• Asian Pacific Journal of Cancer Prevention
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• v.16 no.8
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• pp.3457-3461
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• 2015

Background: Previous studies have suggested that Morinda citrifolia (Noni) has potential to reduce cancer risk. Objective: The purpose of this study was to investigate the effect of Noni, cisplatin, and their combination on DNA repair genes in the SiHa cervical cancer cell line. Materials and Methods: SiHa cells were cultured and treated with 10% Noni, $10{\mu}g/dl$ cisplatin or their combination for 24 hours. Post culturing, the cells were pelleted, RNA extracted, and processed for investigating DNA repair genes by real time PCR. Results: The expression of nucleotide excision repair genes ERCC1, ERCC2, and ERCC4 and base excision repair gene XRCC1 was increased 4 fold, 8.9 fold, 4 fold, and 5.5 fold, respectively, on treatment with Noni as compared to untreated controls (p<0.05). In contrast, expression was found to be decreased 22 fold, 13 fold, 16 fold, and 23 fold on treatment with cisplatin (p<0.05). However, the combination of Noni and cisplatin led to an increase of 2 fold, 1.6 fold, 3 fold, 1.2 fold, respectively (p<0.05). Conclusions: Noni enhanced the expression of DNA repair genes by itself and in combination with cisplatin. However, high expression of DNA repair genes at mRNA level only signifies efficient DNA transcription of the above mentioned genes; further investigations are needed to evaluate the DNA repair protein expression.

• Asian Pacific Journal of Cancer Prevention
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• v.14 no.5
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• pp.3045-3050
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• 2013

Purpose: Hepatic resection is arguably the preferred treatment for huge hepatocellular carcinoma (H-HCC). Estimating the remnant liver volume is therefore essential. This study aimed to evaluate the feasibility of using computer-assisted volumetric analysis for this purpose. Methods: The study involved 40 patients with H-HCC. Laboratory examinations were conducted, and a contrast CT-scan revealed that 30 cases out of the participating 40 had single-lesion tumors. The remaining 10 had less than three satellite tumors. With the consensus of the team, two physicians conducted computer-assisted 3D segmentation of the liver, tumor, and vessels in each case. Volume was automatically computed from each segmented/labeled anatomical field. To estimate the resection volume, virtual lobectomy was applied to the main tumor. A margin greater than 1 cm was applied to the satellite tumors. Resectability was predicted by computing a ratio of functional liver resection (R) as (Vresected-Vtumor)/(Vtotal-Vtumor) x 100%, applying a threshold of 50% and 60% for cirrhotic and non-cirrhotic cases, respectively. This estimation was then compared with surgical findings. Results: Out of the 22 patients who had undergone hepatectomies, only one had an R that exceeded the threshold. Among the remaining 18 patients with non-resectable H-HCC, 12 had Rs that exceeded the specified ratio and the remaining 6 had Rs that were < 50%. Four of the patients who had Rs less than 50% underwent incomplete surgery due to operative findings of more extensive satellite tumors, vascular invasion, or metastasis. The other two cases did not undergo surgery because of the high risk involved in removing the tumor. Overall, the ratio of functional liver resection for estimating resectability correlated well with the other surgical findings. Conclusion: Efficient pre-operative resectability assessment of H-HCC using computer-assisted volumetric analysis is feasible.

• Journal of Auto-vehicle Safety Association
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• v.7 no.2
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• pp.15-18
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• 2015

The availability of in-depth accident data is a prerequisite for each efficient traffic safety management system. Identification and definition of the relevant problem together with knowledge of the data and parameters describing this problem is essential for its successful solution. Comprehensive, up-to-date, accident data is needed for recognition of the scope of road safety problems and for raising public awareness. Reliable and relevant data enable the identification of the contributory factors of the individual accidents, and an unveiling of the background of the risk behaviour of the road users. It offers the best way to explore the prevention of accidents, and ways to implement measures to reduce accident severity. In this study, reviewing the existing iGlad and GIDAS system, KIDAS data format can be finalized through feasibility evaluation. The progressive approach is proposed to successful settlement of Korea in-depth accident study. As the initial stage of in-depth investigation DB construction, the KIDAS is not repetition of the current police based TAAS. It is essential part of improving vehicle safety and reduction of traffic fatality in Korea. 72 Contributing factors like road and traffic characteristics, vehicle parameters, and information about the people involved in the accident have to be investigated and registered as well in the KIDAS.

