• Journal of Applied Biological Chemistry
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• v.57 no.2
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• pp.103-111
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• 2014

A1E is an extract from traditional Asian medicinal plants that has therapeutic activities against cancers, metabolic disease, and other intractable conditions. However, its mechanism of action on cervical cancer has not been studied. In order to ascertain if A1E would have pronounced anti-cervical cancer effect, cervical cancer cells were incubated with A1E and apoptosis was detected by nuclear morphological changes, annexin V-FITC/PI staining, cell cycle analysis, western blotting, Reverse-transcription polymerase chain reaction, and measurement of mitochondrial membrane potential. Expression of human papiloma virus E6 and E7 oncogenes was down-regulated in A1E-treated cervical cancer cells, while p53 and retinoblastoma protein levels were enhanced. A1E also perturbed cell cycle progression at sub-G1 and altered cell cycle regulatory factors in SiHa cervical cancer cells. A1E activated apoptotic intrinsic pathway markers such as caspase-9, caspase-3 and poly ADP-ribose polymerase, and down-regulated expression of Bcl-2 and Bcl-xl. A1E induced mitochondrial membrane potential collapse and cytochrome c release, and inhibited phosphatidylinositol 3-kinase (PI3K)/Akt, key factors involved in cell survival signaling. Taken all these results, A1E induced apoptosis via activation of the intrinsic pathway and inhibition of the PI3K/Akt survival-signaling pathway in SiHa cervical cancer cells. In conclusion, A1E exerts anti-proliferative action growth inhibition on cervical cancer cells through apoptosis which demonstrates its anti-cervical cancer properties.

• Journal of Navigation and Port Research
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• v.33 no.1
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• pp.57-63
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• 2009

In order to effectively isolate the marine wastes with an effluent standard, the pretreatment process is required to isolate solid materials from the liquid-solid mixed wastes. The more effective the pretreatment becomes, the more processing capacity of posttreatment will be improved and process facilities will be downsized. In this paper, we suggested the vibrating reverse-slant screen, investigated the optimal vibration frequency and vibrator installation angle for the separation of the liquid solid mixed wastes. Several experiments for separation efficiency were conducted under the condition of various vibration frequency($35{\sim}60Hz$, 5Hz interval) and vibrator angle($0^{\circ}$, $30^{\circ}$, $45^{\circ}$, $90^{\circ}$) considering the crack of screen. The screen inclination angle is set up the gradient as $3^{\circ}{\sim}5^{\circ}$ through the preliminary experiments. Also, we made two types of screen(respectively rectangle and square screen). The separation device has shown the optimum efficiency at vibrator angle $0^{\circ}$ and vibration frequency 60Hz, and has no relation with the shape of screen. And the proposed technology is verified by comparing with quantity of suspended solids before and after filtration.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.19 no.6
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• pp.9-20
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• 2018

When a large-scale photovoltaic (PV) system is introduced into a distribution system, the customer's voltage may exceed the allowable limit ($220V{\pm}6%$) due to voltage variations and reverse power flow in the PV system. In order to solve this problem, we propose a method for adjusting the customer voltage using the existing step voltage regulator (SVR) installed in the primary feeder. However, due to the characteristics of a mechanically operating SVR, the customer voltage during the tap changing time of the SVR is likely to deviate from the allowable limit. In this paper, an energy storage system (ESS) with optimal operation strategies, and an appropriate capacity calculation algorithm are proposed, and the parallel driving scheme between the SVR and the ESS is also proposed to solve the customer voltage problem that may occur during the tap changing time of the SVR. The simulation results show that the allowable limit of the customer voltage is verified by the proposed methods during the tap changing time of the SVR when the large-scale PV system is connected to the distribution system.

