• Journal of Convergence for Information Technology
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• v.12 no.4
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• pp.126-132
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• 2022

At present, due to the rapid spread of smartphones and activation of IoT, malicious codes are disseminated using SNS, or intelligent intrusions such as intelligent APT and ransomware are in progress. The damage caused by the intelligent intrusion is also becoming more consequential, threatening, and emergent than the previous intrusion. Therefore, in this paper, we propose an intelligent intrusion situation-aware reasoning system to detect transgression behavior made by such intelligent malicious code. The proposed system was used to detect and respond to various intelligent intrusions at an early stage. The anticipated system is composed of an event monitor, event manager, situation manager, response manager, and database, and through close interaction between each component, it identifies the previously recognized intrusive behavior and learns about the new invasive activities. It was detected through the function to improve the performance of the inference device. In addition, it was found that the proposed system detects and responds to intelligent intrusions through the state of detecting ransomware, which is an intelligent intrusion type.

• Journal of the Korea Society of Computer and Information
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• v.26 no.12
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• pp.85-97
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• 2021

In this paper, in order to support rapid and effective decision-making and response in disaster situations, we identified the author's organization of academic research papers and conducted a collaborative relationship analysis study based on this. For this purpose, 2,308 papers in 69 Korean academic journals classified by disaster and safety type were selected for analysis and experimental data were constructed based on the Korea Science Citation Database (KSCD) and institutional identification data provided by KISTI. Collaborative relationship analysis was conducted for each of the four units (Institution, Institution type, Institution region and University department type). First, statistical status such as frequency of appearance was compared, and basic properties and main centrality index of each co-occurrence network were calculated and analyzed using Social Network Analysis Method. In addition, a visualization map was created and presented for each network so that the collaborative relationship could be viewed and understood as a whole. The results of this study are expected to contribute to the search activities of institutions and cooperative groups that support effective disaster response and to lay the foundation for the information service system.

• Journal of the Korea Society of Computer and Information
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• v.14 no.2
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• pp.139-147
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• 2009

BLAST (Basic Local Alignment Search Tool) is a best well-known tool in a bioinformatics area. BLAST quickly compares input sequences with annotated huge sequence databases and predicts their functions. It helps biologists to make it easy to annotate newly found sequences with reduced experimental time, scope, and cost. However, as the amount of sequences is increasing remarkably with the advance of sequencing machines, performance of BLAST has been a critical issue and tried to solve it with several alternatives. In this paper, we propose a new PC-Based Cluster system (E-Cluster), a new physical data design methodology (logical partitioning technique) and a query routing technique (intra-query routing). To verify our system, we measure response time, speedup, and efficiency for various sizes of sequences in NR (Non-Redundancy) database. Experimental result shows that proposed system has better speedup and efficiency (maximum 600%) than those o( conventional approaches such as SMF machines, clusters, and grids.

• Animal Bioscience
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• v.37 no.1
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• pp.61-73
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• 2024

Objective: The main objective of this study was to define molecular mechanisms associated with thermal stress responses of chickens from commercial broilers (BR, Ross 308), Thai native chickens (NT) and crossbreeds between BR×NT (H75). Methods: Twenty days before reaching specific market age, chickens from each breed were divided into control and thermal-stressed groups. The stressed groups were exposed to a cyclic thermal challenge (35℃±1℃ for 6 h, followed by 26℃±1℃ for 18 h) for 20 days. Control group was raised under a constant temperature of 26℃±1℃. Pectoralis major (n = 4) from each group was collected for transcriptome analysis using HiSeq Illumina and analysis of glycogen and lactate. Gene expression patterns between control and thermal-stressed groups were compared within the same breeds. Results: Differentially expressed transcripts of 65, 59, and 246 transcripts for BR, NT, and H75, respectively, were revealed by RNA-Seq and recognized by Kyoto encyclopedia of genes and genomes database. Pathway analysis underlined altered glucose homeostasis and protein metabolisms in all breeds. The signals centered around phosphatidylinositol 3-kinase (PI3K)/Akt signaling, focal adhesion, and MAPK signaling in all breeds with slight differences in molecular signal transduction patterns among the breeds. An extensive apoptosis was underlined for BR. Roles of AMPK, MAPK signaling and regulation of actin cytoskeleton in adaptive response were suggested for H75 and NT chickens. Lower glycogen content was observed in the breast muscles of BR and NT (p<0.01) compared to their control counterparts. Only BR muscle exhibited increased lactate (p<0.01) upon exposure to the stress. Conclusion: The results provided a better comprehension regarding the associated biological pathways in response to the cyclic thermal stress in each breed and in chickens with different growth rates.

• Journal of Microbiology and Biotechnology
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• v.19 no.4
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• pp.351-357
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• 2009

Natural wild-type strains of Bacillus subtilis are extensively used in agriculture as biocontrol agents for plants. This study examined two antagonist B. subtilis strains, KB-1111 and KB-1122, and the results illustrated that KB-1122 was a more potent inhibitor of the indicator pathogen than KB-1111. Thus, to investigate the intrinsic differences between the two antagonist strains under normal culture conditions, samples of KB-1111 and KB-1122 were analyzed using MALDI-TOF-MS. The main differences were related to 20 abundant intracellular and 17 extracellular proteins. When searching the NCBI database, a number of the differentially expressed proteins were identified, including 11 cellular proteins and 10 secretory proteins. Among these proteins, class III stress-response-related ATPase, aconitate hydratase, alpha-amylase precursor, and a secretory protein, endo-l, 4-beta-glucanase, were differentially expressed by the two strains. These results are useful to comprehend the intrinsic differences between the antagonism of KB-1111 and KB-1122.

