• Smart Structures and Systems
• /
• v.20 no.4
• /
• pp.427-440
• /
• 2017

One of the suitable structural damage detection methods using vibrational characteristics are damage-index-based methods. In this study, a damage index for identifying damages in plate structures using frequency response function (FRF) data has been provided. One of the significant challenges of identifying the damages in plate structures is high number of degrees of freedom resulting in decreased damage identifying accuracy. On the other hand, FRF data are of high volume and this dramatically decreases the computing speed and increases the memory necessary to store the data, which makes the use of this method difficult. In this study, FRF data are compressed using two-dimensional principal component analysis (2D-PCA), and then converted into damage index vectors. The damage indices, each of which represents a specific condition of intact or damaged structures are stored in a database. After computing damage index of structure with unknown damage and using algorithm of lookup tables, the structural damage including the severity and location of the damage will be identified. In this study, damage detection accuracy using the proposed damage index in square-shaped structural plates with dimensions of 3, 7 and 10 meters and with boundary conditions of four simply supported edges (4S), three clamped edges (3C), and four clamped edges (4C) under various single and multiple-element damage scenarios have been studied. Furthermore, in order to model uncertainties of measurement, insensitivity of this method to noises in the data measured by applying values of 5, 10, 15 and 20 percent of normal Gaussian noise to FRF values is discussed.

• Asian Pacific Journal of Cancer Prevention
• /
• v.13 no.6
• /
• pp.2459-2465
• /
• 2012

Background: Numbers of epidemiological studies assessing residential radon exposure and risk of lung cancer have yielded inconsistent results. Methods: We therefore performed a meta-analysis of relevant published case-control studies searched in the PubMed database through July 2011 to examine the association. The combined odds ratio (OR) were calculated using fixed- or random-effects models. Subgroup and dose-response analyses were also performed. Results: We identified 22 case-control studies of residential radon and lung cancer risk involving 13,380 cases and 21,102 controls. The combined OR of lung cancer for the highest with the lowest exposure was 1.29 (95% CI 1.10-1.51). Dose-response analysis showed that every 100 Bq/$m^3$ increment in residential radon exposure was associated with a significant 7% increase in lung cancer risk. Subgroup analysis displayed a more pronounced association in the studies conducted in Europe. Studies restricted to female or non-smokers demonstrated weakened associations between exposure and lung cancer. Conclusions: This meta-analysis provides new evidence supporting the conclusion that residential exposure to radon can significantly increase the risk of lung cancer in a dose-response manner.

• Asian Pacific Journal of Cancer Prevention
• /
• v.14 no.3
• /
• pp.1819-1823
• /
• 2013

Objective: Microarray data were analyzed to explore key genes and their functions in progression of colorectal cancer (CRC). Methods: Two microarray data sets were downloaded from Gene Expression Omnibus (GEO) database and differentially expressed genes (DEGs) were identified using corresponding packages of R. Functional enrichment analysis was performed with DAVID tools to uncover their biological functions. Results: 631 and 590 DEGs were obtained from the two data sets, respectively. A total of 32 common DEGs were then screened out with the rank product method. The significantly enriched GO terms included inflammatory response, response to wounding and response to drugs. Two interleukin-related domains were revealed in the domain analysis. KEGG pathway enrichment analysis showed that the PPAR signaling pathway and the renin-angiotensin system were enriched in the DEGs. Conclusions: Our study to systemically characterize gene expression changes in CRC with microarray technology revealed changes in a range of key genes, pathways and function modules. Their utility in diagnosis and treatment now require exploration.

• Asian Pacific Journal of Cancer Prevention
• /
• v.15 no.18
• /
• pp.7737-7740
• /
• 2014

Background: The neutrophil-to-lymphocyte ratio (NLR) is a strong predictor of mortality in patients with pancreatic, colorectal, lung, gastric cancer and renal cell carcinoma. The aim of this study was to determine the relationship between pathological complete response (pCR) and pretreatment NLR values in locally advanced breast cancer (BC) patients receiving neoadjuvant chemotherapy (NACT). Materials and Methods: Datawere collected retrospectively from the Akdeniz University School of Medicine Database for locally advanced BC patients treated with NACT between January 2000-December 2013. Results: A total of 78 patients were analyzed. Sixteen (20%) patients achieved pCR. Estrogen receptor (ER) positivity was lower in pCR+ than pCR-cases (p=0.011). The median NLR values were similar in both arms. The optimum NLR cut-off point for BC patients with PCR+ was 2.33 (AUC:0.544, 95%CI [0.401-0.688], p=0.586) with sensitivity, specificity, positive predictive value and negative predictive value (NPV) of 50%, 51,6%, 21,1%, and 80%, respectively. Conclusions: This study showed no relationship between the pCR and pretreatment NLR values. Because of a considerable high NPV, in the patients with higher NLR who had luminal type BC in which pCR is lower after NACT, such treatment may not be recommended.

