• Molecules and Cells
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• 제45권5호
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• pp.306-316
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• 2022

Chronic stress contributes to the risk of developing depression; the habenula, a nucleus in epithalamus, is associated with many neuropsychiatric disorders. Using genome-wide gene expression analysis, we analyzed the transcriptome of the habenula in rats exposed to chronic restraint stress for 14 days. We identified 379 differentially expressed genes (DEGs) that were affected by chronic stress. These genes were enriched in neuroactive ligand-receptor interaction, the cAMP (cyclic adenosine monophosphate) signaling pathway, circadian entrainment, and synaptic signaling from the Kyoto Encyclopedia of Genes and Genomes pathway analysis and responded to corticosteroids, positive regulation of lipid transport, anterograde trans-synaptic signaling, and chemical synapse transmission from the Gene Ontology analysis. Based on protein-protein interaction network analysis of the DEGs, we identified neuroactive ligand-receptor interactions, circadian entrainment, and cholinergic synapse-related subclusters. Additionally, cell type and habenular regional expression of DEGs, evaluated using a recently published single-cell RNA sequencing study (GSE137478), strongly suggest that DEGs related to neuroactive ligand-receptor interaction and trans-synaptic signaling are highly enriched in medial habenular neurons. Taken together, our findings provide a valuable set of molecular targets that may play important roles in mediating the habenular response to stress and the onset of chronic stress-induced depressive behaviors.

• Steel and Composite Structures
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• 제20권1호
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• pp.57-70
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• 2016

The predominant type of buckling that I-steel concrete composite beams experience in the negative moment area is distortional buckling. The key factors that affect distortional buckling are the torsional and lateral restraints by the bottom flange. This study thoroughly investigates the equivalent lateral and torsional restraint stiffnesses of the bottom flange of an I-steel concrete composite beam under negative moments. The results show a coupling effect between the applied forces and the lateral and torsional restraint stiffnesses of the bottom flange. A formula is proposed to calculate the critical buckling stress of the I-steel concrete composite beams under negative moments by considering the lateral and torsional restraint stiffnesses of the bottom flange. The proposed method is shown to better predict the critical bending moment of the I-steel composite beams. This article introduces an improved method to calculate the elastic foundation beams, which takes into account the lateral and torsional restraint stiffnesses of the bottom flange and considers the coupling effect between them. The results show a close match in results from the calculation method proposed in this paper and the ANSYS finite element method, which validates the proposed calculation method. The proposed calculation method provides a theoretical basis for further research on distortional buckling and the ultimate resistance of I-steel concrete composite beams under a variable axial force.

• 한국전산구조공학회:학술대회논문집
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• 한국전산구조공학회 2001년도 가을 학술발표회 논문집
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• pp.417-424
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• 2001

It is very important to know the magnitude of the restraint moment which is appeared at the inner-support of the continuous PSC girder. The Age-adjusted Effective Modulus Method(AEMM) is used to get the magnitude of the restraint moment for the purpose of the time-dependent analysis of the concrete. The important factors for computing the restraint moment, the creep coefficient and the shrinkage strain are computed by comparing Korean specification with AC1209. The restrain moment is created by the individual continuity load. The main purpose of this paper is ensuring the safety of structure by acquiring the time-dependent stress acting on the concrete because the process of construction is getting difficult due to the advance of technology. The negative moment at the inner-support is decreased about 55% by introducing the process of making the continuous bridge relatively early.

• Structural Engineering and Mechanics
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• 제55권1호
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• pp.1-27
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• 2015

This article presents a theoretical parametric analysis on the ultimate torsional behaviour of axially restrained reinforced concrete (RC) beams. This analysis is performed by using a computing procedure based on a modification of the Variable Angle Truss Model. This computing procedure was previously developed to account for the influence of the longitudinal compressive stress state due to the axial restraint conditions provided by the connections of the beams to other structural members. The presented parametric study aims to check the influence of some important variable studies, namely: torsional reinforcement ratio, compressive concrete strength and axial restraint level. From the results of this parametric study, nonlinear regression analyses are performed and some design charts are proposed. Such charts allow to correct the resistance torque of RC beams (rectangular sections with small height to width ratios) to account for the favorable influence of the axial restraint.

