• 한국환경농학회지
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• 제40권1호
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• pp.1-12
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• 2021

BACKGROUND: G protein-coupled receptors (GPCRs) are widely distributed in various organisms. Insect GPCRs shown as in vertebrate GPCRs are membrane receptors that coordinate or involve in various physiological processes such as learning/memory, development, locomotion, circadian rhythm, reproduction, etc. This study aimed to identify GPCRs expressed in fat body and compare the expression pattern of GPCRs in different temperature conditions. METHODS AND RESULTS: To identify GPCRs genes and compare their expression in different temperature conditions, total RNAs of fat body in Plutella xylostella larva were extracted and the transcriptomes have been analyzed via next generation sequencing method. From the fat body transcriptomes, genes that belong to GPCR Family A, B, and F were identified such as opsin, gonadotropin-releasing hormone receptor, neuropeptide F (NPF) receptor, muthuselah (Mth), diuretic hormone receptor, frizzled, etc. Under low temperature, expressions of GPCRs such as C-C chemokine receptor (CCR), opsin, prolactin-releasing peptide receptor, substance K receptor, Mth-like receptor, diuretic hormone receptor, frizzled and stan were higher than those at 25℃. They are involved in immunity, feeding, movement, odorant recognition, diuresis, and development. In contrast to the control (25℃), at high temperature GPCRs including CCR, gonadotropin-releasing hormone receptor, moody, NPF receptor, neuropeptide B1 receptor, frizzled and stan revealed higher expression whose biological functions are related to immunity, blood-brain barrier formation, feeding, learning, and reproduction. CONCLUSION: Transcriptome of fat body can provide understanding the pools of GPCRs. Identifications of fat body GPCRs may contribute to develop new targets for the control of insect pests.

• 공연문화연구
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• 제39호
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• pp.669-700
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• 2019

풍물굿은 신성한 종교의식이고, 이는 인간이 절대적인 존재에게 바치는 신성한 행사이다. 종교의식에는 공동체 집단의식으로서 제의적인 행동이 수반되고, 음악은 그 중 가장 핵심적인 제의적 요소이다. 즉, 종교와 종교의식은 인간이 만든 것이다. 풍물굿 가락은 풍물굿의 종교성과 신성성을 소리로 구현하는 종교적 의미를 갖는다. 그리고 풍물굿 가락은 인간의 제의성을 발현하는 음악적 상징을 갖기도 한다. 풍물굿의 채굿은 한 가락에 쳐지는 징의 점수에 따라 가락 이름을 부여한다. 즉, 가락 이름이라는 기표(記標)와 가락이라는 기의(記意)를 직접적으로 지칭하는 음악적 기호의 전형적인 사례이다. 그러므로 채굿은 인간이 '만든' 인위적인 가락이다. 이글에서는 채굿의 형성원리를 규명하여 채굿의 제의적 상징성을 밝히고자 한다. 채굿은 삼채~칠채가 기본이다. 그 원리는 조선시대 군사 훈련의 기본진법인 오방진법(五方陳法)의 '고진금퇴가(鼓進金退歌)'의 원리에 따른 것이다. 조선 초기 간행된 각종 병서에서 진법의 기본원리가 된 오방진법은 북과 징의 '오타(五打)'의 원리에 의해 작동한다. 북과 징의 '오타' 원리는 진법 계획을 반영한 것이다. 그리고 '오타'의 구조원리가 채굿 형성의 토대가 되었을 것으로 여겨진다. "채굿의 원형"으로 꼽히는 곡성죽동농악의 삼채~칠채는 기본형인 삼채 가락에 3소박 2장단 가락이 하나씩 더해지면서 다섯 개의 가락인 사채~칠채 가락을 만든다. 삼채 가락은 우리나라에서 가장 흔한 3소박 4박 장단에 징을 제1, 2, 3박에 3점 치는 가락이다. 삼채 가락은 징을 3점 쳐서 '리듬적 요란함(rhythmic noise)'을 통한 규정된 일탈을 통해 제의성을 담지한 가락이다. 그리고, 징 3점에 따라 이름을 붙여서 '삼채 '라는 기표와 삼채 가락이라는 기의가 일치하는 상징성을 갖게 된다. 징 3점의 '삼채' 가락을 기본으로 3소박 2박씩 징이 1점 들어가는 가락을 더해서 사채~칠채 가락이 완성된다. 즉, 삼채~칠채 가락은 오방진법의 '오타' 구조원리가 반영된 것이다. 여기에 오래되고 제의성을 담보한 혼소박 4박의 일채 가락이 더해지고, 일채와 삼채 가락의 다리 역할을 위하여 징을 2점 치는 이채 가락이 더해진다. 이것이 채굿의 형성원리이다. 오채질굿은 징 5점의 '오채'와 제의적 가락인 '질굿(길굿)'이 혼합된 것이다. 오채질굿은 5장단으로 구성된 가락으로서, 각 장단의 매 첫 박에 징 1점이 들어가는 가락이다. 이는 동남아시아 등지에서 흔히 발견되는 콜로토믹(colotomic) 음악형식의 반영으로서, 조선 초기 각종 음악에서 나타나는 '고요편쌍(鼓搖鞭雙)' 장구형의 흔적이기도 하다. 길군악칠채도 징 7점의 '칠채'와 제의적 가락인 '길군악(길굿)'이 혼합된 것이다. 길군악칠채는 3장 형식으로서 경기 지역의 평시조 및 <노랫가락>과 음악적 특징을 공유한다. 결국 채굿은 인간에 의해 인위적으로 만들어진 가락이다. 채굿은 징점에 의한 가락의 이름이라는 기표와 음악적 가락이라는 기의가 일치하게 만들어진 가락이다. 그러므로 채굿은 종교적 제의성을 위해 인위적으로 고도의 음악만들기(music-making)의 원리로 만든 가락이다.

