• 대한약리학회지
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• 제18권1호
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• pp.65-72
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• 1982

It has been known that retinoids are intrinsically of critical importance for control of premalignant epithelial cell differentiation. In the absence of retinoids, normal cellular differentiation and growth does not occur in epithelia such as those of trachea and bronchi. Furthermore, it was also reported that retinoid deficiency enhanced susceptibility to chemical carcinogenesis in the respiratory system, in the bladder, and in the colon of the experimental animal. In 1974, Bollag examined the effects of synthetic retinoids in prevention of development of cancer and demonstrated synthetic retinoids to have more favorable therapeutic index than retinoic acid for causing regression of skin papilloma in mice. Therefore, it was assumed that this anticarcinogenic effect of vitamin A derivatives could be due to modification of the metabolism of the carcinogenic polycyclic hydrocarbon, which must first be activated to exert their effect. Hill and Shih reported that vitamin A compounds and analogs had inhibitory effect on drug metabolizing enzyme from liver and lung tissue of mouse and hamster. Lucy suggested that the chemoprevention effect of vitamin A derivatives is due to reaction with molecular oxygen, and it is possible that inhibition of hydroxybenzpyrene formation is a result of this property. On the other hand, butylated hydroxytoluene which is a potent antioxidant strongly inhibited the formation of mammary tumor induced by dimethylbenranthracene. Also, it was observed that this antioxidant inhibited cancer induction in rats by N-2-fluo-renylacetamide. The purpose of this experiment was to investigate the effect of vitamin A derivatives such as retinoic acid and retinoid on drug-metabolizing enzyme and to determine whether riboflavin tetrabutylate or vitamin E could prevent of modify any changes induced by vitamin A delivatives in the rats. The results obtained were as followings. 1) Body weight was significantly reduced by retinoic acid, but not by retinoid. 2) Retinoic acid markedly increased liver weight while retincid showed no effect on liver weight. Treatment of riboflavin tetrabutylate did not affect retinoic acid-induced change in both body weight and liver weight. 3) Both retinoic acid and retinoid remarkably decreased the activity of aminopyrine demethylase. Pretreatment of riboflavin tetrabutylate, however, prevented inhibitory effect of retinoic acid on the enzyme activity. 4) No significant effect of vitamin E on aminopyrine demethylase was observed in both groups treated with retinoic acid and retinoid.

• 한국식품영양과학회지
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• 제22권5호
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• pp.552-558
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• 1993

아동복지시설 7곳의 미취학아동 70명을 대상으로 신체발육과 영양실태를 조사한 결과 다음과 같은 결론을 얻었다. 조사대상 아동들의 신장, 체중 및 멀리둘레는 한국 소아 발육 표준치보다 다소 적었으며 가슴둘레는 거의 비슷한 경향으로 나타났다. 따라서 이들의 체격발달이 일반 한국 소아의 발육에 비해 다소 떨어짐을 알 수 있다. 또한 식이섭취조사결과 한국인 영양 권장량에 비해 모든 아동들에게서 칼슘의 섭취량이, 또 일부 아동에게서 열량, 철분, 비타민 $B_2$의 섭취량이 다소 낮아서 이들 영양소의 섭취를 보충해야 할 것으로 판단된다. 조사대상 아동들의 생화학적 검사결과 철분 결핍 팔현율은 hemoglobin으로 판정시에는 12.9%, hematocrit으로 판정시에는 18.6%이엇으며 혈청 철분 정상 판정기준 미만인 아동들은 총 인원이 4.3%에 해당하였다. 혈청 총 단백은 정상인 것으로 판명되었다. 따라서 영양상태가 취약한 아동복지시설에서의 영양관리가 효율적으로 이루어지기 위해서는 영양관리 담당 전문인력의 확보 및 여러 사회기관에서의 급식비에 대한 보조지원으로 아동들이 충분히 영양섭취를 할 수 있는 적극적인 지원이 있어야 할 것으로 사료된다.