• 대한가정학회지
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• 제34권3호
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• pp.123-136
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• 1996

This report deals with the relations between the vibration restraint and the stress-strain properties of the stretch fabrics. For this purpose, a survey was carried out about the preferences in sports-brassiere. Six experimental sports-brassieres of an equal design, but of different materials were tested for vibration using an accelerometer and a motion analyzer while the subject is jogging. 1. The results of the survey on sports-brassiere preferences are as follows; Preferable factors are simple design, shield and close adhesion of sports brassiere. Dissatisfied factors on the sports-brassiere are drooping, vibrating of the breast, itching and wetting. The B-cup-size group perceive the bigger vibration and drooping than A-cup-size. 2. The results of the wearing tests are as follow; This experiment shows the vibration restraint effects on different stretch fabrics, such as hard, medium and soft nature. There was a linear relationship between the vibration restraint and combination of different types of stretch fabrics. Among different brassiere types, the 2-layered brassiere (inner layer of high tension fabric and outer layer of lower stretch fabric) showed the least vibration. In the case of 2-lay brassiere, the wearing comfort rate was highest.

• Natural Product Sciences
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• 제15권4호
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• pp.213-221
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• 2009

Longanae Arillus (the rind of fruits of Dimocarpus longan) has been consumed for the treatment of insomnia and anxiety in Asia. To provide further scientific basis to traditional uses of this fruit on insomnia, we evaluated the effects of methanol extract of Longanae Arillus (MELA) on the alteration of sleep architecture and electroencephalogram (EEG) power spectra in acutely and chronically restraint-stressed rats. Following postsurgical recovery, Polygraphic signs of sleep-wake activities were recorded for 24 h after MELA administration in rats. Rats in the acute stress and chronic stress were administered with MELA for 10 days. On the $8^{th},\;9^{th}\;and\;10^{th}$ day of MELA administration, the rats were stressed for 3 h once per day. On the $10^{th}$ day and 1 h after MELA administration, the rats were stressed once for 22 h in the chronic stress group. Acute and chronic stress induced alternations in cortex EEG recordings during non-rapid eye movement (NREM), rapid eye movement (REM) sleep and wakefulness. MELA shortened the total and REM sleep and increased the wakefulness in night time recording without changing daytime recordings. Chronic stress increased wakefulness and REM sleep, decreased total and NREM sleep in the daytime recording, and increased REM and decreased NREM sleep without changing total sleep and wakefulness in night time recording. These findings suggest that MELA ameliorated the alterations in REM and NREM sleep of acutely and chronically stressed rats via modulation of cortical ${\alpha}-$, ${\theta}-$ and ${\delta}-$ wave activity.

• Journal of Advanced Marine Engineering and Technology
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• 제11권3호
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• pp.45-52
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• 1987

Generally the factors affected largely by the cold cracking sensitivity of the weld are the quantity of the diffusible hydrogen, the brittleness and hardness of the bond area and the tensile restraint stress. These factors have relation each other, and if we can reduce one of these factors, it becomes instrumental to the root cracks prevention of weld. This study deals with the gravity type-underwater-welding of KR Grade A-3 marine steel plate using E4303 welding electrode in order to compare wet-underwater-welding with in-air- welding, resulting in obtaining the tensile restraint characteristics, the hardness distribution, the quantity of diffusible hydrogen and the macro- and micro-crack properties in both underwater and in-air welds. The main results obtained are as follows: 1) The quantity of diffusible hydrogen measured for 48 hours is about 18cc/100g-weld-metal for the in-air-weld of one pass and about 48cc/100g-weld-metal for the underwater-weld of one pass which is about 3 times penetration of diffusible hydrogen compairing with the case of the in-air-weld. However, it was experimentally confirmed that, by the multi-pass welding of 2 to 5 passes, the diffusible hydrogen in the underwater weld metal can be reduced as much as 27 to 49%. 2) The hardness of the weld metal indicates the highest value in the heat affected zones of underwater weld for more rapid cooling rate, resulting in the higher sensitivity of cold cracking. So, it is desirable to soften the higher hardness in the HAZ by tempering effect such as the multi-pass welding in the underwater welding. 3) At the bond vicinity of the underwater weld HAZ, micro cracks were found as resulted by both more rapid cooling rate and more diffusible hydrogen and also by the stress corrosion cracking under the tensile restraint stress in the underwater. But this could be prevented by the tempering effect of the following weld bead such as the multi-pass welding.