• 한국발생생물학회지:발생과생식
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• 제5권2호
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• pp.181-187
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• 2001

포유동물의 혈중 프로락틴 농도는 일주기와 연주기의 변화를 나타내며 송과체에서 분비되는 멜라토닌이 조절인자로 관여한다. 인위적인 송과체의 기능 억제는 혈중 프로락틴 농도를 증가시킨다. 임신 후반기에 태반에서는 수종의 프로락틴군 호르몬들이 분비되어 태반기능 및 배아발생에 중요한 역할을 한다. 그러나 이들 호르몬 유전자들의 발현 조절기작과 조절 인자들에 관한 연구 결과는 미비하다. 본 연구에서는 RT-PCR과, in situ hybridization 방법으로 흰쥐의 태반에서 Me $l_{la}$ 유전자의 발현을 확인하였다. 발현되는 주요 세포는 junctional zone과 labyrinth zone의 spongiotrophoblast 세포와 trophoblast giant세포였다. 특이한 것은junctional zone의 Me $l_{la}$ 유전자의 발현이 밤시간(22:00)에 비하여 낮시간(16:00)에 높게 조사되었다. 그리고 멜라토닌 수용체 agonist인 chloromelatonin은 PLP-A 유전자의 발현을 억제하였다. 이러한 결과들로 보아 흰쥐의 태반에서 Me $l_{la}$ 유전자가 발현되며, 멜라토닌에 의해 유도되는 Me $l_{la}$ 의 활성화는 PLP-A유전자의 발현에 중요한 조절인자로 작용할 것이다.