• Archives of Plastic Surgery
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• v.36 no.5
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• pp.605-610
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• 2009

Purpose: Substantial tissue necrosis after snake bites requiring coverage with flap surgery is extremely rare. In this article, we report 7 cases of soft tissue defects in the upper and the lower extremities caused by snake bites, which needed to be covered with flaps. Among the vast mass of publications on snake bites there has been no report that focuses on flap coverage of soft tissue defects due to snake bite sequelae. Methods: Seven cases of soft tissue defects with tendon, ligament, or bone exposure after snake bites were included. All patients were males without comorbidities, the average age was 35 years. All of them required coverage with a flap. In 6 cases, the defect was localized on the upper extremity, in one case the lesion was on the lower extremity. Local flaps were used in 6 cases, one case was covered with a free flap. The surgical procedures included one kite flap, one cross finger flap and digital nerve reconstruction with a sural nerve graft, one reverse proximal phalanx island flap, one groin flap, one adipofascial flap, one neurovascular island flap, and one anterolateral thigh free flap. The average interval from injury to flap surgery was 23.7 days. Results: All flaps survived without complication. All patients regained a good range of motion in the affected extremity. Donor site morbidities were not observed. The case with digital nerve reconstruction recovered a static two point discrimination of 7 mm. The patient with foot reconstruction can wear normal shoes without a debulking procedure. Conclusion: The majority of soft tissue affection after snake bites can be treated conservatively. Some severe cases, however, may require the coverage with flap surgery after radical debridement, especially, if there is exposure of tendon, bone or neurovascular structures. There is no doubt that definite coverage should be performed as soon as possible. But we also want to point out that this principle must not lead to a premature coverage. If the surgeon is not certain that the wound is free of necrotic tissue or remnants of venom, it is better to take enough time to get a proper wound before flap surgery in order to obtain a good functional and cosmetic result.

• Applied Chemistry for Engineering
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• v.19 no.3
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• pp.351-356
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• 2008

Titania nanoparticles were prepared by controlled hydrolysis of titanium tetraisopropoxide (TTIP) in water-in-oil (W/O) and microemulsion stabilized with a nonionic surfactant, N P-10 (Polyoxyethylene Nonylphenol Ether: $C_9H_{19}C_6H_4(OCH_2CH_2)_{10}OH$)). The nanosized particles prepared in W/O microemulsion were characterized by FT-IR, TEM, XRD, TGA, and DTA. In addition, the photocatalytic degradation of p-nitrophenol has been studied by using a batch reactor in the presence of UV light in order to compare the photocatalytic activity of prepared nanosized titania. The nanaosized titania particles calcined at $300{\sim}600^{\circ}C$ showed an anatase structure, but it transformed to a rutile phase above $700^{\circ}C$ of calacination temperature. With an increase of $W_o$ ratio, the crystallite size increased but photocalytic activity decreased. The titania synthesized at $W_o=5$, R = 2, and calcined at $400{\sim}500^{\circ}C$ showed the highest activity on the photocatalytic degradation of p-nitrophenol.

• Resources Recycling
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• v.29 no.4
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• pp.3-14
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• 2020

Titanium sponge is industrially produced by the Kroll process. In order to understand the importance of the emerging smelting and recycling process, it is necessary to review the conventional production process of titanium. Therefore this paper provides a general overview of the conventional titanium manufacturing system mainly by the Kroll process. The Kroll process can be divided into four sub-processes as follows: (1) Chlorination of raw TiO₂ with coke, by the fluidized bed chlorination or molten salt chlorination (2) Magnesium reduction of TiCl₄ and vacuum distillation of MgCl₂ and Mg by reverse U-type or I-type with reduction-distillation integrated retorts (3) Electrolysis process of MgCl₂ by monopolar cells or multipolar cells to electrolyze into chlorine gas and Mg. (4) Crushing and melting process in which sponge titanium is crushed and then melted in a vacuum arc furnace or an electron beam furnace Although the apparatus and procedures have improved over the past 80 years, the Kroll process is the costly and time-consuming batch operation for the reduction of TiCl₄ and the separation of MgCl₂.

• Journal of agriculture & life science
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• v.46 no.5
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• pp.1-10
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• 2012

This study analyzed on the characteristics of vegetation structure, species composition and DBH class distribution in order to conservation and effective management for Taxus cuspidata community in Mt. Seorak, Mt. Balwang, Mt. Taebaek, and Mt. Odae. The vegetation in upper, subtree and shrub layer was consist of 11, 22, 33 species in Mt. Seorak, 15, 21, 33 species in Mt. Balwang, 10, 23, 36 species in Mt. Taebaek, and 14, 30, 32 species in Mt. Odae. As a result of importance value at all study sites, T. cuspidata and Abies nephrolepis in upper layer, T. cuspidata, A. nephrolepis and Acer komarovii in subtree layer, and Tripterygium regelii in shrub layer were high, respectively. Species diversity in upper and subtree layer at all study sited were ranged 0.834~1.234 and 1.125~1.329, respectively. According to the DBH class of major three species, T. cuspidata in Mt. Odae site showed a reverse J-shaped curve, which was estimated that T. cuspidata community of this site might be maintained continuously as a stable state.

