• 정보처리학회논문지D
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• 제11D권1호
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• pp.51-60
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• 2004

개방형 GIS에서 GIS 클라이언트는 동일한 인터페이스를 통해 서로 다른 GIS 서버의 공간 데이터에 접근할 수 있는 장점을 갖는다. 따라서, 개방형 GIS 컴포넌트 소프트웨어는 서로 다른 GIS 서버간의 상호 운용성(interoperability)을 보장한다. 그러나, GIS 클라이언트가 공간 데이터에 접근하기 위해서 표준 인터페이스론 사용한다면, 사용자의 응답시간이 느려지는 단점을 갖는다. 왜냐하면, 상호 운용성을 위해서는 각 GIS 서버로부터 접근된 공간 데이터를 표준 인터페이스를 통해 접근할 수 있도록 OLE/DB의 로셋과 같은 공통된 데이터 모델로 변환해야 하기 때문이다. 이 논문에서는 GIS 클라이언트에서 데이터 버퍼를 통해 사용자 응답 시간의 지연 문제를 해결한다. 이 논문에서는 공간 분할에 의한 버퍼관리 방법을 설계하고, 개방형 GIS 컴포넌트 소프트웨어인 MapBase 컴포넌트를 통해 구현하였다. 또한 성능 평가 실험을 통해 이 논문에서 제안한 버퍼 관리 방법이 GIS 클라이언트에서 데이터 접근 성능을 개선함을 보였다.

• 한국초지조사료학회지
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• 제38권3호
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• pp.190-195
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• 2018

Cold, salt and heat are the most critical factors that restrict full genetic potential, growth and development of crops globally. However, clarification of genes expression and regulation is a fundamental approach to understanding the adaptive response of plants under unfavorable environments. In this study, we applied an annealing control primer (ACP) based on the GeneFishing approach to identify differentially expressed genes (DEGs) in Italian ryegrass (cv. Kowinearly) leaves under cold, salt and heat stresses. Two-week-old seedlings were exposed to cold ($4^{\circ}C$), salt (NaCl 200 mM) and heat ($42^{\circ}C$) treatments for six hours. A total 8 differentially expressed genes were isolated from ryegrass leaves. These genes were sequenced then identified and validated using the National Center for Biotechnology Information (NCBI) database. We identified several promising genes encoding light harvesting chlorophyll a/b binding protein, alpha-glactosidase b, chromosome 3B, elongation factor 1-alpha, FLbaf106f03, Lolium multiflorum plastid, complete genome, translation initiation factor SUI1, and glyceraldehyde-3-phosphate dehydrogenase. These genes were potentially involved in photosynthesis, plant development, protein synthesis and abiotic stress tolerance in plants. However, this study provides new insight regarding molecular information about several genes in response to multiple abiotic stresses. Additionally, these genes may be useful for enhancement of abiotic stress tolerance in fodder crops as well a crop improvement under unfavorable environmental conditions.

• Smart Structures and Systems
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• 제14권5호
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• pp.811-830
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• 2014

A numerical study has been carried out to simulate an innovative monitoring procedure to detect and localize damage in reinforced concrete beams retrofitted with carbon fiber reinforced polymer (CFRP) unidirectional laminates. The main novelty of the present simulation is its ability to conduct the electromechanical admittance monitoring technique by considerably compressing the amount of data required for damage detection and localization. A FEM simulation of electromechanical admittance-based sensing technique was employed by applying lead zirconate titanate (PZT) transducers to acquire impedance spectrum signatures. Response surface methodology (RSM) is finally adopted as a tool for solving inverse problems to estimate the location and size of damaged areas from the relationship between damage and electromechanical admittance changes computed at PZT transducer surfaces. This statistical metamodel technique allows polynomial models to be produced without requiring complicated modeling or numerous data sets after the generation of damage, leading to considerably lower cost of creating diagnostic database. Finally, a numerical example is carried out regarding a steel-reinforced concrete (RC) beam model monotonically loaded up to its failure which is also retrofitted by a CFRP laminate to verify the validity of the present metamodeling monitoring technique. The load-carrying capacity of concrete is predicted in the present paper by utilizing an Ottosen-type failure surface in order to better take into account the passive confinement behavior of retrofitted concrete material under the application of FRP laminate.

