• Asian Pacific Journal of Cancer Prevention
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• v.14 no.12
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• pp.7701-7706
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• 2013

Background: In a prospective cohort study of antiemetic therapy conducted in Malaysia, a total of 94 patients received low emetogenic chemotherapy (LEC) with or without granisetron injections as the primary prophylaxis for chemotherapy-induced nausea and vomiting (CINV). This study is a retrospective cost analysis of two antiemetic regimens from the payer perspective. Materials and Methods: This cost evaluation refers to 2011, the year in which the observation was conducted. Direct costs incurred by hospitals including the drug acquisition, materials and time spent for clinical activities from prescribing to dispensing of home medications were evaluated (MYR 1=$0.32 USD). As reported to be significantly different between two regimens (96.1% vs 81.0%; p=0.017), the complete response rate of acute emesis which was defined as a patient successfully treated without any emesis episode within 24 hours after LEC was used as the main indicator for effectiveness. Results: Antiemetic drug acquisition cost per patient was 40.7 times higher for the granisetron-based regimen than for the standard regimen (MYR 64.3 vs 1.58). When both the costs for materials and clinical activities were included, the total cost per patient was 8.68 times higher for the granisetron-based regimen (MYR 73.5 vs 8.47). Considering the complete response rates, the mean cost per successfully treated patient in granisetron group was 7.31 times higher (MYR 76.5 vs 10.5). The incremental cost-effectiveness ratio (ICER) with granisetron-based regimen, relative to the standard regimen, was MYR 430.7. It was found to be most sensitive to the change of antiemetic effects of granisetron-based regimen. Conclusions: While providing a better efficacy in acute emesis control, the low incidence of acute emesis and high ICER makes use of granisetron as primary prophylaxis in LEC controversial.

• The Transactions of The Korean Institute of Electrical Engineers
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• v.56 no.9
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• pp.1527-1534
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• 2007

This paper proposes a new concept of optimal governor-response power flow (OGPF) to obtain an optimal set of control parameters when the systems are in mid-term conditions after disturbances, ignoring the system dynamics. The idea of GOPF simply comes from the attempt to find an optimal solution of the governor-response power flow (GPF), which is a pre-exiting tool that is used to get power flow solutions that would exist several seconds after an event is applied. GPF incorporates the simplified model of governors in the systems into the power flow equations. This paper explains the concept of OGPF and depicts the OGPF formulation and application of a nonlinear interior point method as the solution technique. Also, this paper includes an example with New England 39-bus test system to illustrate the effectiveness of GOPF.

• Proceedings of the Korean Society for Noise and Vibration Engineering Conference
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• 2005.05a
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• pp.941-944
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• 2005

Asymmetry of rotor systems is an important factor for identification of dynamic characteristics including the stability and response of rotors and for condition monitoring. In this work, asymmetry of rotors is identified by applying curve-fitting method to the directional frequency response functions (dFRFs), which are known as a powerful tool for detecting the presence and degree of asymmetry. This method minimizes least square error between analytical and measured dFRFs by iteratively updating physical parameters associated with rotor asymmetry. The effectiveness of the identification method is demonstrated by experiments with a laboratory test rotor.

• Journal of Power System Engineering
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• v.17 no.6
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• pp.33-39
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• 2013

It is very important to analyze the dynamic responses of the shell structures from the viewpoint of the design of shell structures with a variety of axisymmetric loadings. In this paper, the computational algorithm for the dynamic response analysis of an cylindrical shell with axisymmetric loading is formulated by the transfer mass coefficient method based on the transfer of mass coefficient. After the computational programs for obtaining the dynamic responses of cylindrical shells with axisymmetric loading are made by the transfer mass coefficient method and the finite element method, the computational results by both methods are compared. From the computational results, we can confirm that the transfer mass coefficient method has the effectiveness in the dynamic response analyses of cylindrical shells with a variety of axisymmetric loadings.