• 인간행동과 음악연구
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• 제15권2호
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• pp.69-92
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• 2018

본 연구는 노래만들기 중재가 인공와우이식청소년의 자기표현 능력 향상을 가져오는지 알아보기 위한 사례연구이다. 본 연구의 노래만들기 중재는 인공와우이식자의 음악지각에 관한 선행연구 결과를 반영하여 CI이식청소년의 성공적인 자기표현 경험을 위해 구성되었다. 단계적으로 구성된 노래만들기와 음악테크놀로지(예, iPad의 GarageBand)가 활용되었다. 두 명의 CI이식청소년이 연구에 참여하였고, 중재는 주 1회씩 총 8주간 제공되었다. 결과분석을 위해 중재 과정 중 변화 양상이 중요함에 따라 자기표현과 관련한 언어적 비언어적 행동과 음악적 반응의 변화를 서술하였다. 연구 결과 노래만들기 중재에 참여한 대상자들은 공통적으로 음악을 통한 자기표현의 자신감 향상과 단순한 자기표현에서 자신의 정서 및 의견을 표현으로의 변화가 관찰되어, 자기표현 능력의 향상에 긍정적인 변화를 확인할 수 있었다. 결과적으로 인공와우이식에 따른 청지각적 특징을 반영한 음악 중재가 성취감 및 긍정적인 자기표현 경험을 도울 수 있음을 확인하였으며, 이는 추후 인공와우이식자를 대상으로 노래만들기 연구가 지속적으로 수행될 필요가 있음을 시사한다.

• 조형예술학연구
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• 제10권
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• pp.183-218
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• 2006

Colors change in time corresponding with the value system and aesthetic consciousness of the time. The roles that colors play in painting can be divided into the formative role based on the contrast and harmony of color planes and the aesthetic role expressed by colors to represent the objects. The aesthetic consciousness of the orient starts with the Civility(禮) and Pleasure(樂), which is closely related with restrained or tempered human feelings. In the art world of the orient including poem, painting, and music, what are seen and felt from the objects are not represented in all. Added by the sentiment laid background, the beauty of the orient emphasizes the beauty of restraint and temperance, which has long been the essential aesthetic emotion of the orient. From the very inception of oriental painting, colors had become a symbolic system in which the five colors associated with the philosophy of Yin and Yang and Five Forces were symbolically connected with the four sacred animals of Red Peacock, Black Turtle, Blue Dragon, and White Tiger. In this color system the use of colors was not free from ideological matters, and was further constrained by the limited color production and distribution. Therefore, development in color expression seemed to have been very much limited because of the unavailability and unreadiness of various colors. Studies into the flow in oriental painting show that color expression in oriental painting have changed from symbolic color expression to poetic expression, and then to emotional color expression as the mode of painting changes in time. As oriental painting transformed from the art of religious or ceremonial purpose to one of appreciation, the mast visible change in color expression is the one of realism(simulation). Rooted on the naturalistic color expression of the orient where the fundamental properties of objects were considered mast critical, this realistic color expression depicts the genuine color properties that the objects posses, with many examples in the Flower & Bird Painting prior to the North Sung dynasty. This realistic expression of colors changed as poetic sentiments were fused with painting in later years of the North Sung dynasty, in which a conversion to light ink and light coloring in the use of ink and colors was witnessed, and subjective emotion was intervened and represented. This mode of color expression had established as free and creative coloring with vivid expression of individuality. The fusion of coloring and lyricism was borrowed from the trend in painting after the North Sung dynasty which was mentioned earlier, and from the trend in which painting was fused with poetic sentiments to express the emotion of artists, accompanied with such features as light coloring and compositional change. Here, the lyricism refers to the artist's subjective perspective of the world and expression of it in refined words with certain rhythm, the essence of which is the integration of the artist's ego and the world. The poetic ego projects the emotion and sentiment toward the external objects or assimilates them in order to express the emotion and sentiment of one's own ego in depth and most efficiently. This is closely related with the rationale behind the long-standing tradition of continuous representation of same objects in oriental painting from ancient times to contemporary days. According to the thoughts of the orient, nature was not just an object of expression, but recognized as a personified body, to which the artist projects his or her emotions. The result is the rebirth of meaning in painting, completely different from what the same objects previously represented. This process helps achieve the integration and unity between the objects and the ego. Therefore, this paper discussed the lyrical expression of colors in the works of the author, drawing upon the poetic expression method reflected in the traditional Flower and Bird Painting, one of the painting modes mainly depending on color expression. Based on the related discussion and analysis, it was possible to identify the deep thoughts and the distinctive expression methods of the orient and to address the significance to prioritize the issue of transmission and development of these precious traditions, which will constitute the main identity of the author's future work.

