• Journal of Veterinary Clinics
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• v.19 no.2
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• pp.256-259
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• 2002

A 39 kg, 7-year-old male Labrador Retriever dog with a 3-month history of epistaxis, sneezing, and nasal discharge was referred to the Veterinary Medical Center of the Tokyo University. On the plain X-ray and computed tomography (CT) of the head showed increased density of the soft tissue in the left nasal cavity and the tumor infiltrated to nasal septum. The tumor mass removed by rhinotomy. Histopathological examination of the mass revealed adenocarcinoma. Four weeks after the surgery, the radiation therapy was performed twice a week for f weeks. 4 months after surgery, the dog had a recurrence in nasal cavity and administered carboplatin 300 mg/$m^2$ twice. However, the tumor had no response to chemotherapy, additional surgery and additional radiation therapy, and the dog was euthanized at the owner's request. At necropsy, metastatic proliferation was confirmed in the lung, lymph nodes and nasal cavity.

• Journal of Veterinary Clinics
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• v.15 no.2
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• pp.274-278
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• 1998

The biological father of two Golden Retriever puppies was determined between two proposed stud dogs by using microsatellite DNA analysis. DNA was obtained from all the relevant dogs by buccal swabbing and three loci of tetranucleotide repeat microsatellite were PCR-amplifiedl and analyzed by polyacrylamide gel electrophoresis and silver staining. One of the two proposed stud dogs was assigned as the biological father of the puppies by the genotyping. The result demonstrated that the microsatellite DNA analysis is a simple, efficient method of paternity test in dogs.

• Journal of Veterinary Clinics
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• v.14 no.2
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• pp.297-300
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• 1997

Artificial insemination with frozen canine semen using vaginal endoscope was performed in a two years old Golden Retriever to investigate the feasibility of this technique. The bitch was in her second estrus. Blood progesterone concentration was evaluated every two days to decide the timing of insemination since vaginal bleeding was observed. Insemination was performed twice in 48 hours interval on the fourth and sixth posterior to LH surge, respectively. The volume of frozen semen injected was 1.5 ml $(1{\times}10^{8}$ sperms/1ml of semen). The bitch was pregnant and she whelped a female pup on sixty one days after first insemination.

• Journal of Veterinary Clinics
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• v.36 no.2
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• pp.126-128
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• 2019

A 5-year-old male Labrador Retriever that lived outdoors was presented to the animal hospital with a right hind limb lameness. The lameness had been present for more than 10 days, and there was a severe swelling of the right stifle joint. The dog underwent physical, laboratory, and radiographic examinations. As a result, the dog was diagnosed with infectious monoarthropathy secondary to granulocytic ehrlichiosis. The dog received medication for the rickettsial arthritis and surgical treatment for reconstruction of the soft tissue damage caused by the infection. After treatment, the function of the dog's leg was recovered. This report describes a case of atypical monoarthropathy caused by ehrlichiosis in a dog.

• Korean Journal of Veterinary Research
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• v.61 no.4
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• pp.32.1-32.4
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• 2021

A 12-year-old neutered male Golden Retriever presented with a progressively enlarging mass in the submandibular region. Histopathological diagnosis confirmed lymphangiosarcoma with metastasis to the liver and spleen. The pleomorphic neoplastic endothelial cells of the tumor grow directly on bundles of dermal collagen, forming numerous clefts and interconnecting channels that are devoid of conspicuous hematic elements. As lymphangiosarcoma is an uncommon malignant neoplasm, the number of previously reported cases and information of the tumor is limited. The present report describes the clinical history and histopathological diagnosis of a progressive lymphangiosarcoma in the submandibular region with metastases in a dog.