• Journal of Nutrition and Health
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• 제38권7호
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• pp.578-585
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• 2005

Maternal zinc deficiency is relatively common worldwide, but its consequences for pregnancy outcome are not established. The purpose of this study was to examine the effect of zinc status in the second trimester on pregnancy outcome. Subjects were 248 pregnant Korean women (25-28 wk gestation). Cord blood was collected from subgroup of 69 women and pregnancy outcome data were obtained from 185 babies. Anthropometry measurement, dietary intake, and biochemical characteristics of pregnancy and cord serum substances were measured. The subjects were divided into quartiles on the basis of maternal serum Zn concentration; $ZnQ_1$ (< 25 percentile), $ZnQ_2$ ($26\~50$ percentile), $ZnQ_3$ ($51\~75$ percentile), and $ZnQ_4$ ($76\~100$ percentile). Zn groups were compared in terms of various maternal factors, concentrations of cord serum substances, and pregnancy outcome. Maternal serum Zn concentration was $118.4\;{\pm}\;35.5\;{\mu}g/dl$ as mean. Intake of Zn was lower than Korean RDA. The rate of Zn deficiency among all subjects was $8.5\%$. Maternal serum Zn levels belonged to normal range. Cord serum Zn level was about $154.7\%$ of maternal serum level. Intakes of energy, calcium, iron, folic acid, and riboflavin did not meet the Korean RDA for pregnant women by gestational age. The mean birth weight of neonates is 3083 $\pm$ 697 g, of whom $9.1\%$ were of low birth weight (< 2,500 g). Maternal serum Zn level was positively correlated with pre-pregnancy weight, pre-pregnancy body mass index, and vitamin C intake (p < 0.05). $ZnQ_1$ group had significantly lower maternal serum iron concentration and higher cord serum cholesterol than those in other groups. Maternal serum Zn level, cord serum Zn level, and dietary Zn intake were no related to the pregnancy outcome. The birth weight had a correlation with the maternal hemoglobin and albumin concentration. In conclusion, at this study, we could not find the association with maternal Zn status in 2nd trimester and pregnancy outcome.

• 대한지역사회영양학회지
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• 제8권3호
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• pp.302-310
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• 2003

This study was undertaken to assess nutritional status of the low income elderly residing in Gwangju. Anthropometric data showed that mean height of the subjects was lower than that of Korean Standard Growth data but weight was similar to that standard value. As the subjects became older, their heights and weights were decreased. Body mass index (BMI) in males and females were 22.9 and 24.4 respectively. However, BMI distribution showed that 56% of the elderly females under 75 were underweight. Advancing age conoibutes significant difference in triceps skinfold thickness in females (p < 0.001). Total cholesterol level was higher in the elderly females than the males. It was found that a considerable number of subjects had anemia determined by hemoglobin and hematocrit level, which indicated un iron deficiency. Twenty-four hour dietary recall revealed that, except for phosphorus and vitamin C, all the nutrient intakes of the subjects were below 75％ of Korean RDA. Surprisingly, vitamin A and riboflavin intakes of the elderly were below 50％ of Korean RDA. Energy intakes of the elderly males and females were 58.7% and 59.6% of Korean RDA respectively. Unbalanced energy ratios of carbohydrate, protein and fat were noted in both genders. Nutrient intakes of females' were lower than those of males'. Thus, there was a significant gender difference in nutrient intakes. It might be further suggested that an appropriate nutritional program should be developed and implemented to improve the Poor nutritional status of the low income elderly living in cities.