• Journal of Oral Medicine and Pain
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• 제32권1호
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• pp.57-67
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• 2007

현대인들에게는 다양한 증상과 징후를 나타내는 스트레스성 질환이 증가되고 있는 추세에 있다. 이러한 스트레스 시에 구강 내에는 구강건조이나 구강작열감증후군, 구강점막질환, 구취 등이 호발 된다는 것은 이미 널리 알려진 사실이다. 이때 대부분의 환자에서 공통적으로 나타나는 현상은 타액선의 기능적 및 구조적 변화에 따른 타액성분의 변화이다. 이에 저자는 스트레스가 구강 내 타액선에 어떠한 영향을 미치며, 타액선으로부터 분비되는 ${\alpha}$-amylase에 어떠한 영향을 미치는지를 알아보고자 본 실험을 시행한 결과 다음과 같은 유의성 있는 결과를 얻었다. 1. 구속 스트레스에 의하여 타액선 조직은 선포세포가 공포화되며 변성되었고, 선포간극이 이개되었으며, 도관주위조직도 변성되었다. 2. 구속 3시간 후에는 선포세포가 위축되기 시작하였고, 구속 6시간 후에는 선포 간 이개현상이 관찰되었으며, 구속 72시간 후에는 도관 주위 조직도 변성되기 시작하였고, 점차 심화되어 구속 168시간 후에는 선포와 도관 주위조직이 모두 심하게 변성되었다. 3. 면역조직화학적 검사에서 구속 3시간 후에는 amylase의 발현이 부분적으로 불규칙하게 관찰되었으며, 구속 6시간 후에는 다소 감소되었고, 구속 12시간 후에는 amylase가 부분적으로 응집되었으며, 점차 감소되고 응집되어, 구속 48시간 후에는 전 타액선에 amylase의 응집현상이 심화되었고, 구속 168시간 후에는 amylase의 발현이 매우 감소되었다. 이상의 결과를 바탕으로 정서적인 스트레스를 받으면 타액선이 변성될 수 있으며, 타액선으로부터 분비되는 중요한 소화 효소인 amylase가 변화되어 소화 장애를 일으키거나 구강건강과 관계없이 구취발생에도 영향을 미칠 수 있다고 예측할 수 있어, 향후 amylase의 분비변화에 따른 지속적인 연구가 필요할 것으로 생각된다.

• 한국도로학회논문집
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• 제16권6호
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• pp.95-104
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• 2014

PURPOSES : The purpose of this study is to evaluate the degree of restraint (DOR) of longitudinal steel at continuously reinforced concrete pavement (CRCP) against environmental loadings. METHODS : To measure the longitudinal steel strain, 3-electrical resistance and self-temperature compensation gauges were installed to CRCP test section (thickness = 250mm, steel ratio = 0.7%) and continuously measured 10 min. intervals during 259 days. In order to properly analyze the steel strains first, temperature compensation process has been conducted. Secondly, measured steel strains were divided into 12 phases with different events such as before paving, during concrete hardening, and after first cracking, etc. RESULTS : Thermal strain rate (TSR) concept is defined as the linear strain variations with temperature changes and restraints rate of longitudinal steel against environmental loadings (especially thermal loading) with different cases is defined as degree of restraint(DOR). New concept of DOR could be indirect indicator of crack width behaviors of CRCP. CONCLUSIONS : Before paving, DOR of longitudinal steel is almost same at the coefficient of thermal expansion of steel ($12.44m/m/^{\circ}C$) because of no restraint boundary condition. After concrete pouring, DOR is gradually changed into -1 due to concrete stiffness developing with hydration. After first cracking at crack induced area, values of DOR are around -3~-5. The negative DOR stands for the crack width behavior instead of steel strain behavior. During winter season, DOR reached to -5.77 as the highest, but spring this values gradually reduced as -1.7 as the lowest. Based on this observation, we can presume crack width decreased over time within the time frame of this study. This finding is not consistent with the current theory on crack width variations over time, so further study is necessary to identify the causes of crack width reducing. One of the reasons could be related to concrete stress re-distribution and stress relaxation.

• Steel and Composite Structures
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• 제24권6호
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• pp.689-695
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• 2017

The constitutive relation is an important factor in analysis of confined concrete in composite structures. In order to propose a constitutive model for nonlinear analysis of confined concrete, lateral restraint mechanism of confined concrete is firstly analyze to study the generalities. As the foundation of the constitutive model, peak stress and peak strain is the first step in research. According to the generalities and the Twin Shear Unified Strength Theory, a novel unified equation for peak stress and peak strain are established. It is well coincident with experimental results. Based on the general constitutive relations and the unified equation for peak stress and peak strain, we propose a unified and convenient constitutive model for confined concrete with fewer material parameters. Two examples involved with steel tube confined concrete and hoop-confined concrete are considered. The proposed constitutive model coincides well with the experimental results. This constitutive model can also be extended for nonlinear analysis to other types of confined concrete.