• Proceedings of the Korean Society of Propulsion Engineers Conference
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• 2008.03a
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• pp.89-96
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• 2008

This paper investigates the effect of blade deformation, caused by manufacturing inaccuracies, on the performance of a 2-stage axial steam turbine. A high fidelity 3D coordinate Measurement Machine has been employed to obtain the exact geometrical model of the blades. A Streamline Curvature solver was used to predict the overall performance of the turbine. During the manufacturing process of the casts and of the blades themselves, several types of errors can occur which lead to a different geometry from that envisaged by the designer. The main objective of this study is to investigate the effect of those errors on the performance of a 2-stage experimental axial steam turbine. A high fidelity measurement of the actual geometry of both stator and rotor blades has been carried out, using a 3D Coordinate Measurement Machine. The cross sections of the blades obtained by the measurement were compared with those produced by the design process to evaluate the change in blade inlet/exit angles. In addition, the geometrical deviations from the initial design have been subjected to a statistical study in order to locate the nature of the error. The actual(measured) model has been used as input into a Streamline Curvature solver to evaluate its performance. Finally, a comparison with the performance plots of the original geometry has been carried out. A measurable change of efficiency as well as in the total power delivered by the turbine was found. This suggests that the accumulated error caused during the manufacturing procedure plays a significant role in the overall performance of the machine by making it less efficient by more than 1%. Reverse engineering techniques are proposed to predict and alleviate these errors leading thereby to a final design of each stage with improved performance.

• Journal of the Korea Society of Computer and Information
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• v.18 no.11
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• pp.39-49
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• 2013

In this paper, security mechanism of internal network(CAN) of vehicle is a very incomplete state and the possibility of external threats as a way to build a test environment that you can easily buy from the market by the vehicle's ECU(Electric Control Unit) to verify and obtain a CAN message. Then, by applying it to ECU of the real car to try to attack is proposed. A recent study, Anyone can see plain-text status of the CAN message in the vehicle. so that in order to verify the information is vulnerable to attack from outside, analyze the data in a vehicle has had a successful attack, but attack to reverse engineering in the stationary state and buying a car should attempt has disadvantages that spatial, financial, and time costs occurs. Found through the car's ECU CAN message is applied to a real car for Potential threats outside of the car to perform an experiment to verify and equipped with a wireless network environment, the experimental results, proposed method through in the car to make sure the attack is possible. As a result, reduce the costs incurred in previous studies and in the information absence state of the car, potential of vehicle's ECU attack looks.

• Journal of Soil and Groundwater Environment
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• v.13 no.3
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• pp.52-58
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• 2008

Mn-impregnated activated carbon (Mn-AC) prepared at different conditions was applied in the treatment of synthetic wastewater containing both organic and inorganic contaminants. Phenol and As(III) was used as the representative organic and inorganic contaminants, respectively. After evaluation of the physicochemical characteristic and stability of Mn-AC, oxidation of As(III) as well as adsorption of phenol by activated carbon(AC) and Mn-AC were investigated in a batch reactor. To investigate the stability of Mn-AC, dissolution of Mn from each Mn-AC was measured pH ranging from 2 to 4. Although Mn-AC was unstable at a strong acidic condition, the dissoluted Mn was below 3 ppm at pH 4. XRD analysis of Mn-AC indicated that the mineral type of the impregnated manganese was $Mn_2O_3$. From the simultaneous treatment of As(III) and phenol by AC and Mn-AC, As(III) oxidation by Mn-AC was greater than that by AC at lower pH, while the reverse order was observed at higher pH. After impregnation of Mn onto AC, 13% decrease of the surface area was observed, causing 8% reduction of phenol removal. Considering removal properties of As(III) and phenol, Mn-AC could be applied in the simultaneous treatment of wastewater contaminated with multi-contaminants.