• Journal of Community Nutrition
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• 제6권2호
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• pp.67-77
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• 2004

In order to investigate the differences of nutrient intakes by the economic status and different age groups and to identify the nutritional risk group and its specific nutrition problem, 2001 Korean National Health and Nutrition Survey were analyzed. The subject's numbers of 9,391 were classified into four classes such as low (14.2%), medium (37.2%), high (26.0%), and high above (22.6%) on the basis of the family monthly income and the 2001 Korean minimum cost of living according to the family size. Mean intakes of energy and all nutrients assessed by the RDAs, lipid-energy %, and MAR were increased as the economic status were going up. Na intake expressed per 1,000kcal was in reverse. Nearly a half(45.5%) of the low-income people seemed to take nutritionally inadequate diet in consideration with MAR values. Deficiencies of iron and even energy in the toddlers (1 to 2 years) of low-income class were of great concern. Adolescent age group has been observed that their calcium and iron intakes, and possibly energy, were appeared to be the most deficient among all the age groups regardless of the economic status. For the elderly in all the economic status except high-above class, calcium, vitamin A, and riboflavin were commonly deficient nutrients. Calcium deficiency was appeared throughout nearly all the ages except toddlers and all the economic classes. Even in the high-above class 57.3% took insufficient amount of calcium.

• 대한가정학회지
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• 제20권3호
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• pp.35-43
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• 1982

The purpose of this survey was to investigate the nutrient and food intake and haematology of the latter half of pregnant women in Nam Hae Do. The nutrient intake study was performed by Twenty-four hour dietary recall method. As Haematology, RBC, Hb. and Hct were measured. 1. The results of nutritional survey were, 1) The mean nutrient intakes that were below the RDA were Protein, Calorie, Calcium and Iron. 2) The mean nutrient intakes that were above the RDA were Vitamin A, Thiamin, Riboflavin, Ascorbic acid. 3) Most of calorie and other nutrients were obtained from vegetable food sources. 4) Animal protein intake was 33% of total protein intake and most of this value was obtained from fish and shell fishes. 2. The extent of malnutrition was explained in terms of the amount of calorie, protein, calcium and iron. The results were, The predicted percentage of deficiency, in case of Calorie, 53.3% of total subjects. in case of Protein, 52% of total subjects. in case of Calcium, 78.7% of total subjects. in case of Iron, 54.7% of total subjects. 3. The results of Haematology were, 1) The mean level of RBC, Hb and Hct were 3.76$\times$106cm/㎣, 10.47gm%, and 32.56% 2) There were significant correlation between calorie intake and Hct level, protein intake and RBC level, Iron intake and MCHC level.

• Journal of Nutrition and Health
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• 제32권2호
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• pp.175-181
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• 1999

The prevalence of alcoholism among elderly population is reported to be high in rural areas in Korea. Chronic abuse of alcohol can lead to the development of vitamin B deficiency through inadequate intake, altered absorption and metabolism, and increased excretion. The present study was conducted to assess vitamin B1 and B2 status in seventeen alcohol dependent subjects who do not exhibit any clinical neurological symptoms. Vitamin B1 and B2 nutritional states were determined enzymatically by measurement of transketolase and glutathione reductase activities in erythrocytes, respectively. And dietary intakes of nutrients were determined by a 24-hr recall method. The mean percent activation of erythrocyte transketolase was significantly higher in alcoholics than in alcoholics than in control (p<0.05). The proportion of subjects with a low and borderline status of vitamin B1, was significantly higher in alcoholics than in control (p<0.05). The mean percent activation of erythrocyte glutathione reductase was not different between alcoholics and control. And the proportion of subjects with low and borderline status of Vitamin B2, was higher in alcoholics than in control (p<0.1). Vitamin B1 and B2 status were significantly decreased in alcoholics who were smoking cigarettes compared to non-smoking and non-alcoholic subjects(p<0.05). Whether vitamin supplementation improves the vitamin status of alcohol dependent subjects remains to be researched.