• The Journal of Society for e-Business Studies
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• v.20 no.1
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• pp.79-88
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• 2015

Many servers, such as web and database servers, receive a continual stream of requests. The servers should schedule these requests to provide the best services to users. In this paper, a hybrid genetic algorithm is proposed for scheduling divisible requests without interruption in which the objective is to minimize the total stretch. The stretch of a request is the ratio of the amount of time the request spent in the system to its response time. The hybrid genetic algorithm adopts the idea of seed selection and development in order to improve the exploitation and exploration power of genetic algorithms. Extensive computational experiments have been conducted to compare the performance of the hybrid genetic algorithm with that of genetic algorithms.

• Proceedings of the Korean Society of Plant Pathology Conference
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• 2003.10a
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• pp.81.1-81
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• 2003

Although plants have evolved to possess various defense mechanisms from local biotic and abiotic stressors, most of yield loss is caused by theses stressors. Recent studies have revealed that several different stress responsive reactions are inter-networking. Therefore, the identification and dissection of stress responsive genes is an essential and first step towards understanding of the global defense mechanism in response to various stressors. For this purpose, we applied cDNA microarray analysis, because it has powerful ability to monitor the global gene expression in a specific situation. To date, more than 10,000 non-redundant genes were identified from seven different cDNA libraries and deposited in our EST database (http://plant.pdrs.re.kr/ks200201/pepper.html). For this study, we have built 5K cDNA microarray containing 4,685 unigene clones from three different cDNA libraries. Monitoring of gene expression profiles of hot pepper interactions with biotic stress, abiotic stresses and chemical treatments will be presented. Although this work shows expression profiling at the sub-genomic level, this could be a good starting point to understand the complexity of global defense mechanism in hot pepper.

• IMMUNE NETWORK
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• v.14 no.1
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• pp.7-13
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• 2014

Molecular mimicry is an attractive mechanism for triggering autoimmunity. In this review, we explore the potential role of evolutionary conserved bacterial proteins in the production of autoantibodies with focus on granulomatosis with polyangiitis (GPA) and rheumatoid arthritis (RA). Seven autoantigens characterized in GPA and RA were BLASTed against a bacterial protein database. Of the seven autoantigens, proteinase 3, type II collagen, binding immunoglobulin protein, glucose-6-phosphate isomerase, ${\alpha}$-enolase, and heterogeneous nuclear ribonuclear protein have well-conserved bacterial orthologs. Importantly, those bacterial orthologs are also found in human-associated bacteria. The wide distribution of the highly conserved stress proteins or enzymes among the members of the normal flora and common infectious microorganisms raises a new question on how cross-reactive autoantibodies are not produced during the immune response to these bacteria in most healthy people. Understanding the mechanisms that deselect auto-reactive B cell clones during the germinal center reaction to homologous foreign antigens may provide a novel strategy to treat autoimmune diseases.

• Genomics & Informatics
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• v.14 no.4
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• pp.222-229
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• 2016

Kimchi is a traditional Korean food prepared by fermenting vegetables, such as Chinese cabbage and radishes, which are seasoned with various ingredients, including red pepper powder, garlic, ginger, green onion, fermented seafood (Jeotgal), and salt. The various unique microorganisms and bioactive components in kimchi show antioxidant activity and have been associated with an enhanced immune response, as well as anti-cancer and anti-diabetic effects. Red pepper inhibits decay due to microorganisms and prevents food from spoiling. The vast amount of biological information generated by academic and industrial research groups is reflected in a rapidly growing body of scientific literature and expanding data resources. However, the genome, biological pathway, and related disease data are insufficient to explain the health benefits of kimchi because of the varied and heterogeneous data types. Therefore, we have constructed an appropriate semantic data model based on an integrated food knowledge database and analyzed the functional and biological processes associated with kimchi in silico. This complex semantic network of several entities and connections was generalized to answer complex questions, and we demonstrated how specific disease pathways are related to kimchi consumption.

• Journal of Information Technology Applications and Management
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• v.17 no.1
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• pp.83-105
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• 2010

The competence of enterprise for managing information is evaluated not by the amount of information but by the quality of information such as response time, data consistency, and data correctness. The degradation of data quality is usually caused by the inappropriate process of managing the structure and value of stored data. According to the recent survey on the actual condition of data quality management, the correctness and consistency of data appeared to be the most problematic area among the six criteria of data quality management such as correctness, consistency, availability, timeliness, accessibility, and security. Moreover, the problem was more serious in case of small and medium-sized companies than large enterprises. In this paper, therefore, we attempt to propose a new data quality control methodology for small and medium-sized companies that can improve the correctness and consistency of data without consuming too much time and cost. To adopt the proposed methodology to real application immediately, we provided some scripts for as-is analysis and devised automation tools for managing naming rules of vocabulary, terminology, and data code. Additionally, we performed case study on the distribution service of a small-sized company to estimate the applicability of our tool and methodology.