• IMMUNE NETWORK
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• 제15권2호
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• pp.100-109
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• 2015

Controlling balance between T-helper type 1 (Th1) and T-helper type 2 (Th2) plays a pivotal role in maintaining the biological rhythm of Th1/Th2 and circumventing diseases caused by Th1/Th2 imbalance. Interleukin 4 (IL-4) is a Th2-type cytokine and often associated with hypersensitivity-related diseases such as atopic dermatitis and allergies when overexpressed. In this study, we have tried to elucidate the function of 1-palmitoyl-2-linoleoyl-3-acetyl-rac-glycerol (EC-18) as an essential modulator of Th1/Th2 balance. EC-18 has showed an inhibitory effect on the production of IL-4 in a dose-dependent manner. RT-PCR analysis has proved EC-18 affect the transcription of IL-4. By analyzing the phosphorylation status of Signal transducer and activator of transcription 6 (STAT6), which is a transcriptional activator of IL-4 expression, we discovered that EC-18 induced the decrease of STAT6 activity in several stimulated cell lines, which was also showed in STAT6 reporter analysis. Co-treatment of EC-18 significantly weakened atopy-like phenotypes in mice treated with an allergen. Collectively, our results suggest that EC-18 is a potent Th2 modulating factor by regulating the transcription of IL-4 via STAT6 modulation, and could be developed for immune-modulatory therapeutics.

• 복식문화연구
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• 제24권4호
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• pp.441-456
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• 2016

This study considers the modern expression of oriental esthetics by analyzing the fashion design with the Chinese ink technique based on the concept of Chi-Yun-Sheng-Tung, which was regarded as the best rule of art creation in oriental history. This study was performed by conducting a literature review of related books and advanced studies, and then, collection analysis was done with photos derived from fashion websites (seoulfashionweek.org, chinafashionweek.org, vogue.com, firstview. com) from 2010 S/S to 2016 S/S. A total of 317 fashion photos of designs created using the Chinese ink technique by Korean designers at Seoul Fashion Week and Chinese designers at China Fashion Week were analyzed. The contemporary fashions created with the Chinese ink technique were characterized by, first, the bold brush strokes and natural spreading effects of Chinese ink, second, the emphasis of empty space by taking essential elements, and third, the coexistence of deep Chinese ink colors with modern primary colors. The formativeness of the contemporary fashions created with Chinese ink technique based on Chi-Yun-Sheng-Tung were as follows: first, temperance, pursuing spiritual and minimal expression, second, empty space, making design elements interact and pursue harmony, third, changeable rhythm, symbolizing the growth and variation revealing the power of life, and fourth, vitality, represented in the rhythmical movement of the brush. This study was based on the oriental esthetics inherent in Chi-Yun-Sheng-Tung, and it attempted to analyze contemporary fashion design. The aim was to show the possibility of modern applications to traditional values, and it can be a meaningful case in design planning based on culture.