• 정보처리학회논문지:소프트웨어 및 데이터공학
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• 제7권10호
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• pp.397-404
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• 2018

현재 스마트폰에서는 사용자의 요구에 맞는 다양한 앱(App)들이 활용되고 있는데, 특히 많은 기업들에서 비즈니스 마케팅, 상업적인 홍보 등을 위해 모바일 메신저 형태의 대화형 시스템을 연구 개발하여 고객들에게 다양한 서비스를 제공하고 있다. 이러한 대화형 시스템을 우리는 '챗봇(Chatbot)'이라고 부른다. 이러한 챗봇의 경우 사용자와 대화시 중복 응답이 자주 발생할 수 있는데, 이러한 중복응답의 경우 특정 서비스에 대한 사용자의 흥미와 관심도를 떨어뜨린다. 따라서 본 논문에서는 이러한 챗봇 개발시 사용자로부터 입력된 발화(utterance)에 따른 챗봇의 중복 응답을 정의하고 이를 감소시킬 수 있는 기법을 제안한다. 이를 위해 데이터베이스 내 다중 테이블을 구축하고 테이블별로 사용자 입력에 따른 챗봇의 응답 조합을 구성하여 새로운 중복 회피 알고리즘을 통해 챗봇의 중복 응답을 감소시킬 수 있도록 한다. 이렇게 제안한 기법의 검증을 위해 자동화된 챗봇을 구현하였고, 본 연구에서 제시한 기법과 기존 응답 방식 연구를 분석해본 결과, 본 연구에서 제안한 기법을 통해 평균 70% 정도의 중복 감소 효과를 확인할 수 있었다.

• 융합보안논문지
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• 제6권4호
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• pp.67-73
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• 2006

실시간 사이버위협에서 정형화 방법은 각 보안장비의 이벤트를 실시간 분석하여 인터넷 웜, 바이러스, 해킹 등의 사이버공격에 대한 네트워크 이상 징후를 임계치와 상관관계를 틀 통하여 탐지하고, 동 평가결과의 통계분석을 통해 정형화 방안 기능을 부여하고 실효성 있는 사이버공격대응시스템을 구축하는데 있다. 본 논문은 우선 위협지표 산출과 동 지표의 합산을 통한 위협평가 및 조기 경보 과정의 패키지화로 만들고, 사이버 위협 지표 계산의 기준을 설정한다. 특히 보안사고 발생 시 각 보안장비의 이벤트와 트래픽 양에 대한 정의 및 데이터베이스 입력 방법을 구체화하여 실시간 대응 및 조기예경보체계의 초석이 가능한 정형화 방안을 제시한다. 분석을 위해 축적한 90일간의 데이터 임계치 설정작업을 통해 보다 정확한 적용 값을 계산한다. 산출한 값을 토대로 정형화가 가능한 보안이벤트 정보를 표준데이터로 적용, 각 보안장비 및 HoneyNet 시스템, 기타 취약정보 등과의 상관관계를 분석하여 보안이벤트 표준지수를 산출한다.

• 한국임상약학회지
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• 제27권3호
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• pp.150-160
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• 2017

Background: Recently, a fixed combination of grazoprevir and elbasvir (GE) has been introduced to the arsenal of chemotherapeutics to fight against this virus. The study aimed to provide information on the efficacy and safety of GE for the treatment of HCV infection by performing a meta-analysis of literature data. Methods: PubMed and EMBASE database searches were conducted. Among the literature retrieved, pivotal Phase III clinical studies were analyzed. Statistical analysis of the data was performed by RevMan. Results: Four pivotal Phase III clinical studies compared the efficacy and safety of GE. When HCV patients were treated with GE for 12 weeks, the sustained virologic response, defined as the viral RNA level below the lower limit of quantification at 12 weeks after the cessation of therapy (SVR12), was 94.7%. The clinical advantage of GE involves its use by patients with cirrhosis and/or renal failure without dose adjustment. If the genotype (GT) of the causative virus was GT1a with NS5A polymorphism or GT4 with resistance to peginterferon/ribavirin, treatment with GE plus ribavirin for 16 weeks resulted in a better outcome compared to treatment with GE alone for 12 weeks. Adverse events reported during the four clinical studies were 71.09% in the GE arms and it was 76.61% in the non-GE arms, with the most frequent events being mild central nervous system symptoms. Conclusion: GE was generally safe and effective for the treatment of HCV infection. However, since HCV mutates very rapidly and becomes resistant to antiviral agents, long-term monitoring should be mandatory.

• Earthquakes and Structures
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• 제7권4호
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• pp.485-510
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• 2014

In performance-based seismic design procedures Peak Ground Acceleration (PGA) and pseudo-Spectral acceleration ($S_a$) are commonly used to predict the response of structures to earthquake. Recently, research has been carried out to evaluate the predictive capability of these standard Intensity Measures (IMs) with respect to different types of structures and Engineering Demand Parameter (EDP) commonly used to measure damage. Efforts have been also spent to propose alternative IMs that are able to improve the results of the response predictions. However, most of these IMs are not usually employed in probabilistic seismic demand analyses because of the lack of reliable Ground Motion Prediction Equations (GMPEs). In order to define seismic hazard and thus to calculate demand hazard curves it is essential, in fact, to establish a GMPE for the earthquake intensity. In the light of this need, new GMPEs are proposed here for the elastic input energy spectra, energy-based intensity measures that have been shown to be good predictors of both structural and non-structural damage for many types of structures. The proposed GMPEs are developed using mixed-effects models by empirical regressions on a large number of strong-motions selected from the NGA database. Parametric analyses are carried out to show the effect of some properties variation, such as fault mechanism, type of soil, earthquake magnitude and distance, on the considered IMs. Results of comparisons between the proposed GMPEs and other from the literature are finally shown.