• Annual Conference on Human and Language Technology
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• 2022.10a
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• pp.146-149
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• 2022

최근 검색 태스크에서는 좋은 negative sample을 얻는 방법론들이 적용되어 큰 성능 향상을 이뤘다. 하지만 좋은 negative sample 대부분의 방법들은 큰 계산 비용이 든다. 따라서 본 논문에서는 계산 비용이 적고 효과적인 negative sample을 얻기 위해 Mixed Gaussian Recurrent Chain (MGRC) sampling을 사용하여 feature 공간상에서 의미론적으로 유사한 feature를 얻고 이를 negative sample로 활용하여 기존 baseline 모델보다 좋은 성능을 얻었다.

• Korean Journal of Veterinary Research
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• v.63 no.2
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• pp.9.1-9.5
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• 2023

A 5-year-old Labrador Retriever presented with a subcutaneous mass on the right scapular region with localized calor. On magnetic resonance imaging (MRI), a heterogeneously hypointense mass was seen on T1-weighted images (WI) and hyperintense on T2WI and fat-suppressed T2WI with marginal contrast enhancement on postcontrast T1WI and invasion into the surrounding tissue. Histopathological examination of the mass confirmed subcutaneous mast cell tumor (MCT) infiltrating to the adjacent subcutaneous fat. This is the first report to describe the MRI findings of subcutaneous MCT in veterinary medicine. This study suggests that MRI may help evaluate the extent of invasion of subcutaneous MCT.

• Annual Conference on Human and Language Technology
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• 2023.10a
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• pp.31-35
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• 2023

최근에는 질의응답(Question Answering, QA) 분야에서 거대 언어 모델(Large Language Models, LLMs)의 파라미터에 내재된 지식을 활용하는 방식이 활발히 연구되고 있다. Open Domain QA(ODQA) 분야에서는 기존에 정보 검색기(retriever)-독해기(reader) 파이프라인이 주로 사용되었으나, 최근에는 거대 언어 모델이 독해 뿐만 아니라 정보 검색기의 역할까지 대신하고 있다. 본 논문에서는 거대 언어 모델의 내재된 지식을 사용해서 질의 응답에 활용하는 방법을 제안한다. 질문에 대해 답변을 하기 전에 질문과 관련된 구절을 생성하고, 이를 바탕으로 질문에 대한 답변을 생성하는 방식이다. 이 방법은 Closed-Book QA 분야에서 기존 프롬프팅 방법 대비 우수한 성능을 보여주며, 이를 통해 대형 언어 모델에 내재된 지식을 활용하여 질의 응답 능력을 향상시킬 수 있음을 입증한다.

• Journal of Veterinary Clinics
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• v.41 no.1
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• pp.18-23
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• 2024

A 13-year-old spayed female Golden Retriever with clinical signs of weight loss and lethargy presented with two esophageal masses and one sessile polyp on computed tomography and esophagoscopy. Endoscopic snare resection was performed, and histopathological examination was requested. Based on histopathology and immunohistochemistry of multiple myeloma oncogene 1 staining, the patient was diagnosed with esophageal extramedullary plasmacytoma. The patient remained clinically well without any clinical signs during a follow-up period of 12 months. Herein, we report the successful diagnosis and management of esophageal extramedullary plasmacytoma in a dog using endoscopy.

• Transactions of the Korean Society of Mechanical Engineers B
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• v.38 no.9
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• pp.739-745
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• 2014

Although medication is given to heart disease patients, conventional medication alone is not sufficient to treat heart disease. However, it has been reported that left ventricular assist device (LVAD) transplantation is an effective bridge to heart transplantation by assisting cardiac function. This study used long-term animal testing and emergency situations with a bovine model (Holstein) and canine model (Labrador-retriever) to evaluate the biocompatibility of LibraHeart-I (LH-1), which is a bent-tube type of LVAD that was developed in a previous study. In the long-term animal testing with the bovine model, the subjects survived for 49 days with no irregularities observed in their complete blood cell counts or the vital sign tests that were carried out during the test period. In short-term animal testing with the canine model, it was observed that blood did not remain inside the LH-I even without power support from an external drive source. In this study, the biocompatibility of the LH-I that was developed in a previous study was verified by the ejection performance during long-term animal testing and emergency situations.