• 복식문화연구
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• 제18권5호
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• pp.1003-1016
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• 2010

The purpose of this study is to reorganize any rusty image including natural modeling characteristic presented from the natural phenomenon to certain patterns in order to create the fashion design that are valued in the expansion of independently expressional area and modeling art. As a method for research, the author analyzed the concept and characteristic for rust with a base of theoretical background by the documental research and realistic consideration, analyzed its modeling characteristic through domestic and overseas pictures, and e-documents as data, inspected the modeling activities of various categories that various images were adapted related to rust, looked into the concept of Digital Textile Printing and its producing procedure as an expressional method, and analyzed the examples of modern dress and its ornament making use of Digital Textile Printing. The conclusions of this study are as below. First, the rust occurred due to the natural phenomenon is the bond with different material like metal, each unique modeling characteristic occurs and harmony of various patterns has abundant aesthetic value. Second, the author could endowed sensible characteristic and speciality with works and could produce creative fashion design that painting, abstractive pattern and harmony of unique sense of colors are significant by using the image of rust, Third, to emphasize natural feeling of rust, the author could develop creative design that simple silhouette and impressive pattern look significant by reorganizing and applying rust according to repetition, increment, rhythm, contract, emphasis and harmony. Fourth, Digital Textile Printing method is used to induce visual effect by the expression of feels of rust, and the author could express the natural patterns, delicate expression for the feels of a material and unique design of emotion.

• 복식문화연구
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• 제31권4호
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• pp.504-518
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• 2023

The objective of this study was to explore the symbolism associated with phoenix patterns in China and the temporal aesthetic characteristics of these patterns found in Dunhuang Mogao Grottoes. The study involved collecting examples of clothing designs featuring phoenix patterns from China Fashion Week and the Vogue website, spanning from spring and summer of 2016 to fall and winter of 2022. After collecting and organizing these examples, representative cases were selected for analysis. The objective was to identify effective techniques for incorporating phoenix patterns within the context of Dunhuang Mogao Grottoes and provided insights for future clothing design and textile pattern design research. Phoenix patterns boasted a lengthy history and were laden with symbolic meaning. Early renditions of phoenix patterns found at Mogao Grottoes in Dunhuang were relatively simplistic in design, mainly employing elements like rhythm, coordination, balance and symmetry to convey a sense of nature and gravity. Over time, these patterns evolved under the influence of the prevailing cultural backdrop, employing repeated emphasis to portray notions of abundance and tenacity. Furthermore, regarding the use of phoenix patterns in clothing, there were four prevalent expression techniques: embroidery, beading, printing, and knitting. Traditional techniques like embroidery and beadwork often prioritized aesthetic features like coordination, emphasis, and symmetry, thereby showcasing the opulent characteristics of phoenix patterns. On the other hand, printing and knitting techniques used a single phoenix pattern or a modified version to simplify designs by emphasizing or repeating aesthetic characteristics while adhering to a modern artistic approach.

• BMB Reports
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• 제49권11호
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• pp.587-589
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• 2016

The circadian clock system enables organisms to anticipate the rhythmic environmental changes and to manifest behavior and physiology at advantageous times of the day. Transcriptional/translational feedback loop (TTFL) is the basic feature of the eukaryotic circadian clock and is based on the rhythmic association of circadian transcriptional activator and repressor. In Drosophila, repression of dCLOCK/CYCLE (dCLK/CYC) mediated transcription by PERIOD (PER) is critical for inducing circadian rhythms of gene expression. Pacemaker neurons in the brain control specific circadian behaviors upon environmental timing cues such as light and temperature cycle. We show that amino acids 657-707 of dCLK are important for the transcriptional activation and the association with PER both in vitro and in vivo. Flies expressing dCLK lacking AA657-707 in $Clk^{out}$ genetic background, homologous to the mouse Clock allele where exon 19 region is deleted, display pacemaker-neuron-dependent perturbation of the molecular clockwork. The molecular rhythms in light-cycle-sensitive pacemaker neurons such as ventral lateral neurons ($LN_vs$) were significantly disrupted, but those in temperature-cycle-sensitive pacemaker neurons such as dorsal neurons (DNs) were robust. Our results suggest that the dCLK-controlled TTFL diversify in a pacemaker-neuron-dependent manner which may contribute to specific functions such as different sensitivities to entraining cues.