• Asian Pacific Journal of Cancer Prevention
• /
• v.15 no.8
• /
• pp.3645-3649
• /
• 2014

The aim of this study was to evaluate the efficacy of third-line combined androgen blockade (CAB) therapy for castration-resistant prostate cancer that relapsed after primary and second-line CAB. We retrospectively reviewed the medical records of 52 patients who received first-, second-, and third-line CAB therapy (medical or surgical castration, plus steroidal antiandrogen of chlormadinone acetate, or nonsteroidal antiandrogen of flutamide or bicalutamide). For cumulative analysis, we searched the PubMed database and identified a total of 50 cases published in English. Including our cases, this provided a total of 102 cases for analysis. In our study cohort, 11 cases (21.2%) achieved more than 50% reduction of serum prostate-specific antigen (PSA) on initiation of third-line CAB. We found that third-line CAB with nonsteroidal antiandrogen after second-line CAB with steroidal antiandrogen exhibited favorable results, with a positive response in six of 13 patients (46.2%). Cumulative analysis findings were comparable. Regarding the timing of third-line CAB administration, 15 patients had started at a PSA equal to or less than 4.0 ng/ml, and eight of them (53.3%) showed a positive response to treatment, compared to only three of 37 patients (8.1%) whose PSA at the initiation of third-line therapy was higher than 4.0 ng/ml (p<0.001). We conclude that third-line CAB with nonsteroidal antiandrogen would be particularly useful for patients whose cancer progressed after second-line CAB with steroidal antiandrogen. The timing of treatment seems to be important because the higher the PSA at the start of third-line therapy, the lower the PSA response rate.

• International Journal of Highway Engineering
• /
• v.14 no.2
• /
• pp.11-17
• /
• 2012

This research describes how to predict a model of the tensile strain related to the fatigue cracking performance of several asphalt concrete structures through design of experiments(e.g., Response Surface Methodology) and harmony search(HS) algorithm. The axisymmetric analysis program of finite element method, which is the KICTPAVE, was used to determine the strain level at the interface layer between asphalt layer and lean concrete layer. Once the training database set of various strain levels was constructed under the several condition of layer stiffnesses and thicknesses in the asphalt concrete structures, the data set was trained through the HS algorithm in order to determine the regression coefficients defined based on a response surface methodology. Furthermore, the testing set, which was not used for the training procedure of HS algorithm, was also constructed in order to evaluate whether the regression coefficients of a prediction model can be appropriately applied for other cases in asphalt concrete structures.

• Journal of Digital Convergence
• /
• v.14 no.4
• /
• pp.43-53
• /
• 2016

The purpose of this study is to examine the meaningfulness and the possibility of developing kinetic narrative educational contents based on English literature with convergent approaches. To accomplish the objective, this paper examines three areas of research such as kinetic education, English literature education, and total physical response-storytelling method. It introduces the following three stages of development procedure: 1) selecting and analyzing English literature, 2) designing a prototype including the story flow, the movement and the motion interaction design, and 3) constructing motion database using Laban movement analysis. Then, how to apply it to young learners is illustrated with 'the story of the three little pigs,' Finally, implication for the field of young learner English education and English literature is discussed.

• Journal of the Korea institute for structural maintenance and inspection
• /
• v.18 no.4
• /
• pp.107-117
• /
• 2014

This study tests homogeneity and performs multiple comparison analysis among treatment levels of each factor group through t-test by materials and analysis of variance by structural type and service period. For that descriptive statistical analysis is performed for static and dynamic response characteristics and their ratios of calculated versus measured values based on a good many safety assessment reports for bridges. Homogeneity and post hoc test based on descriptive statistical analysis provide the measures for homogeneity identification among comparison groups in addition to the statistical reference values such as central tendency, variation and shape. This study is expected to be valuable for structural integrity assessment and design by comparing the measured and calculated values with the reference values for the homogeneous group identified, which can help the engineers review the adequacy of the values and put the group database to practical use.

• Journal of Digital Contents Society
• /
• v.15 no.5
• /
• pp.631-642
• /
• 2014

The main memory DBMS is operated which the contents of the table that resides on a disk at the same time as the drive is in the memory. However, because the main memory DBMS stores the data and transaction log file using the disk file system, there are a limit to the speed at which the CPU accesses the memory. In this paper, I evaluated the performance through analysis of the application side difference the technology that has been implemented in Altibase system of main memory DBMS and Sybase of disk-based DBMS. When the application performance of main memory DBMS is in comparison with the disk-based DBMS, the performance of main memory DBMS was outperformed 1.24~3.36 times in the single soccer game, and was outperformed 1.29~7.9 times in the soccer game / special soccer. The result of sale transaction response time showed a fast response time of 1.78 ~ 6.09 times.

• Journal of The Korean Society of Clinical Toxicology
• /
• v.15 no.2
• /
• pp.116-121
• /
• 2017

Purpose: The aim of this study was to compare the toxicologic profiles and outcome of poisoned patients by comparing the data obtained through telephone counselling, each provided by emergency medical information center (1339) and emergency dispatch center (119). Methods: We analyzed the telephone-based poison exposure data before and after Seoul 1339 merged to 119. We compared the Seoul 1339 call response data in 2008 with Seoul and Busan 119 call response data between 2014 and 2016. We analyzed the changes in the trend and quality of data obtained, as well as the quality of service provided by each center before and after this reallocation, by comparing the data each obtained through telephone counselling. Results: The data was collected for a total of 2260 toxin exposure related calls made to Seoul 1339 in 2009, and 1657 calls to 119 in Seoul and Busan between 2014 and 2016. Significant difference was observed for age, sex, and reason for exposure to toxic substance between the two groups. Conclusion: After the integration of 1339 with 119, 119 focused on role of field dispatch and hospital transfer, lacking the consulting on drug poisoning. Moreover, data on exposure to toxic substances at the pre-hospital stage indicate that drug information and counseling are missing or unknown. In addition, first aid or follow-up instructions are not provided. Thus, systematic approach and management are required.