• 대한지역사회영양학회지
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• 제9권4호
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• pp.491-500
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• 2004

To assess the quality of nutrient intake by area of Korean adults, a dietary survey with the 3-day record method was obtained from 324 subjects aged 40 years and older but younger than 70 (52.4 $\pm$ 8.7) living in a rural area (Ansung) and suburban area of a middle-sized city (Ansan). The quality of nutrient intake was assessed by analyzing Nutrient Adequacy Ratio (NAR), Mean Adequacy Ratio (MAR) and Index of Nutritional Quality (INQ). The average daily mean energy intakes were 1,832 ㎉ for Ansung and 1,842 ㎉ for Ansan, respectively. Daily intakes of fat for Ansung and Ansan subjects were 40.9 and 40.3 g, and those for protein were 75.1 and 73.1 g, respectively. The overall calorie: protein: fat ratio (CPF) of energy intake was 63 : 17 : 20. Daily mean intakes of protein, fat, calcium, phosphorus, iron, potassium, carotene, sodium, thiamin, and niacin were significantly higher in Ansung residents than in Ansan subjects (p < .05). The average intakes of energy, calcium, vitamin A were lower than Recommend Dietary Allowance (RDA) in both areas. Note, over 30% of the study subjects had less than 75% of RDA of calcium, vitamin A and riboflavin. The MAR was higher in Ansung than Ansan residents (0.86 and 0.85, respectively; p < .05). INQs were over 1 for most nutrients except calcium (0.87), and that of calcium and phosphorus was each significantly higher in Ansung than Ansan subjects. Based on these results, nutrient intake quality of subjects aged 40 to 69 years living in the surveyed rural area is comparable to that of semi-industrialized suburban area in Korea. Dietary deficiency in all of calcium, vitamin A, and riboflavin, however, was a common problem for both rural and suburban residents.

• Journal of Nutrition and Health
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• 제18권1호
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• pp.5-13
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• 1985

The purpose of this study was to provide the proper nutritional management, and help to improve the health of girl students in a rural area. The nutritional survey, and blood sampling was conducted for five days, from April 26 to 30, 1983. The subjects of this survey were 110 students of girl's high school in Cheongyang area. The results were summerized as follows; 1) The daily food intake was 842.3g and that of animal foods was 34.4g. The average intake of calorie, protein, Ca, Fe, thiamin, riboflavin and niacin except Vit. A and Vit. C was below the RDA. Total calorie intake was l,802kcal. The ratio of carbohydrate, protein and fat was 81:11:8. 2) The extent of malnutrition was explained in terms of the amount of calorie, protein, Ca, Fe, and Vit. C. The predicted percentage of deficiency was 47.3% in calorie, 46.4% in protein, 61.8% in Ca, 48.2% in Fe, and 15.5% in Vit C of total subjects. 3) The mean values of Hgb, Hct and MCHC were 13.15g/dl, 39.57% and 33.2%, thus, the anemic prevalences were 10.9%, 2% and 78.2% respectively. The mean values of SI.TIBCand TS were $109.86{\mu}g$/61, $317.11{\mu}g/dl$ and 34.59%. 4) The correlation between the economic levels and nutrients intake was significant. Correlation between weight and nutrients intake was also significant but nutrients intake was not significantly correlated to blood contents.

• Journal of Nutrition and Health
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• 제4권4호
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• pp.57-67
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• 1971

Cross-sectional studies of adults located in different regions were undertaken to measure changes in food intake and nutritional status. Representativeness of the selected areas was proven through a pilot study and an inquiry into some written materials, and those areas were as following: 1) Mountainous area 2) Farming area 3) Coastal Area 4) City Area The nutrition survey was undertaken by students of the College of Home Economics as follow: 60 children (out of the 25% given detailed examination) and their families were randomly selected for the nutrition survey. The survey team was composed of 30 students of the College of Home Economics. Each member of the survey team was assigned to make home visits to two families in order to obtain information on kinds and amounts of food consumed for three days. Degree of food consumption was measured by weighing the food was calculated in the same manner. Average adult unit for calories and protein in the four study areas was 0.81 and 0.98 with little variation. The total calories ranged from 2,114 Cal to 2,311 Cal. and the protein intake averaged from 57 gm to 67 gm. The calories taken by people of Kaejong were composed of carbohydrate (82% -87%), fat (3%-6%) and protein (10%-12%). Kaejong recorded a sufficient intake of fat and protein. All of the four study areas had a deficiency problem in intake of calcium, vitamin A. thiamine, riboflavin and ascorbic acid.