• The Journal of Information Systems
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• v.12 no.2
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• pp.129-149
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• 2003

One of the important applications in Enterprise Resource Planning(ERP) systems is the Manufacturing Resource Planning(MRPII) system using Bill of Material(BOM). The manufacturing resource planning determines the quantity and timing of the production or purchase of subassemblies and raw materials needed to support the Master Production Scheduling(MPS). The bill of material is the recipe, a list of the materials needed to make a product. This paper intends to suggest a component-based materials management system using Unified Modeling Language(UML), as an application system for automobile part industry. Applying component based materials management systems designed with UML methodology, we analyzed the workflow and the document on materials management process from production planning to inventory management, and implemented a prototype of efficient materials management system, as a surrogate of existing material requirement planning(MRPI) system. To produce many other assemblies for a automobile part firm, component parts are assembled into subassemblies that are joined to assemble the finished product. Through the system suggested in this study, the level of inventory has cut down and the cost of inventory management has decreased. Also, the development method using UML makes the analysis and design phase to shorten in implementation period of MRPII system. The implementation of materials management system using CBD shows the ease of use in software reuse and the interoperability with corporate Internal information system. The result of applying object-oriented CBD technique is to minimize the risk of life cycle and facilitate the reuse of software as mentioned to limitation of information engineering methodology.

• Journal of the Korea Institute of Information and Communication Engineering
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• v.19 no.8
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• pp.1797-1804
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• 2015

Integrated log management system can help to predict the risk of security and contributes to improve the security level of the organization, and leads to prepare an appropriate security policy. In this paper, we have designed and implemented a Hadoop-based log analysis system by using distributed database model which can store large amount of data and reduce analysis time by automating log collecting procedure. In the proposed system, we use the HBase in order to store a large amount of data efficiently in the scale-out fashion and propose an easy data storing scheme for analysing data using a Hadoop-based normal expression, which results in improving data processing speed compared to the existing system.

• KSBB Journal
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• v.27 no.6
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• pp.381-386
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• 2012

Obesity increases the risk of many adult diseases, such as atherosclerosis, diabetes, hypertension, ischemic heart disease and breast cancer. Inhibition of adipogenesis is an effective way in the anti-obesity management. Because of main components of Saururus chinensis is flavonoid, it has been showed some improvement by its antioxidant effects on the atherosclerosis, heart disease and diabetic hyperlipidemia. But mechanism of anti-obesity effect of S. chinensis is not clear. We investigated the effects of ethanol extracts of S. chinensis on adipogenesis in the 3T3-L1 pre-adipocyte. The 3T3-L1 cell line is commonly used to study adipogenesis in vitro. In this study, ethanol extracts of S. chinensis significantly decrease the lipid accumulation in the 3T3-L1 cells proved by measuring triglyceride contents and Oil red O staining. The proposed mechanism of inhibition of adipogenesis in the 3T3-L1 cells with ethanol extracts of S. chinensis is down-regulation of transcriptional factors and adipocyte-specific genes such CCAAT/enhancer binding protein ${\alpha}$ ($C/EBP{\alpha}$) and Peroxisome proliferator activated receptor ${\gamma}$ ($PPAR{\gamma}$) in concentration dependent pattern. These results suggest that ethanol extracts of S. chinensis inhibits adipognesis in the 3T3-L1 cells and can be used as a safe and efficient natural substance to manage anti-obesity.