• Structural Engineering and Mechanics
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• 제61권4호
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• pp.527-538
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• 2017

The evaluation of the loss-of-support conditions of frictional beam-to-column connections using simplified numerical models describing the transverse response of a portal-like structure is presented in this paper considering the effects of the seismic-hazard disaggregation. Real earthquake time histories selected from European Strong-motion Database (ESD) are used to show the effects of the seismic-hazard disaggregation on the beam loss-of-support conditions. Seismic events are classified according to different values of magnitudes, epicentral distances and soil conditions (stiff or soft soil) highlighting the importance of considering the characteristics of the seismic input in the assessment of the loss-of-support conditions of frictional beam-to-column connections. A rigid and an elastic model of a frame of a precast industrial building (2-DoF portal-like model) are presented and adopted to find the minimum required friction coefficient to avoid sliding. Then, the mean value of the minimum required friction coefficient with an epicentral distance bin of 10 km is calculated and fitted with a linear function depending on the logarithm of the epicentral distance. A complete parametric analysis varying the horizontal and vertical period of vibration of the structure is performed. Results show that the loss-of-support condition is strongly influenced by magnitude, epicentral distance and soil conditions determining the frequency content of the earthquake time histories and the correlation between the maxima of the horizontal and vertical components. Moreover, as expected, dynamic characteristics of the structure have also a strong influence. Finally, the effect of the column nonlinear behavior (i.e. formation of plastic hinges at the base) is analyzed showing that the connection and the column are a series system where the maximum force is limited by the element having the minimum strength. Two different longitudinal reinforcement ratios are analyzed demonstrating that the column strength variation changes the system response.

• Asian Pacific Journal of Cancer Prevention
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• 제15권24호
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• pp.10797-10801
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• 2015

Background: To explore the molecular mechanisms of metastatic osteosarcoma (OS) by using the microarray expression profiles of metastatic and non-metastatic OS samples. Materials and Methods: The gene expression profile GSE37552 was downloaded from Gene Expression Omnibus database, including 2 human metastatic OS cell line models and 2 two non-metastatic OS cell line models. The differentially expressed genes (DEGs) were identified by Multtest package in R language. In addition, functional enrichment analysis of the DEGs was performed by WebGestalt, and the protein-protein interaction (PPI) networks were constructed by Hitpredict, then the signal pathways of the genes involved in the networks were performed by Kyoto Encyclopaedia of Genes and Genomes (KEGG) automatic annotation server (KAAS). Results: A total of 237 genes were classified as DEGs in metastatic OS. The most significant up- and down-regulated genes were A2M (alpha-2-macroglobulin) and BCAN (brevican). The DEGs were significantly related to the response to hormone stimulus, and the PPI network of A2M contained IL1B (interleukin), LRP1 (low-density lipoprotein receptor-related protein 1) and PDGF (platelet-derived growth factor). Furthermore, the MAPK signaling pathway and focal adhesion were significantly enriched. Conclusions: A2M and its interactive proteins, such as IL1B, LRP1 and PDGF may be candidate target molecules to monitor, diagnose and treat metastatic OS. The response to hormone stimulus, MAPK signaling pathway and focal adhesion may play important roles in metastatic OS.

• 정보교육학회논문지
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• 제7권2호
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• pp.199-206
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• 2003

XML은 데이터 관리와 표현의 유연성으로 인해 웹의 새로운 개발 도구로 자리를 잡아가고 있으며, 컴퓨터 교육에서는 학습객체라는 많은 웹 컨텐츠들을 통합하는 도구로도 사용되고 있다. 하지만 학습객체를 통합하고 관리하는 온라인 학습 시스템을 구현하기에 앞서, 구현 시스템에서 학습객체를 처리하기 위한 메타데이터를 어떻게 저장하고 추출 및 통합하느냐의 연구가 선행되어져야 한다. 따라서 본 연구에서는 3-tier 방식의 온라인 학습 시스템과 메타데이터가 저장된 데이터베이스 서버를 구현할 때 필요한 메타데이터 추출방법의 하나로 DBMS의 웹서비스를 이용하는 방법을 제안하고자 한다. 제안된 방법의 효율성 측정을 위해 MS SQL Server 2000과 Oracle 9i를 대상으로 30여개의 샘플 메타데이터를 저장하고, 이를 추출하는 응답시간을 측정해 보았다. 이 방법을 사용하기 위해서는 추출된 메타데이터를 DOM/SAX 와 같은 XML 처리 파서가 필요하지만, 측정된 결과 비교적 빠른 응답시간을 보여 데이터베이스에 저장된 메타데이터를 추출하고 통합하는 한 방법으로 충분히 사용할 수 있다는 결과를 얻었다.