• Journal of Korean Association for Spatial Structures
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• v.2 no.3 s.5
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• pp.103-113
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• 2002

This thesis investigates vibration response characteristics of building frames in which dampers are installed. The frames belong to passively vibration-controlled. Structures which utilizes energy dissipation of mechanical dampers provided in the structure. In this thesis, a turbulent flow damper sealed by visco-elastic material was dealt with as the device of passive vibration control. To investigate the resisting force characteristics of the damper, harmonic vibratration tests were carried out. Based on the test results, a theoretical model of the damper resistance was presented and a method of identifying the model parameters was proposed. Shaking table tests of the frame with and without the dampers were carried out and the effectiveness of the damper was examined. The response of the frame with the dampers was reduced to 1/2 or 1/3 of the cases without the damper.

• Journal of KSNVE
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• v.10 no.4
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• pp.648-654
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• 2000

A procedure to determine the realizable optimal positions of rigid supports is suggested to get a maximum fundamental natural frequency. a measured frequency response function based substructure-coupling technique is used to model the supported structure. The optimization procedure carries out the eigenvalue sensitivity analysis with respect to the stiffness of supports. As a result of such stiffness optimization, the optimal rigid-support positions are shown to be determined by choosing the position of the largest stiffness. The optimally determined support conditions are verified to satisfy the eigenvalue limit theorem. To demonstrate the effectiveness of the proposed method, the optimal support positions of a plate model are investigated. Experimental results indicate that the proposed method can effectively find out the optimal support conditions of the structure just based on the measured frequency response functions without any use of numerical model of the structure.

• Transactions of the Korean Society of Automotive Engineers
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• v.5 no.6
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• pp.192-201
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• 1997

The feedback control scheme of the pressure control system of the rear wheel steering gear which has relatively large volume and sprung load was built up in order to improve th response characteristic of the system. The control algorithm chosen was a feedback compensator joined by a feedfoward compensator and the model matching method was used in the process of control system design. The structures and properties of the reference models were inspected and the parameters of the controller were decided. The improvement of the response characteristic of the pressure control valve by means of the feedback control is affirmed. Particularly, when the order of the system model is higher than the 2nd order, the effectiveness of the feedback control on the improvement of the response characteristic of the valve is distinct. And the convenience of the model matching method is the process of control system design is confirmed as well.

• International Journal of Aeronautical and Space Sciences
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• v.9 no.1
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• pp.85-99
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• 2008

The dynamic response analysis for large structures using finite element method requires a large amount of computational resources. This paper presents an efficient vibration analysis procedure by combining node-based substructuring reduction method with a response analysis scheme for structures with undamped, proportional or nonproportional damping. The iterative form of substructuring reduction scheme is derived to reduce the full eigenproblem and to calculate the dynamic responses. In calculating the time response, direct integration scheme is used because it can be applied directly to the reduced model. Especially for the non proportional damping matrix, the transformation matrices defined in the displacement space are used to reduce the system. The efficiency and the effectiveness of the present method are demonstrated through the numerical examples.

• Structural Engineering and Mechanics
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• v.53 no.2
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• pp.249-260
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• 2015

Damage detection based on a reference set of measured data usually has the problem of different environmental temperature in the two sets of measurements, and the effect of temperature difference is usually ignored in the subsequent model updating. This paper attempts to identify the structural damage including the temperature difference with artificial measurement noise. Both local damages and the temperature difference are identified in a gradient-based model updating method based on dynamic response sensitivity. The sensitivities of dynamic response with respect to the system parameters and temperature difference are calculated by direct integration method. The measured dynamic responses of the structure from two different states are used directly to identify the structural local damages and the temperature difference. A single degree-of-freedom mass-spring system and a planar truss structure are studied to illustrate the effectiveness of the proposed method.

• Smart Structures and Systems
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• v.8 no.2
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• pp.157-172
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• 2011

A new method for both local damage(s) identification and input excitation force identification of beam structures is presented using the dynamic response sensitivity-based finite element model updating method. The state-space approach is used to calculate both the structural dynamic responses and the responses sensitivities with respect to structural physical parameters such as elemental flexural rigidity and with respect to the force parameters as well. The sensitivities of displacement and acceleration responses with respect to structural physical parameters are calculated in time domain and compared to those by using Newmark method in the forward analysis. In the inverse analysis, both the input excitation force and the local damage are identified from only several acceleration measurements. Local damages and the input excitation force are identified in a gradient-based model updating method based on dynamic response sensitivity. Both computation simulations and the laboratory work illustrate the effectiveness and robustness of the proposed method.