의 우선순위에서 밀려나 있지만, 라디오 방송의 디지털 전환 추진도 더 이상 미루기 어려운 시점이라 할 수 있다. 디지털라디오 방송은 아날로그 라디오 방송의 고유한 입지를 고수 하면서 청취자에게 CD 수준의 음질과 다양한 데이터서비스를 제공하여 수용자의 편익과 복지 향상에 기여할 것으로 기대된다. 디지털라디오 방송이 시장에 도입되어 활성화되기 위해서는 수용자들의 디지털라디오에 대한 이용 의향이 요구된다. 그러므로 디지털라디오 방송이 수용자들에 의해 채택되고, 이를 바탕으로 확산이 일어나는데 영향을 미치는 요인들에 대한 면밀한 고찰이 필요한 시점이다. 본 논문에서는 디지털라디오 방송에 대한 산업적 관심과 원활한 수요창출을 유도할 수 있는 방안을 모색하기 위하여, 설문조사를 통해 디지털라디오 방송의 이용에 영향을 미치는 요인들을 분석하였다. 이를 통해 향후 디지털라디오 방송이 시작될 경우 수용자의 이해를 바탕으로 디지털라디오 방송시장의 활성화 가능성과 디지털라디오 방송이 제공해야 할 기술적 특성과 서비스의 방향성을 제시하고자 하였다.

• 한국발생생물학회지:발생과생식
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• 제23권4호
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• pp.367-375
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• 2019

Pufferfish (Takifugu spp.) are economically important edible marine fish. Mistakes in pufferfish classification can lead to poisoning; therefore, accurate species identification is critical. In this study, we used the mtDNA cytochrome c oxidase subunit I gene (COI) to design specific primers for six Takifugu species among the 21 domestic or imported pufferfish species legally sold for consumption in Korea. We rapidly and simultaneously identified these pufferfish species using a highly efficient, multiplex polymerase chain reaction (PCR) system with the six species-specific primers. The results showed that species-specific multiplex PCR (multiplex species-specific polymerase chain reaction; MSS-PCR) either specifically amplified PCR products of a unique size or failed. MSS-PCR yielded amplification fragment lengths of 897 bp for Takifugu pardalis, 822 bp for T. porphyreus, 667 bp for T. niphobles, 454 bp for T. poecilonotus, 366 bp for T. rubripes, and 230 bp for T. xanthpterus using the species-specific primers and a control primer (ca. 1,200 bp). We visualized the results using agarose gel electrophoresis to obtain accurate contrasts of the six Takifugu species. MSS-PCR analysis is easily performed and provides identification results within 6 h. This technique is a powerful tool for the discrimination of Takifugu species and will help prevent falsified labeling, protect consumer rights, and reduce the risk of pufferfish poisoning..