• Journal of KIISE:Information Networking
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• v.31 no.2
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• pp.146-157
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• 2004

In order to provide continuous QoS guaranteed to a mobile user, it is required to deploy some kind of mechanisms which reserves resources in advance at the locations to which the mobile user is expected to move. An important issue with regards to these mechanisms is to minimize the waste of resources caused by redundant reservations while keeping up the QoS guaranteed services to the user In this paper, we propose a wireless network domain structure which deploys a special cell, called “a gray cell”. The boundaries of two or more neighboring domains are surrounded by the gray cells, and the gray cells are supposed to belong to all of its neighboring domains. Based on this wireless domain structure, we propose a mechanism which completely removes the waste of redundant resource reservation in the wireless network domain while greatly reducing the risk of reservation disruption caused by inter-domain handover. Using simulation, it is shown that the proposed mechanism can deal with inter-domain handover as effectively as it does with intra-domain handover. It is also presented that the proposed mechanism outperforms existing mechanisms with respect to reservation disruption time and packet losses caused by handovers.

• The KIPS Transactions:PartD
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• v.9D no.6
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• pp.1043-1054
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• 2002

This paper intends to suggest a XML-based secure E-Procurement system using Unified Modeling Language(UML), as an application system for domestic automobile industry. Applying UML methodology, which is Component-based Development (CBD), we analyzed the workflow on procurement operation of automobile industry and implemented a prototype of efficient E-Procurement system for automobile industry, by developing XML/EDI and XML signature. Also, on this paper, object-oriented CBD is employed to minimize the risk of life cycle and reuse software as mentioned to limitation of information engineering methodology. It enables the interoperability with ERP (Enterprise Resource Planning) as corporate legacy system. This system proposes a solution to apply analysis and design of workflow, component development, interoperability with corporate information system, and XML signature for integrity and authentication of electronic documents in other system so far.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.35 no.4B
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• pp.620-629
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• 2010

The analogue radio broadcasting was proven to be a successful and efficient media of delivering information because of free content and wide availability of cheap receivers. But the competition was more dropped than any other media due to the limited amount of radio spectrum that is available. The risk of doing nothing is to miss the opportunity and to loss existing audiences in the long term, or to be locked into inefficient proprietary systems. That is the reason why it is important to act now. It is time for regulators and market participants to hone their strategies, by clearly establishing factors to adopt the digital radio and to facilitate its diffusion. The purpose of this study is to find adoption factors that affected to potential users of digital radio broadcasting. Former research based on diffusion of innovation theory showed that adoption of innovation is affected by demographic variables, media usage and consumer's attitude of innovation. In this study based on a consumer survey, we examined those factors and characteristics of each steps that suggested in diffusion of innovation theory. The findings of this study have implications to explore the suitable technologies and services of digital radio broadcasting.

• Development and Reproduction
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• v.23 no.4
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• pp.367-375
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• 2019

Pufferfish (Takifugu spp.) are economically important edible marine fish. Mistakes in pufferfish classification can lead to poisoning; therefore, accurate species identification is critical. In this study, we used the mtDNA cytochrome c oxidase subunit I gene (COI) to design specific primers for six Takifugu species among the 21 domestic or imported pufferfish species legally sold for consumption in Korea. We rapidly and simultaneously identified these pufferfish species using a highly efficient, multiplex polymerase chain reaction (PCR) system with the six species-specific primers. The results showed that species-specific multiplex PCR (multiplex species-specific polymerase chain reaction; MSS-PCR) either specifically amplified PCR products of a unique size or failed. MSS-PCR yielded amplification fragment lengths of 897 bp for Takifugu pardalis, 822 bp for T. porphyreus, 667 bp for T. niphobles, 454 bp for T. poecilonotus, 366 bp for T. rubripes, and 230 bp for T. xanthpterus using the species-specific primers and a control primer (ca. 1,200 bp). We visualized the results using agarose gel electrophoresis to obtain accurate contrasts of the six Takifugu species. MSS-PCR analysis is easily performed and provides identification results within 6 h. This technique is a powerful tool for the discrimination of Takifugu species and will help prevent falsified labeling, protect consumer rights, and reduce the risk of pufferfish poisoning..